Transfer Factor Research Articles

Phytoremediation of Mercury and Cyanide Contaminated Soils by Physic Nut (Jatropha curcas L.) and Citronella Grass (Cymbopogon nardus)

Mercury and cyanide are compounds that have the potential to pollute the environment, both of which are found in the tailing waste of artisanal and small-scale gold mining (ASGM). The purpose of this study was to determine the ability of physic nut (Jatropha curcas L.) and citronella grass (Cymbopogon nardus) to absorb mercury and cyanide in soils polluted with tailings waste based on the value of transfer factors. During this research stage, the remediation of soil polluted with amalgamation tailings and cyanide tailings was carried out for 28 days. Soil sampling was carried out every seven days for 28 days, while root and leaf sampling was carried out on day 28, analysis of mercury and cyanide content in soil and plants using atomic absorption spectroscopy (AAS) and UV-visible spectrophotometer. After 28 days of remediation, mercury and cyanide levels may decrease in soil by 93.7% for mercury and 81.8% for cyanide. The decrease can be caused by absorption and accumulation in plants, where mercury and cyanide accumulate more in physic nut than citronella grass. Physic nut and citronella grass have a transfer factor value of <1 for mercury and cyanide, so they are an excluder plant, except for the accumulation of mercury in physic nut from cyanide tailings soil, which has a transfer factor value of >1, which is an accumulator plant.

Epidemiology of Emergency Department Visits for Children With Clinically Significant Cardiovascular Disease.

The aim of the study is to determine the epidemiology, cost, and factors associated with hospital admission, deterioration if hospitalized, and mortality for children with a history of clinically significant cardiovascular disease (CVD) presenting to pediatric emergency departments (EDs). Using the Pediatric Health Information System, we performed a retrospective analysis of ED encounters of children ≤17 years old with clinically significant CVD between 2016 and 2021. Patients were included if they had a cardiovascular complex chronic condition, defined by ICD diagnosis, and procedure codes. We assessed the primary diagnosis, admission rate, ICU transfer rate (as a marker of disease progression), mortality, resource utilization, and costs. We conducted multivariable analyses to identify risk factors for admission, ICU transfer, and mortality. There were 201,551 ED visits (mean 33,592 ± 3354 per year) among 129,938 children with clinically significant CVD. Most ED encounters had a primary diagnosis of a circulatory (21.1%) or respiratory (19.7%) illness. Seventy-six percent of visits had at least one blood test or imaging study conducted. The overall admission rate was 59.7%, with 28.7% admitted to the ICU, and 6.2% transferred to the ICU after the first 24 hours. The median costs for encounters resulting in admission were $13,605 in US 2023 dollars. In multivariable analyses, younger age, a greater number of noncardiac complex chronic conditions, and CVD type were associated with increased odds of admission, ICU transfer after 24 hours, and mortality (all P < 0.05). ED visits for children with clinically significant CVD lead to substantial resource utilization, including frequent hospitalization, ICU level of care, and costs. This baseline data aids in the development of prospective studies to inform the appropriate ED management for children with clinically significant CVD.

Controlled-Release Iodine Fertilizer Improved Iodine Accumulation, Antioxidant Capacity, and Quality of Lettuce

To clarify the effects of newly developed controlled-release iodine fertilizer (CRIF) on enhancing lettuce (Lactuca sativa L.) iodine accumulation, improving the physiological traits, and reducing iodine leaching from soil, a greenhouse pot experiment was conducted. Polymer-coated iodate (PCIO), polymer-coated iodide (PCI), and two conventional iodine fertilizers—iodate (CIO) and iodide (CI)—were applied at a rate of 15 mg iodine per kg soil. The study found that the coating of iodine fertilizers had no significant effects on the biomass of lettuce. The iodine concentration in lettuce leaves subjected to PCIO treatment was elevated by 50.1% and 45.5%, respectively, in comparison to leaves treated with CIO and PCI. The soil-to-leaf transfer factor (TFleaf, dry weight basis) for plants treated with PCIO was significantly higher than that of PCI-treated plants. PCIO also significantly reduced iodine leaching by 46.3% compared to CIO. In lettuce leaves with PCIO treatment, the enzymatic activities of superoxide dismutase (SOD) and catalase (CAT) significantly increased by 50.8% and 27.6%, respectively. Likewise, malo-naldehyde (MDA) levels decreased by 23.2% compared to the control samples. PCIO also demonstrated advantages in enhancing the quality of the lettuce. In conclusion, the application of controlled-release iodine fertilizer could be a highly effective and eco-friendly approach to cultivating iodine-rich vegetables.

Headspace and Viscosity: Key Factors in the Thermal Processing of Tomato Paste (A CFD Study)

ABSTRACTThis study investigates the effects of headspace conditions (absence of headspace, full air, and full steam) and product viscosity (Brix values of 18 and 28) on the thermal processing of canned tomato paste. The results show that the presence of an air layer within the can's headspace significantly influences the temperature profile and the location of the slowest heating zone (SHZ), without markedly affecting the overall temperature magnitude. The Brix values, which indicate the paste's viscosity, are found to be crucial factors in heat transfer, with lower Brix values promoting convection and higher values favoring conduction. The average velocity for Brix 18 was approximately 10 times higher than that for Brix 28. Among the three main color parameters, the a* index experienced the most significant changes (maximum drop of 67%), while the b* index showed the least variation (maximum drop of 22%) during processing. The time required to reduce the number of bacteria to 10−6 CFU/g at the cold point of tomato paste cans was 28% higher in the product with Brix 18 compared with Brix 28. These findings underscore the importance of considering headspace conditions and product viscosity to optimize thermal processing methods, thereby enhancing the safety and quality of canned tomato products.

Effect of Fin Configuration on the Early Stage of the Melting Process of a Phase Change Material

Thermal storage systems are essential for optimizing energy resource utilization, particularly in the current context where sustainability and efficiency are critical. Phase Change materials (PCMs) offer a promising solution for improving thermal management efficiency without additional power consumption. Considering that the low thermal conductivity of phase change materials (PCMs) is a limiting factor for heat transfer, this study employs the enthalpy-porosity method to analyze the melting characteristics of a high-Prandtl number PCM. Additionally, this study investigated the effect of varying the number of fins in the heat sink on the heat transfer rate. The material melting process was modeled by considering buoyancy effects and treating the flow as incompressible, Newtonian, transient, and laminar. Lauric acid was selected as the working material with temperature-dependent properties that were incorporated into the simulations for greater accuracy. Three different heat sink configurations were analyzed, varying the number of fins from 5 to 10 and their lengths from 0.02 meters to 0.04 meters. The objective was to optimize the cooling performance using aluminum, which was selected for its excellent balance of lightweight properties and high thermal conductivity. This analysis aimed to assess how these variations in the fin count and dimensions affect the overall heat dissipation efficiency and thermal management of the system. The inclusion of a finned heat sink within a heat exchanger has demonstrated significant efficiency, particularly in regions with substantial boundary layer development, resulting in enhanced heat transfer. These findings highlight the effectiveness of using finned heat sinks in these regions. However, an interesting observation emerged regarding the effect of increasing the number of fins over long periods. Although initially beneficial, a larger number of fins eventually led to a reduced performance over time, notably affecting the thermal storage capacity and molten liquid mass production. Additionally, this study elucidates the influence of natural convection on thermal boundary layer development, highlighting the complexity of the heat transfer processes.

Experimental Investigation for Enhancement of Heat Transfer and Friction Factor Through Using V-pattern Ribs Along with Semi-circular Perforated Manner

Experimental Investigation for Enhancement of Heat Transfer and Friction Factor Through Using V-pattern Ribs Along with Semi-circular Perforated Manner

Contamination and health risk assessment of potentially toxic elements in rice (Oryza sativa) and soil from Ashanti Region.

Anthropogenic activities release potentially toxic elements into the environment, which contaminate the food chain. The main objective of this research was to analyze the concentrations of As, Cd, Cr, Hg, and Pb in rice grains and soils, establish their correlation and transfer factors between soil and rice grains as well as evaluate their human health risk from consumption of rice cultivated in the Asante Akim area. The levels of As, Cd, Cr, Hg, and Pb in soil and rice samples were assayed using an Agilent 7700 Series inductively coupled plasma-mass spectrophotometer. The mean heavy metal content in soil was 7.5, 0.52, 0.47, 1.30, and 8.69mg/kg for As, Cd, Cr, Hg, and Pb, respectively. Mean levels of the potentially toxic elements in rice were 0.082, 0.27, 0.48, 0.028, and 0.14mg/kg for As, Cd, Cr, Hg, and Pb, respectively. Soil pollution indices showed that the soils were unpolluted with the potentially toxic elements studied. The concentrations of the potentially toxic elements in rice were below the maximum allowable concentration (MAC) recommended by the Codex Alimentary Commission except Cd which was marginally higher than the MAC. Dietary exposure to the elements to consumers was assessed by comparing the estimated daily intake (EDI) to the provisional tolerable daily intake (PTDI). The estimated daily intake values for As, Cd, Cr, Hg, and Pb were 1.45 × 10-4, 4.8 × 10-4, 8.5 × 10-4, 4.95 × 10-5, and 2.4 × 10-4, respectively. The HQ for all the potentially toxic elements was less than the permissible value of 1, suggesting that the consumption of rice from the study area constitutes no potential non-carcinogenic health risk to the population. This study is unique because the risk is evaluated from rice that is directly consumed, and this gives a clearer picture of the risk to humans. Regular monitoring studies should be conducted to ascertain the levels of heavy metals in rice cultivated in the area since heavy metals can accumulate and the concentrations could increase to toxic levels with time.

Training transfer in MSMEs of India: examining the role of performance coaching, HRD climate and employee agility

Purpose The relatively low emphasis on training is often attributed to concerns about the uncertain return on investment in training initiatives. However, there has been limited research conducted to understand the critical success factors for training effectiveness in these enterprises. The current research aims to address this gap by examining the role of training transfer factors in enhancing training effectiveness within micro, small and medium enterprises (MSMEs) in India. Influenced by the Learning Transfer System framework proposed by Holton et al. (2007), this study aims to focus on investigating the impact of performance coaching, human resource development (HRD) climate and employee agility on training transfer in MSMEs. Design/methodology/approach Data has been collected from 411 respondents working in MSMEs of India through validated survey instruments. MSMEs have been chosen owing to the increasing contribution of the sector to the Indian gross domestic product and the lack of sufficient management research in the sector. The statistical software SPSS-AMOS has been used to create structural equational modeling for testing the hypotheses. Findings The result shows that performance coaching is the most impactful factor for training transfer, followed by HRD climate and employee agility. Practical implications The result suggests MSME practitioners activate a positive coaching environment in the organization by following the best practices in performance coaching. Further, the research suggests practitioners to realize the significance of HRD climate and employee agility. Appropriate management practices have been suggested to groom and develop HRD climate and employee agility for higher training transfer. Originality/value To the best of the authors’ knowledge, the research is first of its kind to study the impact of performance coaching, employee agility and HRD climate on training transfer in MSMEs.

Assessment of background dose rate on non-human biota in a Mediterranean terrestrial ecosystem.

The assessment of radiological impact to the environment is usually carried out by the dose rate estimation to hypothetical entities named Reference Animals and Plants (RAPs). There are many codes to carry out this assessment, which requires the definition of a scenario and using site-specific transfer parameters when possible. Transfer parameters present a geographical bias, as they are mostly derived from temperate and arctic climate datasets, but there is a scarcity of data for Mediterranean climates. In this study, a terrestrial Mediterranean scenario was defined using the distribution of activity concentrations of anthropogenic (90Sr, 137Cs) and naturally occurring radionuclides (40K, 210Pb, 210Po, 226,228Ra, 235,238U, 232Th) in Cáceres province (Spain). Site-specific transfer factors, CRwo-media, defined as the ratio between the concentration in the whole organism and the medium (soil in this case) were considered. Dose rate assessments for terrestrial RAPs were carried out using Tier 3 in ERICA Tool, ranging 0.23-3.73µGy/h which is below the screening level of 10µGy/h. Therefore, no harmful effects are expected to occur. Internal dose rate predominates over external one because the main contributors are naturally occurring radionuclides (in most cases 40K, 226,228Ra, 210Pb, 210Po), which are mostly α-emitting radionuclides. These results can be used for the evaluation of other radiological and nuclear installations in Mediterranean climates, as they set the background dose rate.

Diffusion capacity and static hyperinflation as markers of disease progression predict 3-year mortality in COPD: Results from COSYCONET.

Chronic obstructive pulmonary disease (COPD) exhibits diverse patterns of disease progression, due to underlying disease activity. We hypothesized that changes in static hyperinflation or KCO % predicted would reveal subgroups with disease progression unidentified by preestablished markers (FEV1, SGRQ, exacerbation history) and associated with unique baseline biomarker profiles. We explored 18-month measures of disease progression associated with 18-54-month mortality, including changes in hyperinflation parameters and transfer factor, in a large German COPD cohort. Analysing data of 1364 patients from the German observational COSYCONET-cohort, disease progression and improvement patterns were assessed for their impact on mortality via Cox hazard regression models. Association of biomarkers and COPD Assessment test items with phenotypes of disease progression or improvement were evaluated using logistic regression and random forest models. Increased risk of 18-54-month mortality was linked to decrease in KCO % predicted (7.5% increments) and FEV1 (20 mL increments), increase in RV/TLC (2% increments) and SGRQ (≥6 points), and an exacerbation grade of 2 at 18 months. Decrease in KCO % predicted ≥7.5% and an increase of RV/TLC ≥2% were the most frequent measures of 18-month disease progression occurring in ~52% and ~46% of patients, respectively. IL-6 and CRP thresholds exhibited significant associations with medium- and long-term disease measures. In a multicentric cohort of COPD, new markers of current disease activity predicted mid-term mortality and could not be anticipated by baseline biomarkers.

A study on the transfer of radionuclides and of the resulting radiation dose assessment for marine organisms on the eastern coast of Yantai city

Oceans are repositories of radionuclides. Radionuclides are transferred through the food chain and cause ionizing radiation hazards for marine organisms. In this study, the transfer characteristics of 226Ra, 40K, 14C, 3H, 137Cs and 90Sr in organisms at different trophic levels in the eastern coast of Yantai city were investigated. The risk of ionizing radiation to organisms was assessed using the ERICA Tool 2.0. The results show no significant changes in the concentration of any of the nuclides in the coastal area compared to the preoperation period of the nuclear power plant. The transfer factor of 137Cs, 40K, 226Ra, 14C, 90Sr and 3H at the different trophic levels of marine organisms were 2.09, 1.29, 1.17, 1.15, 1.06 and 0.74, respectively. The dose rates of ionizing radiation to organisms from six radionuclides ranged from 32.02 nGy·h-1 to 195.49 nGy·h-1 and had a mean value of 102.86 ± 57.30 nGy·h-1. The main artificial radionuclides (14C, 3H, 90Sr, 137Cs) released by nuclear power plants in the study area produced negligible radiation doses to marine organisms. However, other artificial radionuclides present in the effluents of nuclear power plants (99Tc, 110mAg and 131I) as well as other natural radionuclides (includes 210Po, 210Pb, etc) were not included, and further evaluation of these is recommended.

Migration of Plutonium, Micro- and Macroelements in the “Soil–Plant” System at Different Soil Moisture

In the vegetation experiment, the plutonium, micro- and macroelements migration in the “soil–agricultural plant” system depending on soil moisture in the range from 15 to 40٪ of absolute soil moisture were studied. The content of 239Pu was analyzed by α-spectrometry with preliminary radiochemical isolation. The elemental composition was analyzed by the ICP-MS and ICP-AES methods. Beans (Fabaceae) variety “Amber” were used as a test culture. The plutonium transfer factor obtained in the vegetation experiments are in the range of of 5.3×10–4–1.5×10–2, with an average value of 5.4×10–3 for the aboveground part of bean and range of 4.5×10–2–2.7×10–1, with an average of 1.6×10–1 for bean roots. It was determined that the distribution of plutonium, micro and macro elements in the vegetative organs of plants is not equally, the transfer factor of plutonium for the aboveground part of plants is lower than for the root part. It has been established that the accumulation of plutonium, micro- and macroelements, depending on soil moisture, is different for the organs of beans. The dependence of plutonium accumulation by plants on soil moisture is significantly higher than for other considered elements. A decrease in the coefficient of accumulation of plutonium in the aerial part of the beans is recorded with an increase in soil moisture up to two orders of magnitude. There is a trend towards a slight decrease in the accumulation coefficients of Fe, Mg, Mn, Cr, Mo, Ni, Co, Cu. For the root system of beans, a clear dependence of the accumulation of the considered elements on soil moisture is not observed.

Investigating the Effect of Heat Transfer Influenced by the Application of Wavy Corrugated Twisted Tape Inserts in Double Pipe Heat Exchangers

This study investigates the heat transfer and friction factor characteristics in a heat exchanger utilizing copper wavy (corrugated) twisted tape inserts. By inducing turbulent flow within the inner tube of the heat exchanger, these inserts generated increased turbulence, thereby enhancing heat transfer and causing a rise in pressure drop. The copper twisted tapes, with various twist ratios (TR=10.7, 8.5, 7.1), measured 1 meter in length and 14 mm in width. The heat exchanger's outer tube was made of mild steel, with an outer diameter of 0.0198 m and an inner diameter of 0.0142 m, while the inner tube was constructed of copper, with an outer diameter of 0.038 m and an inner diameter of 0.032 m. The overall length of the pipe-in-pipe heat exchanger was 1.4 m. Bulk mean temperatures were recorded at different positions for various water flow rates, and new correlations for the Nusselt number and friction factor were derived from the results for the twisted tape inserts. The Reynolds number ranged from 5000 to 17000. Comparative analyses revealed that the wavy twisted tape with a twist ratio of 7.1 provided the highest heat transfer rate, showing a 172% increase in the Nusselt number and a 32.11% increase in the friction factor relative to a smooth tube.

The seed germination and seedling phytotoxicity of decabromodiphenyl ethane to tall fescue under citric acid amendment.

The novel brominated flame retardant decabromodiphenyl ethane (DBDPE) has biological toxicity, persistence, long-range migration and bioaccumulation ability. However, there is currently little research on the phytotoxicity of DBDPE in plants. The perennial herbaceous plant tall fescue (Festuca elata Keng ex E. B. Alexeev) was selected as the model organism for use in seed germination experiments, and the phytotoxicity of DBDPE in the soil of tall fescue was studied. The results indicated that DBDPE had a significant effect on the germination and growth of tall fescue seedlings. Citric acid reduced the stress caused by DBDPE in plants, effectively alleviating the phytotoxicity of DBDPE in tall fescue. The root vitality and protein content significantly increased after the application of citric acid, increasing by 74.93-183.90%, 146.44-147.67%, respectively. The contents of proline and soluble sugars significantly decreased after the application of citric acid, decreasing by 45.18-59.69% and 23.03%, respectively (P < 0.05). There was no significant difference in superoxide dismutase (SOD) or peroxidase (POD) activity in tall fescue seedlings, and the catalase (CAT) activity and malondialdehyde (MDA) content were significantly lower after the application of citric acid, decreasing by 64.62-67.91% and 29.10-49.80%, respectively (P < 0.05). Tall fescue seedlings bioaccumulated DBDPE, with biological concentration factors (BCFs) ranging from 4.28 to 18.38 and transfer factors (TFs) ranging from 0.43 to 0.54. This study provides theoretical support for the study of the toxicity of DBDPE to plants and offers a research foundation for exploring the phytoremediation of DBDPE-contaminated soil by tall fescue.

Health risk assessment of potentially toxic elements of corn fields in southern Iran

Potentially toxic elements (PTEs) are among the stable and dangerous environmental pollutants that cause complications in the human body. The present study was conducted to assess the health risk of PTEs in corn fields in southwestern Iran. In the summer and autumn of 2022, 180 samples were collected from corn fields in six regions of Khuzestan Province. Potential elements were measured using the atomic absorption method and an AA240Z device. The average concentrations of Cd, Ni, Zn, and Cu in soil samples from corn fields were found to be 0.20 ± 0.01, 48.96 ± 12.63, 59.93 ± 8.77, and 27.31 ± 5.92 mg/kg, respectively. There was no significant difference in the concentrations of PTEs between the two sampling periods (p > 0.05), but a significant difference was observed among the concentrations of PTEs in the six studied farms (p < 0.05). The highest transfer factor for Zn in corn was 0.62, while the transfer factor for Cu was 0.12, which was lower than that of other elements. The average concentrations of Cd, Ni, Zn, and Cu in corn samples from agricultural fields during the summer and autumn seasons were 0.058, 21.39, 36.52, and 6.60 mg/kg, respectively. The Target Hazard Quotient (THQ) for Cd, Ni, Zn, and Cu was 0.33, 6.11, 0.69, and 0.94 for adults and 1.54, 28.52, 3.24, and 4.4 for children. THQ values for the metals in corn for children were higher than 1. Additionally, the THQ for Ni in adults was higher than 1, indicating a potential health risk. Therefore, based on the data analysis, the THQ of Cd, Ni, Cu, and Zn in corn can pose a danger to human health. According to the results of the Cd carcinogenesis risk index, corn consumption appears to be hazardous for both adults and children.

Experimental study of acute toxicity of the intramuscular form of a specific immunobiostimulator — transfer factor

Relevance. The article presents data on the toxicological assessment of the safety of the specific immunobiostimulant of antigen-directed action “Transfer Factor” in a form ready for intramuscular administration and obtained from the blood of hyperimmunized donors on laboratory animals in an acute experiment.Methods. The object of the study was the finished form of “Transfer Factor”, the acute toxicity of which was determined in models on laboratory animals (nonlinear mice, nonlinear rats).Results. It was found that after administration of the drug to mice intramuscularly (0.25 ml/head) and intraperitoneally (0.5 ml/head), to rats intramuscularly (2.5 ml/head) and intraperitoneally (2.5 ml/head), muscle tremor is observed, disappearing after 15–20 minutes. Intraperitoneal administration of the drug to mice and rats in dosages of 0.75 ml/head and 3.75 ml/head, respectively, determines the presence of tremor lasting 40 minutes. During the 14-day observation period, the body weight of mice and rats increases by 10.15-14.25 and 11.84-17.67%. Autopsy of animals does not reveal visible changes in the location of organs and fluid in the abdominal and pleural cavities. However, some pathological changes in color, consistency and size are found in the lungs, heart, spleen and liver with intramuscular administration of Transfer Factor to mice and rats at a dose of 0.25 ml/head and 2.5 ml/head, intraperitoneal administration to mice at a dose of 0.5 ml/head and 0.75 ml/head and to rats 2.5 ml/head and 3.75 ml/head. Based on the totality of changes in the vital signs of laboratory animals, body weight and macroscopic characteristics of internal organs according to GOST 12.1.007-76, the drug “Transfer Factor” can be classified as hazard class IV “Low-hazard substances”.

Quantitative tracking of nanoplastics along the food chain from lettuce (Lactuca sativa) to snails (Cantareus aspersus)

Terrestrial systems are a significant sink for plastic contamination, including nano- and microplastics (NMPs). To date, limited information is available about the transfer of NMPs up the food web via trophic transfer, however, concerns about this exposure pathway for invertebrates and higher-level organisms have been raised. We aim to examine and quantify the trophic transfer of europium doped polystyrene nanoplastics (Eu-PS; NPs) within a terrestrial food chain. The uptake of 100 nm spherical Eu-PS particles from water through the roots of the plants to the leaves and finally to garden snails (Cantareus aspersus) was assessed. Lettuce (Lactuca sativa) was cultivated in Hoagland solution spiked with different concentrations of Eu-PS (15, 150 and 1500 μg/L) for three weeks. Then, lettuce shoots were used as food for snails for 19 days at a rate of 1 g of shoots per day. The Eu-PS primarily accumulated in the lettuce roots for all treatments, with a limited transfer to the shoots (only quantifiable in the highest treatment; translocation factor: TF < 1). No detectable levels of Eu-PS were found in the snails' digestive gland; however, the Eu-PS particles were detected in their feces (trophic transfer factor: TFF > 1). Moreover, only limited effects were observed on lettuce biomass by NPs treatments. No effects of the Eu-PS particles on snails were observed, with the exception of a consistent decrease in the shell diameter. Overall, our research illustrates that NPs can be absorbed by plants through their roots, subsequently transported to the shoots. However, our findings show limited transfer of NPs into snail tissues, but direct excretion into their feces. We provide an important insight into the potential transfer within the human food chain.

Optimizing thermal performance in internal passage cooling with extended rib: Applying response surface method with artificial neural networks

Efficient cooling technology is crucial for high-temperature gas turbines which are significant applications in thermal processes particularly in industries such as power generation aerospace and marine propulsion. Enhancing cooling efficiency in these systems not only improves energy utilization but also plays a critical role in reducing fuel consumption increasing operational reliability and minimizing environmental impacts. This research focuses on optimizing the thermal performance of internal passage cooling channels with extended ribs using a combination of the response surface method and artificial neural networks. By varying the extended rib length and rib width the study aims to enhance heat transfer and minimize flow loss leading to improvements in overall system efficiency. Latin Hypercube Sampling is employed to strategically select variables and automated numerical simulations are conducted to perform a thorough parametric analysis. A steady-state k-ω shear stress transport turbulence model is applied in the simulations and the numerical results are validated against experimental data ensuring accuracy. The combined response surface method–artificial neural network approach integrated with TensorFlow-based modeling allows for the prediction of heat transfer and friction factor ultimately generating a comprehensive response surface to identify the optimal design point. Applying the optimized design leads to a 23.99 % improvement in the thermal performance factor compared to the reference case. The findings of this study highlight a significant enhancement in the thermal performance of the cooling channel structure particularly in high heat flux environments. This research provides valuable insights into the design of more efficient thermal management systems for gas turbines and has broader implications for other high-temperature thermal processes. The proposed optimization methodology offers a reliable approach for improving cooling technologies contributing to the development of the next generation of energy-efficient high-performance gas turbines and other industrial applications where effective thermal management is essential.

Uptake of Per- and Polyfluoroalkyl Substances in Mixed Forages on Biosolid-Amended Farm Fields.

Models to predict perfluorooctanesulfonic acid (PFOS) concentrations in livestock based on soil concentrations are essential to guide decisions surrounding food testing and farm management. A key parameter in modeling soil-to-livestock exposure pathways is the plant transfer factor (TF) from soil into forages. Uptake of PFOS and other individual per- and polyfluoroalkyl substances (PFASs) were examined in perennial mixed grasses and legumes on PFAS-contaminated farm fields. In a field plot study, PFOS TFs were similar within each plot over three consecutive years but varied 10-fold among the four plots with mean TFs ranging from 0.026 to 0.27. In a multifarm field survey study, mean PFOS TFs ranged from 0.039 to 0.37. Increasing concentrations of two PFOS precursors in soil were significantly associated with increasing PFOS TFs. These data represent a substantial increase in empirical observations of PFAS TFs for grass-based forages for use in modeling soil-to-livestock exposure scenarios.

Некоторые особенности токсикологических свойств специфического иммунобиостимулятора «Трансфер-фактор» в доклинических испытаниях

Abstract. The purpose of the study is to evaluate some aspects of toxicological safety of a specific immunobiostimulant “Transfer factor” in laboratory animal models. Methods. The experiments were performed on mice, rats and guinea pigs. The toxicological safety assessment of the “Transfer factor” preparation included the determination of the following characteristics: chronic toxicity, assessment of specific activity, assessment of embryotoxic and teratogenic properties, assessment of allergenic properties Results. It was established that the introduction of the “Transfer factor” preparation in a chronic toxicological experiment is accompanied by the development of muscle tremor in the rodents’ body, the duration of which depends on the administered dose, route of administration and exposure time, but their body weight increases by 6.29–10.63 %. Autopsy of experimental group animals revealed no visible changes in the arrangement of internal organs and fluid accumulation in the abdominal and pleural cavities, although some pathological changes in color, consistency and size of the lungs, spleen, liver and heart were noted. The mass coefficients of these organs change with an increase in the dose of the administered drug “Transfer factor”, especially with the intraperitoneal route of administration up to 10.39 %. The tested drug in the reaction of lymphocyte blast transformation increases the number of blasts from 0.20 to 1.40 %. The totality of data allows us to state that the drug “Transfer factor” in accordance with GOST 12.1.007-76 belongs to the IV hazard class “low-hazard substances” and it can be recommended for further clinical trials, in which a dosage exceeding 6 ml/kg of live weight will not be used, when administered to laboratory animals, a complex of changes in the internal organs develops. Scientific novelty. The introduction of “Transfer factor” does not affect the condition and functions of the reproductive organs (uterus, ovaries) of pregnant rats, and the drug does not exhibit a negative embryotoxic and teratogenic effect in their body. When studying the allergenic properties of the drug, it was found that it does not cause a general anaphylaxis reaction in the body of guinea pigs, does not irritate the skin in the reaction of immune complexes and the conjunctiva of the eye in the conjunctival test.