e13501 Background: Nearly 70% of diagnostics lab test errors occur due to variability in preanalytical factors. Preanalytical factors comprise parameters from the time tissue is extracted from the patient to the time it is tested in the lab. For lack of standardized preanalytical protocols, integrity of collected specimens is often compromised. This is particularly pronounced when specimens are collected in remote or low resource settings and shipped to testing facilities. Establishing preanalytical protocols could serve as an important resource for remote collection sites and substantially reduce variability in the integrity of specimens thereby improving lab test rigor and reproducibility and promote innovation in live tissue diagnostic tests for personalized medicine. Objective: The aim of this study is to analyze impact of cold chain logistics on integrity of collected solid tumor tissue specimens. Specifically, duration in transit, container and wet ice packing, and composition of transport media were assessed. Methods: Baseline protocols for biospecimen preanalytical parameters were established from literature review. Standard aseptic lab protocols were implemented for all experiments including preparation of transport media, tissue transport kits, transport kit packaging, tumor tissue transfer in tissue transport kits, tissue receiving, and tissue integrity assessment. Transport was simulated for human and murine pancreatic ductal adenocarcinoma (PDAC) tissue by holding packaged tumor tissue containers in storage for the duration of transport. Saline solution, basal media, and complete media were evaluated as transport media. Specimen integrity was evaluated using live/dead assays in high-content imaging systems at 24- and 48-hour intervals. Results: For human and murine tumor tissue, viability was optimal when tissue was transported in Nalgene jars containing complete media packaged in ¼” thick wall Styrofoam containers tightly packed in wet ice for transport. While specimens fared well over both 24- and 48- hour simulated shipping durations, temperature and humidity logs from sensors embedded in the packages showed sharp degradation in packaging environment with longer durations of time. Conclusions: Establishing preanalytical protocols would improve rigor and reproducibility in diagnostic lab tests by improving tissue viability and integrity. Such protocols would also enable next generation cancer models to further enhance predictive capacity in translational research and subsequently in personalized medicine applications at the bedside.