Training-related Improvements Research Articles

Training-related improvements in mental well-being through reduction in negative interpretation bias: A randomized trial of online socio-emotional dyadic and mindfulness interventions

BackgroundEffects of online contemplative practices, especially partner-based practices, on psychological well-being remain mixed, with sparse understanding of potential affective-cognitive mechanisms. The study aimed to assess the efficacy of two online contemplative interventions in improving depression, anxiety, emotion regulation (ER), and resilience, and to evaluate the mechanistic role of negative attention and interpretation biases. MethodsEmploying a randomized controlled design (n = 285), we compared the efficacy of 10-week online mindfulness-based and partner-based socio-emotional dyadic interventions, both supported by weekly coaching sessions. Mental health aspects were assessed using validated self-report measures and negative biases using the mouse-contingent Scrambled Sentences Task. ResultsBoth interventions, compared to waitlist control, led to reductions in depression and ER difficulties, while trait anxiety decreased only after mindfulness training. Increases in multidimensional resilience were observed only after socio-emotional training and in stress recovery only after mindfulness-based training, both compared to waitlist control. Socio-emotional training led to significant reductions in negative interpretation bias and this mediated reductions in depression and trait anxiety. Neither training led to reductions in state anxiety or negative attention bias. LimitationsThe subclinical nature and overrepresentation of females in the sample limits generalizability. ConclusionsFindings indicate that online mindfulness-based and socio-emotional partner-based interventions, supported by online coaching sessions, can reduce depression and ER difficulties. Though mindfulness practice reduced trait anxiety and enhanced stress recovery, socio-emotional training increased multidimensional resilience. Socio-emotional training reduced negative interpretation bias, which emerged as an intervention-specific mechanism. These findings highlight the potential benefits of online contemplative intervention approaches for psychological well-being.

A Pilot Study Comparing the Efficacy, Fidelity, Acceptability, and Feasibility of Telehealth and Face-to-Face Creative Movement Interventions in Children with Autism Spectrum Disorder.

We compared the efficacy, fidelity, acceptability, and feasibility of a creative movement (CM) intervention for children with autism spectrum disorder (ASD), delivered face-to-face (F2F) or through telehealth (TH). Fifteen children with ASD received the CM intervention F2F or through TH. Motor assessments were used to evaluate effects of F2F and TH interventions on children's motor skills, while video coding was used to assess affect, socially directed verbalization, interpersonal synchrony, and motor coordination during training. Stakeholder feedback and training fidelity data on the intervention were also collected. Children in both subgroups showed similar baseline performance and training-related improvements in motor skills, positive/interested affect, socially directed verbalization, interpersonal synchrony, and dual/multilimb coordination. Parents in the TH subgroup considered the intervention feasible and acceptable; however, they reported greater effort to supervise and redirect their child's attention compared to the F2F subgroup. Trainers for the TH subgroup reported more communication difficulties, technological issues, and longer session lengths, but found greater parental involvement compared to the F2F subgroup. CM interventions are consistent, acceptable, feasible, and effective in improving social, behavioral-affective, and motor skills of children with ASD, regardless of the method of delivery. Clinicians should make efforts to reduce communication/technological issues and parental burden when delivering CM interventions through TH. ClinicalTrials.Gov Study ID-NCT04258254.

Subjective Well-Being and Bilateral Anterior Insula Functional Connectivity After Exercise Intervention in Older Adults With Mild Cognitive Impairment.

While it is well known that exercise training is associated with improvement in subjective well-being among older adults, it is unclear if individuals with cognitive impairment experience the same effects elicited by exercise on subjective well-being. We further explored whether the bilateral anterior insula network may be an underlying neural mechanism for the exercise training-related improvements in subjective well-being. We investigated the effects of exercise training on subjective well-being in older adults (78.4 ± 7.1 years) with mild cognitive impairment (MCI; n = 14) and a cognitively normal (CN; n = 14) control group. We specifically assessed the relationship between changes in subjective well-being and changes in functional connectivity (FC) with the bilateral anterior insula from before to after exercise training. Cardiorespiratory fitness, subjective well-being, and resting-state fMRI were measured before and after a 12-week moderate-intensity walking intervention. A seed-based correlation analysis was conducted using the bilateral anterior insula as a priori seed regions of interest. The associations between bilateral anterior insula FC with other brain regions and subjective well-being were computed before and after exercise training, respectively, and the statistical difference between the correlations (before vs after exercise training) was evaluated. There was a significant Group (MCI vs CN) × Time (before vs after exercise training) interaction for subjective well-being, such that while those with MCI demonstrated significantly increased subjective well-being after exercise training, no changes in subjective well-being were observed in CN. Participants with MCI also showed an exercise training-related increase in the bilateral anterior insula FC. While there was no significant correlation between subjective well-being and bilateral anterior insula FC before exercise training, a positive association between subjective well-being and bilateral anterior insula FC was found in the MCI group after exercise training. Our findings indicate that 12 weeks of exercise training may enhance subjective well-being in older adults diagnosed with MCI and, further, suggest that increased bilateral anterior insula FC with other cortical regions may reflect neural network plasticity associated with exercise training-related improvements in subjective well-being.

Cogmed Training Does Not Generalize to Real-World Benefits for Adult Hearing Aid Users: Results of a Blinded, Active-Controlled Randomized Trial.

Objectives:Performance on working memory tasks is positively associated with speech-in-noise perception performance, particularly where auditory inputs are degraded. It is suggested that interventions designed to improve working memory capacity may improve domain-general working memory performance for people with hearing loss, to benefit their real-world listening. We examined whether a 5-week training program that primarily targets the storage component of working memory (Cogmed RM, adaptive) could improve cognition, speech-in-noise perception and self-reported hearing in a randomized controlled trial of adult hearing aid users with mild to moderate hearing loss, compared with an active control (Cogmed RM, nonadaptive) group of adults from the same population.Design:A preregistered randomized controlled trial of 57 adult hearing aid users (n = 27 experimental, n = 30 active control), recruited from a dedicated database of research volunteers, examined on-task learning and generalized improvements in measures of trained and untrained cognition, untrained speech-in-noise perception and self-reported hearing abilities, pre- to post-training. Participants and the outcome assessor were both blinded to intervention allocation. Retention of training-related improvements was examined at a 6-month follow-up assessment.Results:Per-protocol analyses showed improvements in trained tasks (Cogmed Index Improvement) that transferred to improvements in a trained working memory task tested outside of the training software (Backward Digit Span) and a small improvement in self-reported hearing ability (Glasgow Hearing Aid Benefit Profile, Initial Disability subscale). Both of these improvements were maintained 6-month post-training. There was no transfer of learning shown to untrained measures of cognition (working memory or attention), speech-in-noise perception, or self-reported hearing in everyday life. An assessment of individual differences showed that participants with better baseline working memory performance achieved greater learning on the trained tasks. Post-training performance for untrained outcomes was largely predicted by individuals’ pretraining performance on those measures.Conclusions:Despite significant on-task learning, generalized improvements of working memory training in this trial were limited to (a) improvements for a trained working memory task tested outside of the training software and (b) a small improvement in self-reported hearing ability for those in the experimental group, compared with active controls. We found no evidence to suggest that training which primarily targets storage aspects of working memory can result in domain-general improvements that benefit everyday communication for adult hearing aid users. These findings are consistent with a significant body of evidence showing that Cogmed training only improves performance for tasks that resemble Cogmed training. Future research should focus on the benefits of interventions that enhance cognition in the context in which it is employed within everyday communication, such as training that targets dynamic aspects of cognitive control important for successful speech-in-noise perception.

Testing the Efficacy of a 1-Day Police Decision-Making and Autonomic Modulation Intervention: A Quasi-Random Pragmatic Controlled Trial.

Contemporary discourse has identified several urgent priorities concerning police training and education, including: (a) empirically testing and validating the effectiveness of current programming in reducing lethal force decision-making errors; (b) integrating evidence-based content and pedagogical approaches into police curriculum; and (c) understanding the breadth and length of programming necessary to ensure learning and transfer of skills to operational field settings. Widespread calls to identify effective and actionable training programs have been met with numerous research studies, systematic reviews, and policy recommendations that reveal the need to train officers’ internal physiological awareness, which is foundational in shaping cognitive decision-making, emotion regulation, and behavior under stressful conditions. Several investigations have shown improvements to both lethal force errors and physiological recovery following a multi-day autonomic modulation (AM) intervention. Immediate and sustained training gains are observed following repeated practice with clinically validated protocols integrated into training scenarios. Despite evidence-based support for AM in addressing the aforementioned priorities, police organizations are faced with limited time and funding for training and education. The goal of the current quasi-random pragmatic controlled trial was to evaluate the effectiveness of a modified 1-day version of an established AM intervention. A sample of active-duty police officers were quasi-randomly assigned to an AM intervention (n = 82) or waitlist control group (n = 105). Lethal force errors and objective measures of autonomic arousal and recovery were measured during reality-based scenarios pre- and post-training and at 12-month follow-up. In contrast to previous investigations of longer AM intervention protocols, no significant training-related improvements to behavioral or physiological outcomes were found immediately post-intervention or at follow-up. The current results suggest that single-day training is insufficient to learn the physiological awareness and regulation skills necessary to perform effectively during lethal force encounters, as demonstrated by a lack of immediate or sustained training effects. Practical considerations, such as resource allocation, that may undermine the effectiveness of implementing evidence-based police training are discussed.

Short report on research trends during the COVID-19 pandemic and use of telehealth interventions and remote brain research in children with autism spectrum disorder.

The COVID-19 pandemic has caused disruption in F2F healthcare delivery and neuroimaging research, especially when involving vulnerable populations such as children with autism spectrum disorder. Given the easy access to multiple video conferencing platforms, many healthcare services have moved to an online delivery format (i.e. telehealth). It is important to monitor the behavioral and neural effects of telehealth interventions and resume neuroimaging research while adopting public health safety protocols to control the risk of COVID-19 transmission. We summarize existing safety protocols and our own experience from in-person functional near-infrared spectroscopy neuroimaging data collection (on-site, at home, and in outdoor settings), as well as potential opportunities of using online data sharing and low-cost, remote neuroimaging/electrophysiological techniques to continue brain research during the pandemic.

Combined Transcutaneous Spinal Stimulation and Locomotor Training to Improve Walking Function and Reduce Spasticity in Subacute Spinal Cord Injury: A Randomized Study of Clinical Feasibility and Efficacy.

Locomotor training (LT) is intended to improve walking function and can also reduce spasticity in motor-incomplete spinal cord injury (MISCI). Transcutaneous spinal stimulation (TSS) also influences these outcomes. We assessed feasibility and preliminary efficacy of combined LT + TSS during inpatient rehabilitation in a randomized, sham-controlled, pragmatic study. Eighteen individuals with subacute MISCI (2–6 months post-SCI) were enrolled and randomly assigned to the LT + TSS or the LT + TSSsham intervention group. Participants completed a 4-week program consisting of a 2-week wash-in period (LT only) then a 2-week intervention period (LT + TSS or LT + TSSsham). Before and after each 2-week period, walking (10 m walk test, 2-min walk test, step length asymmetry) and spasticity (pendulum test, clonus drop test, modified spinal cord injury—spasticity evaluation tool) were assessed. Sixteen participants completed the study. Both groups improved in walking speed and distance. While there were no significant between-groups differences, the LT + TSS group had significant improvements in walking outcomes following the intervention period; conversely, improvements in the LT + TSSsham group were not significant. Neither group had significant changes in spasticity, and the large amount of variability in spasticity may have obscured ability to observe change in these measures. TSS is a feasible adjunct to LT in the subacute stage of SCI and may have potential to augment training-related improvements in walking outcomes.

Cultivating Affective Resilience: Proof-of-Principle Evidence of Translational Benefits From a Novel Cognitive-Emotional Training Intervention.

Available evidence highlights the importance of emotion regulation (ER) in psychological well-being. However, translation of the beneficial effects of ER from laboratory to real-life remains scarce. Here, we present proof-of-principle evidence from a novel cognitive-emotional training intervention targeting the development of ER skills aimed at increasing resilience against emotional distress. This pilot intervention involved training military veterans over 5–8 weeks in applying two effective ER strategies [Focused Attention (FA) and Cognitive Reappraisal (CR)] to scenarios presenting emotional conflicts (constructed with both external and internal cues). Training was preceded and followed by neuropsychological, personality, and clinical assessments, and resting-state functional MRI data were also collected from a subsample of the participants. Results show enhanced executive function and psychological well-being following training, reflected in increased working memory (WM), post-traumatic growth (PTG), and general self-efficacy (GSE). Brain imaging results showed evidence of diminished bottom-up influences from emotional and perceptual brain regions, along with evidence of normalized functional connectivity in the large-scale functional networks following training. The latter was reflected in increased connectivity among cognitive and emotion control regions and across regions of self-referential and control networks. Overall, our results provide proof-of-concept evidence that resilience and well-being can be learned through ER training, and that training-related improvements manifested in both behavioral change and neuroplasticity can translate into real-life benefits.

Relationship between Upper Quarter Y Balance Test performance and throwing proficiency in adolescent Olympic handball players

BackgroundOlympic handball is a sport mainly focused on executing throwing and passing techniques with the throwing arm. Functional specialization due to the unilateral characteristic and dominance of the throwing arm may lead to adapted control of shoulder stability and mobility. Thus, we examined side differences between the throwing and the non-throwing arm. Additionally, correlations between the Upper Quarter Y Balance Test (YBT-UQ) and handball-specific performance measures were investigated.MethodsAll participants (F = 13 yrs., n = 14, training experience [te] 5.9 ± 1.3 yrs.; M = 14 yrs., n = 24, te 6.5 ± 2.5 yrs.; M = 15 yrs., n = 18, te 9.3 ± 2.2 yrs) were Olympic handball players of a regional youth selection team. YBT-UQ was executed assessing performance in medial, inferolateral and superolateral reach direction normalized to the upper limb length together with a composite score of the mean of all reach directions. A radar gun and a target net were used for the assessment of throwing velocity and throwing accuracy. The paired t-test was used to detect side differences in YBT-UQ performance. Pearson’s correlation analysis was calculated for associations between YBT-UQ and throwing velocity/accuracy.ResultsSignificant differences between the throwing and non-throwing arm were only detected for the superolateral reach direction in the 14-year-old males. Small correlations between YBT-UQ performance and throwing velocity/accuracy (13-year-old females: − 0.01 ≤ r ≤ − 0.37 / 0.01 ≤ r ≤ 0.31; 14-year-old males: 0.10 ≤ r ≤ 0.45 / -0.01 ≤ r ≤ .-0.51; 15-year-old males: 0.06 ≤ r ≤ 0.34 / 0.01 ≤ r ≤ − 0.45) were observed, irrespective of age and sex category.ConclusionsThere was only a minimal difference in performance of the YBT-UQ between the throwing and non-throwing arm and only weak if any relationships between throwing performance and stability/mobility of the upper extremities in adolescent Olympic handball players existed. Further research is needed to investigate whether the YBT-UQ is a useful tool to detect training-related improvements in measures of shoulder stability/mobility and functional performance.

The Table-top Visual Search Ability Test for children and young people: Normative response time data from typically developing children

Five table-top tasks were developed to test the visual search ability of children and young people in a real-world context, and to assess the transfer of training-related improvements in visual search on computerised tasks to real-world activities. Each task involved searching for a set of target objects among distracting objects on a table-top. Performance on the Table-top Visual Search Ability Test for Children (TVSAT-C) was measured as the time spent searching for targets divided by the number of targets found. A total of 108 typically developing children (3–11 years old) and eight children with vision impairment (7–12 years old) participated in the study. A significant correlation was found between log-transformed age and log-transformed performance ( R2 = .65, p = 4 × 10−26) in our normative sample, indicating a monomial power law relationship between age and performance with an exponent of [Formula: see text], [Formula: see text] We calculated age-dependent percentiles and receiver operating characteristic curve analysis indicated the third percentile as the optimal cut-off for detecting a visual search deficit, giving a specificity of [Formula: see text], [Formula: see text] and sensitivity of [Formula: see text], [Formula: see text] for the test. Further studies are required to calculate measures of reliability and external validity, to confirm sensitivity for visual search deficits, and to investigate the most appropriate response modes for participants with conditions that affect manual dexterity. In addition, more work is needed to assess construct validity where semantic knowledge is required that younger children may not have experience with. We have made the protocol and age-dependent normative data available for those interested in using the test in research or practice, and to illustrate the smooth developmental trajectory of visual search ability during childhood.

Effects of a Traditional versus an Alternative Strengthening Exercise Program on Shoulder Pain, Function and Physical Performance in Individuals with Subacromial Shoulder Pain: A Randomized Controlled Trial.

A manual shoulder-training device may represent an alternative training device to improve symptoms and function in patients with subacromial shoulder pain by strengthening the external rotators. Thus, we examined the effects of a traditional versus an alternative strengthening exercise program on shoulder pain/function and physical performance in individuals with subacromial shoulder pain. Fifty-six adults with subacromial shoulder pain were randomly assigned to a passive control group (CON; n = 20), a traditional training group (TRA; n = 19), or an alternative training group (ALT; n = 17). Both training groups conducted a progressive home-based strengthening exercise program for the external rotators for eight weeks using elastic bands only (TRA group) or in combination with the shoulder-training device (Schulterhilfe®) (ALT group). Pre- and post-training assessment included measures of shoulder pain/function (i.e., shoulder pain and disability index (SPADI)) and physical performance (i.e., shoulder flexibility, maximal isometric strength, and strength endurance). We found significant test × group interactions in most of the investigated variables. Post hoc analyses showed significant training-related improvements for proxies of shoulder pain/function, shoulder flexibility, maximal isometric strength, and strength endurance in favor of the ALT and TRA group in comparison to the CON group. Further, larger and more frequent effects were found for the ALT compared to the TRA group. Measures of shoulder pain/function and physical performance can be significantly improved by both training regimens in individuals with subacromial shoulder pain. However, strength training using elastic bands with the manual shoulder device (ALT group) as compared to elastic bands (TRA group) only was more effective and may thus be a recommendable alternative in order to mitigate subacromial shoulder pain.

What Versus How in Visual Search: Effects of Object Recognition Training, Strategy Training, and Non-invasive Brain Stimulation on Satellite Image Search

Visual search is required in many professions where an undetected threat, such as a weapon, can put the well-being of others at risk. Given the importance of detecting these threats, researchers have used various experimental techniques to improve performance in visual search tasks, albeit with varying degrees of success. Here, we explore two promising techniques to improve visual search using ecologically valid synthetic aperture radar stimuli: object recognition training and search strategy training. Search strategy training is intended to make observers search more systematically through a display, whereas object recognition training is intended to improve observers’ ability to recognize critical targets. Search strategy training was implemented by instructing participants to scan through the display in a pre-specified pattern. Object recognition training was implemented by having participants discriminate between targets and non-targets. We also manipulated whether observers received anodal or sham transcranial direct current stimulation (tDCS) during training, which has been shown to improve visual search performance and target learning. To measure the effectiveness of the training and stimulation conditions, we tested object recognition accuracy and overall visual search performance before and after three sessions of increasingly difficult training. Results indicated that object recognition training significantly improved object recognition accuracy relative to the search strategy group, whereas search strategy training was effective in improving visual search accuracy in those who adhered to the training. However, tDCS did not interact with training type, and although both training types yielded significant improvements, training-related improvements were not significantly different between the different approaches. This evidence suggests that strategy-based training could be as effective as the more prototypical object recognition training. Implications for future training protocols are discussed.

The Effect of Baseline Performance and Age on Cognitive Training Improvements in Older Adults: A Qualitative Review.

Findings that the brain is capable of plasticity up until old age have led to interest in the use of cognitive training as a potential intervention to delay the onset of dementia. However, individuals participating in training regimens differ greatly with respect to their outcomes, demonstrating the importance of considering individual differences, in particular age and baseline performance in a cognitive domain, when evaluating the effectiveness of cognitive training. In this review, we summarize existing literature on cognitive training in adults across the domains of episodic memory, working memory and the task-switching component of executive functioning to clarify the picture on the impact of age and baseline performance on cognitive training-related improvements. Studies targeting episodic memory induced greater improvements in younger adults with more intact cognitive abilities, explained in part by factors specific to episodic memory training. By contrast, older, lower baseline performance adults improved most in several studies targeting working memory in older individuals as well as in the majority of studies targeting executive functioning, suggesting the preservation of neural plasticity in these domains until very old age. Our findings can have important implications for informing the design of future interventions for enhancing cognitive functions in individuals at the prodromal stage of Alzheimer's Disease and potentially delaying the clinical onset of Alzheimer's Disease. Future research should more clearly stratify individuals according to their baseline cognitive abilities and assign specialized, skill-specific cognitive training regimens in order to directly answer the question of how individual differences impact training effectiveness.

Exercise Training Induced Changes In Nuclear Magnetic Resonance-Measured Lipid Particles In Mild Cognitively Impaired Elderly African American Volunteers: A Pilot Study.

PurposePoor cardiorespiratory fitness (CRF) is linked to cognitive deterioration, but its effects on lipid heterogeneity and functional properties in older African American (AA) subjects with mild cognitive impairment (MCI) need elucidation. This study determined whether exercise training-induced changes in blood lipid particle sizes (LPS) were associated with CRF determined by VO2Max in elderly AAs with MCI. Given the pivotal role of brain-derived neurotrophic factor (BDNF) on glucose metabolism, and therefore, “diabetic dyslipidemia”, we also determined whether changes in LPS were associated with the levels of serum BDNF.MethodsThis analysis included 17 of the 29 randomized elderly AAs with MCI who had NMR data at baseline and after a 6-month training. We used Generalized Linear Regression (GLM) models to examine cardiorespiratory fitness (VO2Max) effects on training-induced change in LPS in the stretch and aerobic groups. Additionally, we determined whether the level of BDNF influenced change in LPS.ResultsCollectively, mean VO2Max (23.81±6.17) did not differ significantly between aerobic and stretch groups (difference=3.17±3.56, P=0.495). Training-related changes in very low-density lipoprotein, chylomicrons, and total low-density lipoprotein (LDL) particle sizes correlated significantly with VO2Max, but not after adjustment for age and gender. However, increased VO2Max significantly associated with reduced total LDL particle size after similar adjustments (P = 0.046). While stretch exercise associated with increased protective large high-density lipoprotein particle size, the overall effect was not sustained following adjustments for gender and age. However, changes in serum BDNF were associated with changes in triglyceride and cholesterol transport particle sizes (P < 0.051).ConclusionPromotion of stretch and aerobic exercise to increase CRF in elderly AA volunteers with MCI may also promote beneficial changes in lipoprotein particle profile. Because high BDNF concentration may reduce CVD risk, training-related improvements in BDNF levels are likely advantageous. Large randomized studies are needed to confirm our observations and to further elucidate the role for exercise therapy in reducing CVD risk in elderly AAs with MCI.

Cognitive training in children with hypoplastic left heart syndrome: A pilot randomized trial

Neurodevelopmental disabilities are common sequelae of congenital heart disease, particularly cognitive impairments that impede academic achievement. Cognitive training has been shown to be effective in improving working memory in other patient groups. Computerized cognitive training programs may hold potential for children and adolescents with congenital heart disease, but are untested in this population. In this single-center, single-blinded, randomized controlled trial, the feasibility and efficacy of Cogmed Working Memory Training (Cogmed) was compared with observation in children with hypoplastic left heart syndrome 8 to 16 years of age. Participants were randomized to either Cogmed at home for 5 weeks with coaching by a study team member or an observation control group. Baseline, 6–8 weeks later (post-intervention), and 6-month assessments of working memory were completed. Participants randomized to the Cogmed intervention (n = 10) demonstrated greater improvement than controls (n = 10) on measures of working memory, the Wechsler Intelligence Scale for Children-V Working Memory Index and the National Institutes of Health Toolbox Cognitive Battery post-training that were statistically significant (Cohen's d = 0.76, p < .001 and d = 0.43, p < .01) compared to controls over the same time period. Improvements were not maintained at 6-month follow-up. Three children withdrew from cognitive training, and one additional child did not complete at least 20 of 25 cognitive training sessions despite coaching. In conclusion, study findings show computerized cognitive training is feasible for most children with hypoplastic left heart syndrome, but shorter sessions may improve adherence. Training-related improvements in working memory occur, though continued reinforcement may be necessary for these gains to be maintained.

NOVEL FINDINGS TWO DECADES FOLLOWING COGNITIVE TRAINING: FINDINGS FROM THE ACTIVE TRIAL

Although the only demonstrated panacea against cognitive decline, behavioral cognitive training usually fails to demonstrate transfer either to untrained cognitive abilities or to distal outcomes like everyday functioning. No such trials, however, have leveraged more than a decade of follow-up to adapt life-course perspectives. The Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study remains the largest NIA-funded clinical trial of cognitively normal older adults. Efforts to re-invigorate the cohort after 20 years with external data linkages have coalesced around renewed interests in how training-related cognitive improvements affect long-term dementia risk, health care utilization and costs, credit scores, and active years in later life. The first presentation by Rebok overviews ACTIVE and its 20-year follow-up plans. Next, Gross and colleagues tested whether cognitive training attenuates the relationship between IADL difficulty and mortality; negative findings suggest proposed relationships between cognition and IADL difficulty are correlational, not causal, which has implications for transfer and trial outcomes. Third, Thomas tests a novel algorithm for classifying MCI, ushering opportunities to examine training effects on incidence of MCI after up to 20 years post-training. Marsiske then evaluates temporal transfer of training in reasoning ability, concluding that reasoning training and age, but not other baseline demographics, predict maintained alterations in reasoning abilities. Finally, Felix evaluates the stifling role of depressive symptoms on ability to benefit from training. Dr. Wally Boot, a recognized thought leader in transfer of cognitive training, will provide an illuminating discussion of promises and pitfalls of these lines of research.

Brain network modularity predicts cognitive training-related gains in young adults

The brain operates via networked activity in separable groups of regions called modules. The quantification of modularity compares the number of connections within and between modules, with high modularity indicating greater segregation, or dense connections within sub-networks and sparse connections between sub-networks. Previous work has demonstrated that baseline brain network modularity predicts executive function outcomes in older adults and patients with traumatic brain injury after cognitive and exercise interventions. In healthy young adults, however, the functional significance of brain modularity in predicting training-related cognitive improvements is not fully understood. Here, we quantified brain network modularity in young adults who underwent cognitive training with casual video games that engaged working memory and reasoning processes. Network modularity assessed at baseline was positively correlated with training-related improvements on untrained tasks. The relationship between baseline modularity and training gain was especially evident in initially lower performing individuals and was not present in a group of control participants that did not show training-related gains. These results suggest that a more modular brain network organization may allow for greater training responsiveness. On a broader scale, these findings suggest that, particularly in low-performing individuals, global network properties can capture aspects of brain function that are important in understanding individual differences in learning.

Independent Components of Neural Activation Associated with 100 Days of Cognitive Training.

Some cognitive training studies have reported working memory benefits that generalize beyond the trained tasks, whereas others have only found task-specific training effects. What brain networks are associated with general training effects, rather than task-specific effects? We investigated this question in the context of working memory training using the COGITO data set, a longitudinal project including behavioral assessments before and after 100 days of cognitive training in 101 younger (20-31 years) and 103 older (65-80 years) adults. Pre- and postassessments included verbal, numerical, and spatial measures of working memory. It was therefore possible to assess training effects on working memory at a general latent ability level. Previous analyses of these data found training-related improvements on this latent working memory factor in both young and old participants. fMRI data were collected from a subsample of participants (24 young and 15 old) during pre- and post-training sessions. We used independent component analysis to identify networks involved in a perceptual decision-making task performed in the scanner. We identified five task-positive components that were task-related: two frontal networks, a ventral visual network, a motor network, and a cerebellar network. Pre-training activity of the motor network predicted latent working memory performance before training. Additionally, activity in the motor network predicted training-related changes in working memory ability. These findings suggest activity in the motor network plays a role in task-independent working memory improvements and have implications for our understanding of working memory training and for the design and implementation of future training interventions.

MaGrid: A Language-Neutral Early Mathematical Training and Learning Application

Given that the use of educational technologies is increasingly popular in kindergarten and among young students, these technologies have been shown to be able to solve the difficulties (existing in school) that are either not possible to be solved in traditional schooling or cost a lot of time and resources. In this paper, we present a pedagogical training and learning application called MaGrid (Math on Grid), which has been developed to foster early mathematical skills in pre-schoolers. MaGrid is a tablet-based application, which provides a wide range of training tasks targeting fundamental mathematical concepts for the preschool level. The language-neutral property of MaGrid is an innovative aspect that makes MaGrid different from existing mathematical training applications. This property may reduce the barrier of language from mathematical education for second language learners encountered in multilingual school settings. MaGrid allows individual learning in an interactive way and provides real-time feedback. Moreover, MaGrid is capable of recording students’ activities while working on the training tasks, which can help teachers and parents keep track of a student’s progress in different tasks and observe potential training-related improvements over time. Finally, we describe a series of experiments carried out using the MaGrid application during special training and assessment sessions in several preschools in Luxembourg.

(Un)Great Expectations: The Role of Placebo Effects in Cognitive Training

A growing body of literature demonstrating the malleability of critical higher-order cognitive functions by means of targeted interventions has incited widespread scientific interest, most notably in the form of cognitive training programs. The results are mixed and a point of contention: It has been argued that gains observed in cognitive training are mainly due to placebo effects. To address this, we examined the effect of participant expectations on one type of cognitive training that has been central to the controversy, namely n-back training, by inducing beliefs about expected outcomes. Participants receiving n-back training showed improvements in non-trained n-back performance regardless of expectations, and furthermore, expectations for positive outcomes did not result in any significant gains in an active control group. Thus, there was no detectable expectancy effect in either direction as a function of the cognitive intervention used, suggesting that training-related improvements are unlikely due solely to a placebo effect.