Seismicity associated with hydrothermal systems (e.g., submarine volcanoes, mid-oceanic ridges, oceanic transform faults, etc.) share a complex relationship with the tidal forcing and induced fluid flow process under different tectonic settings. The hydrothermal circulation drives the deformation at the brittle-ductile transition zone within a permeable brittle crust. Although the tidal loading amplitudes are too small to generate a brittle deformation, the incremental pressure exerted by the tidal loading can modulate the flow of hydrothermal fluid circulation and trigger the critically stressed faults or fracture zones. We present a compelling case of tidal modulation in seismicity along the Blanco Ridge Transform Fault Zone (BRTFZ), in the northeast Pacific. The strong diurnal and fortnightly periodicity has been observed in the deeper seismic swarm (7–15 km), whereas the shallow seismic swarm (0–7 km) does not exhibit any such tidal periodicity. The dominance of diurnal and fortnightly periodicity in the deeper seismic swarm is explained by the high amplitude tidal cycles providing additional stress on the fluid circulation at the crust-mantle boundary. Moreover, our robust statistical correlation of seismicity with tidal stress and resonance destabilization model under rate-and-state friction formalism suggests that the fault segments are conditionally unstable and more sensitive to periodic tidal stress perturbation.