Transmission Measurements Research Articles

Detection of breast cancer using machine learning on time-series diffuse optical transillumination data.

Optical mammography as a promising tool for cancer diagnosis has largely fallen behind expectations. Modern machine learning (ML) methods offer ways to improve cancer detection in diffuse optical transmission data. We aim to quantitatively evaluate the classification of cancer-positive versus cancer-negative patients using ML methods on raw transmission time series data from bilateral breast scans during subjects' rest. We use a support vector machine (SVM) with hyperparameter optimization and cross-validation to systematically explore a range of data preprocessing and feature-generation strategies. We also apply an automated ML (AutoML) framework to validate our findings. We use receiver operating characteristics and the corresponding area under the curve (AUC) to quantify classification performance. For the sample group available ( , 18 cancer patients), we demonstrate an AUC score of up to 93.3% for SVM classification and up to 95.0% for the AutoML classifier. ML offers a viable strategy for clinically relevant breast cancer diagnosis using diffuse-optical transmission measurements. The diagnostic performance of ML on raw data can outperform traditional statistical biomarkers derived from reconstructed image time series. To achieve clinically relevant performance, our ML approach requires simultaneous bilateral scanning of the breasts with spatially dense channel coverage.

Thermophysical Properties of Silicon Oxide Nanoparticles in Water and Ethylene Glycol–Water Dispersions

Measurements of transmission as well as thermophysical properties have been carried out for different concentrations of SiO2 nanoparticles (0, 1, 2, 5, 10, and 20 wt.%) in pure water (W) and ethylene glycol–water mixture (EG/W) in a weight ratio of 25/75, from 298 to 323 K at 100 kPa. In particular, the density, specific heat capacity, and thermal diffusivity are measured by a density meter, differential scanning calorimetry, and the laser flash method. In the case of 20 wt.% SiO2, transmission in the visible range is reduced by 9.3%. Simultaneously, the density rises linearly to 12.3% (in W) and 11.3% (in EG/W). The specific heat capacity decreases to 15.9% (in W) and 17.3% (in EG/W), while the thermal diffusivity rises to 16.4% (in W) and 20.4% (in EG/W). While the density measurements are in very good agreement with the literature, the measured values of the specific heat capacity deviate more than 5%, especially for concentrations below 5 wt.% SiO2. Moreover, it is shown that the thermal conductivity increases less for fluids in small gaps compared to other authors, which could be due to the suppression of the Brownian motion. Based on the measurement results, temperature- and concentration-dependent correlations for the investigated thermophysical properties are developed using two adjustable parameters. In general, these correlations show deviations of less than 4% from the experimental results, which will help to fill the gaps in the variation of experimental results due to size, SiO2 nanofluid production, and different measurement devices, and thus optimize solar thermal applications with SiO2 nanofluid.

A novel polyurethane-based silver foam dressing with superior antimicrobial action for management of infected chronic wounds.

Wound healing is a complex and dynamic process supported by several cellular events. Around 13 million individuals globally suffer from chronic wounds yearly, for which dressings with excellent antimicrobial activity and cell viability (>70%, as per ISO 10993) are needed. Excessive use of silver can cause cytotoxicity and has been linked to increasing antimicrobial resistance.In this study, HDI Ag foam was synthesized using a safer hexamethylene diisocyanate-based prepolymer (HDI prepolymer) instead of commonly used diisocyanates like TDI and MDI and substantially lower Ag content than that incorporated in other Ag foams. In vitro characteristics of the HDI Ag foam were evaluated in comparison with leading clinically-used foam-based dressings. All dressings underwent a detailed characterization in accordance with industrially accepted BS EN 13726 standards. The HDI Ag foam exhibited highest antimicrobial efficiency against Staphylococcus aureus and Pseudomonas aeruginosa (static condition), with the lowest amount of Ag (0.2 wt%) on the wound contact surface. The extracts from HDI Ag foam showed superior cell viability (>70%), when tested on the L929 mouse fibroblast cell line. Measurements of moisture vapour transmission, fluid handling, physico-chemical and mechanical properties ensured that the HDI foam was clinically acceptable for chronic wound patients.&#xD.

Microscale chemical imaging to characterize and quantify corrosion processes at the metal-electrolyte interface

We introduce an experimental setup to chemically image corrosion processes at metal-electrolyte interfaces under stagnant, confined conditions—relevant in a wide range of situations. The setup is based on a glass capillary, in which precipitation of corrosion products in the interfacial aqueous phase can be monitored over time with optical microscopy, and chemically and structurally characterized with microscopic synchrotron-based techniques (X-ray fluorescence, X-ray diffraction, and X-ray absorption spectroscopy). Moreover, quantification of precipitates through X-ray transmission measurements provides in-situ corrosion rates. We illustrate this setup for iron corrosion in a pH 8 electrolyte, revealing the critical role of O2 and iron diffusion in governing the precipitation of ferrihydrite and its transformation to goethite. Corrosion and coupled reactive transport processes can thus be monitored and fundamentally investigated at the metal-electrolyte interface, with micrometer-scale resolution. This capillary setup has potential applications for in-situ corrosion studies of various metals and environments.

Auto Aligning, Error-Compensated Broadband Collimated Transmission Spectroscopy.

Broadband spectral measurements of the ballistic transmission of scattering samples are challenging. The presented work shows an approach that includes a broadband system and an automated adjustment unit for compensation of angular distortions caused by non-plane-parallel samples. The limits of the system in terms of optimal transmission and detected forward scattering influenced by the scattering phase function are investigated. We built and validated a setup that measures the collimated transmission signal in a spectral range from 300 nm to 2150 nm. The system was validated using polystyrene spheres and Mie calculations. The limits of the system in terms of optimal transmission and detected forward scattering were researched. The optimal working parameters of the system, analyzed by simulations using the Monte Carlo method, show that the transmission should be larger than 10% and less than 90% to allow for a reliable measurement with acceptable errors caused by noise and systematic errors of the system. The optimal transmission range is between 25% and 50%. We show that the phase function is important when considering the accuracy of the measurement. For strongly forward-scattering samples, errors of up to 80% can be observed, even for a very small numerical aperture of 6.6·10-4, as used in our experimental system. We also show that errors increase with optical thickness as the ballistic transmission decreases and the multiscattered fraction increases. In addition, errors caused by multiple reflections in the sample layer were analyzed and also classified as relevant for classical absorption spectroscopy.

Poroelastic Response of a Fractured Rock to Hydrostatic Pressure Oscillations

AbstractPoroelastic coupling between fractures and the surrounding rock is important to numerous applications in geosciences. We measure the in‐situ fluid pressure and local strain response of a fractured carbonate sample to hydrostatic pressure oscillations. A linear poroelastic model that represents the rock sample is parameterized using X‐ray imaging and ultrasonic wave transmission measurements. The numerical solution, based on Biot's quasistatic equations, is consistent with the measured frequency dependent dispersion of the apparent bulk modulus of the background matrix and the in‐situ pore pressure response, which is caused by fluid pressure diffusion from the compliant fractures into the stiffer matrix. The observed fluid pressure diffusion is causally related to the numerically quantified intrinsic attenuation at seismic frequencies, which is a major contributor to the dissipation of seismic waves. Our analysis supports the use of a simple approximation of fractures as compliant and planar inclusions in numerical simulations based on linear poroelasticity.

Synchrotron CT dosimetry for wiggler operation at reduced magnetic field and spatial modulation with bow tie filters.

The Australian Synchrotron Imaging and Medical Beamline (IMBL) uses a superconducting multipole wiggler (SCMPW) source, dual crystal Laue monochromator and 135 m propagation distance to enable imaging and computed tomography (CT) studies of large samples with mono-energetic radiation. This study aimed to quantify two methods for CT dose reduction: wiggler source operation at reduced magnetic field strength, and beam modulation with spatial filters placed upstream from the sample. Transmission measurements with copper were used to indirectly quantify the influence of third harmonic radiation. Operation at lower wiggler magnetic field strength reduces dose rates by an order of magnitude, and suppresses the influence of harmonic radiation, which is of significance near 30 keV. Beam shaping filters modulate the incident beam profile for near constant transmitted signal, and offer protection to radio-sensitive surface organs: the eye lens, thyroid and female breast. Their effect is to reduce the peripheral dose and the dose to the scanned volume by about 10% for biological samples of 35-50 mm diameter and by 20-30% for samples of up to 160 mm diameter. CT dosimetry results are presented as in-air measurements that are specific to the IMBL, and as ratios to in-air measurements that may be applied to other beamlines. As CT dose calculators for small animals are yet to be developed, results presented here and in a previous study may be used to estimate absorbed dose to organs near the surface and the isocentre.

Development of a multi-layer high-efficiency GEM-based neutron detector for spallation sources

Neutron detection is nowadays mostly based on 3He gas detectors, but its shortage and the continuous upgrades of the neutron facilities require new devices to perform experiments with maximum performances. This work presents a new detector based on the Gas Electron Multiplier (GEM) combined with several boron layers. This detector combines the features of GEM technology with the properties of boron as a neutron converter and the device is produced to sustain high neutron fluxes with high detection efficiency. The detector has been characterised at the ISIS Pulsed Neutron and Muon Source (UK). Based on the analysis of our results, the detector has shown a good response to thermal and epithermal neutrons reaching a detection efficiency of 16% at 1.8 Å (25 meV). The good detection efficiency (even increasable with the addition of further boron GEM foils) and the good time resolution, make the detector a unique device for the neutron techniques. In particular, its use can easily be envisaged in techniques involving neutron transmission measurements, that require high fluxes impinging on the detectors, with the added bonus of a 2D-resolved capability due to the padded anode.

Evaluation and analysis of the electro-optic effect and the Stark effect in electro-optic polymers by the simple transmission measurement technique without an aperture

A simple and reliable transmission measurement technique without an aperture was utilized to evaluate both the electro-optic (EO) effect and the Stark effect of EO polymers. For some EO polymers, both the EO effect and the Stark effect were evaluated using laser light sources with various wavelengths of 1550 nm, 1308 nm, 980 nm, and 640 nm and the analysis method was also described. We showed that both the magnitude and the phase of the modulated light signal in lock-in detection at both the π/2 and 3π/2 points are very important for appropriate analysis.

Combined Acoustic Emission and Ultrasonic Measurements in Cross Laminated Timber-Steel Composite Beam

Combined acoustic emission and ultrasonic measurements were carried out before and during a four-point bending test on a composite floor beam made of cross-laminated timber with length of 11.6 m, width of 1.5 m, and thickness of 0.28 m. One key aspect of the composite design is the formation of the shear-resistant connection between the panel and steel girder. For the measurements a 16-channel system with combined acoustic emission and transmission measurements was used. The signals were digitized with a very high frequency of 10 MHz with amplitude resolution of 16 bits. To monitor acoustic emission activity a network of 16 AE sensors were attached to the surface of the specimen in the central part of the specimen where the highest deflection and load were expected. For this purpose, broadband AE sensors with measurement frequency of up to 200 kHz were used. The ultimate failure of the specimen occurred at a maximum test load of approximately 200 kN. The deflection at this force was about 200 mm. During the tests which lasted about 50 minutes approximately 8,500 AE events were detected. More than 2,600 events were recorded by at least six channels which makes them well suited for three-dimensional localization. Because of the inhomogeneous cross-laminated timber conventional localization using an unique velocity model are not possible. Therefore, a velocity model was experimentally determined by measure the velocity of the elastic waves in all directions. The greatest value was measured in the longitudinal direction along the beam axis. The average value is approximately 4000 m/s. While in the transverse direction the velocity drops down to approximately 2800 m/s. The lowest value was measured in thickness direction of about 1800 m/s.

Experimental determination of the sulfur K-shell fundamental parameters employing the holistic approach

Abstract Sulfur and its compounds are both very abundant in the environment and very important for technological applications such as batteries. X-ray spectroscopic characterizations of sulfur compounds for a quantitative determination of the present amount of sulfur often requires a good knowledge on the atomic fundamental parameters involved. These quantitatively describe the processes of photoionization and X-ray fluorescence emission, making them crucial for X-ray spectroscopy-based quantifications. 
By employing the recently demonstrated holistic approach, the atomic fundamental parameters of the sulfur K-shell were experimentally determined using the radiometrically calibrated instrumentation of the Physikalisch-Technische Bundesanstalt (PTB). The transition probabilities of the main K-shell fluorescence lines, the K-shell fluorescence yield, the K-shell Auger yield, the subshell photoionization cross section and fluorescence production cross section were determined by means of photon energy dependent X-ray fluorescence and transmission measurements on a thin InS coated silicon nitride membrane. The results are also downloadable from Zenodo as plain text.

Fabrication of kesterite Cu2ZnSnS4 thin films using sequentially sputtered multilayers of Cu2SnS3 and Zinc.

Radio-frequency sputtered Cu2ZnSnS4 (CZTS) thin films deposited on glass substrates were characterized. The film deposition was carried out in an argon atmosphere with RF powers of 200 W for zinc and 300 W for the CTS films. After the deposition, the films were annealed at temperatures ranging from 350 °C to 500 °C in a nitrogen and sulfur atmosphere. By using X-ray diffraction, the CZTS films were observed to crystallize in a tetragonal structure with some minor secondary phases in some samples. The absorption coefficient and optical band gap are identified by the ultraviolet-visible-near-infrared optical transmission measurements and the calculated band gap was found to range between 1.4 eV and 1.51 eV. This research comprehensively addresses the effects of layer thickness and annealing temperature on our CTS/Zn films. The annealing process was oberved to result in a significant improvement in electrical conductivity, particularly in films without secondary phases.

56 Gbps externally modulated widely tunable lasers with SOA boosters heterogeneously integrated on silicon

We demonstrate externally modulated widely tunable lasers co-integrated with semiconductor optical amplifiers (SOAs) heterogeneously integrated on silicon. The widely tunable laser enables continuous single-mode operation over a tuning range of approximately 40 nm, with a side-mode suppression ratio (SMSR) of at least 50 dB and an average waveguide-coupled optical power of 5 mW. The integrated electro-absorption modulator (EAM) exhibits an extinction ratio (ER) of 16 dB when reversed biased at -2 V. The bit-error-rate (BER) measurements conducted across the available optical bandwidth (15 nm) showcase error-free transmission at 32 Gbps using non-return-to-zero (NRZ) signals for the majority of wavelengths in a back-to-back (B2B) configuration. Additionally, transmission measurements over distances of up to 10 km through a standard single-mode fiber (SSMF) have been successfully demonstrated. Dynamic extinction ratio (DER) values exceeding 4.5 dB are achieved for all wavelengths. Open-eye diagrams were measured up to 56 Gbps. These results demonstrate that this compact mono-epitaxial externally modulated tunable laser with integrated optical amplification can be a cost-effective transmitter solution for dense wavelength division multiplexing (DWDM) metropolitan and access networks.

Interaction of acoustic waves with spin waves using a GHz operating GaN/Si SAW device with a Ni/NiFeSi layer between its IDTs.

A two port surface acoustic wave (SAW) device was developed to be used for the control and excitation via spin waves (SW). The structure was manufactured using advanced nanolithography techniques, on GaN/Si, enabling fundamental Rayleigh interdigitated transducer (IDT) resonances in GHz frequency range. The ferromagnetic resonance of the magnetostrictive Ni/NiFeSi layer placed between the IDTs of the SAW device can be tuned to the SAW resonance frequency by magnetic fields. Using structures with finger and interdigit spacing of 170 nm and 100 nm, fundamental Rayleigh IDT resonance frequencies of 6.4 and 10.4 GHz have been obtained. Coupling of SAW to SW was demonstrated through transmission measurements at the fundamental Rayleigh frequencies in a magnetic field, μ0H from -280 to +280 mT, at different angles (θ) between the SAW propagation direction and the magnetic field direction. For the 6.4 GHz resonator a maximum decrease of about 1.2 dB occurred in |S21|, at μ0H = 30 mT and at θ = 45. Time-gated processing of the frequency domain raw data was used to remove the direct electromagnetic cross talk and triple transit effects. Nonreciprocity associated to the coupling was analyzed for the two SAW structures. The quantitative influence of the magnetic field strength on the phase of the transmission parameters is also presented.

Thin Film TaFe, TaCo, and TaNi as Potential Optical Hydrogen Sensing Materials.

This paper studies the structural and optical properties of tantalum-iron-, tantalum-cobalt-, and tantalum-nickel-sputtered thin films both ex situ and while being exposed to various hydrogen pressures/concentrations, with a focus on optical hydrogen sensing applications. Optical hydrogen sensors require sensing materials that absorb hydrogen when exposed to a hydrogen-containing environment. In turn, the absorption of hydrogen causes a change in the optical properties that can be used to create a sensor. Here, we take tantalum as a starting material and alloy it with Fe, Co, or Ni with the aim to tune the optical hydrogen sensing properties. The rationale is that alloying with a smaller element would compress the unit cell, reduce the amount of hydrogen absorbed, and shift the pressure composition isotherm to higher pressures. X-ray diffraction shows that no lattice compression is realized for the crystalline Ta body-centered cubic phase when Ta is alloyed with Fe, Co, or Ni, but that phase segregation occurs where the crystalline body-centered cubic phase coexists with another phase, as for example an X-ray amorphous one or fine-grained intermetallic compounds. The fraction of this phase increases with increasing alloyant concentration up until the point that no more body-centered cubic phase is observed for 20% alloyant concentration. Neutron reflectometry indicates only a limited reduction of the hydrogen content with alloying. As such, the ability to tune the sensing performance of these materials by alloying with Fe, Co, and/or Ni is relatively small and less effective than substitution with previously studied Pd or Ru, which do allow for a tuning of the size of the unit cell, and consequently tunable hydrogen sensing properties. Despite this, optical transmission measurements show that a reversible, stable, and hysteresis-free optical response to hydrogen is achieved over a wide range of hydrogen pressures/concentrations for Ta-Fe, Ta-Co, or Ta-Ni alloys which would allow them to be used in optical hydrogen sensors.

Controlling Isotropic Reflectivity with Multi‐Oriented Self‐Assembled Hexagonal Arrays in Plasmonic Metasurfaces

AbstractThe fabrication of plasmonic metasurfaces on large surfaces is the next challenge to adapt them to augmented reality systems. The optical properties of a self‐assembled hexagonal plasmonic metasurface, realized with a large‐area compatible approach, are compared at different levels and a correlated‐disorder plasmonic metasurface fabricated by electron‐beam lithography and considered here as the reference: the contribution of plasmonic nanostructure arrangements is studied using the structure factor, physical properties are assessed by optical transmission and reflection measurements, and finally the entire metasurfaces are tested macroscopically in a head‐up display system.

Synthesis and Upconversion Luminescence Fine-tuning of Yb3+/Ho3+-Doped Indium and Gallium Oxide Nanoparticles.

Rare earth (RE) dopants can modulate the bandgap of oxides of indium and gallium and provide extra upconversion luminescence (UCL) abilities. However, relevant UCL fine-tuning strategies and energy mechanisms have been less studied. In this research, InGaO, Ho3+ monodoped and Yb3+/Ho3+ codoped In2O3, and Ho3+ monodoped Yb3Ga5O12 nanoparticles (NPs) were synthesized by a solvothermal method. The effects of Yb3+ and Ho3+ dopants on the crystal structures, UCL properties, and optical bandgaps of the oxides were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), UCL spectroscopy, and measurements of decay times, pump power dependence, and transmittance spectra. The crystal structures of oxide products of indium and gallium were significantly modified with RE dopants. In2O3 and Yb3Ga5O12 were selected as the host materials. For Yb3+/Ho3+ codoped In2O3 NPs, there existed energy transfers from the defect states of In2O3 to Ho3+ and from Yb3+ to Ho3+. With a fixed Ho3+ concentration, In2O3:0%Yb3+,2%Ho3+ NPs showed the optimal UCL properties mainly due to In2O3-Ho3+ energy transfer and Ho3+-Yb3+ energy-back-transfer, while with a fixed Yb3+ concentration, In2O3:5%Yb3+,3%Ho3+ NPs with a slight Yb2O3 impurity and Yb3Ga5O12:2%Ho3+ NPs did mainly due to Ho3+-Ho3+ cross-relaxation. Besides, the optical bandgaps of In2O3 and Yb3Ga5O12 were noticeably broadened with RE dopants. These findings can offer feasible directions for the synthesis and UCL fine-tuning of RE-doped oxides of indium and gallium and improve their multifunction application prospects in the fields of semiconductor and UCL nanomaterials.

An Automated pre-Dilution Setup for Von Willebrand Factor Activity Assays.

Accurate quantification of von Willebrand factor ristocetin cofactor activity (VWF:RCo) is critical for the diagnosis and classification of von Willebrand disease, the most common hereditary and acquired bleeding disorder in humans. Moreover, it is important to accurately assess the function of von Willebrand factor (VWF) concentrates within the pharmaceutical industry to provide consistent and high-quality biopharmaceuticals. Although the performance of VWF:RCo assay has been improved by using coagulation analyzers, which are specialized devices for blood and blood plasma samples, scientists still report a high degree of intra- and inter-assay variation in clinical laboratories. Moreover, high, manual sample dilutions are required for VWF:RCo determination of VWF concentrates within the pharmaceutical industry, which are a major source for assay imprecision. For the first time, we present a precise and accurate method to determine VWF:RCo, where all critical pipetting and mixing steps are automated. A pre-dilution setup was established on CyBio FeliX (Analytik-Jena) liquid handling system, and an adapted VWF:RCo method on BCS-XP analyzer (Siemens) is used. The automated pre-dilution method was executed on three different, most frequently used coagulation analyzers and compared to manual pre-dilutions performed by an experienced operator. Comparative sample testing revealed a similar assay precision (coefficient of variation = 5.9% automated, 3.1% manual pre-dilution) and no significant differences between the automated approach and manual dilutions of an expert in this method. While no outliers were generated with the automated procedure, the manual pre-dilution resulted in an error rate of 8.3%. Overall, this operator-independent protocol enables standardization and offers an efficient way of fully automating VWF activity assays, while maintaining the precision and accuracy of an expert analyst. Key features • Automated pre-dilution setup for von Willebrand factor concentrates of various natures. • Combination of a liquid handling system (CyBio FeliX) with a coagulation analyzer (BCS-XP). • Simplifies method transfer to other laboratories. • Basic training for CyBio FeliX and BCS-XP is required. Graphical overview VWF:RCo assay principle and measurement setup. Platelets (yellow ellipsoids) with negative surface charge (- - -) are treated with formaldehyde, which partly denatures the cell surface and thus stabilizes platelets for use as assay reagents. Stabilized platelets (dark-yellow-framed yellow ellipsoids) are then brought in contact with ristocetin A (chemical structure shown; black dots), which binds to the platelet surface and facilitates binding of VWF (green circles). The graphs show an example of quantitative determination of platelet agglutination by measurement of light transmission, where increasing amounts of VWF increase light transmission over time. The photo in the left-bottom corner shows the CyBio FeliX setup for VWF sample dilution and the photo in the right-bottom corner displays the BCS-XP system, which is used for VWF:RCo measurements.

Infrared optical properties of SiGeSn and GeSn layers grown by molecular beam epitaxy

The infrared optical properties of thick GeSn films (>500 nm) having 10% Sn concentration and of SiGeSn layers, utilized for the growth of strain-relieved, direct-gap GeSn films by molecular beam epitaxy, are investigated. Two growth methods are used: a graded-growth structure and a stepped-growth structure that help us to illustrate the properties of the GeSn and SiGeSn layers. Interestingly, there can be strong absorption in SiGeSn films throughout the infrared. We observe an increase in infrared absorption with increasing Sn concentration up to 21% Sn and in films, where the Sn is held constant at 18%, with increasing Si concentration up to 30%. Cavity effects in the infrared transmission measurement of stepped-growth structures are observed and associated with reflections at growth interfaces. Si–Si bond formation is proposed to occur at high Si concentrations in SiGeSn films, and the bandgap in SiGeSn films appears to decrease with increasing Si and Sn concentrations.

A pulse-echo measurement setup to determine viscoelastic material parameters

Abstract Due to their versatility, the application of polymers in research and industry continues to increase. Since the majority of design processes are simulation-aided, precise material parameters are required to obtain realistic results. The quasi-statically and destructively measured material parameters provided by manufacturers for this purpose are usually insufficient. An acoustic method is generally capable of measuring the frequency-dependent viscoelastic material parameters in a non-destructive manner. In particular, an ultrasonic transmission measurement setup for determining these parameters has already been presented in previous publications. However, this approach has several drawbacks, including a low sensitivity to shear parameters. To increase the sensitivity to shear parameters, a measurement setup using a pulse-echo method with a corresponding inverse approach is presented to obtain viscoelastic material parameters of polymers. A brief comparison is made between the transmission and pulse-echo methods.