Translation Of Research Findings Research Articles

Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy.

The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment is increasingly recognized as a critical factor in cancer progression and the efficacy of immunotherapy. This review comprehensively discusses the key factors regulating ECM remodeling, including the activation of cancer-associated fibroblasts and the accumulation and crosslinking of ECM proteins. Furthermore, it provides a detailed exploration of how ECM stiffness influences the behaviors of both tumor and immune cells. Significantly, the impact of ECM stiffness on the response to various immunotherapy strategies, such as immune checkpoint blockade, adoptive cell therapy, oncolytic virus therapy, and therapeutic cancer vaccines, is thoroughly examined. The review also addresses the challenges in translating research findings into clinical practice, highlighting the need for more precise biomaterials that accurately mimic the ECM and the development of novel therapeutic strategies. The insights offered aim to guide future research, with the potential to enhance the effectiveness of cancer immunotherapy modalities.

A Descriptive Analysis of a Sample of Hispanic PCOS Patients Living in Puerto Rico [ID 2683511

INTRODUCTION: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies during the reproductive years. Research has shown that Hispanic women with PCOS have the most severe phenotype, in terms of hyperandrogenism and metabolic disturbances. Absence of detailed characterization of PCOS in Puerto Rican patients poses significant barriers to translating research findings into clinical practice. Our aim is to provide an in-depth exploration of the gynecological profile of this population. METHODS: This was a cross-sectional study involving 105 female participants aged 21–45 years who underwent clinical evaluation during their routine health visit at endocrinology and gynecology clinics at the UPR-RCM clinics. The study cohort comprised 79 individuals with PCOS and 26 individuals without PCOS. IRB approval number is 2290034657 (B0790117). RESULTS: Significant differences were found in the prevalence of oligomenorrhea (90%; P<.001), amenorrhea (94.5%; P<.0004), clinical hirsutism (90.7%; P<.0001), and smoking (97.3%; P<.0001) among PCOS patients. These results align with existing literature on PCOS patients. There were no significant differences in menarche, thelarche, metrorrhagia, menorrhagia, sociodemographic profile, or toxic habits between the two groups. Additionally, both groups exhibited similarly high body mass index, fasting blood sugar, and hemoglobin A1C levels. CONCLUSION: Our study population’s characteristics align with those reported in other studies. However, the observed metabolic disturbances in our control group may be attributed to unique factors prevalent within the Puerto Rican population. Although this research contributes valuable insights, it is essential to acknowledge the study’s limitations, particularly the relatively small sample size. Further investigation and broader sampling are warranted to substantiate and refine these initial findings.

Recent contributions of single-cell and spatial profiling to the understanding of bladder cancer.

Current risk stratification and treatment decision-making for bladder cancer informed by histopathology as well as molecular diagnostics face limitations. This review summarizes recent advancements in single-cell and spatial omics methodologies for understanding bladder cancer biology and their potential impact on development of novel therapeutic strategies. Single-cell RNA sequencing and spatial omics techniques offer unprecedented insights into various aspects of tumor microenvironment (TME), bladder cancer heterogeneity, cancer stemness, and cellular plasticity. Studies have identified multiple malignant cell subpopulations within tumors, revealing diverse transcriptional states and clonal evolution. Additionally, intratumor heterogeneity has been linked to tumor progression and therapeutic response. Immune cell composition analysis has revealed immunosuppressive features in the TME, impacting treatment response. Furthermore, studies have elucidated the role of cancer-associated fibroblasts and endothelial cells in shaping the tumor immune landscape and response to therapy. Single-cell and spatial omics technologies have revolutionized our understanding of bladder cancer biology, uncovering previously unseen complexities. These methodologies provide valuable insights into tumor heterogeneity and microenvironmental interactions, with implications for therapeutic development. However, challenges remain in translating research findings into clinical practice and implementing personalized treatment strategies. Continued interdisciplinary collaboration and innovation are essential for overcoming these challenges and leveraging the full potential of single-cell and spatial omics in improving bladder cancer diagnosis and treatment.

Vector-Mediated Delivery of Transgenes and RNA Interference-Based Gene Silencing Sequences to Astrocytes for Disease Management: Advances and Prospectives.

Astrocytes are a type of important glial cell in the brain that serve crucial functions in regulating neuronal activity, facilitating communication between neurons, and keeping everything in balance. In this abstract, we explore current methods and future approaches for using vectors to precisely target astrocytes in the fight against various illnesses. In order to deliver therapeutic cargo selectively to astrocytes, researchers have made tremendous progress by using viral vectors such as adeno-associated viruses (AAVs) and lentiviruses. It has been established that engineered viral vectors are capable of either crossing the blood-brain barrier (BBB) or being delivered intranasally, which facilitates their entrance into the brain parenchyma. These vectors are able to contain transgenes that code for neuroprotective factors, synaptic modulators, or anti-inflammatory medicines, which pave the way for multiple approaches to disease intervention. Strategies based on RNA interference (RNAi) make vector-mediated astrocyte targeting much more likely to work. Small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) are two types of RNA that can be made to silence disease-related genes in astrocytes. Vector-mediated delivery in conjunction with RNAi techniques provides a powerful toolkit for investigating the complex biological pathways that contribute to disease development. However, there are still a number of obstacles to overcome in order to perfect the specificity, safety, and duration of vector-mediated astrocyte targeting. In order to successfully translate research findings into clinical practise, it is essential to minimise off-target effects and the risk of immunogenicity. To demonstrate the therapeutic effectiveness of these strategies, rigorous preclinical investigation and validation are required.

Climate change and zoonotic diseases: a conceptual framework for predicting and managing health risks in the USA

The executive summary will provide a concise overview of the conceptual framework aimed at understanding the relationship between climate change and zoonotic diseases in the USA. It will highlight the significance of addressing this issue, the objectives of the framework, expected outcomes, and the proposed methodology for research and implementation. It encapsulates the essence of the proposed framework, highlighting its significance, objectives, methodology, and expected outcomes. Climate change poses a significant threat to public health, exacerbating the emergence and transmission of zoonotic diseases across the USA. This executive summary underscores the critical need for a proactive approach to understanding and managing the complex interplay between climate change and zoonotic diseases to safeguard the health of communities. The framework aims to address this pressing issue by elucidating the mechanisms through which climate change influences the dynamics of zoonotic diseases. By integrating multidisciplinary research, predictive modeling, and public health strategies, the framework seeks to enhance the nation's capacity to predict, prevent, and mitigate the health risks associated with climate change-driven zoonotic diseases. Key objectives of the framework include developing predictive models to identify high-risk areas and vulnerable populations, elucidating the pathways of disease transmission, and proposing evidence-based interventions to mitigate health risks. By fostering collaboration among researchers, policymakers, and public health practitioners, the framework aims to translate research findings into actionable strategies and policies that protect public health and promote resilience in the face of climate change. Expected outcomes of the framework include improved understanding of the complex relationship between climate change and zoonotic diseases, enhanced surveillance and early warning systems, and informed decision-making to guide public health interventions. Ultimately, the framework seeks to empower communities and decision-makers with the knowledge and tools needed to adapt to changing environmental conditions and mitigate the health impacts of zoonotic diseases in the USA.

The process of developing a joint theory of change across three global entities: can this help to make their efforts to strengthen capacity for implementation research more effective?

IntroductionA theory of change is a visual representation of the pathway by which a programme anticipates it will achieve its goal. It usually starts with discussions around the goal and...

Codesign of Lynch ChoicesTM : Using implementation science to create a clinically deliverable patient decision support website to transform cancer genetics care pathways.

Resources including Patient Decision Aids (PtDA) are useful and valued by patients and clinicians to provide information and complement shared decision-making. Despite their promise, few PtDA exist for patients with genetic cancer susceptibility facing difficult decisions about risk management. We aimed to fill this gap, partnering with patients to codesign Lynch ChoicesTM , a PtDA website for families with Lynch Syndrome. In addition to a Patient Reference Panel, we purposively invited an international stakeholder panel including charities, public bodies, clinical and academic experts. Implementation strategies and frameworks were employed to optimise translation of research findings to improve care. Patient/stakeholder suggestions were incorporated in a transparent Table of Changes and prioritised using the Person-Based Approach throughout planning and codesign of Lynch ChoicesTM . An interactive stakeholder meeting was convened to identify barriers and facilitators to clinical implementation of the PtDA. Patient and stakeholder partnerships drove the direction of the research throughout codesign, resulting in several iterative refinements to the PtDA prior to roll out including the addition of illustrations/videos, clearer presentation of cancer risks and increased accessibility for lower literacy. Barriers and facilitators identified from stakeholders were used to create an implementation process map. Creating an effective, engaging PtDA is not enough. Systematic uptake in real world clinical practice, with its resource limitations, is needed to optimise benefit to patients and clinicians. Assessment of speed and breadth of dissemination and usage will be collected to further evidence the benefit of embedding implementation science methods from the outset to translate research findings into clinical practice.

Initiatives to promote the intergenerational transmission of basque: the case of workshops for parents

ABSTRACT In the European context, some revitalisation movements have seen the widespread adoption of minority language schooling among parents who do not speak the minority language. This research discusses the role of the ‘school for fathers and mothers’ or talleres (workshops) to encourage a more Basque-focused household among parents who have low proficiency in Basque. The talleres translate knowledge from the field of language socialisation into messages that orient these parents on how to foster positive attitudes towards Basque within the family. Focusing on an analysis of the workshops’ messages, specifically the techniques of consciousness raising employed by the programme, this research discusses the role of these programmes in catalysing new attitudes and new conceptualisations of a pro-minority Family Language Policy in the context of low-to-no proficiency speakers. They do so by underscoring the role of ‘cultural transmission’ and encouraging low-proficiency parents to see themselves as attitudinal referents through their use of affective linguistic repertoires in Basque. Finally, I discuss the case of the talleres as an example of how the fields of Family Language Policy and Language Socialisation can play an important role in grassroots initiatives by translating research findings into practical information for parents.

Technical report: The clinically useful selection of proteins protocol: An approach to identify clinically useful proteins for validation

Clinical proteomics studies aiming to develop markers of clinical outcome or disease typically involve distinct discovery and validation stages, neither of which focus on the clinical applicability of the candidate markers studied. Our clinically useful selection of proteins (CUSP) protocol proposes a rational approach, with statistical and non-statistical components, to identify proteins for the validation phase of studies that could be most effective markers of disease or clinical outcome. Additionally, this protocol considers commercially available analysis methods for each selected protein to ensure that use of this prospective marker is easily translated into clinical practice. SignificanceWhen developing proteomic markers of clinical outcomes, there is currently no consideration at the validation stage of how to implement such markers into a clinical setting. This has been identified by several studies as a limitation to the progression of research findings from proteomics studies. When integrated into a proteomic workflow, the CUSP protocol allows for a strategically designed validation study that improves researchers' abilities to translate research findings from discovery-based proteomics into clinical practice.

Research and Practice in Quality Improvement and Implementation Science: The Synergy for Change Model.

Nurses play an essential role in the achievement of quality depicted by the Quintuple Aim to improve clinical outcomes, patient experience, equity, provider well-being, and reduction of costs. When quality gaps occur, practice change is required and is facilitated by quality improvement (QI) and implementation science (IS) methods. QI and IS research are required to advance our understanding of the mechanisms that explain how evidence is implemented and improvements are made. Despite past efforts of the evidence-based practice and QI movements, challenges persist in sustaining practice improvements and translating research findings to direct patient care. The purpose of this article is to describe the Synergy for Change Model that proposes that both QI and IS research and practice be used to accelerate improvements in health care quality. Recognizing the synergy of QI and IS practice and research will accelerate nursing's contributions to high-quality and safe care.

Nanotechnology-based delivery of therapeutics through the intranasal pathway and the blood-brain barrier for Alzheimer's disease treatment.

Background: drugs for Alzheimer's disease (AD) fail to exhibit efficacy in clinical trials for a number of reasons, a major one being blood-brain barrier (BBB) permeability. Meanwhile, the increasing incidence of this disease emphasizes the need for effective therapeutics. Herein, we discuss novel nanoplatform technologies developed for the effective delivery of AD drugs by traversing the BBB. Main text: the interfacial and surface chemistry of nanomaterials is utilized in several industries, including pharmaceutical, and has drawn considerable attention in the field of nanotechnology. Various reports have suggested the potential of nanotechnology for AD treatment, describing unique drug carriers that improve drug stability and solubility while maintaining therapeutic dosages. These nanotechnologies are harnessed for the transport of drugs across the BBB, with or without surface modifications. We also discuss the transfer of drugs via the nose-to-brain pathway, as intranasal delivery enables direct drug distribution in the brain. In addition, nanomaterial modifications that prolong drug delivery and improve safety following intranasal administration are addressed. Conclusion: although several studies have yielded promising results, limited efforts have been undertaken to translate research findings into clinical contexts. Nevertheless, nanomaterials hold considerable potential for the development of novel effective therapeutic solutions against AD.

WHEN OLDER ADULTS GOT TRAUMATIC INJURY: EFFECTS OF CASE MANAGEMENT

Abstract Case management can improve patient outcomes from the acute to rehabilitation phase after traumatic injury. However, a lack of evidence on effects of case management in older patients with traumatic injury makes it difficult to translate research findings into practice. The study was to examine the effects of a case management intervention on illness perception, coping strategies used, and quality of life in older patients with traumatic injury across a 9-month span after hospital discharge. A 4-wave longitudinal, experimental design was used in older patients with traumatic injury hospitalized at a regional hospital in Taiwan. Subjects were randomly assigned to case management (experimental) or usual care (control) group. The intervention started during hospitalization and ended with a phone follow-up two weeks post discharge. Illness perception and/or coping strategies used along with health-related quality of life were measured at baseline, 3, 6 and 9 months after discharge. Generalized estimating equations were used for analysis. Findings showed significant differences of illness perceptions at 3 and 6 months as well as coping strategies used at 6 and 9 months after discharge between the two groups. However, no significant difference on quality of life over time between the two groups was found. While case management appears to help older patients with traumatic injury decrease illness perception and better cope with their injury, it does not significantly improve their quality of life nine months after discharge. It is recommended that healthcare professionals develop a comprehensive long-term case management program for older patients with traumatic injury.

A Comprehensive Review of Treatment Strategies for Early Avascular Necrosis.

Avascular necrosis (AVN), characterised by compromised blood supply leading to bone necrosis, poses a significant challenge in orthopaedic and rheumatologic practice. This review comprehensively examines early AVN treatment strategies, including aetiology and risk factors, clinical presentation, conservative and surgical approaches, emerging therapies, and rehabilitation. Key findings underscore the importance of early detection, personalised treatment plans, and a multidisciplinary approach involving orthopaedic specialists, rheumatologists, and physical therapists. The implications for clinical practice emphasise individualised care, staying abreast of emerging therapies, and patient education. Recommendations for future management strategies highlight the need for imaging technology advancements, regenerative therapies integration, and ongoing research into genetic and molecular pathways. As the field continues to evolve, translating research findings into clinical practice holds promise for improving outcomes and enhancing the overall quality of life for individuals affected by AVN.

Gut microbiota defined epigenomes of Alzheimer's and Parkinson's diseases reveal novel targets for therapy.

The origins of Alzheimer's disease (AD) and Parkinson's disease (PD) involve genetic mutations, epigenetic changes, neurotoxin exposureand gut microbiota dysregulation. The gut microbiota's dynamic composition and its metabolites influence intestinal and blood-brain barrier integrity, contributing to AD and PD development. This review explores protein misfolding, aggregationand epigenetic links in AD and PD pathogenesis. It also highlights the role of a leaky gut and the microbiota-gut-brain axis in promoting these diseases through inflammation-induced epigenetic alterations. In addition, we investigate the potential of diet, probioticsand microbiota transplantation for preventing and treating AD and PD viaepigenetic modifications, along with a discussion related to current challenges and future considerations. These approaches offer promise for translating research findings into practical clinical applications.

Challenges and strategies for conducting research in primary health care practice: an integrative review

BackgroundProviding accessible and high-quality patient-centered healthcare remains a challenge in many countries, despite global efforts to strengthen primary health care (PHC). Research and knowledge management are integral to enhancing PHC, facilitating the implementation of successful strategies, and promoting the use of evidence-based practices. Practice-based research in primary care (PC-PBR) has emerged as a valuable approach, with its external validity to diverse PHC settings, making it an effective means of translating research findings into professional practice.ObjectiveTo identify challenges and strategies for conducting practice-based research in primary health care services.MethodAn integrative literature review was conducted by searching the PubMed, Embase, Scopus, Web of Science, and Lilacs databases. The research question, guided by the PICo framework, directed the execution of study selection and data extraction. Data analysis followed the RAdAR method's three phases: pre-analysis, data analysis, and interpretation of results.ResultsOut of 440 initially identified articles, 26 met the inclusion criteria. Most studies were conducted in high-income countries, primarily the United States. The challenges and strategies for PC-PBR were categorized into six themes: research planning, infrastructure, engagement of healthcare professionals, knowledge translation, the relationship between universities and health services, and international collaboration. Notable challenges included research planning complexities, lack of infrastructure, difficulties in engaging healthcare professionals, and barriers to knowledge translation. Strategies underscore the importance of adapting research agendas to local contexts, providing research training, fostering stakeholder engagement, and establishing practice-based research networks.ConclusionThe challenges encountered in PC-PBR are consistent across various contexts, highlighting the need for systematic, long-term actions involving health managers, decision-makers, academics, diverse healthcare professionals, and patients. This approach is essential to transform primary care, especially in low- and middle-income countries, into an innovative, comprehensive, patient-centered, and accessible healthcare system. By addressing these challenges and implementing the strategies, PC-PBR can play a pivotal role in bridging the gap between research and practice, ultimately improving patient care and population health.

Abstract C024: Room temperature stabilization of fecal samples supports important microbiome insights to expand access

Abstract Analysis of microbial signatures associated with colorectal cancer has potential to improve access and adherence to cancer screening programs through non-invasive sampling, particularly in underserved communities. Lack of reproducibility between studies remains a challenge and has limited the ability to translate research findings into scalable clinical applications. The common practice of storing samples at -80°C/-112°F is inconvenient, often not feasible, and may introduce bias if samples are not handled carefully and consistently. Large-scale screening programs would benefit from room temperature stabilization and sample homogenization at the point of collection, without the logistical considerations for rapid and long-term freezing. To evaluate the potential of room temperature stability, fecal samples from adult and pediatric individuals were self-collected at home using the OMNIgene™•GUT Dx device with corresponding unstabilized samples stored at -80°C/-112°F. Metagenomics sequencing was utilized to generate microbiome profiles and identify taxa-associated biomarkers relevant to gastrointestinal health and aging. Stabilized samples were compared to freshly collected unstabilized samples (n=18) to evaluate any bias introduced by the stabilizing solution. The same stabilized samples were compared to unstabilized samples stored at -80°C/-112°F to evaluate stability over time. In addition, reproducibility was evaluated by performing DNA extractions in triplicate from ten stabilized fecal samples. Finally, the ability of the room temperature stabilization to capture expected differences between groups was evaluated by comparing adult and pediatric (n=30 per group) samples and looking for known signatures specific to each group. This research demonstrated equivalent stability over time between stabilized samples at room temperature and unstabilized samples stored at -80°C/-112°F, showing preservation of both highly abundant and rare members of the microbial community. Findings indicate that room temperature stabilization does not introduce bias relative to freshly collected unstabilized samples and produces sufficient sample homogenization to yield reproducible microbial profiles. The comparison between adult and pediatric stabilized fecal samples highlights an enrichment for pediatric-specific signatures, such as Bifidobacterium and Veillonella species, and further captures the lower diversity of pediatric samples relative to more developed adult microbiota. These results demonstrate that the OMNIgene™•GUT Dx device enables the preservation of microbial community structure with room temperature stabilization and sample homogenization for use in the detection of biomarkers in fecal samples. Simple logistics of room temperature storage, combined with an easy-to-use self-collection design and compatibility with standard postal shipping assist integration into clinical workflows and enable at-home collections from diverse populations, especially at-risk, minority populations without easy access to clinical services. Citation Format: Savannah Colameco, Jean M. Macklaim, Ashlee Brown, Tara Crawford Parks. Room temperature stabilization of fecal samples supports important microbiome insights to expand access [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr C024.

Assessment on the Utilization of Completed Basic Education Research Fund in SOCSARGEN: Basis for Policy Enhancement

An assessment of the utilization of the Completed Basic Education Research Fund (BERF) in the divisions of South Cotabato, Sarangani, and General Santos City, Philippines, was conducted using a descriptive-correlational research design on the 40 BERF-recipient, teacher-researchers from School Year 2019-2021. It looked into whether the utilization had a significant influence on the proficiency of learners. The quantitative results revealed that completed BERF research was moderately utilized. Likewise, learners' proficiency in the recipient school during the first quarter of School Year 2022-23 was very satisfactory. Furthermore, using a Spearman Rank correlation, the variables in utilizing completed BERF did not significantly influence learners' proficiency in the recipient school. It can be seen that the research findings may not have reached the intended audience in a way that is accessible, understandable, and relevant to their needs. Accordingly, the learners had a very satisfactory performance. This can be attributed to their improved digital skills during the pandemic may have contributed to their face-to-face classes’ performance. The translation of research findings into actionable strategies and interventions was likely affected by other concerns in school management. Therefore, it is imperative to guarantee that the research supported by BERF closely corresponds with the unique requirements and difficulties students face in the school system.

Assessment on the Utilization of Completed Basic Education Research Fund in SOCSARGEN: Basis for Policy Enhancement

An assessment of the utilization of the Completed Basic Education Research Fund (BERF) in the divisions of South Cotabato, Sarangani, and General Santos City, Philippines, was conducted using a descriptive-correlational research design on the 40 BERF-recipient, teacher-researchers from School Year 2019-2021. It looked into whether the utilization had a significant influence on the proficiency of learners. The quantitative results revealed that completed BERF research was moderately utilized. Likewise, learners' proficiency in the recipient school during the first quarter of School Year 2022-23 was very satisfactory. Furthermore, using a Spearman Rank correlation, the variables in utilizing completed BERF did not significantly influence learners' proficiency in the recipient school. It can be seen that the research findings may not have reached the intended audience in a way that is accessible, understandable, and relevant to their needs. Accordingly, the learners had a very satisfactory performance. This can be attributed to their improved digital skills during the pandemic may have contributed to their face-to-face classes’ performance. The translation of research findings into actionable strategies and interventions was likely affected by other concerns in school management. Therefore, it is imperative to guarantee that the research supported by BERF closely corresponds with the unique requirements and difficulties students face in the school system.

Embracing the Wisdom of Ancient Greece in the Era of Personalized Medicine-Uncertainty, Probabilistic Reasoning, and Democratic Consensus.

Further improvements of outcome after solid organ transplantation will depend on our ability to integrate personalized medicine in clinical routine. Not only better risk stratification or improved diagnostics, also targeted therapies and predictive markers of treatment success are needed, as there is a virtual standstill in the development and implementation of novel therapies for prevention and treatment of allograft rejection. The integration of clinical decision support algorithms and novel biomarkers in clinical practice will require a different reasoning, embracing concepts of uncertainty and probabilistic thinking as the ground truth is often unknown and the tools imperfect. This is important for communication between healthcare professionals, but patients and their caregivers also need to be informed and educated about the levels of uncertainty inherent to personalized medicine. In the translation of research findings and personalized medicine to routine clinical care, it remains crucial to maintain global consensus on major aspects of clinical routine, to avoid further divergence between centres and countries in the standard of care. Such consensus can only be reached when experts with divergent opinions are willing to transcend their own convictions, understand that there is not one single truth, and thus are able to embrace a level of uncertainty.

Topical Iron Chelator Therapy: Current Status and Future Prospects.

Systemic iron chelation therapy has long been used for iron overload, providing a role in returning iron levels to proper homeostatic concentrations. Recently, topical iron chelation therapy has emerged as a potential strategy for treating skin damage. This narrative review explores the current status and future prospects of topical iron chelation therapy for treating ultraviolet (UV) and non-UV skin damage, as well as its potential application in wound healing. The review was conducted through a literature search across PubMed, Web of Science, and EMBASE databases, spanning publications from 1990 to 2023. The selection of articles was focused on primary research studies, either experimental or clinical, that explored the implications and formulations of topical iron chelators used alone or in conjunction with another therapeutic agent. The search strategy employed a combination of terms, including "topical iron chelation", "topical deferoxamine", "UV", "wound healing", "skin inflammation", "radiation-induced fibrosis", and "skin cancer". Relevant studies, including methods, intervention strategies, measured outcomes, and findings, are summarized. The review also considered the potential challenges in translating research findings into clinical practice. Results indicate that topical iron chelators, such as deferoxamine, are effective in mitigating UV-induced skin damage, reducing tumorigenesis, and decreasing oxidative damage. In addition, the use of these agents in radiation-induced fibrosis has been shown to significantly increase skin elasticity and reduce dermal fibrosis. Several studies also highlight the use of topical iron chelators in difficult-to-treat chronic wounds, such as diabetic neuropathic ulcers and sickle cell ulcers. In conclusion, topical iron chelation therapy represents a novel and promising approach for skin protection and wound healing. Its potential makes it a promising area of future research.