Training In Older Adults Research Articles

Cerebral blood flow and arterial transit time responses to exercise training in older adults

Brain vascular health worsens with age, as is made evident by resting grey matter cerebral blood flow (CBFGM) reductions and lengthening arterial transit time (ATTGM). Exercise training can improve aspects of brain health in older adults, yet its effects on CBFGM and ATTGM remain unclear. This randomised controlled trial assessed responses of CBFGM and ATTGM to a 26 week exercise intervention in 65 healthy older adults (control: n = 33, exercise: n = 32, aged 60–81 years), including whether changes in CBFGM or ATTGM were associated with cognitive function changes. Multiple-delay pseudo-continuous arterial spin labelling data were used to estimate resting global and regional CBFGM and ATTGM. Results showed no between-group differences in CBFGM or ATTGM following the intervention. However, exercise participants with the greatest cardiorespiratory gains (n = 17; ∆V̇O2peak >2 mL/kg/min) experienced global CBFGM reductions (-4.0 [-7.3, -0.8] mL/100 g/min). Cognitive functions did not change in either group and changes were not associated with changes in CBFGM or ATTGM. Our findings indicate that exercise training in older adults may induce global CBFGM reductions when high cardiorespiratory fitness gains are induced, but this does not appear to affect cognitive functions.

Effectiveness of combined physical exercise and cognitive training in older adults with cognitive impairment: A systematic review and meta-analysis

Falls among cognitively impaired older adults are a global concern. The aim of this study was to assess the efficacy of combining physical exercise and cognitive training to improve balance among older adults. A systematic search of databases, including Embase, Medline-OVID, CINAHL-EBSCOhost, and Central-Cochrane Library, was conducted from March 9 to April 6, 2023. The search used keywords based on the PICO question, where the population was older adults with cognitive impairment. Compared to a single therapy, the intervention involved a combination of muscle strengthening and cognitive therapy, with the outcome of falls or balance. Inclusion criteria were randomized controlled trials (RCTs) in any setting. Studies with participants under 60 years old and lacking baseline clinical assessments were excluded. EndNote 20 was used as a reference manager tool, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 flow diagram was used to map out the number of identified records. Two investigators worked independently, and the Jadad scale was used for critical appraisal. The PROSPERO registration number is CRD42023454876. A fixed-effects meta-analysis was performed using an inverse-variance method. Four articles met the inclusion criteria, three of which were included in the meta-analysis. Studies were from Europe, New Zealand, and the Philippines, with a total sample of 255 participants and mean ages of 65.9–87.5 years. The studies used combined physical and cognitive training in one group. Results showed a significant moderate effect size (effect size (ES): 2.29; standardized mean difference (SMD): 0.41; p<0.05; heterogeneity (I2): 0%) indicating no heterogeneity. In conclusion, the combined intervention displayed the potential to improve balance for cognitively impaired older adults.

Effects of Resistance Training Volume on Physical Function, Lean Body Mass and Lower-Body Muscle Hypertrophy and Strength in Older Adults: A Systematic Review and Network Meta-analysis of 151 Randomised Trials.

The optimal prescription and precise recommendations of resistance training volume for older adults is unclear in the current literature. In addition, the interactions between resistance training volume and program duration as well as physical health status remain to be determined when assessing physical function, muscle size and hypertrophy and muscle strength adaptations in older adults. This study aimed to determine which resistance training volume is the most effective in improving physical function, lean body mass, lower-limb muscle hypertrophy and strength in older adults. Additionally, we examined whether effects were moderated by intervention duration (i.e. short term, < 20weeks; medium-to-long term, ≥ 20weeks) and physical health status (i.e. physically healthy, physically impaired, mixed physically healthy and physically impaired; PROSPERO identifier: CRD42023413209). CINAHL, Embase, LILACS, PubMed, Scielo, SPORTDiscus and Web of Science databases were searched up to April 2023. Eligible randomised trials examined the effects of supervised resistance training in older adults (i.e. ≥ 60years). Resistance training programs were categorised as low (LVRT), moderate (MVRT) and high volume (HVRT) on the basis of terciles of prescribed weekly resistance training volume (i.e. product of frequency, number of exercises and number of sets) for full- and lower-body training. The primary outcomes for this review were physical function measured by fast walking speed, timed up and go and 6-min walking tests; lean body mass and lower-body muscle hypertrophy; and lower-body muscle strength measured by knee extension and leg press one-repetition maximum (1-RM), isometric muscle strength and isokinetic torque. A random-effects network meta-analysis was undertaken to examine the effects of different resistance training volumes on the outcomes of interest. We included a total of 161 articles describing 151 trials (n = 6306). LVRT was the most effective for improving timed up and go [- 1.20 standardised mean difference (SMD), 95% confidence interval (95% CI): - 1.57 to - 0.82], 6-min walk test (1.03 SMD, 95% CI: 0.33-1.73), lean body mass (0.25 SMD, 95% CI: 0.10-0.40) and muscle hypertrophy (0.40 SMD, 95% CI: 0.25-0.54). Both MVRT and HVRT were the most effective for improving lower-limb strength, while only HVRT was effective in increasing fast walking speed (0.40 SMD, 95% CI: - 0.57 to 0.14). Regarding the moderators, our results were independent of program duration and mainly observed for healthy older adults, while evidence was limited for those who were physically impaired. A low resistance training volume can substantially improve healthy older adults' physical function and benefits lean mass and muscle size independently of program duration, while a higher volume seems to be necessary for achieving greater improvements in muscle strength. A low volume of resistance training should be recommended in future exercise guidelines, particularly for physically healthy older adults targeting healthy ageing.

A partial loss-of-function variant (Ile191Val) of the TAS1R2 glucose receptor is associated with enhanced responses to exercise training in older adults with obesity: A translational study

BackgroundThe TAS1R2 receptor, known for its role in taste perception, has also emerged as a key regulator of muscle physiology. Previous studies have shown that genetic ablation of TAS1R2 in mice enhances muscle fitness mimicking responses to endurance exercise training. However, the translational relevance of these findings to humans remains uncertain. MethodsWe explored responses to endurance exercise training in mice and humans with genetic deficiency of TAS1R2. First, we assessed the effects of muscle-specific deletion of TAS1R2 in mice (mKO) or wild type controls (mWT) following 4 weeks of voluntary wheel running (VWR). Next, we investigated the effects of the TAS1R2-Ile191Val (rs35874116) partial loss-of-function variant on responses to a 6-month diet-induced weight loss with exercise training (WLEX), weight loss alone (WL), or education control (CON) interventions in older individuals with obesity. Participants were retrospectively genotyped for the TAS1R2-Ile191Val polymorphism and classified as conventional function (Ile/Ile) or partial loss-of-function (Val carriers: Ile/Val and Val/Val). Body composition, cardiorespiratory fitness, and skeletal muscle mitochondrial function were assessed before and after the intervention. ResultsIn response to VWR, mKO mice demonstrated enhanced running endurance and mitochondrial protein content. Similarly, TAS1R2 Val carriers exhibited distinctive improvements in body composition, including increased muscle mass, along with enhanced cardiorespiratory fitness and mitochondrial function in skeletal muscle following the WLEX intervention compared to Ile/Ile counterparts. Notably, every Val carrier demonstrated substantial responses to exercise training and weight loss, surpassing all Ile/Ile participants in overall performance metrics. ConclusionsOur findings suggest that TAS1R2 partial loss-of-function confers beneficial effects on muscle function and metabolism in humans in response to exercise training, akin to observations in TAS1R2 muscle-deficient mice. Targeting TAS1R2 may help enhancing exercise training adaptations in individuals with compromised exercise tolerance or metabolic disorders, presenting a potential avenue for personalized exercise interventions.

The Effectiveness Of One Day A Week Group Exercise Training In Older Adults

The Effectiveness Of One Day A Week Group Exercise Training In Older Adults

Real-Time fMRI Neurofeedback Training of Selective Attention in Older Adults.

Selective attention declines with age, due to age-related functional changes in dorsal anterior cingulate cortex (dACC). Real-time functional magnetic resonance imaging (rtfMRI) neurofeedback has been used in young adults to train volitional control of brain activity, including in dACC. For the first time, this study used rtfMRI neurofeedback to train 19 young and 27 older adults in volitional up- or down-regulation of bilateral dACC during a selective attention task. Older participants in the up-regulation condition (experimental group) showed greater reward points and dACC BOLD signal across training sessions, reflective of neurofeedback training success; and faster reaction time and better response accuracy, suggesting behavioral benefits on selective attention. These effects were not observed for older participants in the down-regulation condition (inverse condition control group), supporting specificity of volitional dACC up-regulation training in older adults. These effects were, unexpectedly, also not observed for young participants in the up-regulation condition (age control group), perhaps due to a lack of motivation to continue the training. These findings provide promising first evidence of functional plasticity in dACC in late life via rtfMRI neurofeedback up-regulation training, enhancing selective attention, and demonstrate proof of concept of rtfMRI neurofeedback training in cognitive aging.

A 24-Week Combined Resistance and Balance Training Program Improves Physical Function in Older Adults: A Randomized Controlled Trial

Abstract Jiang, G, Tan, X, Zou, J, and Wu, X. A 24-week combined resistance and balance training program improves physical function in older adults: a randomized controlled trial. J Strength Cond Res XX(X): 000–000, 2024—This randomized controlled trial assessed the feasibility of older adults performing combined resistance and balance training (RBT) and compared the effects of RBT on physical function with those of resistance training (RT) alone and with no exercise training in older adults. In total, 65 community-dwelling adults aged 60–74 years were randomly assigned to an RT (n = 22), RBT (n = 22), or control (n = 21) group. The exercise intervention consisted of RT or RBT for 45 minutes, 3 times per week for 24 weeks. The control group engaged in no exercise training. The compliance rates were 93% in the RT group and 92% in the RBT group. No training-related adverse effect was observed. In the RT and RBT groups, dynamic balance (p = 0.017; p &lt; 0.001, respectively), maximum walking speed (p = 0.014; p &lt; 0.001), upper extremity (p = 0.013; p = 0.009) and lower extremity (p = 0.009; p &lt; 0.001) muscle strength, and spirometry (p = 0.043; p = 0.018) were significantly improved at 24 weeks compared with the control group. Only the RBT group showed significant improvement in normal walking speed (p = 0.002). Compared with the RT group, the RBT group showed additional significant improvements in dynamic balance (p = 0.001) and lower limb muscle strength (p = 0.027). The findings of this randomized controlled trial indicated that RBT was safe and feasible for older adults. Long-term RBT had better effects than either no exercise training or RT alone on improving physical function in older adults. Compared with RT, RBT additionally benefited dynamic balance and lower limb muscle function, which are clinically important factors in preventing falls, frailty, disability, and other geriatric syndromes.

Effects of detraining on neuromuscular function and structural adaptations following once- or twice-weekly eccentric resistance training in older adults

BackgroundEccentric resistance training elicits greater preservation of training-induced muscular adaptations compared with other training modalities, however the detraining profiles of different training dosages remain unknown.AimsTo examine the detraining effects following once- or twice-weekly eccentric-specific resistance training in older adults.MethodsTwenty-one older adults (age = 70.5 ± 6.0 year) completed a 12-week detraining period following the 12-week eccentric training programmes with neuromuscular function and muscle structure assessed six (mid-detraining) and 12 (post-detraining) weeks following training cessation.ResultsFrom post-training to post-detraining, no significant regression of the training-induced improvements (collapsed group data reported) occurred in power (0%), strength (eccentric = 0%, isometric = 39%), or explosive strength over numerous epochs (0–32%), resulting in values that remained significantly greater than at pre-training. However, significant regression in the improvements in muscle thickness (91%) and fascicle angle (100%) occurred, resulting in values that were not significantly greater than pre-training.DiscussionThe limited regression in neuromuscular function following a 12-week detraining period has important implications for supporting eccentric exercise prescription in older adults who often face periods of inactivity. However, further work is required to develop an effective maintenance dosage strategy that preserves improvements in muscle structure.ConclusionsEccentric resistance training elicits improvements in the neuromuscular function of older adults, which are sustained for at least 12 weeks after eccentric training cessation.

Multisensory training based on an APP for enhanced verbal working memory in older adults

With the increasing aging population, contemporary society faces the imperative to develop approaches that efficiently delay the age-related decline in working memory capacity, which is a critical area within cognitive aging research. Nevertheless, there is insufficient evidence to support the efficacy of verbal working memory training across various sensory modalities (visual, auditory, and audiovisual) in enhancing the verbal working memory capacity of older adults. In this study, 60 healthy older adults (mean age = 67.07 ± 3.79 years, comprising 34 women and 26 men, mean education = 15.55 ± 2.53 years) were randomly assigned to one of four groups: visual verbal working memory (V-VWM) group, auditory verbal working memory (A-VWM) group, visual-auditory verbal working memory (VA-VWM) group, and a control group. The training duration spanned 12 days. We also investigated whether baseline level and education predicted the outcomes. Findings indicated that V-VWM training had a large effect on improving V-VWM task performance (Cohen's d = 1.765), A-VWM training showed a substantial effect on A-VWM task performance (Cohen's d = 1.904), and VA-VWM training demonstrated a significant effect on VA-VWM task performance (Cohen's d = 2.319) over pretest scores in older adults. Enhancements achieved through V-VWM training exhibited near transfer effects, improving performance in both A-VWM and VA-VWM tasks. In contrast, gains from A-VWM training were selectively transferred to the VA-VWM task. Furthermore, VA-VWM training led to improvements not only in V-VWM and A-VWM tasks but also extended to verbal operation span task with a significant 29.7 % increase. However, no significant transfer effects were observed for the DSF and DSB tasks across the three training groups. The maintenance effect of VA-VWM training persisted for two weeks across tasks involving VA-VWM, V-VWM, and A-VWM. The baseline of VWM span score influence the effect of V-VWM training and transfer effect of VA-VWM training. Education level did not predict the training effects of V-VWM, A-VWM, and VA-VWM. These findings highlight the nuanced effects of sensory-specific verbal working memory training in older adults, emphasizing the potential of tailored interventions to enhance specific aspects of cognitive function, while also highlighting the promising applications of mobile device training in enhancing cognitive skills among the elderly.

Muscle-derived microRNAs correlated with thigh lean mass gains during progressive resistance training in older adults.

Resistance training (RT) remains the most effective treatment for age-related declines in muscle mass. However, many older adults experience attenuated muscle hypertrophy in response to RT when compared with younger adults. This may be attributed to underlying molecular processes that are dysregulated by aging and exacerbated by improperly prescribed RT weekly volume, intensity, and/or frequency doses. MicroRNAs (miRNAs) are key epigenetic regulators that impact signaling pathways and protein expression within cells, are dynamic and responsive to exercise stimuli, and are often dysregulated in diseases. In this study, we used untargeted miRNA-seq to examine miRNA in skeletal muscle and serum-derived exosomes of older adults (n = 18, 11 M/7 F, 66 ± 1 yr) who underwent three times per wk RT for 30 wk [e.g., high intensity three times/wk (HHH, n = 9) or alternating high-low-high (HLH) intensity (n = 9)], after a standardized 4-wk washin. Within each tissue, miRNAs were clustered into modules based on pairwise correlation using weighted gene correlation network analysis (WGCNA). Modules were tested for association with the magnitude of RT-induced thigh lean mass (TLM) change [as measured by dual-energy X-ray absorptiometry (DXA)]. Although no modules were unique to training dose, we identified miRNA modules in skeletal muscle associated with TLM gains irrespective of exercise dose. Using miRNA-target interactions, we analyzed key miRNAs in significant modules for their potential regulatory involvement in biological pathways. Findings point toward potential miRNAs that may be informative biomarkers and could also be evaluated as potential therapeutic targets as an adjuvant to RT to maximize skeletal muscle mass accrual in older adults.NEW & NOTEWORTHY In this work, we identified a set of microRNAs correlated with thigh lean mass gains in a group of older adults. To our knowledge, this is the first time these microRNAs have been identified as novel predictive biomarkers correlating with lean mass gains in aging adults. As biomarkers, these may help interventionalists identify older individuals that are positively responding to an exercise intervention.

One Year of Heavy Resistance Training Modifies Muscle Fiber Characteristics in the Elderly.

Physical function declines with age, accelerating during the 6th decade of life, primarily due to loss in muscle mass and strength. The present study aimed to investigate the effect of one year of heavy resistance training in older adults (62-70 years) on muscle mass and strength. Further, we investigated muscle characteristics after the intervention by obtaining muscle biopsies from the vastus lateralis to compare muscle fiber characteristics between the heavy resistance training (HRT) (n=10) and the sedentary control group (CON) (n=10). We found that one year of resistance training increased isometric muscle strength (p<0.0001, ES: 2.43 (Hedges' g)) and lean body mass (p<0.05, ES: 0.96), whereas cross-sectional area of the vastus lateralis and lean leg mass were unaltered. At year 1, the percentage of type IIX muscle fibers was lower in HRT compared to CON (p<0.05, ES: 0.99), whereas the muscle fiber size did not differ between groups for the major fiber types (I and II). In conclusion, one year of resistance training in elderly improved muscle strength and lean body mass but not cross-sectional area and lean leg mass. This indicates that the increase in muscle strength may be caused by neuromuscular adaptations rather than morphological muscle tissue changes per se.

Student nurses’ views on an E-Learning module on comfort, safety, and mobility with older adults: a cross-sectional study

ABSTRACT Background Nursing students often receive insufficient training in older adults’ care. Purpose Examine nursing students’ perceptions of an e-learning module developed to enhance their knowledge about the comfort, safety, and mobility of older adults. Methods A cross-sectional survey was administered to third-year baccalaureate nursing students at a Canadian university after they had completed the comfort, safety, and mobility module. The survey assessed students' perceptions of the e-learning module using four 5-pointLikert-type items. The survey also contained demographic questions and one open-ended question that invited participants to make any comments they wished. Descriptive statistics were used to summarize participants’demographic characteristics. Responses to the open-ended quesiton were summative content analyzed. Results The survey was completed by 119 participants, who reported that the module increased their confidence, perceptions and knowledge in working with older adults. Participants also found the method of instruction to be convenient, interactive, and enjoyable. Conclusions Results suggest that the learning module has the potential to facilitate student nurses’ learning about comfort, safety, and mobility.

Low adherence to prescribed time under tension in elastic band resistance training in older adults. An observational study

Time under tension (TUT) is an important variable in resistance training (RT). A stretch sensor (Bandcizer) attached to an elastic band during RT can quantify TUT reliably. ObjectiveTo explore adherence to prescribed TUT for elastic band RT with the Bandcizer during supervised and unsupervised RT at different time points. Methods22 men and women (66.2 ± 2.1 years) performed one supervised and two unsupervised sessions weekly of elastic band RT for the upper and lower extremities with the Bandcizer during a 25-week period. Prescribed TUT was 4 s/repetition. Bandcizer data were extracted from week: 1, 8, and median 24. The effects of time point and supervision on adherence (%) to TUT and number of repetitions were analyzed by Two-way ANOVA. ResultsDuring supervised sessions, adherence to prescribed TUT was 79 ± 4%, 60 ± 4%, and 53 ± 5% in week: 1, 8, and median 24, respectively (p < 0.001). There was no difference in adherence between supervised and unsupervised sessions at any time points. Adherence to the prescribed number of repetitions in each training session was close to 100%. ConclusionAdherence to prescribed TUT was low during both supervised and unsupervised, home-based elastic band RT and decreased over time despite weekly supervision. Our results highlight the need to focus on TUT when planning and implementing elastic band resistance training in retirement age individuals.

Effects of bottom-up versus top-down digital cognitive training in older adults: A randomized controlled trial

IntroductionImpairments in bottom-up perceptual processing have been associated to the age-related cognitive decline. Digital cognitive training focusing on bottom-up and/or top-down processes have been studied as a tool to remediate age-related cognitive decline. However, the most effective training type and order of application remain unclear. MethodsOne hundred and fifteen older adults were randomly assigned to 40 h of bottom-up then top-down or top-down then bottom-up digital cognitive training or an active control group. We evaluated cognition at baseline, after 20 h and 40 h of training and at follow-up using a mixed-model analysis. ResultsGlobal cognition improved, for the top-down group, after 20 h of training (p = 0.04; d = 0.7) and for all three groups after 40 h. The improvement in global cognition remained five months after the bottom-up/ top-down training (p = 0.009; d = 4.0). There were also improvements in the recall cognitive domain, after 20 h of training, for the bottom-up group and, after 40 h, for all three groups. Gains were observed in verbal fluency after 40 h of training for both therapeutic groups. Processing speed was significantly slower, after 20 h of training, for the control and bottom-up groups and, after 40 h, only for the control group. Emotion recognition improved, after 20 h, for the control group as compared to the therapeutic groups. ConclusionsThese results indicate that the bottom-up/top-down training has the most endurable effects, which reveals the importance of the order of application of the exercises for gains in cognition in older adults.

Limited training and transfer effects in older and young adults who participated in 12 sessions of process-based working memory training. A three-armed pretest-posttest design study

ObjectiveNumerous studies confirm the effectiveness of cognitive training in older adults. However, there is limited evidence of the transfer occurrence. The part of the study presented here tested the effect of 12 process-based working memory training sessions on the performance of the trained task (training effect) and other cognitive tasks (transfer effect). A pretest-posttest study design with one experimental group and two control (passive and active) groups. The sample comprised three groups of older adults: experimental (n = 25), passive control (n = 22), active control (n = 7), and young adults: experimental (n = 25), passive control (n = 25), and active control (n = 12). The study was registered after completion with a ClinicalTrials.gov Identifier: NCT06235840 on 31 January 2024.ResultsUnder the influence of training, the performance of the trained task improved significantly, but only in young adults. Transfer of WM training effects was not revealed. Among young adults, a testing effect was observed for the indicator of attentional focus and psychomotor speed. Moreover, the obtained results suggest the transfer from practice in multi-domain training, implemented in the active control group, to tasks that require the use of fluid intelligence. However, this finding should be interpreted with great caution due to the small size of active control groups.

APOE genotype, hippocampal volume, and cognitive reserve predict improvement by cognitive training in older adults without dementia: a randomized controlled trial.

Cognitive training (CT) programs aim to improve cognitive performance and impede its decline. Thus, defining the characteristics of individuals who can benefit from these interventions is essential. Our objectives were to assess if the cognitive reserve (CR), APOE genotype (e4 carriers/non-carriers) and/or hippocampal volume might predict the effectiveness of a CT program. Participants were older adults without dementia (n = 226), randomized into parallel experimental and control groups. The assessment consisted of a neuropsychological protocol and additional data regarding total intracranial, gray matter, left/right hippocampus volume; APOE genotype; and Cognitive Reserve (CR). The intervention involved multifactorial CT (30 sessions, 90min each), with an evaluation pre- and post-training (at six months); the control group simply following the center's routine activities. The primary outcome measures were the change in cognitive performance and the predictors of change. The results show that APOE-e4 non-carriers (79.1%) with a larger left hippocampal volume achieved better gains in semantic verbal fluency (R2 = .19). Subjects with a larger CR and a greater gray matter volume better improved their processing speed (R2 = .18). Age was correlated with the improvement in executive functions, such that older age predicts less improvement (R2 = .07). Subjects with a larger left hippocampal volume achieved more significant gains in general cognitive performance (R2 = .087). In conclusion, besides the program itself, the effectiveness of CT depends on age, biological factors like genotype and brain volume, and CR. Thus, to achieve better results through a CT, it is essential to consider the different characteristics of the participants, including genetic factors.Trial registration: Trial retrospectively registered on January 29th, 2020-(ClinicalTrials.gov -NCT04245579).

Promoting elderly mobility and fall prevention through virtual reality: a sustainable approach to gait balance training

Background: Deterioration of physical coordinative capacity, balance and falls cause significant physical repercussions in the older adult population. Objective: to design a program for gait balance training in older adults at risk of falls using Virtual Reality. Methods: descriptive study, with quantitative approach, longitudinal cut, fifteen older adults with an age range from 65 to 84 years belonging to the care unit "Dulce Hogar" of one of the MIES projects participated, all of them executed the program through virtual reality for 16 weeks with a frequency of 1 session per week. Participants were evaluated before and after the intervention using the Tinetti scale and the unipodal (timed) station. Results: for the statistical analysis the SPSS version 29.0 computer system was used, the Student's t-test was used with a statistical significance p&lt;0.05, yielding results of p&lt;0.001 in all parameters tested: balance, gait and risk of falls. The results were expressed in statistical tables with their respective analyses. Conclusions: Virtual Reality applied in a gait balance training program for the elderly is beneficial because it showed a better balance, better gait performance and decreased the risk of falls in the elderly.

Is high intensity interval training superior to moderate intensity continuous training in older adults with cardiovascular disease? The Generation 100 study

Is high intensity interval training superior to moderate intensity continuous training in older adults with cardiovascular disease? The Generation 100 study

Facilitation of working memory capacity by transcranial direct current stimulation: a secondary analysis from the augmenting cognitive training in older adults (ACT) study.

Aging is a public health concern with an ever-increasing magnitude worldwide. An array of neuroscience-based approaches like transcranial direct current stimulation (tDCS) and cognitive training have garnered attention in the last decades to ameliorate the effects of cognitive aging in older adults. This study evaluated the effects of 3months of bilateral tDCS over the frontal cortices with multimodal cognitive training on working memory capacity. Two hundred ninety-two older adults without dementia were allocated to active or sham tDCS paired with cognitive training. These participants received repeated sessions of bilateral tDCS over the bilateral frontal cortices, combined with multimodal cognitive training. Working memory capacity was assessed with the digit span forward, backward, and sequencing tests. No baseline differences between active and sham groups were observed. Multiple linear regressions indicated more improvement of the longest digit span backward from baseline to post-intervention (p = 0.021) and a trend towards greater improvement (p = 0.056) of the longest digit span backward from baseline to 1year in the active tDCS group. No significant between-group changes were observed for digit span forward or digit span sequencing. The present results provide evidence for the potential for tDCS paired with cognitive training to remediate age-related declines in working memory capacity. These findings are sourced from secondary outcomes in a large randomized clinical trial and thus deserve future targeted investigation in older adult populations.

Effects of elastic band resistance training on the physical and mental health of elderly individuals: A mixed methods systematic review.

Elastic band resistance training in elderly individuals can improve physical fitness and promote mental health in addition to other benefits. This systematic review aimed to review, summarize, and evaluate quantitative, qualitative, and mixed methodological studies on the use of elastic band resistance training in elderly individuals, and to investigate the influence of elastic band resistance training on the physical and mental health of elderly individuals, as well as their preferences and obstacles in training. A convergent separation approach was used to synthesize and integrate the results, specifically the mixed systematic review approach recommended by the Joanna Briggs Institute. The extensive search strategy included electronic database searches in the Cochrane Library, PubMed, Embase, Web of Science, Google Scholar, MEDLINE, and CINAHL. The researchers rigorously screened the literature, extracted and analyzed the data, and evaluated the quality of the included studies using the Mixed Methods Appraisal Tool (MMAT). Twenty-eight studies were included, of which 25 were quantitative studies, 2 were qualitative studies, and 1 was a mixed-methods study. A total of 1,697 subjects were investigated across all studies. Quantitative evidence supports the notion that elastic band resistance training can improve upper and lower limb flexibility, endurance, upper strength, physical balance, and cardiopulmonary function and enhance the mental health of elderly individuals. Participants in the qualitative study reported some preferences and obstacles with band resistance training, but most participants reported physical benefits. Despite the heterogeneity between studies, this review is the first systematic review to comprehensively evaluate the effectiveness of elastic band resistance training in older adults. It not only shows the influence of elastic band resistance training on the physical and mental health of the elderly, but also emphasizes the preference and obstacles of elderly individuals face.