Treatment Of Alcoholic Pancreatitis Research Articles

Ulinastatin in the Management of Severe Acute Alcoholic Pancreatitis: A Case Series.

Severe acute alcoholic pancreatitis is a second common form of pancreatitis that requires intensive care unit care and has high morbidity and mortality due to lacking specific treatment. Management of alcoholic pancreatitis is generally non- specific and supportive. We hereby present a case-series of three patients that describes the successful treatment of severe acute alcoholic pancreatitis with ulinastatin and other supportive treatment. From this we want to emphasize that ulinastatin a protease inhibitor can be used in the treatment of alcoholic pancreatitis.

Failure of glucagon in the treatment of alcoholic pancreatitis

Glucagon has been claimed to be an effective treatment for pancreatitis, but the studies reporting this were either uncontrolled or did not use concurrent controls, and none were double blind. To evaluate the efficacy of glucagon for alcohol-related pancreatitis, we performed a controlled, randomized, double blind study. Twenty-six patients with pancreatitis associated with alcohol ingestion received either glucagon or placebo in addition to intravenous fluids, nasogastric suction, and meperidine as needed. There were no statistically significant differences between the group which received glucagon and the group which did not in any of 12 parameters which included symptoms, signs, laboratory tests, and requests for analgesia. We conclude that glucagon in addition to conventional therapy is no better for the treatment of alcoholic pancreatitis than conventional therapy alone.

Nasogastric Suction in Pancreatitis

To the Editor.— We wish to respond to Dr. Palmer's editorial critique (229:73, 1974) of our article Nasogastric Suction in the Treatment of Alcoholic Pancreatitis (229:51, 1974). The results of our study indicated that nasogastric suction provided no clear-cut therapeutic advantage over no suction in the treatment of attacks of mild to moderately severe, uncomplicated, acute alcoholic pancreatitis. Dr. Palmer dismisses these results: Misappropriation of the scientific method results when a clinical trial utilizes case material that is not classified precisely. Consequently the mix of patients proves too heterogenous to permit a fair effort at comparison.... Apparently, he believes that we erred by grouping mild and moderately severe cases of pancreatitis together. This raises two questions: (1) Were our treatment groups satisfactorily matched in regard to severity? and (2) Is there a category of pancreatitis patient that we failed to identify that is benefited by suction? As described in the

Nasogastric Suction in the Treatment of Alcoholic Pancreatitis

Twenty-nine patients with mild to moderately severe acute alcoholic pancreatitis were randomly allocated to treatment with or without nasogastric suction. Antibiotics, anticholinergics, and antacids were not used. No significant differences were found between the two groups in duration of the following: abdominal pain, abdominal tenderness, nausea, narcotic requirement, fever, and elevated serum and urine amylase levels. The data suggested that even though a larger proportion of patients treated with suction became pain-free within the first two days of treatment, treatment without suction was associated with earlier return of normal bowel sounds and smaller risk of prolonged hyperamylasemia. Because nasogastric suction provided no clear-cut advantages in this admittedly small group, it might be considered elective rather than mandatory in the treatment of mild to moderately severe acute alcoholic pancreatitis. (<i>JAMA</i>229:51-52, 1974)

Nasogastric suction in the treatment of alcoholic pancreatitis. A controlled study

Nasogastric suction in the treatment of alcoholic pancreatitis. A controlled study

Pancreatitis: The role of vagotomy, antrectomy, and Billroth II gastroenterostomy in the treatment of alcoholic pancreatitis

The etiology and pathogenesis of pancreatitis with special reference to alcoholic pancreatitis are discussed. The physiologic rationale of vagotomy, antrectomy, and Billroth II gastroenterostomy in the treatment of alcoholic pancreatitis is presented. The results in fourteen patients treated in this manner, who have been followed for up to five years, were good in five, fairly good in six, and fair in three.

Treatment of alcoholic pancreatitis (Case report)

Treatment of alcoholic pancreatitis (Case report)