Treatment Of Renal Failure Patients Research Articles

CARARIME: Interactive web server for comprehensive analysis of renal allograft rejection in immune microenvironment.

Renal transplantation is a very effective treatment for renal failure patients following kidney transplant. However, the clinical benefit is restricted by the high incidence of organ rejection. Therefore, there exists a wealth of literature regarding the mechanism of renal transplant rejection, including a large library of expression data. In recent years, research has shown the immune microenvironment to play an important role in renal transplant rejection. Nephrology web analysis tools currently exist to address chronic nephropathy, renal tumors and children's kidneys, but no such tool exists that analyses the impact of immune microenvironment in renal transplantation rejection. To fill this gap, we have developed a web page analysis tool called Comprehensive Analysis of Renal Allograft Rerejction in Immune Microenvironment (CARARIME). CARARIME analyzes the gene expression and immune microenvironment of published renal transplant rejection cohorts, including differential analysis (gene expression and immune cells), prognosis analysis (logistics regression, Univariable Cox Regression and Kaplan Meier), correlation analysis, enrichment analysis (GSEA and ssGSEA), and ROC analysis. Using this tool, researchers can easily analyze the immune microenvironment in the context of renal transplant rejection by clicking on the available options, helping to further the development of approaches to renal transplant rejection in the immune microenvironment field. CARARIME can be found in http://www.cararime.com.

Sensor Data Classification for Renal Dysfunction Patients Using Support Vector Machine

Breath analysis is a non-invasive technique used in clinical laboratories for the identification of several morbid conditions. Renal failure patients can be distinguished by observing the degree of ammonia in exhaled breath. Standard treatment for renal failure patients is haemodialysis. Ammonia as a biomarker can also provide the efficiency of dialysis. This study proposes a system that uses metal oxide semiconductor sensors, which is capable of detecting ammonia from exhaled breath and identify whether the patient has been subjected to renal failure. Breath samples are gathered using a specially designed breath collecting tube and the steady-state responses are recorded after the samples have been passed through sensors TGS2444, MQ135, MQ137, and TGS826. From the steady-state response, geometric features are extracted and the support vector machine technique is used for classifying the pre- and post-dialysis groups. The results shown an accuracy of 88 % for the designed classifier for sensor TGS2444.

1461 - Awareness of Cancer Screening During the Treatment of Renal Failure Patients: Physician Questionnaire

ABSTRACT Background Survival of patients with renal insufficiency has increased. With the prolonged survival, diagnosis of cancers is not infrequently seen. The aim of cancer screening is to increase the curability. Method This study was done by face to face questionnaire in the 27th National Nephrology Congress to determine if the physicians dealing with chronic renal failure, hemodialysis or renal transplanted patients, recommend cancer screening or not and the methods of screening for cervix, prostate, breast and colon cancer. Results One hundred and forty four physicians were included in the survey. 101 participants were male. The most common age interval was between the ages of 40–49 (55.6%). About 28.5% of the participants were specialist on nephrology, 27% on internal medicine, 47.9% of participants were hemodialysis certified general practitioners and 4.9% were other areas of expertise. About 81.9% of the participants were working in the city and 59.7% of the participants in private dialysis centers. Patients were grouped as compensated chronic renal failure, hemodialysis or renal transplanted. Of the 144 123 physicians recommended breast cancer screening and the most recommended subgroup was HD patients (15.5%). The most preferred methods of screening were combinations of mammography, self breast examination and physicians' breast examination. One hundred and nine physicians recommended cervix cancer screening, and the most preferred method of screening was papsmear. Colon cancer screening was recommended by 105 physicians and prostate screening by 114 physicians. The most preferred methods of screening were fecal occult blood test and PSA plus rectal digital test, respectively. Conclusion It is not obvious whether cancer screening in renal failure patients is different from the rest of society. There is a variety of screening methods. An answer can be found to these questions as a result of studies by a common follow-up protocol and cooperation of nephrologists and oncologists. Disclosure All authors have declared no conflicts of interest.

Effects of synthetic androgen fluoxymesterone on triglyceride secretion rates in the rat.

Fluoxymesterone, a C-17 methylated derivative of testosterone employed in the treatment of renal-failure patients with refractory anemia, was administered to Sprague-Dawley rats and the effects on plasma triglyceride (TG) and immunoreactive insulin (IRI) levels and the rate of hepatic triglyceride secretion (TGSR) into plasma determined (Triton). Animals treated with fluoxymesterone demonstrated significantly lower TG (less than 0.05) and no alteration in TGSR. These findings are consistent with other observations which suggest that the triglyceride-lowering effect of androgens results from an accelerated rate of removal of triglyceride-rich lipoproteins from plasma.