This paper offers a thorough examination of a unified class of Humbert’s polynomials in two variables, extending beyond well-known polynomial families such as Gegenbauer, Humbert, Legendre, Chebyshev, Pincherle, Horadam, Kinnsy, Horadam–Pethe, Djordjević, Gould, Milovanović, Djordjević, Pathan, and Khan polynomials. This study’s motivation stems from exploring polynomials that lack traditional nomenclature. This work presents various expansions for Humbert–Hermite polynomials, including those involving Hermite–Gegenbauer (or ultraspherical) polynomials and Hermite–Chebyshev polynomials. The proofs enhanced our understanding of the properties and interrelationships within this extended class of polynomials, offering valuable insights into their mathematical structure. This research consolidates existing knowledge while expanding the scope of Humbert’s polynomials, laying the groundwork for further investigation and applications in diverse mathematical fields.