Abstract The importance of research in designing for the vulnerable lies in its commitment to address the inherent inequalities and injustices that pervade our socio-cultural fabric. This article presents a comprehensive systematic review and meta-analysis focused on the transition from vulnerability to accessibility in design for vulnerable populations, exploring the possibilities of extending this vital area to information design. Employing the PRISMA approach, the study meticulously analyses 30 selected papers to uncover insights into how design practices and methodologies are evolving to better address the needs of those often marginalized or overlooked. The findings illuminate the multifaceted nature of vulnerability, challenging information designers to think beyond traditional norms and engage in innovative practices that not only make solutions accessible but also ensure they are comprehensible. This research underscores the necessity of interdisciplinary collaboration and participatory approaches, emphasizing the importance of culturally sensitive, user-centered design solutions. The study culminates in identifying novel areas for future research, particularly emphasizing the development of information design that is tailored to the unique needs of vulnerable populations, thereby fostering inclusive growth.