The superimposed coupling of flow oscillations generated by transient external forces under ocean conditions and flow oscillations in parallel helical tubes during two-phase flow instability may lead to more complex flow oscillation phenomena in parallel helical tubes. However, there is still a lack of understanding regarding the effect of ocean conditions on the two-phase flow instability within parallel helical tubes. The two-phase flow instability in parallel helical tubes under ocean conditions is numerically investigated in the present study. The effects of ocean conditions on the flow behavior and instability threshold in parallel helical tubes are studied with mass flux 200 kg/m2s and inlet subcooling within 5–70 °C. The results show that the mass flow rate decreases as the inclination angle increases. A larger rolling amplitude or shorter period increases the flow and temperature oscillation amplitude. Two characteristic frequencies are found in the natural circulation flow instability under the rolling motion. As the rolling amplitude increases, the compound flow oscillation amplitude is larger and more chaotic with a certain phase shift. The effect of stationary inclining on the flow instability threshold is rather significant than rolling effect. The results of the present study can serve as a significant reference for the operation and design of the helical-coiled once-through steam generator under ocean conditions.