Transfer Time Research Articles

Real world delays in antivenom administration: patient, snake or hospital factors (ASP-33)

Objective Early antivenom administration is essential for effective treatment. We investigated the delays in antivenom administration. Methods We reviewed snakebites from the Australian Snakebite Project (2006–2021) given antivenom, presenting to hospital within 12 h. We extracted demographics, snake type, time of bite, hospital arrival, blood collection, antivenom treatment and hospital transfer. Results There were 2,169 patients recruited to Australian Snakebite Project 1,132 patients received antivenom within 12 h of the bite, and 1,019 of these were envenomated: median age 41 years (IQR: 24–57 years); 738 (72%) males. A pressure bandage was applied in 950 (93%), a median of 15 min (IQR: 5–30 min) post-bite. Specific snakes were identified by venom assays in 855 patients (80%), including 328 brown snakes (32%), 173 tiger snakes (17%), 74 rough-scaled snakes (7%), 85 red-bellied black snakes (8%), 49 taipans (5%) and 26 death adders (3%). Seventy-seven patients (7%) received antivenom without envenomation. The median length of hospital stay was 41 h (IQR: 24–67 h). The median time to hospital was 60 min (IQR: 30–105 min), to first blood tests was 90 min (IQR: 59–154 min) and to antivenom was 235 min (IQR: 155–345 min). There was a median delay in blood tests of 20 min (IQR: 10–37 min) and a median delay to antivenom of 147 min (IQR: 84–249 min). Non-specific systemic symptoms occurred in 641 (63%) patients, which occurred a median of 24 min (IQR: 10–60 min) post-bite, which was at a median of 180 min (IQR: 106 to 275 min) prior to antivenom administration. Time to antivenom in the 314 transferred patients was similar to those not transferred. Time to antivenom was significantly shorter for 189 patients given antivenom prior to transfer, median 183 min (IQR: 110–270 min), compared to 130 patients given antivenom after transfer, median 363 min (IQR: 289–513 min; P <0.001). Discussion Antivenom administration was delayed on average by 2.5 h after hospital presentation, despite three-quarters arriving in hospital within 3 h, the optimal time for antivenom administration. Patients requiring transfer received antivenom in a similar time, but earlier if administered prior to transfer, highlighting the possible benefits of pragmatic clinical decision-making prior to blood tests. Conclusion We found the leading cause of delays to antivenom administration after patients arrive in hospital was waiting for blood results. Systemic symptoms occurred early in most cases and could be given greater weight in decisions about early antivenom.

A simple and cost-effective sample preparation and storage method for stable isotope analysis of atmospheric CO2 for GasBench II/continuous flow isotope ratio mass spectrometry.

The stable isotope compositions of atmospheric CO2 can provide useful insight into various geochemical processes and carbon cycles on Earth, which is critical for understanding of Earth's changing climate. Here, we present a simple and cost-effective analytical method for the collection and measurement of carbon and oxygen isotope compositions of atmospheric CO2. Air samples of ~150 mL were collected individually or collectively using our simple active air collection system and then extracted on a vacuum purification line to remove noncondensable gases and atmospheric water vapor. The efficiency of removing atmospheric water vapor was tested by using a magnesium perchlorate desiccant trap and a dry ice/ethanol trap. Lastly, a "J-Cut tube sealing/cracking method" was developed to store and transfer purified atmospheric CO2 to the GasBench II and CF-IRMS system for δ13C and δ18O measurements. The collective active air collection method combined with the full sample air extraction method for a 3-min transfer time or "Full 3m TE" yields the best analytical precision of 0.07‰ (δ13C) and 0.04‰ (δ18O). Removing atmospheric water vapor from air samples is not necessary for δ13C, but essential for δ18O measurements. The J-Cut tube sealing/cracking method shows a near 100% effectiveness for the storage and transfer of atmospheric or any CO2. A simple and cost-effect method was developed for the collection, purification, storage, and isotopic analysis of indoor/outdoor atmospheric CO2 samples for general users. This method utilizes a popular headspace gas sample preparation system for CF-IRMS and an easy-to-build vacuum purification line without involving complex and high-cost devices for the preparation of atmospheric CO2.

The impacts of yaw attitude strategies for eclipsing GNSS satellites on precise point positioning time transfer

The impacts of yaw attitude strategies for eclipsing GNSS satellites on precise point positioning time transfer

Fast-Vid2Vid++: Spatial-Temporal Distillation for Real-Time Video-to-Video Synthesis.

Video-to-Video synthesis (Vid2Vid) gains remarkable performance in generating a photo-realistic video from a sequence of semantic maps, such as segmentation, sketch and pose. However, this pipeline is heavily limited to high computational cost and long inference latency, mainly attributed to two essential factors: 1) network architecture parameters, 2) sequential data stream. Recently, the parameters of image-based generative models have been significantly reduced via more efficient network architectures. Existing methods mainly focus on slimming network architectures but ignore the size of the sequential data stream. Moreover, due to the lack of temporal coherence, image-based compression is not sufficient for the compression of the video task. In this paper, we present a spatial-temporal hybrid distillation compression framework, Fast-Vid2Vid++, which focuses on knowledge distillation of the teacher network and the data stream of generative models on both space and time. Fast-Vid2Vid++ makes the first attempt at time dimension to transfer hierarchical features and time coherence knowledge to reduce computational resources and accelerate inference. Specifically, we compress the data stream spatially and reduce the temporal redundancy. We distill the knowledge of the hierarchical features and the final response from the teacher network to the student network in high-resolution and full-time domains. We transfer the long-term dependencies of the features and video frames to the student model. After the proposed spatial-temporal hybrid knowledge distillation (Spatial-Temporal-HKD), our model can synthesize high-resolution key-frames using the low-resolution data stream. Finally, Fast-Vid2Vid++ interpolates intermediate frames by motion compensation with slight latency and generates full-length sequences with motion-aware inference (MAI). On standard benchmarks, Fast-Vid2Vid++ achieves a real-time performance of 30-59 FPS and saves 28-35× computational cost on a single V100 GPU.

Analysis of Nanobubble-oxygenated Water for Horticultural Applications

The theoretical properties of nanobubbles (NBs), such as a negative surface charge and large interfacial surface area, allow for highly efficient gas transfer and stagnation time in water and may reduce the surface tension of NB-treated water sources. These properties make NBs unique candidates for addressing issues like root zone oxygen deficiency, common in conventional and hydroponic crop production. Therefore, the objectives of this research were to confirm the presence of NBs in treated water and determine how time and temperature affect dissolved oxygen (DO) retention in NB-oxygenated water. Two membrane-based NB injection systems were compared with a standard method of aeration (aquarium air stone) and untreated potable water to determine the effect of NB oxygenation on DO retention time and nanoscopic particle size and concentration of potable water sources. NB oxygenation of potable water generally resulted in a greater number of nanoparticles detected compared with untreated potable water. NB oxygenation increased initial levels of DO in potable water when compared with the standard air stone. NB oxygenation failed to increase DO retention time compared with a standard air stone, regardless of water temperature. NB oxygenation remains a method of efficiently oxygenating large volumes of water, although the NBs investigated in the study did not increase DO retention in a potable water source.

ANALYSIS OF THE EFFECT OF SWIRL FLAME SHAPING ON EMISSIONS FROM THE CO-FIRING OF AMMONIA AND METHANE

This paper presents experimental and numerical insights into the behaviour of lean swirl flames with co-combustion of ammonia and methane. In order to evaluate the accuracy of the emissions modelling for CH4/NH3/air preheated (473K) mixtures with an increasing share of ammonia, experimental investigations were performed, varying the share of ammonia up to 25% in the fuel and the equivalence ratio of air to fuel of 0.71. A burner featuring swirl outflow blades with a 30-degree angle of outflow and a convergent-divergent nozzle was employed in the experimental setup. In order to determine the size of the reaction zone, the concentrations of NO and CO along the probing radius inside the combustion chamber were measured. A complete geometry of the combustion chamber and burner was modelled with RSM and EDC models. The outcomes of the Okafor, Xiao, and San Diego mechanisms were compared to the test data. A further DES simulation was conducted to assess the potential applicability of the models. For the flames tested with 3D RSM, a good agreement was achieved for NO emissions. In the case of a fuel containing between 10% and 25% ammonia, the Okafor mechanism demonstrated the most favourable qualitative and quantitative agreement. The reactor volume, residence time and heat transfer conditions for the CRN reactor network were calculated using numerical CFD methods. A satisfactory correlation was observed between the calculated and experimental NO emissions, with a discrepancy of only 10%. In view of the considerable computational expense associated with the models employed and the high degree of accuracy demonstrated in the emission predictions, the 3D RSM simulation was deemed to be an appropriate means of modelling small-scale applications.

Pediatric Esophageal Button Battery Protocol Reduces Time From Presentation to Removal.

Evaluate implementation of an institutional protocol to reduce the time to removal of esophageal button battery (BB) and increase use of mitigation strategies. We developed a protocol for esophageal BB management [Zakai's Protocol (ZP)]. All cases of esophageal BB impaction managed at a tertiary care center before and after implementation from 2011 to 2023 were reviewed. Time to BB removal, adherence to critical steps, and use of mitigation strategies (honey/sucralfate, acetic acid) were evaluated. Fifty-one patients (38 pre-ZP, 13 post-ZP) were included. Median age was 2.3 years (IQR 1.3-3.4). After implementation, the time from arrival at the institution to arrival in the operating room (OR) reduced by 4.2 h [4.6 h (IQR 3.9-6.5) to 0.4 h (IQR 0.3-0.6), p < 0.001] and there was improvement in all management steps. The number of referrals direct to otolaryngology increased from 51% to 92%, arrival notification increased from 86% to 100%, avoidance of second x-ray increased from 63% to 100%, and direct transfer to OR increased from 92% to 100%. Adherence to mitigation strategies such as preoperative administration of honey or sucralfate increased from 0% to 38%, intraoperative use of acetic acid from 3% to 77%, and nasogastric tube insertion from 53% to 92%. Implementation of ZP substantially reduced the time to BB removal and the use of mitigation strategies in our tertiary care institution. Additional strategies focused on prevention of BB ingestion, and shortening the transfer time to the tertiary care hospital are required to prevent erosive complications. 3, Case-series Laryngoscope, 134:5170-5177, 2024.

The influence of atmospheric turbulence-induced optical intensity scintillation on the accuracy of satellite-to-ground laser one-way timing

This paper elucidates the mechanism by which atmospheric turbulence leads to errors in satellite-to-ground laser one-way timing, investigates the influence of optical intensity scintillation on the time delay jitter of laser signal arrival in single-satellite-to-ground transmission link. Furthermore, the impact patterns and the magnitude of atmospheric turbulence-induced one-way timing errors and positioning errors across various gradients of observation zenith angles in the GPS four-satellite-to-ground transmission link is also investigated. Besides, the study also explores the impact patterns and magnitude ranges of the effects of optical intensity scintillation on the four-satellite-to-ground time transfer system under different observed zenith angles with similar geometric dilution of precision (GDOP) conditions. The results show that smaller receiver zenith angles result in reduced errors caused by atmospheric turbulence-induced optical intensity scintillation, leading to higher accuracy in four-satellite positioning. When the GDOP factors range from 6.5 to 7.5, the timing errors for multiple sets of satellites consistently exhibit a normal distribution. Specifically, the four-satellite-to-ground laser one-way time transfer deviation averages around 2 ns, with jitter remaining within 1 ns.

Vertical vibration characteristics of wheelset-gearbox-bogie frame system in different track irregularity conditions: simulation and full-scale test

ABSTRACT The vibration characteristics of a wheelset-gearbox-bogie frame system are studied under wheel-roller roughness and varying track irregularities utilizing a full-scale rolling test rig. A corresponding dynamic model is developed based on the discrete time transfer matrix method, which integrates a modular flexible wheelset model. The results reveal that, (1) low-frequency vibrations (0–50 Hz): dominated by track irregularities below 200 km/h but by wheel-roller rotation above 350 km/h; (2) mid-frequency vibrations (50–500 Hz): prominent shock effects appear at discrete frequencies above 350 km/h, related to wheel-roller roughness; (3) high-frequency vibrations (500–1000 Hz): great differences under various irregularities and distinguishing structural natural frequencies becomes difficult. Amplitude contributions at speeds below 200 km/h are mid (57–62%), low (26–32%), and high (11–14%). Above 350 km/h, mid-frequency increases while low-frequency decreases by 15%, respectively. To improve vibration performance at superspeed (e.g., 500 km/h), stricter wheel-rail roughness control becomes imperative.

Optimizing Top-K query processing on GPU using data compression and pre-filtering

In large-scale data analysis, efficient Top-K query processing is critical for numerous applications in science, industry, and society. Traditional approaches often involve substantial data transfer and computational overhead, making it difficult to meet the scalability and efficiency demands of modern datasets. This paper proposes a GPU-accelerated Top-K query processing method that integrates data compression and pre-filtering techniques to address these challenges. By partitioning and compressing data on the host side, it alleviates common PCIe bottlenecks in heterogeneous computing environments. A metadata-driven pre-filtering technique further reduces the data volume processed on the GPU, significantly improving query performance, particularly when handling anti-correlated datasets. Experimental results demonstrate that this method markedly reduces data transfer and processing time, confirming its effectiveness in enhancing the efficiency and scalability of Top-K query processing compared to existing methods.

Comparative Evaluation of Microleakage below the Orthodontic Brackets after Bonding with Various Adhesive Agents: An In Vitro Study.

The aim of the current study was to assess the microleakage below orthodontic brackets after bonding with three different adhesive materials. In total, 75 healthy human premolars that had been extracted for orthodontic treatment were utilized in this investigation. The samples were divided into three groups of 25 samples randomly. Premolar brackets with stainless steel bondable 0.022 slot pre-adjusted edgewise appliances were utilized. Group I: Brackets bonded with Nanocomposite Filtek Z350 XT, group II: brackets bonded with Transbond XT, group III: brackets bonded with resin-reinforced glass ionomer cement-GC Fuji Ortho LC. A surveyor applied a 200 g weight to each bracket, making minor adjustments to ensure the adhesive thickness was consistent. Thermocycling was then carried out for 1000 cycles at 5 ± 2°C to 55 ± 2°C with a dwell time of 30 s and a transfer time of 5 s. The samples were incubated in a 0.5% basic fuchsine solution for a day. Every sample was inspected using a stereomicroscope with a ×16 magnification. The data were collected and analyzed. The least microleakage was found in Transbond XT adhesive group (1.84 ± 0.12), followed by Filtek Z350 XT (1.96 ± 0.08) and GC Fuji Ortho LC (2.44 ± 0.10) group. There was a highly significant difference between the different adhesive agent groups. There was a statistically significant difference found between Filtek Z350 XT vs GC Fuji Ortho LC and Transbond XT vs GC Fuji Ortho LC with a mean difference of -0.48 and 0.60, respectively. However, there was no significant difference between Filtek Z350 XT vs Transbond XT with a mean difference of 0.12. Within the limitation, the present study concluded that the Transbond XT showed better adhesive properties and least microleakage compared with Filtek Z350 XT and GC Fuji Ortho LC. There are many undesirable side effects of orthodontic therapy, including cavities, demineralization, and discoloration of the enamel. Unpleasant "white-spot lesions" or secondary caries under and around the brackets can result from microleakage between the adhesive and the base of the orthodontic bracket as well as between the adhesive and the enamel. How to cite this article: Singh S, Brajendu, Haque I, et al. Comparative Evaluation of Microleakage below the Orthodontic Brackets after Bonding with Various Adhesive Agents: An In Vitro Study. J Contemp Dent Pract 2024;25(8):722-725.

Interaction of driven ‘cold’ electron plasma wave with thermal bulk via ion spatial inhomogeneity

Abstract Using high resolution Vlasov - Poisson simulations, evolution of driven ``cold" electron plasma wave (EPW) in the presence of stationary inhomogeneous background of ions is studied. Mode coupling dynamics between ``cold'' EPW with phase velocity $v_{\phi}$ greater than thermal velocity i.e $v_{\phi} \gg v_{thermal}$ and its inhomogeneity induced sidebands is illustrated as an initial value problem. In driven cases, formation of BGK like phase space structures corresponding to sideband modes due to energy exchange from primary mode to bulk particles via wave-wave and wave-particle interactions leading to particle trapping is demonstrated for inhomogeneous plasma. Qualitative comparison studies between initial value perturbation and driven problem is presented, which examines the relative difference in energy transfer time between the interacting modes. Effect of variation in background ion inhomogeneity amplitude as well as ion inhomogeneity scale length on the driven EPWs is reported.

Analysis of the performance of the PPP-B2b satellite clock and its effects on time transfer

Abstract BDS-3 is capable of providing precise point positioning (PPP) services via B2b signals for the Asia–Pacific region. The performance of the satellite clock plays a dominant role in the transmission interval of B2b clock correction and PPP time transfer. In this work, first, the coverage of B2b signals is analysed, and the performance of the satellite clock is evaluated (including orbit accuracy, clock stability, clock accuracy and prediction accuracy). Second, the results of time transfer based on BDS-3 PPP-B2b are investigated. The values show that the orbit error of BDS-3 recovered from PPP-B2b is better than that of the GPS recovered from PPP-B2b. The stability of BDS-3 recovered from the PPP-B2b clock is superior to that of the GPS PPP-B2b clock. The stability of the BDS-3 clock is approximately 1∼2 e-13, 5∼9 e-14, and 3∼5 e-14 at 100 s, 1000 s, and 10000 s, respectively. No obvious discrepancy exists in the BDS-3 clocks of different types. The mean prediction accuracy of BDS-3 is 0.03 ns when the prediction time is up to 120 s, and the prediction accuracy of the GPS is 0.28 ns when the prediction time is merely 30 s. This result shows that it is possible to decrease the transmission interval of BDS-3 B2b clock correction and save much space. The time transfer based on BDS-3 PPP-B2b can subsequently achieve a 0.50 ns level. The frequency stability of the time link is approximately 9.25E-14, 2.42E-14, and 9.34E-15 at 100 s, 1000 s, and 10000 s, respectively. We can conclude that the BDS-3 PPP-B2b solution is reliable for time transfer.

Multifunctional Triboelectric Metamaterials with Unidirectional Charge Transfer Channels for Linear Mechanical Motion Energy Harvesting

AbstractConventional triboelectric generators (TEGs) have been developed to mainly harvest the energy of linear mechanical motions and convert it usually into oscillating or pulsive, but not sustainable, electrical outputs. In this study, unidirectional charge transfer mechanisms are introduced to develop a triboelectric mechanical metamaterial (TMM) with sustainable electrical outputs. Density functional theory and experimental analyses demonstrate three minimum necessary components of TMMs fabricated by only two triboelectric materials (i.e., copper and PTFE) to generate sustainable electrical outputs. Under a wide range of compression‐tension strain of ±50%, the maximum open‐circuit voltage, short‐circuit current, and volumetric power density are 3860 V, 8 µA, and 365.3 kW m−3, respectively. Different from most conventional cellular solids, the mechanical energy dissipation of the TMMs increases quadratically with the unit cell number. High volumetric electromechanical efficiency is achieved when the unit cell is miniaturized. In addition to energy harvesting and mechanical energy dissipation, TMMs can sense the displacement by counting the number of distinctive peaks in the short‐circuit charge transfer or reaction force versus time curves. The extreme electromechanical functionalities of the TMMs facilitate their applications in intelligent suspension systems, miniaturized green power sources, and self‐sensing energy harvesters.

Full-process supported Simulation Platform Framework based on cloud computing and HPC integration

Simulation technology is widely used in many fields, it usually involves three processes, (i) pre-process, (ii) analysis solver, and (iii) post-process. Simulation calculations require a large amount of computing resources, and users usually need to use cloud and High-Performance Computing (HPC) systems to complete works. Simulation works are increasingly depending on the capacity of HPC or cloud, for cost reasons, people are more willing to use the services than self-built an HPC or Cloud computing cluster. However, that leads to the isolation of calculations and pre- and post-processing work, adding additional time for data transfer. Moreover, simulation engineers also want to use cloud servers in pre-processing and post-processing, since compared with local workstations, cloud servers have significant advantages in saving hardware investment, remote office collaboration, and data integration management. Therefore, we provide a platform framework based on cloud computing and HPC integration that supports the full process of simulation. Then, we implemented it in Tianhe-1A and Tianhe exascale supercomputers and THCloud environments. Through a city area-level explosion simulation experiment, it was verified that the framework can fully support the whole process of simulation, and effectively reduce the time of simulation work, improving the simulation engineer’s work efficiency. The study shows that the platform provides a feasible solution for full-process simulation. Compared with other platforms, it has the characteristics of full-process, high performance and high security.

Abstract 4138225: In-Hospital Outcomes of Percutaneous Coronary Intervention (PCI) in patients primarily admitted with ST-Elevation Myocardial Infarction (STEMI) at PCI centers versus patients transferred from non-PCI centers, a retrospective study involving the National Inpatient Sample (NIS 2016-2021) database.

Background: Timely transfer for PCI is paramount in the management of STEMI. This has been shown to reduce myocardial damage, optimize reperfusion therapy and mitigate the post procedural complications associated with PCI. This study's aim was to describe the in-hospital outcomes associated with acute inter-hospital transfer of patients with STEMI for PCI in comparison with patients directly admitted to a primary PCI center. Methods: The National Inpatient Sample (NIS) was used to identify patients who underwent PCI for STEMI between the years 2016-2021. Based on several transfer indicators, primarily admitted patients and patients with acute inter-hospital transfer were identified. Logistic and linear regression models were used to analyze the primary outcome of in-hospital mortality and secondary outcomes of length of hospital stay, hospital charge, and occurrences of post-procedure complications. Results: Observations were weighted to obtain a national estimate of 748,430 patients with known transfer status who underwent PCI for STEMI. Of these, 625,520 patients were primarily admitted at PCI centers and 122, 910 patients were transferred from non-PCI centers. The mean age of patients with STEMI undergoing PCI was 62 years, and 72 % of the patients were male. There was no significant difference in mortality between patients transferred and patients primarily admitted for PCI due to STEMI. However, patients transferred had longer hospital stay and significantly higher healthcare cost, with a mean difference of 0.72 days (95% CI: 0.65 - 0.81 days, p-value &lt;0.000) and $3,354 (95% CI: $339 - $6371, p-value &lt;0.029), respectively. Patients transferred also had significantly higher odds of post procedure complications, including cardiogenic shock (Odds ratio: 1.49, 95% CI: 1.08 - 2.06, p-value &lt;0.014), cerebrovascular accident (Odds ratio: 3.64 , 95% CI: 1.15 - 11.45, p-value &lt;0.014) and kidney failure (Odds ratio: 2.10 , 95% CI: 1.09 - 4.02, p-value &lt;0.026). Conclusion: Patients with STEMI who were transferred for PCI experienced longer hospital stay and incurred higher healthcare costs. These patients had significantly higher odds of post procedure complications including cardiogenic shock, cerebrovascular accidents and kidney failure.

Quantum two-way time transfer over a 250 km direct fiber-optic link

Quantum two-way time transfer over a 250 km direct fiber-optic link

Assessment of transfer-time and time-to-surgery as risk factors to survival in Gastroschisis (GS) in a LMIC; an eight-year review

BackgroundThe management of Gastroschisis in LMICs continues to be a challenge and is associated with very poor outcomes in contrast with HICs where survival rates near 100%. The purpose of this work is to provide an overview of survival over the past 8 years in a high-flow tertiary centre in Africa. It also investigates the effect of transfer-time and time-to-surgery on outcome.MethodsRetrospective case note review of all GS admissions. The variables assessed were gender, gestational age, weight, type of GS, transfer time, time to surgery and type of surgery. The primary outcome was survival.ResultsA total of 171 GS cases were identified: 148 simple, 23 complex. Seven died before surgery. The median age at surgical intervention was 8.5 h (range, 0–48). Closure options ranged from single-staged (primary fascial, skin, umbilical flap and sutureless closure) or a staged (silo) closure. Overall survival was 34.5%. Cases transferred under 8 h had a 46% survival. Surgery under 12 h of life had highest survival, 45%. Simple GS survived better than complex GS (40% vs 10%). Primary closure had a significantly better survival compared to staged closure (51% vs 18%).ConclusionsTransfer-time < 8 h plays a vital role in survival of GS cases. Surgical intervention within 12 h of birth showed a statistically significant improvement in outcome. Primary closure was associated with better survival rates.Level of EvidenceLevel III.

An Audit of a Modified Pediatric Early Warning Scoring System in a Tertiary Pediatric Hospital.

Pediatric early warning systems identify patients at risk for deterioration. We aimed to determine if a locally adapted pediatric early warning system [KK hospital early warning score (KEWS)] can distinguish patients who require transfer from general ward to high dependency unit (HDU) or PICU, from those who do not. We conducted a retrospective case-control single-center audit. All unplanned general ward to PICU/HDU transfer from January to December 2021 were included as cases. We collected KEWS at the time of transfer and at 2, 4 and 6 hours prior to transfer. Univariate and multivariable logistic regression with imputation analysis were performed to identify variables associated with unplanned PICU/HDU transfer. There were 784 patients (196 cases and 588 controls). Median age of cases and controls were 3.3 (interquartile range: 1.0-9.7) and 3.9 (0.8-11.3) years, respectively. At the time of transfer, median (interquartile range) KEWS for cases and controls were 3 (0, 4) and 0 (0, 1), respectively (P <.001). At all timepoints, KEWS was able to distinguish between children who did and did not require transfer to HDU/PICU (At time of transfer: area under the curve = 0.80, 95% CI = 0.75-0.85, P <.001). After adjusting for age, category of admission, frequency of ordered monitoring, KEWS predicted HDU/PICU transfer with an odds ratio of 2.34 (95% CI 1.82 to 3.00, P <.001). KEWS was able to distinguish patients requiring transfer from GW to HDU/PICU from those not needing a transfer.

Improved gas sensing properties of copper-doped MoSe2 monolayers: a first-principles study on CO2 and NO2 adsorption

Abstract This paper investigates the impact of copper (Cu)-doped MoSe2 monolayer (ML) on gas sensing properties. The adsorption behaviour of CO2 and NO2 gas molecules on Cu-doped MoSe2 ML is reported and various sensing and electronic parameters such as adsorption energy, charge transfer and recovery time, are computed to delineate the adsorption characteristics and gas sensitivity. In our study, the doped Cu-atom in Se vacant MoSe2 ML shows the adsorption energies to be −1.32 eV (O-orient) and −1.72 eV (C-orient), for CO2, while for NO2, they are −0.879 eV (O-orient) and −1.06 eV (N-orient), respectively. The negative formation energy of −6.62 eV shows the electronic stability of Cu-doped MoSe2 ML and thermal stability, demonstrated by the molecular dynamics study through the Nose-Vervlet Thermostat (NVT) algorithm. Also, significant changes are observed in electronic conductivity and work function upon adsorbed Cu-MoSe2 ML. Lastly, these outcomes illustrate that Cu doping amplifies the capture ability of MoSe2 ML towards gas molecules, fostering improved electron interaction between the substrate surface and gas molecules, consequently enhancing its gas sensing ability.