You have accessJournal of UrologyProstate Cancer: Basic Research III1 Apr 2015MP55-18 RACE IMPACTS ETS FAMILY TRANSCRIPTION FACTOR EXPRESSION IN PROSTATE CANCER: DATA FROM A MULTI-INSTITUTIONAL COHORT Farzana Faisal, Debasish Sundi, Ashley Ross, Eric Klein, Robert Den, Adam Dicker, Voleak Choeurng, Nicholas Erho, Mohammed Alshalalfa, Elai Davicioni, Tamara Lotan, and Edward Schaeffer Farzana FaisalFarzana Faisal More articles by this author , Debasish SundiDebasish Sundi More articles by this author , Ashley RossAshley Ross More articles by this author , Eric KleinEric Klein More articles by this author , Robert DenRobert Den More articles by this author , Adam DickerAdam Dicker More articles by this author , Voleak ChoeurngVoleak Choeurng More articles by this author , Nicholas ErhoNicholas Erho More articles by this author , Mohammed AlshalalfaMohammed Alshalalfa More articles by this author , Elai DavicioniElai Davicioni More articles by this author , Tamara LotanTamara Lotan More articles by this author , and Edward SchaefferEdward Schaeffer More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2061AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Studies have demonstrated overexpression of erythroblastosis virus E26 transforming sequence (ETS) genes in prostate cancer (PCa) predominantly in Caucasian American (CA) populations. We recently demonstrated that tumors in African American (AA) men, even those classified as low risk, are more aggressive when compared to CA men. Here we examine if molecular subclassfications based on the expression of ETS family genes (ERG, ETV1, ETV4, ETV5, FLI1) and the SPINK1 biomarker vary by race. METHODS The multi-institutional study cohort was comprised of a matched subset of 300 men (179 CA, 121 AA) with localized PCa treated with radical prostatectomy. CA men were matched to AA men within the same institution. ETS and SPINK1 expression was profiled using transcriptome-wide microarray analysis. A subset of 109 men with very-low risk PCa from our institution (50 CA, 59 AA) was additionally assessed by immunohistochemistry to examine the impact of race on molecular subtype in very-low risk patients. Differences in gene expression categories were evaluated with the Fisher exact test. RESULTS In the overall cohort (n=300), ERG overexpression was present in 85/179 tumors (47%) in CA men but only 27/121 tumors (22%) in AA men (p<0.001). There were no racial differences in the expression of other ETS family genes (17% AA vs 11% CA p=0.16). There was a trend towards SPINK1 overexpression in AA men (13% AA vs 7% CA, p=0.06). AA men were more likely to have a triple-negative phenotype (ERG, ETS, and SPINK1 negative) (50%) compared to CA men (37%) (p=0.04). In the subset of very-low risk patients (n=109), AA men were still less likely to have ERG-positive tumors compared to CA men (20% vs 46%, p=0.007) but more likely to express other ETS family genes (14% vs 2%, p=0.04). There were no racial differences in SPINK1 expression (p=0.37) or the triple-negative phenotype (p=0.24) among very-low risk PCa patients. CONCLUSIONS There are significant racial differences in gene expression in PCa. Overall, overexpression of ERG is more common in CA than AA men. AA men are more likely to express SPINK1 or to harbor a phenotype negative for ERG, ETS, and SPINK1 expression. However, among very-low risk patients, AA men are more likely to express other ETS family genes (ETV1, ETV4, ETV5, FLI1). Future research is warranted to determine if these differences in gene expression contribute to the racial disparities in pathologic and oncologic outcomes of PCa. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e679-e680 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Farzana Faisal More articles by this author Debasish Sundi More articles by this author Ashley Ross More articles by this author Eric Klein More articles by this author Robert Den More articles by this author Adam Dicker More articles by this author Voleak Choeurng More articles by this author Nicholas Erho More articles by this author Mohammed Alshalalfa More articles by this author Elai Davicioni More articles by this author Tamara Lotan More articles by this author Edward Schaeffer More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...