6066 Background: ASCO abstracts are a leading source of cancer research information. The ASCO Breast Cancer Information Exchange (BCIE) project was developed to better organize and access abstracts in breast cancer for a faster, more precise, and targeted search. Methods: Traditional web search engines allow simple keyword-based queries. Improvements in precision and ease of use require software that “knows” the domain. We developed XML/Java models of breast cancer clinical studies, from molecular diagnostics to disease stages. From these models, we developed a study characterization form, included as a voluntary author step in the 2003 Annual Meeting abstract submission process, to capture the study clinical parameters. We also developed a corresponding user search form, publicly available onhttp://webapp.asco.org/bcie. Results: Almost 95% of breast cancer abstract first authors (352) participated, completing the web-based form to characterize their studies from a uniform descriptive variable set. Since 8/02, www.asco.org visitors have used the BCIE search tool to formulate queries. Analysis of a subset of queries (N=691) revealed that 90% selected form-based search variables exclusively or combined with traditional open keyword search terms. On average, 7 search variables were entered per search. The three most selected search variables were study phase, patient sex, and chemotherapeutic agent. In addition, the repository of characterized studies created a detailed index of author-selected consistent-variable descriptors, offering potential for examination of abstract trends within one disease-type, including study types, prognostic factors, therapies, diagnostics, and biomarkers. Heretofore, such analysis has been time consuming, performed manually, and not reflective of authors direct involvement. Conclusions: The BCIE project demonstrates the feasibility of a new technology and process for uniform XML-Java indexing, search, and analysis of published material. The project continues in 2004. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Medstory Medstory
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