Although the amount of oil and gas reserves and the reservoir properties in the East China Sea Shelf Basin (ECSSB) indicate good prospects for oil and gas exploration in the Mesozoic strata, there has not yet been a significant breakthrough in oil and gas production. An important reason is that there are few detailed studies on the sedimentary paleogeography of the ECSSB which make it difficult to predict the distribution of sand bodies. In this paper, well-core observations, thin-section identifications, electron probe microanalysis, trace elements analysis and seismic interpretations were synthetically applied to study the sedimentary environments and the tectonic setting of the Upper Cretaceous in the southern ECSSB. In the Oujiang Sag, red mudstones and pyroclastic rocks were deposited, accompanied by wedged, chaotic pro-grading reflections in the seismic profile, indicating a volcano-alluvial fan sedimentary system. Abundant sedimentary structures including double-mud drapes, asymmetric herringbone cross-beddings and burrows, such as Planolites and Skolithos, were developed in the Minjiang Sag, typically indicating a high-energy tidal environment. The autogenetic glauconites in situ and the fossil Tintinnid also indicate a shallow marine environment. The resulting sedimentary characteristics are in accordance with the littoral facies revealed by the seismic reflections in the Minjiang Sag. Moreover, volcanic conduit facies, effusive facies, and pyroclastic facies were also recognized in the seismic profile in the Minjiang Sag. Therefore, it was presumed that subaqueous volcanic eruptions occurred in the Minjiang Sag. In the Keelung Sag, the littoral facies were dominant. The tectonic setting of the Upper Cretaceous in the southern ECSSB is the transitional arc accompanied by large-scale volcanic activities. In conclusion, the volcano-alluvial fan sedimentary system was developed in the Oujiang Sag and volcano-littoral sedimentary system was developed from the Minjiang Sag to the Keelung Sag. This study is intended to promote the understanding of the sedimentary paleogeography of the Upper Cretaceous in the southern ECSSB and to provide help in oil and gas exploration.