Thickness Of Transverse Carpal Ligament Research Articles

Time-Dependent Change in Carpal Tunnel Cross-Sectional Area and Transverse Carpal Ligament Thickness Using Serial Magnetic Resonance Imaging Studies—An Anatomical Study

Idiopathic carpal tunnel syndrome (CTS) is a common compressive neuropathy. Aging and female sex are risk factors, but the reasons are unclear. The purpose of this study was to evaluate whether identifiable radiographic changes resulting in a decrease in carpal tunnel area (CTA) over time exist. A database search of a multicenter, academic, tertiary institution from 1998 to 2021 identified 433 patients with serial wrist magnetic resonance images (MRI) at least 5 years apart. Fifty-six met the inclusion criteria with adequate films to measure CTA and transverse carpal ligament (TCL) thickness at the same slice location-the carpal tunnel inlet, hook of the hamate, and carpal tunnel outlet-independently by two observers who were blinded to each other's measurements. Rates for the change in CTA and TCL thickness were calculated at all three locations. Thickness of the TCL increased, whereas that of the CTA decreased over time. Inlet CTA decreased by 0.9 mm2 per year (95% CI: 0.34-1.5), outlet CTA decreased by 1.8 mm2 per year (95% CI: 1.2-2.5), and CTA at the hook of the hamate decreased by 1.6 mm2 per year (95% CI: 1.0-2.0 per year). The TCL thickened by 0.02 mm per year at all three sections. Taller patients had a decreased rate of CTA loss. In this select cohort, TCL thickened and CTA decreased with time. TCL thickening accounted for about half of the variation in CTA, suggesting that this is a possible contributor to this change. Hypertrophy of the carpal tunnel floor may account for the remaining variation in CTA. The question of whether these results are reliable and generalizable to the general population, or a major influence in the pathophysiology of CTS, is unknown. Small decreases in CTA and thickening of the TCL occur with aging. Whether this is a contributing factor in the development of CTS requires further study.

Robot and ultrasound assisted needle insertion to the transverse carpal ligament

BackgroundA potential alternative treatment to surgery for carpal tunnel syndrome is to inject enzymes into the transverse carpal ligament to decrease its stiffness and alleviate pressure off the median nerve. An accurate injection is needed for delivery to achieve the effects of tissue degradation. The purposes of this study were to 1) determine injection sites using 3D reconstructed anatomy, and 2) insert the needle to the middle of the transverse carpal ligament thickness in situ. MethodsSix fresh-frozen cadaveric hands were used in this study. Five injection sites were determined in the sagittal plane along the center of the transverse carpal ligament thickness ulnar to the thenar muscle attachment using 3D ultrasonographic reconstruction. Each injection was delivered by rigidly fixing a 27-gauge needle to a six degrees of freedom robot arm programmed to insert the needle tip to the intended target. Ultrasound images were taken of the needle after insertion to measure accuracy and precision of the needle placement. FindingsThe needle tip was successfully delivered to the middle region of the transverse carpal ligament thickness and visualized using ultrasound imaging. The accuracy and precision of the needle insertion were 0.83 and 0.31 mm, respectively. InterpretationMethodology was established for robot-assisted needle insertion to the transverse carpal ligament using 3D ultrasonographic reconstructed anatomy. This methodology can be used in the future to deliver enzymatic injections to the transverse carpal ligament as a potential treatment for carpal tunnel syndrome.

Dose- and time-dependent effects of collagenase clostridium histolyticum injection on transverse carpal ligament elastic modulus and thickness in vitro.

A potential treatment for carpal tunnel syndrome is to biochemically alter the mechanical properties of the transverse carpal ligament (TCL) through Collagenase Clostridium Histolyticum (CCH) injection. The purpose of this study was to determine the time- and dose-dependent effects of CCH injection on TCL elastic modulus and thickness. Nine TCLs were dissected from cadaveric hands for this study. CCH doses of 50U, 100U, 150U, 200U, and 250U were injected into five points on the TCL, respectively. B-mode and shear wave elastography images were taken of each injection point using robot-assisted ultrasound imaging immediately after injection, as well as 2, 4, 6, 8, and 24 hours after injection. TCL thickness and mean shear wave speed were measured for each CCH dose at each time point. CCH doses of 200U and 250U decreased shear wave speed by 18.70% and 30.01% (p<0.05), respectively, after 24 hours. CCH doses of 150U, 200U, and 250U decreased TCL thickness by 7.28%, 10.97%, and 14.92%, respectively, after 24 hours (p<0.05). Our findings suggest that CCH injection may be effective in degrading TCL tissue, with higher doses of CCH resulting in greater tissue degradation up to 24 hours after injection.

Evaluation of the Transverse Carpal Ligament in Carpal Tunnel Syndrome by Shear Wave Elastography: A Non-Invasive Approach of Diagnosis and Management.

ObjectivesThe goal of this work is to determine the clinical value of the transverse carpal ligament (TCL) in carpal tunnel syndrome (CTS) for guiding subsequent treatment.MethodsThis study analyzed patients who underwent median nerve (MN) ultrasound (US) examination of the wrist from April 2020 to April 2021. The cross-sectional area and anteroposterior diameter of the MN, as well as the TCL thickness and stiffness, were measured from images. The intra-group and intra-patient subgroup differences were compared using a t-test and a rank test. We also utilized receiver operating characteristic (ROC) curves to diagnose CTS and evaluate the severity.ResultsThe final cohort consisted of 120 wrists (bilateral) from 60 samples, evenly balanced across the patient and control groups according to their CTS diagnosis. In the unilateral positive patient subgroup, the MN and TCL of the positive hand were significantly thicker and stiffer than the negative counterparts (both, p < 0.05). The values from the right were also thicker and stiffer than the left (both, p < 0.05) in patients with bilateral CTS. The MN and TCL of the patient group were also significantly thicker and stiffer than those of the control group (both, p < 0.001). For diagnosing CTS, the area under the curve (AUC) of TCL thickness and stiffness at the distal carpal tunnel (DCT) ranged between 0.925 and 0.967. For evaluating CTS severity, we found that the optimal TCL stiffness is sufficient for diagnosing mild and non-mild patient cases (AUC: Emean = 0.757, Emax = 0.779).ConclusionsShear wave elastography is therefore an effective method for CTS diagnosis and management.

Correlations between transverse carpal ligament thickness measured on ultrasound and severity of carpal tunnel syndrome on electromyography and disease duration

This study aimed to evaluate the relationship between transverse carpal ligament thickness on ultrasonography and disease severity according to electromyography findings. Fifty-eight patients with carpal tunnel syndrome, aged 30–75 years, with severe (Group 1) or moderate (Group 2) electromyography findings, who underwent surgery for carpal tunnel syndrome complaints in the previous 2 years were enrolled. Patient characteristics and clinical information were recorded. The patients completed the Boston carpal tunnel syndrome questionnaire and visual analog scale (VAS) pain score. Ultrasonography and electromyography records were examined. Electromyography showed that the median nerve area was similar in the two groups. Mean age, transverse carpal ligament thickness and symptom duration were greater in group 1, but not significantly. Mean VAS and Boston scores were significantly higher in group 1. Symptom duration did not affect median nerve area. Nerve area did not correlate significantly with VAS or Boston scores, transverse carpal ligament thickness or mean age, although averages were higher in patients with long symptom duration. Disease severity and symptom duration did not affect the ultrasonography findings. Disease severity in carpal tunnel syndrome could not be determined by measuring transverse carpal ligament thickness and median nerve area on ultrasonography without electromyography.

Ultrasound examination of the median nerve in the diagnosis of carpal tunnel syndrome

Median nerve (MN) compression neuropathy (CN) at the carpal tunnel (CT) level goes up to 90 % of all tunnel neuropathies. Instrumental methods of examination that are used to diagnose this pathology are electromyography (EMG) and ultrasound (US). Objective: to systematize diagnostic possibilities and to determine the value of US for the patients with carpal tunnel syndrome (CTS). Methods: 99 patients (160 MN) of the main group with CTS (38 — unilateral, 61 — bilateral) clinical signs were analyzed. Control group included 35 patients (70 MN) without symptoms of CTS. Patients were examined clinically and with US on «Esaote MyLab 20 Plus» and PHILIPS HD 11 XE with a 5–12 MHz multi-frequency sensor. Cross-sectional nerve area (CSNA), flattening coefficient (FC), nerve deformation index (NDI), thickness of transverse carpal ligament, its shape, contours, nerve structure, median nerve and carpal ligament echogenicity were studied. EMG was performed in 64 (64.7 %) patients. Thresholds of sonographic parameters for the diagnosis of CTS were determined with ROC analysis with sensitivity and specificity calculation. Results: main qualitative ultrasound parameters of CTS were: change of nerve shape and decreased echogenicity with loss of structural pattern. CSNA in main group was (14.1 ± 4.59) mm², and control — (8.32 ± 1.92) mm², FC — 3.02 ± 0.63 and 2.48 ± 0.60, NDI — 1.21 ± 0.09 and 1.03 ± 0.06, respectively. Optimal threshold level for CSNA was value ˃ 10 mm², FC — ˃ 2.73; NDI — ≤ 1.09 (sensitivity 84.3; 68.0; 81.7 %, respectively). Total frequency of concomitant pathology in main group was 54 (33.8 %) cases, in control group — 13 (18.6 %) (p < 0.02). Conclusions: ultrasound is objective and valuable method to diagnose MN compression neuropathy at the CT level and allow to assess the adjacent structures.

The Influence of Transverse Carpal Ligament Thickness on Treatment Decisions for Idiopathic Mild to Moderate Carpal Tunnel Syndrome.

The main cause of carpal tunnel syndrome (CTS) is pathological changes in the flexor synovium, which is a known cause of pressure elevation in the carpal tunnel. The importance of the transverse carpal ligament (TCL) in the pathogenesis of CTS has hitherto been overlooked. However, the TCL significantly affects carpal biomechanics; the TCL is known to affect the carpal bone to a greater extent when intra carpal tunnel pressure is high. In addition, the effect of TCL properties on the progression course of idiopathic CTS is unknown.Therefore, we hypothesized that TCL thickness, measured using ultrasonography, would influence the results of conservative treatment for CTS patients with mild to moderate symptoms. We aimed to investigate the relationship between the ultrasound-measured TCL thickness and idiopathic carpal tunnel conservative treatment surgery rate. We analyzed the wrists of 127 patients with mild to moderate symptoms of CTS. The patients were diagnosed on the basis of electrophysiological assessment outcomes, median nerve cross-sectional area in the carpal tunnel, and clinical symptoms. The Boston carpal tunnel questionnaire score was also measured. Patients with a TCL thinner than 1.5 mm were classified into group A (n = 62), and those with a TCL thicker than 1.5 mm were classified into group B (n = 65). Patients with severe symptoms or other diseases were excluded. The patients were initially treated with night splinting after diagnosis. If symptoms were not ameliorated, steroid injection and surgical treatment were performed consecutively. The procedures were determined by a single surgeon. The mean TCL thickness was 1.51 mm: 0.98 mm in group A and 2.28 mm in group B. The percentages of patients who underwent surgery were 43.0% in group A and 67.7% in group B. Group B was 1.77 times more likely to have surgery, and the interval between diagnosis and surgery and/or steroid injection was shorter. The TCL thickness in group B was also related to cross-sectional area and symptom duration. Transverse carpal ligament thickness affects disease progression and may affect treatment efficacy, depending on the treatment method. Transverse carpal ligament thickness may be a criterion for deciding between surgical and conservative treatments based on a thickness threshold of 1.5 mm.

Effectiveness and Safety in Closed Mini-Transverse Incision with Hydro-Dissection Technique in Carpal Tunnel Release: A Cadaveric Study.

Background: Closed mini-wrist transverse incision for carpal tunnel release has been reported in decreasing surgical scar problems, but there were few cadaveric studies that proved the effectiveness and safety in this technique without protective instrument to the median nerve. Hydro-dissection was previously showed to separate median nerve and deep structures during percutaneous ultrasound guided transverse carpal ligament release. This cadaveric study aims to demonstrated effectiveness and safety of closed transverse carpal ligament (TCL) release though the mini-transverse incision at distal wrist crease combined with hydrodissection technique. Neither special instrument nor retractor was used to protect neurovascular structures. Methods: Twelve fresh frozen cadaveric wrists were included in this study. Completeness of TCL release and injury to the adjacent neurovascular structures were assessed by direct visualization. Thickness of TCL, TCL length and distance from incision to adjacent neurovascular structures were also recorded. Results: Complete release of TCL was demonstrated in all 12 (100%) wrists underwent the mini-transverse incision TCL release at distal wrist crease and hydro-dissection technique. No injury to the adjacent neurovascular structures was found in all 12 wrists. Mean of thickness of TCL and TCL length were 3 mm and 28.7 mm, respectively. The ulnar artery was the nearest structure to the incision (mean = 3.7 mm). Conclusions: The closed mini-transverse incision TCL release at distal wrist crease with hydro-dissection technique demonstrated completeness of TCL division and safety to the neurovascular structures without protecting retractor or special instrument.

New technique of ultrasound-guided injection in the carpal tunnel syndrome

In conventional ultrasound-guided corticosteroid injection in carpal tunnel syndrome (CTS), the entry point is usually at the distal crease of the wrist. However, actual pathology of CTS is caused by thickening of the transverse carpal ligament (TCL). Injection of corticosteroid can reduce inflammation and ameliorate the symptoms, but it cannot reduce the thickness of TCL. If we change the entry point to just 10 mm below the distal crease rather than at the distal crease, we can inject corticosteroid around the median nerve and into the TCL. Five patients with CTS treated with ultrasound-guided corticosteroid injection around median nerve and into the TCL. The diagnosis of CTS was made by history, physical examination, sonographic evaluation, and electrophysiologic confirmation. Sonographic examinations were performed by one physiatrist using Samsung scanner with a 5–12 MHz linear transducer. Standard 23-gauge needles were used for administration of local anesthetics and triamcinolone mixture (total 1 cm 3 ). After transverse view and longitudinal view, the entry point was determined. The entry point was below the distal crease, where the needle could easily introduce the injection material into the thickened TCL. The direction of the needle entry point was from lateral to ulnar side. Total of five female patients with CTS were included. The mean age was 55.4 ± 3.6 years. The mean duration of disease was 4.6 (range 3–8 mo) months. The results were good to excellent in all patients. There were no complications during the procedure. Ultrasound-guided corticosteroid injection in CTS, combined with injection at the thickened TCL may be a good method and further research is needed to confirm the usability.

Influence of the thickness of the transverse carpal ligament in carpal tunnel syndrome

ObjectiveTo determine if the thickness of the transverse carpal ligament measured by T2 axial magnetic resonance imaging actually influences the onset of carpal tunnel syndrome. Material and method94 patients between January 2015 and June 2016, of whom 28 had carpal tunnel syndrome, underwent magnetic resonance imaging, 37 with discomfort in different carpus regions without symptoms of carpal tunnel and 29 healthy subjects. Two observers performed 3 measurements in 3 different levels, and in the 3 groups of patients. ResultsNo statistically significant differences in transverse carpal ligament thickness measurements between the carpal tunnel syndrome group and the group without carpal tunnel involvement became apparent, but statistical differences between the control group and the carpal tunnel syndrome group, and between the control group and the group without involvement of the carpal tunnel were observed. In both these groups, the thickness of the transverse ligament was higher than in the control group. DiscussionAn increase in the thickness of the transverse ligament in was found in this study in subjects with involvement of carpal tunnel syndrome as evidenced by numerous studies in the literature. There is no certain causative factor, but rather a set of facts that make onset of the syndrome possible in a specific group of patients. ConclusionCarpal tunnel syndrome is multifactorial. The thickness of the transverse ligament does not directly affect the onset of symptoms.

Influencia del espesor del ligamento transverso del carpo en el síndrome del túnel carpiano

ObjectiveTo determine if the thickness of the transverse carpal ligament measured by T2 axial magnetic resonance imaging actually influences the onset of carpal tunnel syndrome. Material and method94 patients between January 2015 and June 2016, of whom 28 had carpal tunnel syndrome, underwent magnetic resonance imaging, 37 with discomfort in different carpus regions without symptoms of carpal tunnel and 29 healthy subjects. Two observers performed 3 measurements in 3 different levels, and in the 3 groups of patients. ResultsNo statistically significant differences in transverse carpal ligament thickness measurements between the carpal tunnel syndrome group and the group without carpal tunnel involvement became apparent, but statistical differences between the control group and the carpal tunnel syndrome group, and between the control group and the group without involvement of the carpal tunnel were observed. In both these groups, the thickness of the transverse ligament was higher than in the control group. DiscussionAn increase in the thickness of the transverse ligament in was found in this study in subjects with involvement of carpal tunnel syndrome as evidenced by numerous studies in the literature. There is no certain causative factor, but rather a set of facts that make onset of the syndrome possible in a specific group of patients. ConclusionCarpal tunnel syndrome is multifactorial. The thickness of the transverse ligament does not directly affect the onset of symptoms.

Carpal canal ultrasound examination in patients with mild hand-arm vibration disease

Objective: To investigate the clinical value of ultrasound examination of carpal canal structure in patients with mild hand-arm vibration disease. Methods: A total of 29 patients (58 wrists) with mild hand-arm vibration disease who were treated in Shenzhen Prevention and Treatment Center for Occupational Diseases from May to December, 2015 were enrolled as observation group, and 20 healthy volunteers (40 wrists) were enrolled as the control group. Color Doppler ultrasound was used to observe the morphology and echo of the median nerve in the carpal canal and 9 muscle tendons and transverse carpal ligament. The thickness of transverse carpal ligament and diameter of the median nerve at the level of the hamulus of hamate bone were measured, as well as the cross-sectional area of the median nerve at the level of pisiform bone. Results: In the 29 patients with hand-arm vibration disease patients in the observation group, 8 experienced entrapment of the median nerve in the carpal canal, among whom 5 had entrapment in both wrists; there were 13 wrists (23%) with nerve entrapment and 45 wrists (77%) without nerve entrapment. Compared with the control group, the patients with hand-arm vibration disease and nerve entrapment in the observation group showed significant thickening of the transverse carpal ligament at the level of the hamulus of hamate bone and a significant increase in the cross-sectional area of the median nerve at the level of pisiform bone (P<0.05) , while there were no significant differences in the thickness of transverse carpal ligament at the level of the hamulus of hamate bone and the cross-sectional area of the median nerve at the level of pisiform bone (t=-9.397 and -4.385, both P>0.05) . Conclusion: Ultrasound examination can clearly show the radiological changes of carpal canal contents in patients with mild hand-arm vibration disease and has a certain diagnostic value in nerve damage in patients with hand-arm vibration disease.

Page Header Logo Acta Orthop Traumatol Turc Language User Username Password Remember me Journal Content Search Browse By Issue By Author By Title Other Journals Font Size Make font size smaller Make font size default Make font size larger Open Journal Systems Journal Help Home About Log In Register Search Current Archives Information for Authors Home &gt; Vol 47, No

The aim of this study was to sonographically evaluate the anatomy of the transverse carpal ligament (TCL) after open surgical release in the treatment of carpal tunnel syndrome (CTS) and to establish new ultrasonographic criteria for the completeness of TCL release. Thirty-six patients who underwent open surgical release for CTS were recruited prospectively. Patients were evaluated with physical examination and ultrasonography before and after the operation. All patients' symptoms resolved after surgery. TCL was found to be diffusely thickened and to have lost its smooth form after surgery. Postoperative TCL thickness showed a statistically significant increase when compared with preoperative values (p<0.05). Sonography is a capable imaging method for assessment of the TCL after open release surgery. In addition, ultrasound may be considered as a complementary tool to exclude diagnosis of incomplete transection of TCL in patients with persistent symptoms.

Ultrasound Assessment of Transverse Carpal Ligament Thickness: A Validity and Reliability Study

The transverse carpal ligament (TCL) forms the palmar boundary of the carpal tunnel and plays an important role in carpal tunnel mechanics. TCL hypertrophy has been observed for individuals with carpal tunnel syndrome (CTS) and postulated as a potential etiologic factor. Ultrasound is particularly advantageous for TCL imaging because of its capability of detecting the interfaces between the TCL and other tissues. The purposes of this study were to develop an ultrasound based method to measure the TCL thickness and to test the validity and reliability of this method. Three operators conducted two sessions of ultrasound examination on eight cadaveric specimens and eight healthy volunteers. A custom script was used to calculate TCL thickness along the TCL length from the ultrasound images. The ultrasound based TCL thickness of the cadaveric specimens was compared with the dissection based TCL thickness for validation. The results showed Pearson’s correlation coefficients of 0.867–0.928, intraclass correlation coefficient (ICC) values of 0.726–0.865, a standard error of measurement of 0.02–0.07 mm and a minimal detectable difference of 0.05–0.15 mm. The high correlation coefficients and small errors indicate that the ultrasound based method is valid for measuring TCL thickness. Furthermore, ultrasound measurements showed excellent intraoperator and interoperator reliability with ICC values as 0.826–0.933 and 0.840–0.882, respectively. The ultrasound based TCL thickness was in the range of 0.93–2.34 (1.54 ± 0.33) mm and agreed well with previous studies. The ultrasound method developed in this study is a valuable tool to examine morphologic properties of healthy and pathologic TCLs.

Morphological Analysis of the Transverse Carpal Ligament

Transection of the transverse carpal ligament (TCL) for carpal tunnel syndrome is commonly performed, yet actual knowledge of TCL morphology is rudimentary and the anatomical terminology is inconsistently used. The purpose of this study was to perform a morphological analysis of the TCL, to redefine the anatomical terminology concerning the TCL and surrounding structures, and to evaluate any correlation between external, measurable hand dimensions, and TCL dimensions. A silicone casting technique and digitization were employed to measure the morphology of the TCL in cadaveric specimens and to construct a three-dimensional TCL model. The TCL was the thickest distally at the midline and ulnar segments and the thickest proximally at the radial segment. External hand dimensions did not significantly correlate with TCL dimensions. The TCL thickness distribution is variable along the radioulnar axis. The thickness of the TCL was 2.1 ± 0.8mm, ranging from 1.3 to 3.0mm.

手根管症候群の家族発生例

We treated surgically 54 wrists in 48 patients with carpal tunnel syndrome (CTS) between April, 1976 and October, 1988: idiopathic CTS, 34 wrists in 29 patients; traumatic CTS 10 wrists; specific inflammatory CTS, 5 wrists; familial CTS, 4 wrists in 3 patients; and other 1 wrist.This reported family consists of 7 members of one generation. Within 7 siblings, 5 patients (two brothers and three sisters) were found to have the carpal tunnel syndrome and 4 wrists in 3 patients were operatively treated at our hospital. Operative and pathological findings were considerable thickening and degeneration of the transverse carpal ligaments in 4 wrists in 3 patients of familial CTS.We think that this thickness of transverse carpal ligament was the most common cause of the familial CTS, but on the other hand, thickness of flexor synovialis was the most common cause of idiopathic CTS.