We propose a two-dimensional grating waveguide structure based on guided-mode resonance (GMR) to greatly enhance the Goos-Hänchen (GH) shift due to the asymmetric Fano peak. In addition, the enhancement of the GH shift is located at the peak of the reflectivity, which enables a more accessible measurement compared to the conventional GH shift enhancement based on Brewster angle or transmission-type resonance. In particular, such structure supports four channels for the GH shift enhancements, with a maximum value of 4.8×104λ0 for the positive one and -6000 λ0 for the negative one. Our results benefit the potential applications for optical sensors, optical filters, optical absorbers and surface plasmon resonators, etc.