Introduction. The aim of this study was to present oncological and functional results of surgical treatment of the base of tongue cancer by analyzing retrospectively 115 patients treated during a ten-year period. During this period, 150 patients with cancer of the base of tongue were diagnosed, which accounts for 5.6% of all diagnosed head and neck cancers and 24.1% of all oropharyngeal cancers. In 111 patients (96.5%), planocellular carcinoma with various degrees of differentiation was pathohistologically verified. Neck metastases were found in 88 (76.5%) patients. Advanced III and IV stages of disease were verified in 92.9% of patients (stage III in 23.4%, IV A in 59.1%, IV % B in 10.4%). Transmandibular approach was performed in 5.2% of patients, while 94.8% of patients were approached through pharynx The defects were covered by primary reconstruction; the pectoralis major myocutaneous flap was used in 4 patients . During immediate postoperative period, 17 (14.7%) patients developed complications: bleeding occurred in 7 patients (6%), fistula and wound infection developed in 5 (4.3%) and 11 (9.5%) patients, respectively. Postoperatively, 61 (53%) patients were treated by radiation therapy. Swallowing function was resumed in all patients except in three, who underwent gastrostomy due to the lesion of both hypoglossal nerves. Gasrostoma was closed after six months when swallowing was resumed. Local and regional recurrence developed in 13 (11.3%) and 24 (20.8%) patients, respectively, and distant metastases developed in 4 (3.5%) patients. Second primary cancer was diagnosed in 9 (7.8%) patients Disease-specific 3-year survival rate (according to the T category) was 73%, 60%, 45% and 21% in patients with T1, T2, T3 and T4, respectively. Diseasespecific 3-year survival rate (according to category N) was 68% in N0 and 32%) in N +. The overall 3-year survival rate was 42%.