Background. Chest injuries and wounds are common during armed conflicts, with frequent nosocomial infections and mortality up to 35-45% [1-4]. Infectious complications associated with multidrug-resistant microorganisms are an urgent issue in the management of patients with trauma. Aim. To conduct a retrospective review of the main causative agents of infectious complications in patients with traumatic chest injuries and evaluate antibiotic resistance of isolated pathogens. Materials and methods. Samples for microbiological examination were obtained from 160 patients with chest trauma and nosocomial complications. The samples included sputum, pleural fluid, bronchial washings obtained by fiberoptic bronchoscopy, and tracheal secretions. Antibacterial susceptibility tests were performed, and the antibiotic resistance mechanisms in isolated microorganisms were determined. Results. Gram-negative pathogens accounted for 93% of cases. The following organisms prevailed: Klebsiella pneumoniae – 42%, Acinetobacter baumannii – 28%, Pseudomonas aeruginosa – 18%, Escherichia coli – 9%. Of note, 91.4% of K. pneumoniae strains produced extended-spectrum β-lactamases and carbapenemases. The percentage of multidrug-resistant and pandrug-resistant strains was 48.2% and 52%, respectively. Conclusion. The data obtained indicate a wide spread of gram-negative microorganisms and their multiple resistance in patients with traumatic breast injuries complicated by nosocomial infection.