Transdisciplinarity is creative human agency including cognitive, intellectual and behavioural activities of individuals and groups. These activities define and are mutually defined by beliefs and ideas, knowledge and know-how, language and meanings, norms and rules, and opinions and values. The cultivation of transdisciplinary projects should embrace these cultural, social and psychological predispositions because they are core constituents of a trans-anthropo-logic. This requires transcending common research methods used in scientific studies and using scaffolding that facilitates agency, and positioning individuals and groups. However, scientists are rarely trained to pilot projects involving multiple stakeholders with different positions. This article explains why trained facilitators are needed to pilot transdisciplinary projects. They can cultivate transcendence and transgression – both analysed by the late Julie Thompson Klein – beyond the scope and purpose of common research methods. In essence, transdisciplinary practices respect different ontologies and epistemologies while incorporating ethical principles and moral values. The cultivation of transdisciplinary projects should accommodate and reduce asymmetries of power between politicians, public administrators, property owners, researchers and laypeople that are shaped by extant historical and societal variables in specific situations. Transdisciplinary projects should also apply multiple sources of quantitative data and qualitative information that represent the complexity, diversity and perhaps incommensurability of intentions, meanings, perceptions and values about specific subjects or situations. This is being achieved by innovative projects that should become beacons for change.