ABSTRACT The emergence of trans-governmental policy regimes in Europe has fundamentally changed the role of National Regulatory Agencies (NRAs). Here we move away from the idea that there is a meaningful divide between the domestic and the European levels of governance and suggest that a different logic has emerged in recent decades, combining multiple chains of delegation and innovative coordination schemes. NRAs have come to occupy a ‘broker’ or intermediary position between domestic and European polities, that is no longer adequately described by the prevailing, mainly dyadic models of bureaucratic autonomy conceived just for national states. In this paper, we build the concept of entangled agencies to make sense of the linkages between NRAs and European Agencies (EAs) and provide some preliminary empirical evidence to show how they effectively articulate various levels of government, presenting empirical findings on the connections that ties NRAs representatives with EAs management boards.