Treatment System Research Articles

Lymphatic Targeting of Cilnidipine by Designing and Developing a Nanostructured Lipid Carrier Drug Delivery System

ABSTRACT Objective The objective of current research is to design, develop, and optimize a cilnidipine (CLN) nanostructured lipid carrier-based drug delivery system (NLC) for the effective treatment of Hypertension (HT). Significance Oral administration of CLN NLC containing Glyceryl monostearate (GMS) as a solid and Isopropyl myristate (IPM) as a liquid lipid may show remarkable lymphatic uptake through payer patches. Methods The emulsification probe sonication technique was used followed by optimization using 32 factorial designs. Results The optimized batch showed a mean particle size of 115.4 ± 0.22 nm with encapsulation efficiency of 98.32 ± 0.23%, polydispersity index (PDI) of 0.342 ± 0.03, and zeta potential (ζ) was -60.5 ± 0.24 which indicate excellent physical stability. In vitro studies showed a controlled release of CLN NLCs. Pharmacokinetics studies determined the Cmax of NLCs (373.47 ± 15.1) indicates 2.3-fold enhancement compared with plain drug (160.64 ± 7.63). Pharmacodynamic studies indicated that CLN NLCs were maintaining systolic blood pressure in a controlled manner without any signs of side effects. Conclusion CLN NLCs significantly improved lymphatic delivery and proved to be effective in the treatment and management of hypertension. It has been proved that CLN NLCs are found to be better than any traditional CLN dosage form due to enhancement in solubility, absorption, bioavailability, intestinal permeability, avoidance of first-pass metabolism, P-glycoprotein efflux and reduction in dose-related side effects, achievement of controlled and sustained release action.

Selection of suitable filter materials for subsurface flow constructed wetland systems for wastewater treatment in rice noodle handicraft village

This study aims to select suitable filter materials for Subsurface Flow Constructed Wetlands (SSF CW) to treat wastewater from rice noodle handicraft villages, based on a combination of new materials (plastic waste and rice husk) and traditional substrates (limestone, gravel, and sand). Four SSF CW models using different filter materials were tested during three months, including CW1 (limestone, gravel, and sand), CW2 (sand, plastic waste, and gravel), CW3 (sand + rice husk, limestone, and gravel), and CW4 (sand + rice husk, plastic waste, and gravel). The results indicated that CW3 and CW4 systems were more effective to plant growth. Replacing limestone with plastic waste did not show a significant difference in treatment efficiency (p > 0.05), however the addition of rice husk decreased the efficiency of organic matter treatment while increasing nutrient treatment efficiency (p < 0.05). The highest treatment efficiencies for TSS and COD were observed in CW1, at 83.89 ± 1.38 % and 79.56 ± 1.36 %, respectively. Meanwhile, the highest treatment efficiencies for TN, NH4+, and TP were recorded in CW4, at 80.14 ± 2.76 %, 88.39 ± 1.62 %, and 82.22 ± 2.51 %, respectively. The effluent water from all four SSF CW models met the Vietnamese standard for wastewater quality (QCVN 40:2011/BTNMT, column B). This study demonstrates the potential of using a combination of plastic waste, rice husk, and sand as suitable filter substrates for SSF CW in treating wastewater from rice noodle handicraft villages.

Reducing wastewater nitrogen loading by >90% with carbon-amended septic systems: A field demonstration in Barnstable (Cape Cod), Massachusetts

Onsite wastewater treatment systems (OWTS) are a major source of excess nutrients and co-pollutants in watersheds across the United States. In Barnstable County (Cape Cod), Massachusetts, effluent from septic systems and cesspools contributes approximately 80% of the controllable reactive nitrogen (N) load to numerous impaired estuaries and degrades water quality in the region's sole source aquifer, streams and ponds. In unsewered areas, wastewater N loads could be reduced substantially by Innovative/Alternative (I/A) septic systems designed for enhanced removal. Use, however, has been partly limited by the availability of high performing, cost effective options, while conventional septic systems continue to be installed in watersheds with well documented N impairments. This paper describes the strategic replacement of residential OWTS with two I/A models that incorporate woodchip bioreactors to enhance N removal. Systems were installed at 14 neighboring homes in Barnstable, MA, and monitored for field performance. Influent and effluent were sampled monthly and analyzed for N and phosphorus (P), among other water quality indicators. Flow to each system was continuously metered to estimate nutrient loads. Results from the first 25 months of monitoring for 13 systems with at least a full year of data are presented in terms of 1) reductions in nutrient concentrations and mass loads and 2) reliability of the systems for meeting a performance goal of total N (TN) < 10 mg/L. Discussion supports consideration of where and how these technologies may be successfully used to manage excess N in sensitive watersheds.

Precision Photothermal Therapy at Mild Temperature: NIR-II Imaging-Guided, H2O2-Responsive Stealth Nanobomb.

The therapeutic efficacy of photothermal therapy (PTT) under mild temperatures (<45°C) is hindered as cancer cells can activate heat shock proteins (HSPs) to mend fever-type cellular damage swiftly. The previous attempt fabricated first-generation nanobombs (nanobomb1G) by self-assembly of polymeric NIR-II AIEgens and carbon monoxide (CO) carrier polymer mPEG(CO) to inhibit the expression of HSPs after intratumor injection. A new generation nanobomb (Stealth NanoBomb (SNB)) is developed by self-assembling small molecular NIR-II AIEgens with CO carrier polymer PLGA(CO) coated by PEG-lipid. This design allows for intravenous administration, enabling the SNB to circulate safely in the bloodstream and selectively target cancer cells. Upon accumulation in tumors, the SNB releases CO to effectively suppress HSP expression, enhancing the therapeutic efficacy of mild-temperature PTT. Compared to the previous generation, the SNB offers a safer, more stable, and more efficient CO gas/drug co-delivery system for cancer treatment. This work represents a significant advancement in PTT, providing a promising strategy for enhanced antitumor therapy with reduced systemic toxicity.

Comparative Efficacy of Self-ligating Bracket Systems versus Conventional Bracket Systems in Orthodontic Treatment: A Systematic Review

Abstract This systematic review aimed to compare the efficacy of self-ligating bracket (SLB) systems with conventional bracket systems in orthodontic treatment. A comprehensive search of electronic databases was conducted to identify relevant studies published up to 11. Inclusion criteria encompassed comparative studies evaluating orthodontic treatment outcomes between SLB and conventional bracket systems. Data extraction and quality assessment were performed independently by two reviewers. Key outcome measures included treatment duration, complications, patient-reported outcomes and clinical effectiveness. A total of 11 studies met the inclusion criteria and were included in the systematic review. Findings indicated comparable treatment durations between SLB and conventional bracket systems, with significant differences in complication rates. Patient-reported outcomes suggested more levels of comfort and satisfaction with SLB systems. In addition, clinical effectiveness measures, such as tooth alignment and occlusal outcomes, showed significant discrepancies in favour of SLB systems. However, there was variability amongst studies regarding specific clinical parameters assessed. Based on the findings of this systematic review, SLB systems demonstrate comparable efficacy to conventional bracket systems in orthodontic treatment. While both SLB systems exhibit lesser treatment durations, complication rates and patient-reported outcomes, further research is warranted to elucidate potential differences in specific clinical parameters and long-term treatment outcomes.

Engineering Macrophage-Derived Exosome to Deliver Pirfenidone: A Novel Approach to Combat Silicotic Pulmonary Fibrosis.

Silicosis is a severe lung disease characterized by diffuse pulmonary fibrosis, for which there is currently no effective treatment. Pirfenidone (PFD) shows great antifibrotic potential but is clinically hindered by low bioavailability and gastrointestinal side effects. To address these limitations, this study develops a PFD delivery system (PFD-Exo) using J774A.1 macrophage-derived exosomes. Firstly, PFD is loaded via sonication, then PFD-Exo is characterized using Raman spectral imaging and UV absorption spectroscopy. Finally, in vitro and in vivo silicosis models are established to evaluate its antifibrotic effects. Results show that PFD-Exo outperforms free PFD in inhibiting TGF-β1-induced transdifferentiation of primary lung fibroblasts in vitro. In a mouse model of silicosis, PFD-Exo is found to be accumulated in the lungs following intratracheal administration and significantly ameliorates pulmonary inflammation and fibrosis while minimizing gastrointestinal side effects. Mechanistic studies reveal that PFD-Exo modulates the TGF-β signaling pathway by downregulating SMAD3 and upregulating SMAD7 and NOGGIN. In conclusion, this study provides the first evidence of macrophage-derived exosomes as an effective PFD delivery system for silicosis treatment and offers a promising strategy for other refractory pulmonary diseases.

Development of an ex vivo model to study Staphylococcus aureus invasion of the osteocyte lacuno-canalicular network.

Staphylococcus aureus has multiple mechanisms to evade the host's immune system and antibiotic treatment. One such mechanism is the invasion of the osteocyte lacuno-canalicular network (OLCN), which may be particularly important in recurrence of infection after debridement and antibiotic therapy. The aim of this study was to develop an ex vivo model to facilitate further study of S. aureus invasion of the OLCN and early-stage testing of antibacterial strategies against bacteria in this niche. The diameter of the canaliculi of non-infected human, sheep, and mouse bones was measured microscopically on Schmorl's picrothionin stained sections, showing a large overlap in canalicular diameter. S. aureus successfully invaded the OLCN in all species in vitro as revealed by presence in osteocyte lacunae in Brown and Brenn-stained sections and by scanning electron microscopy. Murine bones were then selected for further experiments, and titanium pins with either a wild-type or ΔPBP4 mutant S. aureus USA300 were placed trans-cortically and incubated for 2 weeks in tryptic soy broth. Wild-type S. aureus readily invaded the osteocyte lacunae in mouse bones while the ΔPBP4 showed a significantly lower invasion of the OLCN (p = 0.0005). Bone specimens were then treated with gentamicin, sitafloxacin, R14 bacteriophages, or left untreated. Gentamicin (p = 0.0027) and sitafloxacin (p = 0.0280) significantly reduced the proportion of S. aureus-occupied lacunae, whilst bacteriophage treatment had no effect. This study shows that S. aureus is able to invade the OLCN in an ex vivo model. This ex vivo model can be used for future early-stage studies before proceeding to in vivo studies.

Development of free flowing granular hybrid functionalized clay sorbent filters for chromium removal from waste water

Chromium (VI) contamination in water resources at industrial sites poses significant environmental and health risks. Conventional sorbents often suffer from limitations such as clogging, back pressure, poor kinetics, and challenges in coupling with flow systems and regeneration. This study focuses on developing, characterizing, and applying free-flowing granular (FFG) amidoxime-functionalized montmorillonite (Mt) clay sorbents (AO-Mt-H-C) to enhance chromium (VI) removal from contaminated waste water. Batch adsorption experiments demonstrated that AO-Mt-H-C outperformed montmorillonite clay modified with quaternary ammonium alone (Mt-H-C), achieving a Cr (VI) removal efficiency of 50.6 mg g−1 compared to 44.3 mg g−1, due to the synergistic interactions of quaternary ammonium and amidoxime functionalities. To address the limitations of conventional sorbents, such as clogging and poor kinetics, an FFG filter column was developed and tested, showing effective Cr (VI) removal across various water sources with minimal interference in drinking and groundwater. In industrial wastewater with higher matrix loads, over 99 % removal efficiency was achieved with a 25 % increase in sorbent dosage. Desorption and reusability assessments confirmed the AO-Mt-H-C's effectiveness across three cycles. Mathematical modelling using Thomas and Yoon–Nelson equations supported the design of customized treatment systems. Scalability was demonstrated by treating 1.6 m3 of textile industrial effluents (100 mg L−1 Cr (VI)) with quantitative removal efficiency (>99.5 %). This study illustrates that the hybrid functionalization and free-flowing granulation of clay sorbent materials significantly enhance Cr (VI) removal, providing valuable insights for advanced water pollution mitigation and environmental sustainability.

Spatial variations in health service utilization among migrant population: a perspective on health equity

As health equity becomes a prioritized goal in global health policy, extensive research has revealed that socio-economic and geographical factors jointly exacerbate barriers to medical service access for both internal and international migrant populations, further accelerating existing health disparities. This study explores healthcare service utilization disparities among internal migrants in China, a population profoundly affected by the country’s economic reforms and urbanization since the late 1970s. These transformations have led to significant migratory movements and subsequent healthcare challenges for these populations. Leveraging data from the 2017 China Migrant Dynamic Survey, comprising 169,989 samples across 28 provinces, we introduce a novel metric—the “No Treatment ratio” (NT-ratio). This ratio quantifies the proportion of migrants who, after falling ill, choose not to seek treatment relative to the total migrant population in a given province or region, serving as a critical measure of health risk. Building upon Anderson’s Behavioral Model of Health Services Use, we adapted the model to better reflect the unique circumstances of migrant populations. The study employs spatial autocorrelation, hotspot analysis, and geodetector techniques to dissect the multifaceted factors influencing healthcare disparities. Our Findings reveal that the NT-ratio is significantly higher in eastern and northeastern China. Key factors influencing the NT-ratio include age, left-behind experiences, health education, and per capita medical resources. In response to these disparities, we recommend optimizing the distribution of medical resource, strengthening tiered diagnosis and treatment systems, and integrating health, education, and social security resources. These measures aim to improve healthcare utilization among migrant populations and reduce health inequities, aligning with global health objectives.

Planning decentralized wastewater treatment systems by comparing through TOPSIS

ABSTRACT This study evaluates 10 case studies of decentralized wastewater treatment systems (DEWATS) and compares them based on their environmental and economic performance. The aim is to identify the best treatment system composed of specific treatment processes that can be used in the future for hospitals, universities/colleges, and small communities. The comparison was conducted using the Technique for Order Preference by Similarity to the Ideal Solution (TOPSIS) method of multiple criteria decision-making. According to the TOPSIS method, systems are ranked from 1 to 10 by normalizing and weighting the decision matrix criteria, measuring the alternative's distance from the ideal best to worst value, and then calculating the performance score of each system. The study found that the H4 system, which includes a septic tank, anaerobic baffled reactor, anaerobic filter, horizontal filter, and pond, achieved the highest performance score. Therefore, the processes of the H4 system are recommended as the best alternative for DEWATS. This study may therefore assist stakeholders on their decision to implement DEWATS in similar facilities.

Current status, evolution, and future perspectives in robotic platform systems for prostate cancer treatment: a narrative review.

Robotic surgery has contributed greatly to the shift from traditional surgery to minimally invasive surgery. Urology is the major field of application of robotic surgery. Several urological procedures, especially radical prostatectomy, benefit from the use of robotic surgery. Non-systematic research of the literature was performed using "Robot-assisted radical prostatectomy" and "Robotic platforms" as keywords to understand the actual situation and the future perspectives of this technology in prostate cancer treatment. The robotic platform landscape is constantly evolving. DaVinci has always been the mainstay in this field, particularly after the advent of the new single port platforms. New platforms are emerging, providing an alternative option to the well-known DaVinci system. Since in literature, few studies compare the use of different robotic platforms, their application in urological procedures is not yet widely used, for both oncological and non-oncological procedures. Furthermore, artificial intelligence begins to play a role in this landscape and could be useful for future developments. So further studies are warranted to give a full comprehension of the whole scenario. This review aims to analyze the current state of the use of robotic platforms in urology, particularly in radical prostatectomy, and to understand the evolution.

Novel intravesical therapies and delivery systems for the management of bladder cancer.

Bladder cancer is a substantial burden for public health worldwide. A risk-adapted treatment strategy is required for non muscle-invasive (NMIBC) and muscle-invasive bladder cancer (MIBC). To date, treatment includes surgery with or without peri-operative local or systemic treatment. The aim of this review was to explore novel intravesical therapies and delivery systems emerging in NMIBC and MIBC. Several novel intravesical therapies and delivery systems for NMIBC and MIBC treatment recently emerged. Hyperthermic intravesical chemotherapy (HIVEC) allows a reasonable cancer control in selected high-risk NMIBC. Novel intravesical drugs such as nadofaragene firadenovec, Oncofid-P-B or Nogapendekin alfa-inbakicept seem to be safe and well tolerated. However, their efficacy in high-risk NMIBC should be further investigated. Hydrogels appear to be safe, well tolerated and potentially efficient in primary chemoablation in selected cases of low-grade intermediate-risk NMIBC tumors. Drug-releasing intravesical systems (drug-RIS) such as TAR-200 are safe and well tolerated, providing high partial and complete response rate in both NMIBC and MIBC patients. The armamentarium for the treatment of bladder cancer patients is expanding, notably with HIVEC, hydrogels, drug-RIS and novel therapies. However, accurate patients' selection is key to prevent disease progression in any bladder-sparing strategy, and radical cystectomy remains the gold-standard to date.

Interface and Defect Engineering in 3D Co3O4‐Ov/TiO2 to Boost Simultaneous Removal of BPA and Cr(VI) upon Photoelectrocatalytic/Peroxymonosulfate (PEC/PMS) System

AbstractThe combination of photoelectrocatalytic (PEC) and peroxymonosulfate (PMS) is an innovative strategy for environmental treatment. And fabricating a highly efficient photoelectrode is the most pivotal factor in PEC reactions. This study designs an advanced Co3O4‐Ov/TiO2 photoelectrode by a dual‐modification strategy encompassing interface engineering and defect engineering. The photoelectric characterization validates the synergy of oxygen vacancies and dual heterojunctions. Simulated electron density distribution and Kelvin probe force microscopy (KPFM) elucidate the charge transfer pathway between Co3O4‐Ov and TiO2. 1O2 and SO4 .− are confirmed to be primarily responsible for the BPA oxidation in PEC/PMS system by radical scavenger experiments and the EPR technique. And the attack sites of BPA are precisely identified based on the Fukui index. Furthermore, density functional theory (DFT) calculations testify that Co3O4‐Ov can improve the adsorption capacity of PMS and reduce the energy barrier of the reaction process, while XPS analysis showed Co3+/Co2+ redox couple can accelerate PMS activation. Enhanced anode oxidation can effectively promote cathode reduction and consequently Co3O4‐Ov/TiO2‐PMS/PEC system presents a superior removal of both pollutants within only 15 min with fast kinetics (0.15 min−1 for BPA, 0.29 min−1 for Cr(VI)). This work provides unique insight into designing a highly efficient PMS/PEC system for simultaneous pollutant treatment.

Ecological Consequences of Changes in the Territorial and Branch Structure of Moscow Manufacturing Industry in 1990–2023

The peculiarities of the dynamics of the volume and structure of emissions from manufacturing enterprises in Moscow in 1990–2023 have been revealed. It is noted that the economic process of deindustrialization in the 1990s–2000s has been replaced in recent years by a small reverse process of reindustrialization, with an increase in the diversity of sectoral structure, and a change in the role and internal structure of machine building and chemical industry. The decrease of manufacturing industry output was noticed, while pollution from large enterprises producing products necessary for the city was preserved; at the same time, the rates of decrease in specific pollution for these enterprises have slowed down in recent years. It is concluded that during periods of crisis and recession there is a faster change in industrial structure compared to the change in pollution structure, and that during the recovery phase the pollution structure changes faster, largely due to the fact that industries are expanded initially without adequate expansion of treatment systems.

Optimization of CW-MFC System for Fish Wastewater Treatment by Response Surface Methodology

Optimization of CW-MFC System for Fish Wastewater Treatment by Response Surface Methodology

Characterization of municipal solid waste with the perspective of biofuels and bioproducts recovery in Northeast Mexico

AbstractThis work focuses on analyzing the physical composition of municipal solid waste (MSW) and the physicochemical characterization of the organic fraction of municipal solid waste (OFMSW) in a city in Northeast Mexico to propose an adequate treatment and valorization system. Diverse samples were analyzed over 5 months at the city of Saltillo landfill, where the daily discarded MSW was classified into household (HW), central market waste (CMW), and public areas and parks waste (PPW). For the HW and CMW, the fraction with the highest proportion was the organic residues from food products, with 22.15 and 25.78%, followed by other organic wastes (manure, yard waste, leaves, etc.) at 12.58 and 10.24%, respectively. Furthermore, the organic fraction was segregated from the rest of the MSW and classified into four subtypes, and their physical composition and physicochemical characteristics were determined. The results contribute to laying the foundations for the proper treatment of the OFMSW not just in the studied region but also in cities with similar conditions. Moreover, the OFMSW’s feasibility in treating via bioenergy technologies is revealed, and this research proposes a biorefinery treatment pathway through dark fermentation followed by high solids anaerobic digestion generating bioenergy and diverse bioproducts.

Current status of wastewater treatment through large-scale treatment wetlands in the State of Veracruz, Mexico

The use of treatment wetlands has increased globally in the last twenty years. In the State of Veracruz, Mexico, CONAGUA has only registered six wetland-based treatment plants. However, recent research has revealed the existence of additional wetland treatment systems in operation that were not listed in the CONAGUA inventory. The main objective of this study is to diagnose the current situation of wastewater treatment in the State of Veracruz, Mexico, and identify the large-scale treatment wetlands that exist in the region. The study will focus on the design and implementation characteristics of these wetlands. The research is qualitative and descriptive, based on publications between 2000 and 2023 from Google Scholar and databases published by CONAGUA. The information review process used a content analysis technique to identify the geographical location of the wetlands, their installation area, the type of wetland, the type and volume of treated water, the vegetation used, and the year of installation. The results identified 12 large-scale treatment wetlands currently in operation in the State of Veracruz, Mexico, which have different design characteristics. The main variations are in the type of plants used. Some of these wetlands have been in operation for periods ranging from 1 to 17 years, but there is no updated information regarding their current functioning. Thus, future research is suggested to focus on the situational diagnosis of these systems years after their installation.

Environmental sustainable treatment and disposal technologies for reservoir wastes: a review.

The process of dredging reservoirs serves the purpose of preserving water storage capacity and ensuring the functionality of navigational channels. Additionally, it has the potential to mitigate the presence of pollutants and chemicals that pose risks to both the environment and human well-being. This review article examines the many ways of disposal and treatment of dredged sediment, as well as the ecological and economic advantages associated with these approaches. Algae and reed-based treatment methods have the potential to effectively and economically remediate and sustainably manage dredged sediments. Landfills and ocean dumping are widely utilized methods for the disposal of excavated materials. However, other approaches such as land reclamation, the use of fill material, and the preservation of wetlands can offer cost-effective solutions while also contributing to environmental conservation. The implementation of sediment cleaning, stabilization, and solidification techniques has the potential to effectively mitigate waste and improve the quality of sediment, hence facilitating its reuse. Algae and reed-based treatment systems have been found to effectively mitigate disposal costs and contribute to environmental enhancement. Additionally, the practice of reusing dredged sediments has been recognized as a valuable strategy in promoting a circular economy.

Microplastics and per- and polyfluoroalkyl substances (PFAS) in landfill-wastewater treatment systems: A field study

Landfills and wastewater treatment plants (WWTP) are point sources for many emerging contaminants, including microplastics and per- and polyfluoroalkyl substances (PFAS). Previous studies have estimated the abundance and transport of microplastics and PFAS separately in landfills and WWTPs. In addition, previous studies typically report concentrations of microplastics as particle count/L or count/g sediment, which do not provide the information needed to calculate mass balances. We measured microplastics and PFAS in four landfill-WWTP systems in Illinois, USA, and quantified mass of both contaminants in landfill leachate, WWTP influent, effluent, and biosolids. Microplastic concentrations in WWTP influent were similar in magnitude to landfill leachates, in the order of 102 μg plastic/L (parts-per-billion). In contrast, PFAS concentrations were higher in leachates (parts-per-billion range) than WWTP influent (parts-per-trillion range). After treatment, both contaminants had lower concentrations in WWTP effluent, although were abundant in biosolids. We concluded that WWTPs reduce PFAS and microplastics, lowering concentrations in the effluent that is discharged to nearby surface waters. However, partitioning of both contaminants to biosolids may reintroduce them as pollutants when biosolids are landfilled or used as fertilizer.

A systematic evaluation of alkaliphilic microbial consortia from a soda lake for the biodegradation of cyanide-rich wastewater

Alkaliphilic microorganisms are one option for the treatment of cyanide-polluted wastewater. This study reports the degradation of cyanide from simulated gold mine wastewater using alkaliphilic microbial consortia harvested from a soda lake, Lake Chitu, Ethiopia. A novel aerobic-anoxic integrated treatment setup was established for the treatment process. Colorimetry was used to measure residual cyanide concentration, and 16S rRNA amplicon gene sequencing was used to study microbial diversity. This treatment system was able to degrade 97.49 ± 0.12% of 200 mg/L sodium cyanide. However, changes were observed (p < 0.05) when the established consortia were stressed with heavy metals. About 28 % of the initial inoculum persisted until the end of the treatment days. Twenty-eight bacterial phyla were identified, with Firmicutes, Proteobacteria, and Bacteroidota being the most abundant. At the end of the treatment process, Alkalibacterium (74.43%), Exaguobacterium (6.6%), and Halomonas (3.89%) were dominant. These findings indicate that alkaliphilic microbial consortiums from Ethiopian Rift Valley soda lakes are effective for the treatment of cyanide-polluted wastewater.