Transvaginal Color Doppler Sonography Research Articles

Serum miRNA Combined With Transvaginal Color Doppler Ultrasound Diagnosis Clinical Research on Cervical Cancer.

To explore clinical value of miRNA-18a, miRNA-130a, and miRNA-92a combined with transvaginal color Doppler ultrasound (TVCDS) in the diagnosis of cervical cancer (CC). One hundred patients with pathologically confirmed CC (CC group), 100 patients with cervical epithelial neoplasia (disease group), and 100 patients with benign uterine lesions (control group) were selected. TVCDS was performed, and the levels of serum miRNA-18a, miRNA-130a, and miRNA-92a were detected. The systolic blood velocity of the cancer group, the disease group, and the control group decreased sequentially, while the resistance index and pulsatility index increased sequentially. The serum miR-18a, miR-130a, miR-92a, and expression levels of the patients' increased sequentially. Multivariate logistic regression analysis showed that age, high-risk human papillomavirus (HR-HPV) infection, menopause, blood flow RI, serum miRNA-18a, miRNA-92a, and miRNA-130a were the influencing factors of CC. The receiver operating characteristic curve showed that the sensitivity, specificity, accuracy, and area under curve of transvaginal Doppler ultrasound in the diagnosis of CC were 86.43%, 88.01%, 84.32%, and 0.913; serum miR-18a were, respectively, 76.56, 81.30, 80.36, and 0.839; serum miR-130a were 77.88%, 76.97%, 78.32%, and 0.0.864; serum miR-92a were 71.04%, 80.39%, 80.74%, and 0.894; 90.33%, 95.14%, 91.25%, and 0.947, the area under curve of the combined detection of the 3 was greater than that of the single detection. Serum miRNA combined with TVCDS has the advantages of it being noninvasive, and having high sensitivity and high specificity in the diagnosis of CC.

Retracted: Value of Transabdominal Combined Transvaginal Color Doppler Ultrasonography in the Distinguish between Uterine Adenomyoma and Uterine Fibroids

Retracted: Value of Transabdominal Combined Transvaginal Color Doppler Ultrasonography in the Distinguish between Uterine Adenomyoma and Uterine Fibroids

Retracted: The Diagnostic Accuracy of Transabdominal and Transvaginal Color Doppler Ultrasound for Pregnant Women with Vasa Previa and Velamentous Cord Insertion.

[This retracts the article DOI: 10.1155/2022/1685783.].

The diagnostic value of transvaginal color Doppler ultrasonography plus serum β-HCG dynamic monitoring in intrauterine residue after medical abortion

To probe the diagnostic value of transvaginal color Doppler ultrasonography plus serum β-human chorionic gonadotropin (β-HCG) dynamic monitoring in intrauterine residue after medical abortion.In total, 200 pregnant women undergoing medical abortion in our institution from January 2017 to December 2019 were picked, and assigned to either group A (n = 75, with residue) or group B (n = 125, without residue). We detected serum β-HCG, progesterone (P), follicle stimulating estrogen (FSH) levels and ultrasonic indicators endometrial thickness (ET), peak systolic velocity (PSV), resistance index (RI) values, dissected correlation of indicators using logistic linear regression analysis, and prospected the diagnostic value of relevant indicators in intrauterine residue after medical abortion utilizingreceiver operating characteristic curve.At 7 days after abortion (T3), total vaginal bleeding and visual analogue scalescore in group A were saliently higher in contrast to group B ( P < .05). At 72 hours after abortion (T2) and T3, serum β-HCG, P and FSH levels declined strikingly in both groups, but group B held plainly higher decrease rate than group A ( P HC.05). At T3, ET and PSV levels in both groups considerably waned, whereas RI levels notedly waxed, and group B owned markedly higher decrease/increase than group A ( P wa.05). At T3, serum β-HCG in group A possessed positive association with serum P, FSH, intrauterine ET, PSV levels separately ( P HC.05), whereas negative link with RI levels ( P , .05). The specificity and sensitivity of β-HCG, P, FSH, β-HCG/ET, β-HCG/PSV and β-HCG/RI in the diagnosis of intrauterine residue after medical abortion were high ( P < .05).Serum β-HCG dynamic monitoring plus transvaginal color Doppler ultrasonography is of great value in diagnosing intrauterine residue after medical abortion. Serum β-HCG, P, FSH levels can be combined with the results of intrauterine ET, PSV, RI values, so as to boost the diagnostic accuracy of the intrauterine residue after medical abortion.

Doppler in threatened abortion

Threatened Abortion is one of the most common complication in early pregnancy. Its incidence varies between 20-25%.Transvaginal Color Doppler ultrasonography has permitted assessment of uteroplacental circulation in early pregnancy, irregularities of which have been linked to pregnancy complications such as hypertension, fetal growth restriction (FGR), fetal distress, and early pregnancy failure). The capability of trans-vaginal Doppler sonography to analyze the pattern of circulation in even terminal branches of the uteroplacental circulation has encouraged research for its potential use in predicting early and late pregnancy complications related to abnormal placentation. Impaired vascular remodelling in the maternal - fetal interface is one of the most significant factors associated with early and late complications in pregnancy.

Endometrial microstimulation effects on endometrial receptivity assessed by transvaginal color Doppler sonography.

This study investigated the effect of endometrial microstimulation (EM) on endometrial receptivity using transvaginal color Doppler sonography (TVCDS). Women of childbearing age who were preparing to conceive (n = 90) were randomly divided into the EM group (n = 30), who were examined by EM on days 3-5 of the menstrual cycle, and the control group (n = 60). TVCDS was conducted during the implantation window phase, and endometrial thickness, endometrial pattern, endometrial movement, blood flow type, and uterine and spiral arterial hemodynamic parameter measurements were made. The groups were compared to identify differences. Endometrial thickness (0.97 ± 0.18cm and 0.95 ± 0.17cm), endometrial movement (type 1: 46.7% and 51.7%; type 2: 30.0% and 28.3%; type 3: 6.7% and 5.0%; type 5: 16.7% and 15.0%), and hemodynamic parameters of the uterine (pulsatility index [PI]: 2.46 ± 0.50 and 2.41 ± 0.48; resistance index [RI]: 0.85 ± 0.05 and 0.84 ± 0.05) and spiral (PI: 1.11 ± 0.32 and 1.19 ± 0.33; RI: 0.48 ± 0.11 and 0.51 ± 0.08) arteries did not differ significantly between groups (P > 0.05). However, the endometrial pattern (a trilaminar pattern: 80.0% and 58.3%; P = 0.041) and blood flow type (type I: 16.7% and 43.3%; type II: 63.3% and 40.0%; type III 20.0% and 16.7%; P = 0.038) differed significantly between groups. Endometrial microstimulation did not alter endometrial pathological staging, endometrial thickness, or movement, nor did it affect uterine and spiral arterial blood flow parameters. However, it may be able to abrade abnormal endometrial tissue, optimizing the endometrial pattern. Endometrial microstimulation may support local spiral artery regeneration and increase endometrial blood supply in new cycles.

The Diagnostic Accuracy of Transabdominal and Transvaginal Color Doppler Ultrasound for Pregnant Women with Vasa Previa and Velamentous Cord Insertion.

Objective The objective of this study is to evaluate feasibility and accuracy of transabdominal color Doppler ultrasound (TA-CDUS) and transvaginal color Doppler ultrasound (TV-CDUS) as screening methods for pregnant women with vasa previa (VP) and velamentous cord insertion (VCI). Methods A retrospective diagnostic accuracy study was performed on 5,434 pregnant women from 2018 to 2021, who underwent both TA-CDUS and TV-CDUS. Diagnostic performance of TA-CDUS and TV-CDUS was determined using specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy, and positive and negative likelihood ratios (LR+ and LR−), using the delivery information (gross examination) as the “Gold-standard”. Patient records were reviewed for demographics and diagnosis. Results The combination of VP and VCI was diagnosed in 37/5434 (0.68%) women at delivery. The sensitivity, specificity, PPV, NPV, and overall test accuracy of TA-CDUS were 72.97%, 99.85%, 77.14%, 99.81%, and 99.67%, respectively, for diagnosing VP with VCI. The corresponding values for TV-CDUS were 89.19%, 99.87%, 82.50%, 99.93%, and 99.80%, respectively. Moreover, the sensitivity of combination of TA-CDUS and TA-CDUS in determining VP with VCI was 97.30%, specificity 99.98%, PPV 97.30%, NPV 99.98%, and accuracy 99.96%. No significant difference in the misdiagnosis and missed diagnosis was found between the examination by TA-CDUS and TV-CDUS. Conclusions Both TA-CDUS and TV-CDUS can be acceptable diagnostic tools for assessment of pregnant women with VP and VCI, with a better application of TV-CDUS with higher accuracy. The combination of TA-CDUS and TV-CDUS could provide an objective imaging basis for choosing clinical treatment strategies and predicting prognosis.

Analysis of the Diagnosis and Prognostic Evaluation Value of Transvaginal Color Doppler Ultrasound

Analysis of the Diagnosis and Prognostic Evaluation Value of Transvaginal Color Doppler Ultrasound

Value of Transabdominal Combined Transvaginal Color Doppler Ultrasonography in the Distinguish between Uterine Adenomyoma and Uterine Fibroids.

Objective To investigate the value of transabdominal combined transvaginal color Doppler ultrasonography in the diagnosis of uterine adenomyoma. Methods A total of 80 patients with suspected uterine adenomyoma in our hospital from January 2019 to December 2021 were selected as the study subjects. All of them were examined by transabdominal color Doppler ultrasound (TA-CDUS) and transvaginal color Doppler ultrasound (TV-CDUS), and the postoperative pathological examination results were taken as the gold standard to analyze the diagnostic efficacy of different examination methods for uterine adenomyoma. Results By postoperative pathological biopsy, 46 cases (57.50%) were diagnosed as positive and 34 cases (42.50%) were diagnosed as negative, including 29 cases of uterine adenomyoma and 5 other cases. The sensitivity, accuracy, and negative predictive value of TA-CDUS combined with TV-CDUS in the diagnosis of adenomyoma were higher than those of TA-CDUS (P < 0.05), and the Kappa value between TA-CDUS and pathological diagnosis was 0.923, which was higher than the 0.615 between TV-CDUS and pathological diagnosis. TA-CDUS combined with TV-CDUS showed that there were significant differences in the distribution of Adier blood flow grades between patients with uterine adenomyoma and uterine fibroids (P < 0.05), and the Adier blood flow grades of patients with uterine adenomyoma were mainly grade 0 and grade I; and the resistance index (RI), peak systolic velocity (Vs), and pulsatile index (PI) in patients with uterine adenomyoma were higher than those in patients with uterine fibroids (P < 0.05). Conclusion Compared with TA-CDUS, TA-CDUS combined with TV-CDUS is more sensitive and accurate in the diagnosis of uterine adenomyoma and has a good consistency with pathological diagnosis results. Attention should be paid to the blood flow parameter values in the differential diagnosis of uterine fibroids.

Investigation of Doppler Indices in Copper Intrauterine Device-induced Heavy Menstrual Bleeding

Background: Copper intrauterine devices (IUDs) are one of the most commonly used methods of contraception all over the world. However, nearly 20% of users have their IUD removed due to increased or irregular uterine bleeding. We aimed to investigate if the occurrence of heavy menstrual bleeding (HMB) after application of IUDs could be predicted using transvaginal color Doppler ultrasonography in women without dysmenorrhea. Method: Fifty-five women with regular menstruation without dysmenorrhea who were willing to use an IUD were included in the study. The women were divided into two groups as those whose menstrual characteristics did not change after IUD insertion (group A, n = 31) and those who developed HMB secondary to IUD insertion (group B, n = 24). IUDs were inserted on the 2nd or 3rd day of menstruation in all women and color Doppler assessments of the uterine, arcuate, and utero-ovarian arteries were performed twice; the first measurement was performed just before IUD deployment and the second measurement was performed on the 2nd or 3rd day of menstruation after 2 months. After recording these two measurements, Doppler parameters were compared between the groups. Results: The first and the second pulsatility index (PI) and resistance index (RI) values of the uterine arteries were significantly lower in group B when compared with group A (p &lt; 0.05). Likewise, the first and the second PI values of the arcuate arteries in group B were significantly lower than in group A (p = 0.009 and p = 0.035, respectively). The second RI measurements of the arcuate arteries were significantly lower in group B than in group A (p = 0.037); however, the first RI measurement of the arcuate arteries showed no statistically significant differences between the groups (p = 0.073). The first and the second PI and RI values of the utero-ovarian arteries showed no statistically significant difference between groups A and B. Conclusions: The results propose that low impedance to blood flow in the uterine and arcuate arteries prior to IUD insertion may help predict HMB secondary to IUD insertion in women without dysmenorrhea.

Application of Color Doppler Ultrasound in Microscopic Imaging Diagnosis of Adenomyosis.

In order to explore the value of color Doppler ultrasonography (TVCDS) in the diagnosis and differential diagnosis of adenomyosis. A total of 150 patients with adenomyosis admitted to a hospital from January 2020 to December 2021 were selected, taking transvaginal three-dimensional color Doppler ultrasound and abdominal ultrasound for examination, all results were compared with patient pathology or surgical results, in order to compare the accuracy of the two inspection methods. The positive predictive value of three-dimensional color Doppler ultrasonography was higher than that of abdominal ultrasonography, and the difference was statistically significant (P < 0.05). The coincidence rate, sensitivity, and specificity of three-dimensional color Doppler ultrasonography were higher than those of abdominal ultrasonography, while the misdiagnosis rate was lower than that of abdominal ultrasonography, and the differences were statistically significant (all P < 0.05). The imaging features of vaginal three-dimensional color Doppler ultrasound in patients with adenomyosis are mainly enlarged uterus, slightly stronger echoes in the myometrium with enhanced echogenic spots, and short or short branch blood flow signals in the lesions. After statistical analysis, there was a significant difference in the blood flow changes between benign and malignant endometrial echoes and abnormal echoes in the uterine cavity, P < 0.05. Normal endometrium and benign intrauterine lesions mainly showed no blood flow signal, while malignant lesions in the uterine cavity mostly showed changes in blood flow signal. Compared with abdominal examination, transvaginal color Doppler ultrasonography has obvious advantages in the diagnosis of adenomyosis. According to the characteristics of ultrasound images, blood flow distribution, frequency spectrum, etc., it can provide a more accurate basis for clinical timely, provide the identification points of uterine fibroids, and provide help for clinicians to choose a treatment plan.

Transvaginal Colour Doppler Ultrasound Study of Uterine Tumours with Histopathological Correlation

A cross-sectional study was conducted in the Department of Radiology &amp; Imaging, in collaboration with the Department of Obstetrics &amp; Gynaecology, in Dhaka Medical College Hospital and Bangabandhu Sheikh Mujib Medical University Hospital, Dhaka, Bangladesh, between July 2010 and March 2012, to evaluate the diagnostic usefulness of transvaginal color doppler ultrasonography (TVCDU) in differentiating benign and malignant uterine tumours. A total of fifty women, diagnosed as having uterine tumours both clinically and using ultrasound, participated in the study. They were evaluated preoperatively using TVCDU. All the study participants underwent surgical operation and resected specimens were sent for histopathological examination. Histopathology reports were correlated with the of colour Doppler findings. The mean age of the patients was 47.72±8.79 years. Major complaints were menorrhagia (58%), dysmenorrhoea (50%) and lump in the lower abdomen (48%). Neovascularization was found in 16(32%) cases. The mean resistance index and pulsatility index were much lower in malignant tumours than that of the benign counterpart (0.35±0.03 vs. 0.67±0.01 and 0.65±0.14 vs. 1.35±0.11 respectively); the difference was statistically significant (P&lt;0.001). The sensitivity, specificity, positive and negative predictive values of TVCDU were found 86.7%, 97.14%, 92.85% and 94.4% respectively. Overall diagnostic accuracy was 94%. To summarize, blood flow characteristics of benign and malignant uterine tumours, as evident on color Doppler imaging, have distinct diagnostic value. Hence, transvaginal colour Doppler ultrasound examination can be used as an easily available, efficient, and non-invasive diagnostic modality in differentiation of uterine tumours, which can be histologically confirmed later.&#x0D; CBMJ 2021 January: vol. 10 no. 02 P: 105-110

Role of Saline Infusion Sonohysterography and Transvaginal Colour Doppler Ultrasonography in Evaluating Uterine Polyps: A Prospective Study

Role of Saline Infusion Sonohysterography and Transvaginal Colour Doppler Ultrasonography in Evaluating Uterine Polyps: A Prospective Study

Doppler Study of Uterine Artery and Ultrasonography of Endometrial Thickness in Perimenopausal and Postmenopausal Bleeding

Background: Transvaginal color Doppler sonography of the uterine artery has been reported useful for evaluation of abnormal uterine bleeding in peri-/post-menopausal women. It may differentiate physiological from malignant endometrial changes. Objective: Evaluating the endometrial thickness and uterine artery Doppler as an initial diagnostic tool to identify patients with abnormal endometrial pathology. Methods: This is a prospective case control study consisted of total 50 women with peri-(n = 35) and post-(n = 15) menopausal bleeding, with 20 women consisting control group (no bleeding) (peri-(n = 10) and post-menopausal (n = 10)). Double layer endometrial thickness and uterine-artery-Doppler waveforms were measured, with the latter being S/D ratio, RI and PI. These were related to histological findings (endometrial biopsy). Result: Patients with abnormal uterine bleeding (both peri- and postmenopausal) had a significantly higher mean endometrial thickness than the control women. Study group showed a significantly lower value of all Doppler indices (S/D ratio, RI and PI). In study group, patients with malignant endometrial pathology showed significantly thicker endometrium and significantly lower Doppler indices than those with benign pathology. Conclusion: The combination of endometrial thickness and uterine artery color Doppler pattern might predict uterine endometrial malignancy, although whether it can discriminate (screen) patients requiring endometrial biopsy is not evident. Further study is needed.

Application of ultrasound markers measured at different time points of COH cycle in the prediction of ovarian response for individualised ovulation induction

The purpose of this study was to evaluate the predictive value of ultrasound markers measured at different time points of the controlled ovarian hyperstimulation (COH) cycle on ovarian response and outcome indicators in the IVF-ET cycle. According to the oestrogen level and the number of retrieved oocytes, patients who planned for COH treatment were separated into low-response group, normal and high-response group. The ovarian stromal artery flow parameters on the day of pituitary down-regulation, day 1, day 7, day 10, and the day of hCG injection were collected prospectively. We also have collected the data of cumulus oophorus count on the day of hCG injection by transvaginal sonography. Compared with the low-response group, on the first day of the COH cycle PI, RI, and S/D were lower in the high-response group than they were in the low-response group (p < .05). PSV and EDV were significantly higher in the high-response group than they were in the low-response group (p < .01), and the PSV on the first day of the COH cycle have statistical significance in predicting the number of high-quality embryos. The number of cumulus oophorus on the day of hCG injection has statistical significance in predicting the number of oocytes retrieved and fertilised oocytes. We conclude that the ovarian stromal artery flow parameters on the first day of the COH cycle and cumulus oophorus count on hCG injection day can serve as efficient indicators for an early assessment of ovarian response and individualised ovulation induction. IMPACT STATEMENT What is already known on this subject? AMH, AFC, and the age of the patient are well-known effective parameters for the evaluation of ovarian response, but these are insufficient and full of individual differences. Some researchers have investigated the value of colour Doppler ultrasound and cumulus oophorus in assessing ovarian response, but no definitive conclusion has been reached. What do the results of this study add? The hemodynamic parameters of ovarian stromal artery on the first day of the COH cycle and the number of cumulus oophorus on the day of hCG injection detected by Transvaginal Colour Doppler Sonography (TV-CDS) could be used to predict the ovarian response. What are the implications of these findings for clinical practice and/or further research? Ovarian stromal artery flow parameters and cumulus oophorus detected by TV-CDS can potentially be offered as a complementary parameter for ovarian reserve.

Clinical Comparison of Transabdominal and Transvaginal Color Doppler Ultrasound in Diagnosis of Ectopic Pregnancy

Clinical Comparison of Transabdominal and Transvaginal Color Doppler Ultrasound in Diagnosis of Ectopic Pregnancy

Diagnostic Value of Serum Markers Combined with TVCDS in Ovarian Cancer Patients Treated with Bushen Yiqi Quyu Prescription.

Background To compare the diagnostic value of serum markers human epididymal protein 4 (HE4) and cyclooxygenase-1 (COX-1) combined with transvaginal color Doppler sonography (TVCDS) in ovarian cancer (OC) treated with Bushen Yiqi Quyu prescription. Methods A total of 232 OC patients treated at the hospital from January 2018 to October 2020 were randomly divided into an observation group (n = 116) and control group (n = 116). The control group was treated with essential Western medication, and the observation group was treated with essential Western medication and Bushen Yiqi Quyu prescription. The clinical efficacy of the two groups was compared. The levels of HE4 and COX-1 were compared between the two groups before and after treatment. The ultrasonic features of TVCDS were compared between the two groups before and after treatment. The ROC curve was drawn to compare the sensitivity, specificity, and accuracy of single and combined detection of HE4, COX-1, and TVCDS in the observation group. Results The total effective rate of the observation group was significantly higher than that of the control group. After treatment, HE4 and COX-1 levels in both groups were considerably lower than those before treatment, and in the observation group, they decreased significantly than in the control group. HE4 and COX-1 were positively correlated with the clinical stage of OC. The higher the clinical stage, the higher the levels of HE4 and COX-1. After treatment, there was no significant difference in tumor location and the boundary between the two groups. There were statistically significant differences in tumor echo, nature, morphology, calcification, internal blood flow, and lymph node metastasis, and the difference in the observation group was more evident than in control group. The sensitivity, specificity, accuracy, positive detection rate, and negative detection rate of combined detection were higher than those of single detection. Conclusions Bushen Yiqi Quyu prescription has certain curative effects in the treatment of OC patients, which can significantly reduce the level of tumor markers and improve the symptoms of OC patients. The combined detection of HE4, COX-1, and TVCDS has high sensitivity, specificity, and accuracy, which can effectively detect OC and reduce missed diagnosis and misdiagnosis.

Study on the Application of Transvaginal Color Doppler Ultrasound in the Diagnosis of Uterine Fibroids

Study on the Application of Transvaginal Color Doppler Ultrasound in the Diagnosis of Uterine Fibroids

Effect of Transvaginal Color Doppler Ultrasonography and Transabdominal Ultrasonography in the Early Diagnosis of Ectopic Pregnancy

Effect of Transvaginal Color Doppler Ultrasonography and Transabdominal Ultrasonography in the Early Diagnosis of Ectopic Pregnancy

Analysis of Clinical Value of Transvaginal Color Doppler Ultrasound in the Diagnosis of Cesarean Scar Pregnancy in Lower Uterine Segment

Analysis of Clinical Value of Transvaginal Color Doppler Ultrasound in the Diagnosis of Cesarean Scar Pregnancy in Lower Uterine Segment