Upper-room ultraviolet germicidal irradiation (UR-UVGI) and ceiling-mounted air cleaner (CM-AC) technologies contribute to curbing the spread of infectious diseases such as COVID-19. However, there is a lack of detailed studies on the performance differences between these two control technologies for reducing viral concentrations and infection risk in isolation ward environments with different ventilation modes, especially when used alone versus in combination. Therefore, this study performed numerical simulations under three ventilation modes, namely, downward ventilation (DWV), stratum ventilation (SV), and displacement ventilation (DV), by the Eulerian-Lagrangian method combined with the UV inactivation model. The viral disinfection performance of UR-UVGI and CM-AC was parametrically analyzed. The effectiveness of the combined application of these two control technologies in wards was evaluated. The results showed that expanding the irradiation range was more effective in enhancing the UR-UVGI performance with the same total UV flux. When using UR-UVGI only, DWV disinfected better at the same irradiation flux. In CM-AC cases, the viral aerosol removal efficiency was the greatest in DV. UR-UVGI and CM-AC had advantages in active bioaerosol removal in overall and localized indoor spaces, respectively. The combined application was recommended to maximize the air cleanliness. Under the role of UR-UVGI, a high level of disinfection could be achieved using CM-AC with low ventilation rates. When the CM-AC ventilation rate was 150 m3/h and the UV irradiance was 30 μW/cm2, the viral disinfection of DV exceeded 90%, while that of DWV was also close to 90%. The findings could provide insights to further lower the transmission risk of infectious diseases.