Micropollutants (MPs) have increasingly become a matter of concern owing to potential health risks associated with human inhalation exposure, particularly in densely-occupied indoor environments. This study employed numerical simulations in a traditional built indoor workspace and a public transport cabin to elucidate the transport dynamics and health impacts of particulate and gaseous type of indoor MPs on varying groups of occupants. The risk of infection from pathogen-bearing MPs was evaluated in the workspace using the integrated Eulerian-Lagrangian and modified Wells-Riley model. In the cabin environment, the health impact of inhaled TVOC within the human nasal system was assessed via the integrated nasal-involved manikin model and cancer/non-cancer risk model. The results demonstrated that when ventilation layout was in favour of restricting particulate MPs spread, considerably high health risks (up to 17.22% infection possibility) were generally found in near-fields of emission source (< 2.25 m). Conversely, if the ventilated flow interacts robustly with emission source, every occupant has a minimum 5% infection risk. Incorporating the nasal cavity in the human model offers a nuanced understanding of gaseous MP distributions post-inhalation. Notably, the olfactory and sinus regions displayed heightened vulnerability to TVOC exposure, with a 62.5%–108% concentration increase compared to other nasal areas. Cancer risk assessment plausibly explained the rising occurrence of brain and central nervous system cancer for aircrew members. Non-cancer risk was found acceptable. This study was expected to advance the understanding of environmental pollution and the health risks tied to indoor MPs in densely-populated environments.