Traditional Medicine Products Research Articles

First Report of Leaf Spot Caused by Corynespora cassiicola on Pogostemon cablin in Guangdong, China.

Pogostemon cablin (Blanco) Benth. is a vital source of patchouli oil, utilized in traditional Chinese medicine, Ayurveda, cosmetics, and hygiene products(Swamy et al. 2016). In 2022, a leaf spot disease outbreak on patchouli plants occurred nearly 10 acres in Yunfu, Guangdong (21°2' N; 110°3' E), with an average incidence rate of 50%. Infected leaves initially showed circular spots with tan centers and yellow halos. Within five to ten days, these spots expanded, crossed leaf veins, and became polygonal with rough surfaces. As the disease progressed, the spots merged, darkening the veins and eventually causing leaf loss. Five symptomatic leaves were soaked in 75% ethanol for 10 s, and 2.5% sodium hypochlorite for 30 s, followed by a final rinse in sterile water. These samples were then placed on potato dextrose agar (PDA) plates. After 3-5 days of incubation at 28 °C, the mycelial growth was transferred to fresh PDA plates and purified by isolating the hyphal tip three times. Four of the five isolates had similar morphology and caused leaf spot symptoms upon inoculation. During culture on PDA, these isolates formed colonies with downy, gray-brown mycelium and darker centers. Microscopic examination revealed branched, septate mycelium; solitary, erect, unbranched grayish-brown conidiophores; and club-shaped conidia. Conidia were faint brown, segmented, contained 2 to 15 septa(predominant number being 3 to 4), ranged from 32 to 220 μm in length and 8.4 to 22.4 μm in width (n = 30). The morphology of these isolates was identical to that of Corynespora cassiicola (Ellis 1971). Pathogenicity tests were conducted on 3-month-old seedlings of P. cablin using the conidium infection method. A suspension of conidia (1 × 106 conidia/ml) was prepared from cultures induced to sporulate by 90-minute near-UV exposure followed by 2-day dark incubation at 28 °C, and 30 ml of this suspension was sprayed onto leaves of each seedling. Inoculated plants were incubated at 28 °C in an incubator. Potted plants treated only with sterile water were used as controls. Each treatment was inoculated into five potted plants. After seven days, all the inoculated leaves displayed symptoms similar to those observed in the fields, whereas the control leaves did not exhibit these symptoms. The pathogenicity test was repeated three times. Following Koch's postulates, the pathogen was re-isolated and identified as C. cassiicola through morphological and ITS sequence each time. To further identify, we selected a representative isolate, LD-TJ, for multi-locus sequence analysis of its ITS, LSU, and TEF1-α genes (GenBank Accession Nos. PQ042036, PQ035023, PQ060235)(Voglmayr et al. 2017). BLASTN analysis of the sequences obtained showed a high similarity of 99 to 100% with the ITS (JAEMHE010000031.1:51214-51777, 481/481 nucleotides), LSU (JAEMHE010000018.1:728464-729373, 910/910 nucleotides), and TEF1-α (JAEMHE010000005.1:656736-657712, 969/970 nucleotides) sequences of C. cassiicola CC01. The phylogenetic tree showed that the LD-TJ strain, C. cassiicola CC01(isolated from rubber trees), and C. cassiicola CC_29(isolated from soybean leaves) clustered into a clade with a 99% bootstrap value. C. cassiicola was identified as the cause of patchouli leaf spot in Hainan(Chen et al. 2010), but it has not yet been reported in Guangdong. Identifying P. cablin leaf spot disease is crucial in Guangdong Province because it is the main growing area for P. cablin in China (Yan et al. 2021).

Application progress of ultrasound in the production and processing of traditional Chinese herbal medicines

Application progress of ultrasound in the production and processing of traditional Chinese herbal medicines

Research and development investment of Chinese chemical pharmaceutical companies under the national pooled procurement: a retrospective panel data analysis, 2013–2022

ObjectiveTo generate evidence about changes in the research and development (R&D) investment of Chinese chemical pharmaceutical companies before and after the implementation of the national pooled procurement, to respond to...

Effect of Disintegrating Agents on Red Ginger (Zingiber officinale Roxb) Dry Extract Fast Disintegrating Tablets Using Direct Compression Method

Red ginger (Zingiber officinale Roxb) is one of the medicinal plants that is effective as a medicine for nausea and vomiting. One of the techniques for developing traditional medicinal products is to make fast disintegrating tablets (FDT). This research aims to compare the effect of these various disintegrating materials on the physical properties of FDT. FDT red ginger extract is made using the direct compression method. The tablets obtained were physically evaluated including weight uniformity, hardness, friability, and disintegration time. The statistical results using the one-way ANOVA test show that between tablet formulas there are significant differences in tablet disintegration time with differences in the type of disintegrating agent. The data obtained shows that all formulas meet the physical properties test requirements for tablets. The tablet formula using crospovidone produces tablets with high hardness, low friability, and fast disintegration time

Development of Indonesian Original Medicines Study of Standardized Herbal Medicine Products "Tolak Angin" as Traditional Medicine

The use of traditional medicine continues to grow rapidly in Indonesia, reflecting the country's abundant natural and cultural wealth. One of the leading herbal medicine products is Tolak Angin, which is produced by PT. Sidomuncul Herbal and Pharmaceutical Industry, Tbk. Tolak Angin is a Standardized Herbal Medicine (OHT) that has been scientifically tested for its safety, quality, and benefits. This article presents an overview of the ingredients, production process, and clinical trials of Tolak Angin, as well as its impact in the context of Indonesian public health. By involving literature studies and secondary data analysis, this article highlights the importance of standardization in the development of effective and safe traditional medicine products. In conclusion, Tolak Angin not only represents local cultural heritage and knowledge, but also plays a vital role in providing affordable and reliable treatment alternatives for the community.

PERANCANGAN MESIN PENGERING RIMPANG UNTUK RUMAH PRODUKSI JAMU CELUP TRADISIONAL

Rhizomes are one of the main ingredients in the production of traditional herbal medicine, which plays an important role in the food, beverage and medicine industries. The process of drying rhizomes greatly affects the quality and shelf life of the product, so an efficient drying device is needed to ensure optimal quality. This research aims to design a rhizome drying tool for traditional dipping herbal medicine production houses, which can speed up the drying process and maintain the quality of the rhizomes produced. This type of research is development research with the research object being rhizomes used in herbal medicine production. Data was collected through testing the designed tool, using temperature and drying time testing methods. Data analysis was carried out by measuring the quality of the rhizomes post-drying, including moisture and color. The research results showed that the designed dryer was capable of drying rhizomes at a temperature of 40°C within 1 hour, while maintaining the quality of the rhizomes and meeting the standards for herbal medicine production. In conclusion, this tool has the potential to be a practical solution for traditional herbal medicine production houses, speeding up the production process and increasing efficiency.

Combination aquaphotomics study and LF-NMR to monitor the drying process of honey pills

As one of the factors affecting the quality of honey pills (HP), there are few researches on its quality control and solutions. But water can directly affect the appearance, stability and potency of the HP. In this study, near-infrared spectroscopy was used to monitor the moisture content of HP with different drying conditions, and multiple linear regression analysis was carried out to establish the moisture content prediction model, and the R2 of the model prediction is 0.9532. The visualization of HP drying process were carried out by aquaphotomics method characterizes the status of the water molecular network at different drying stages. At the same time, low-field nuclear magnetic resonance (LF-NMR) information was carried out to analyze the water distribution in the drying process, and further verified the water solvent shell action in the water balance process of aquaphotomics analysis. The surface water of the pill disperses to the air, and the internal water diffuses outwards. We adopted the techniques such as rheology to comprehensively characterize the state of HP, and to evaluate the quality of them by using the dissolution test. The quality state of the pills was analyzed by the aquaphotomics analysis of water species. The above research system provided the scientific basis for revealing the drying process of HP from the viewpoint of aquaphotomics, as well as showed potential for expansion and application to other Chinese traditional medicine products.

Mechanisms of traditional Chinese medicine in the treatment and prevention of gastric cancer

BackgroundGastric cancer (GC) ranks as the fifth most prevalent malignancy worldwide. Conventional treatments, including radiotherapy and chemotherapy, often induce severe side effects and significant adverse reactions, and they may also result in drug resistance. Consequently, there is a critical need for the development of new therapeutic agents. Traditional Chinese Medicine (TCM) and natural products are being extensively researched due to their low toxicity, multi-targeted approaches, and diverse pathways. Scholars are increasingly focusing on identifying active anticancer components within TCM. PurposeThis review aims to summarise research conducted over the past 14 years on the treatment of GC using TCM. The focus is on therapeutic targets, mechanisms, and efficacy of Chinese medicine and natural products, including monomer compounds, extracts or analogues, and active ingredients. MethodsRelevant articles on TCM and GC were retrieved from PubMed using appropriate keywords. The collected articles were screened and classified according to the types of TCM, with an emphasis on the molecular mechanisms underlying the treatment of GC. ResultsThe research on TCM indicates that TCM and natural products can effectively inhibit the metastasis, proliferation, and invasion of tumour cells. They can also induce apoptosis, autophagy and improve the chemosensitivity of drug-resistant cells. Additionally, injections derived from Chinese herbal medicine, when used as an adjunct to conventional chemotherapy, can significantly improve the prognosis of GC patients by reducing chemotherapy toxicity. ConclusionThis review summarises the progress of TCM treatment of GC over the past 14 years, and discusses its therapeutic application of GC, which proves that TCM is a promising treatment strategy for GC in the future.

Successful corticosteroid therapy for severe liver injury secondary to herbal traditional Chinese medicine, Mega Defends X, assessed for causality by the updated RUCAM: A case report.

In China, herbal traditional Chinese medicine products are readily obtained without any requirement of prescription and widely used in real life, thereby increasing the incidence of their related herb-induced liver injury (HILI). However, the diagnosis of HILI is still challenging because its clinical manifestations are variable due to lack of any specific biomarkers. Misdiagnosis and inappropriate treatment may result in the progression of HILI. A 55-year-old female patient was admitted to the hospital due to progressive jaundice. The diagnoses of HILI secondary to Mega Defends X, an herbal traditional Chinese medicine product, for which the score was 9 based on the updated Roussel Uclaf Causality Assessment Method of 2016. The patient received corticosteroid with a stepwise dosage reduction. The liver injury significantly improved by corticosteroid treatment. Corticosteroids should be potentially effective and safe in patients with severe HILI.

Study on the TCM Products Descriptions Translation on Cross-border E-commerce Platforms

In recent years, with the vigorous development of the international internet and cross-border logistics, the cross-border e-commerce industry has gained tremendous momentum in China. Traditional Chinese medicine products have also been venturing into foreign markets in large quantities through the cross-border e-commerce platforms. However, the author has noticed that the English copywriting for some traditional Chinese medicine products on cross-border e-commerce platforms is of uneven quality, which harms the overseas sales of these products. Therefore, this article analyzes the characteristics and text types of English copywriting for traditional Chinese medicine products on Alibaba and proposes some translation strategies in accordance with Newmark's text type theory. The author believes that for titles and efficacy descriptions, which have the characteristics of both informational and vocative texts, it is advisable to utilize the domestication translation strategy as possible as we can. However, given the unique roles of product titles and efficacy descriptions, there should be some differences in the translation process. Titles translation should prioritize the use of trending keywords, while translating efficacy descriptions should primarily rely on domestication and paraphrasing strategies.

Neutrophil extracellular traps: Potential targets for the treatment of rheumatoid arthritis with traditional Chinese medicine and natural products.

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Abnormal formation of neutrophil extracellular traps (NETs) at the synovial membrane leads to the release of many inflammatory cytokines, including IL-1β, IL-6, and TNF-α. Elastase, histone H3, and myeloperoxidase, which are carried by NETs, damage the soft tissues of the joints and aggravate the progression of RA. The balance of NET formation coordinates the pro-inflammatory and anti-inflammatory effects and plays a key role in the development of RA. Therefore, when NETs are used as effector targets, highly targeted drugs with fewer side effects can be developed to treat RA without damaging the host immune system. Currently, an increasing number of studies have shown that traditional Chinese medicines and natural products can regulate the formation of NETs through multiple pathways to counteract RA, which shows great potential for the treatment of RA and has a promising future for clinical application. In this article, we review the latest biological progress in understanding NET formation, the mechanism of NETs in RA, and the potential targets or pathways related to the modulation of NET formation by Chinese medicines and natural products. This review provides a relevant basis for the use of Chinese medicines and natural products as natural adjuvants in the treatment of RA.

Integrating deep learning and near-infrared spectroscopy for quality control of traditional Chinese medicine extracts

Extraction is a key fundamental step in producing most traditional Chinese medicine (TCM) products. Influenced by factors such as herbs and production techniques, the quality of TCM extracts may vary significantly, leading to high variability between batches and unstable quality of the products. Currently, high-performance liquid chromatography (HPLC) and other analytical methods have been employed for the quality control of TCM extracts, but these methods are time-consuming, environmentally unfriendly, and complicated in sample pre-treatment, which cannot meet the needs of actual production. Therefore, a rapid and effective method for the quality analysis and control of TCM extracts is urgently needed. In this study, the traditional Chinese medicine Radix Gentianae Macrophyllae (RGM) was taken as the research object, and a quantitative analysis model for the active ingredients loganic acid (LA) and gentiopicroside (GPS) was constructed based on near-infrared (NIR) spectroscopy, combining with convolutional neural network (CNN) and gated recurrent unit (GRU). Moreover, the multi-task mean square error (MTMSE) loss function proposed in this paper was used to train the model to ensure the prediction accuracy for different tasks. Meanwhile, this model integrated Bayesian optimization to automatically find the optimal hyperparameters without manual involvement. The results showed that the CNN-GRU model had higher prediction accuracy compared with CNN, BP, and PLS models. In addition, the feasibility of the CNN-GRU model was comprehensively analyzed. Finally, the feature extraction process of the CNN-GRU model was visualized to enhance the interpretability. This research creatively integrated deep learning with near-infrared spectroscopy to achieve rapid and accurate analysis of the active ingredient content of TCM extracts, providing new ideas and methods for quality control of TCM preparations.

Transcending antibiotic resistance: The potential of mass Galla chinensis et camelliae Fermentata to Dismantle Helicobacter pylori biofilms and enhance anti-biotic activity

Ethnopharmacological relevanceHelicobacter pylori (H. pylori) infections are on the rise, presenting a significant global health challenge. Mass Galla chinesis et camelliae Fermentata (Chinese gall leaven, CGL), a traditional Chinese medicinal product made from the fermentation of Rhus chinensis Mill., is frequently employed to address digestive system ailments. Contemporary pharmacological research reveals that CGL exhibits anti-inflammatory, anti-diarrheal, and enzyme-inhibitory activities and holds potential as a treatment for H. pylori infections. However, the precise mechanisms underlying CGL's efficacy against H. pylori remain to be fully elucidated. AimThe objective of the study is to evaluate CGL's ability to disrupt the H. pylori biofilm and to explore its synergistic potential with antibiotics in targeting the biofilm-efflux pump system, a mechanism implicated in bacterial resistance. MethordsThe study determined the Minimum Inhibitory Concentration (MIC) of CGL and metronidazole against H. pylori and evaluated their effects on H. pylori biofilms using an in vitro model. Structural changes induced by drug interventions were compared to those in untreated and antibiotic-treated models through scanning electron microscopy and laser confocal microscopy. The accumulation of H33342 dye in planktonic and biofilm H. pylori before and after drug treatment was assessed to evaluate cell viability and biofilm disruption. The study also involved adding experimental drugs to a biofilm H. pylori medium containing D-glucose, measuring glucose concentrations post-intervention using the glucose oxidase method, and calculating changes in glucose uptake. Finally, the relative expression levels of several genes in planktonic and biofilm H. pylori treated with CGL alone or in combination with antibiotics were measured to understand the impact on the biofilm-efflux pump system. ResultsBoth CGL alone and in combination with metronidazole demonstrated effective disruption of H. pylori biofilms. The combination therapy was particularly effective in reducing the biofilm transfer-enhancing effect of metronidazole and decreasing SpoT expression in the 'SpoT-(p)ppGpp' pathway, especially in biofilms. It showed a greater inhibition of the 'σ54-gluP-sugar uptake' pathway, with significant reductions in rpoN and gluP expression under biofilm conditions compared to CGL or metronidazole alone. The treatment also suppressed H. pylori proliferation and may have altered glucose uptake mechanisms. Moreover, it significantly inhibited the 'hp0939/hp0497/hp0471-RND efflux pump' pathway, with a notable reduction in gene expression compared to the 1/2 MIC metronidazole treatment. ConclusionThis study demonstrates that CGL effectively hinders the development of drug resistance in H. pylori by targeting biofilm formation and critical molecular pathways associated with antibiotic resistance. The synergistic effect of combining CGL with metronidazole notably enhances biofilm disruption and inhibits the bacterium's metabolic and reparative mechanisms. Further in vivo studies are needed to confirm these results and to investigate additional mechanisms of CGL's action.

Integrating traditional medicine into a modern health care system

Traditional Medicine collectively referred to as complementary and alternative medicine (CAM) when commonly used outside their traditional context, alongside other medical systems, including Western biomedicine.The World Health Organization officially promoted traditional medicine in developing countries in 1978, there have been increasing interests among developing countries in integrating traditional medicine into a national health care system. Integrating traditional medicine into a modern health care system, moreover, can benefit industrialized nations as well. The contributions of Traditional and Modern Scientific Medicines to health care delivery have attracted a great deal attention in most communities worldwide. Traditional Chinese medicine, Ayurveda, Kampo, traditional Korean medicine, and Unani have been practiced in some areas of the world and have blossomed into orderly-regulated systems of medicine. More than 80% of the world’s population in over 170 of WHO’s 194 Member States currently use some form of traditional medicine, such as herbal medicine, yoga, Ayurveda, acupuncture and acupressure, and indigenous therapies.To generate awareness about traditional medicine, since the 1980s, a number of publications on self-health care have been developed to inform people about the benefits and uses of traditional medicine. Some of the areas of focused research include studies on the development of anticancer drugs, cardiovascular diseases such as arteriosclerosis and angina pectoris, respiratory diseases such as bronchial asthma, obesity, diabetes and other metabolic disorders, and basic studies on acupuncture therapeutic mechanisms for various bone and joint and spinal disorders, and on different kinds of composition of the human body. To ensure the safety, standardization, efficacy and quality of traditional medicines, the practitioners must follow the same stringent standards and regulations for production and use of traditional medicines as are followed for allopathic medicines. This study aims to summarize the advancements made in understanding the efficacy, effectiveness of Traditional Medicine. Traditional and local knowledge systems need to be protected, preserved, and studied as different ways to approach modern healthcare, science, and technology at large. Significant challenges exist in integrating the differing perspectives. Traditional knowledge is derived from years of history and experience and is preserved through long, complex narrations lacking the traditionally rigorous scientific scrutiny required by modern medicine. Modern scientists are prone to quickly dismiss its merit, considering it to be irrelevant as a result. For many, traditional medicine is the first port of call, and practitioners of traditional medicine have played an important role in treating chronic illnesses. These traditional medicines and practices have been preserved, organized and modernized during the past several decades, and have been fully integrated into the national health-care delivery systems from the central to the most peripheral administrative levels.

TOGA education: Introduction of eco orphanage concept in Bekonang, Sukoharjo

The community service was conducted at the Putri Aisyiyah Orphanage in Bekonang, Sukoharjo, Central Java. This orphanage has yard space that has not been utilized for Family Medicinal Plants (TOGA) and is not yet familiar with the concept of an eco orphanage. The main objective of this service is to provide education about TOGA to the children at the Putri Aisyiyah Bekonang Orphanage. The service activities comprise six phases: pre-test, socialization, TOGA planting, practices in processing traditional medicinal products, post-test, and maintenance and supervision. The outcomes of the service activities include the planting of twenty types of medicinal plants in the orphanage's yard. Participants' knowledge increased after receiving education about TOGA, encompassing basic knowledge of TOGA (12.4%), types of TOGA and their characteristics (38%), and the health benefits of TOGA (33%). There was an enhancement in participants' knowledge regarding the types and benefits of TOGA, with an average total increase of 27.7%. Thus, this service has succeeded in providing education about TOGA to the children at the Putri Aisyiyah Bekonang Orphanage and enhancing their understanding of the types of TOGA and their health benefits.

Caesalpinia sappan Reduce Fever with An Anti-inflammatory and Antioxidant Mechanism: A Review

<p><em><span lang="EN-US">Caesalpinia sappan L</span></em><span lang="EN-US"> (Sappan wood) is an herbal plant that has long been trusted by the public as an herbal medicine for tuberculosis, diarrhea, dysentery, skin infections, anemia, and other diseases by utilizing the decoction of <em>C.sappan</em>. Sappan wood is an herbal plant widely used as a raw material for traditional medicinal products. Sappan wood has been reported to have substantial pharmacological effects in analgesic, antioxidant, antibacterial, anti-inflammatory, and anti-viral. Fever is a clinical manifestation of certain conditions or diseases characterized by increased body temperature above the normal range (36.5–37.5 °C). Many studies declare that antioxidant and anti-inflammatory activity in <em>C.sappan</em> reduces oxidative stress and pro-inflammatory cytokines. This literature review shows that the antioxidant and anti-inflammatory properties of <em>C.sappan</em> are linked to fever as a sign of illness. Literature review using the last ten years' Scopus, ScienceDirect, and Pubmed databases. There are as many as 20 journals regarding sappan wood's antioxidant and anti-inflammatory effects. Sappan wood has been shown to have an antioxidant effect by lowering reactive oxygen species levels via SOD, GPx, or CAT markers. It inhibits inflammation cytokines such as IL-1, IL-6, TNF-</span><span lang="EN-US">𝝰</span><span lang="EN-US">, and INF produced during fever. Sappan wood also has an anti-inflammatory effect by inhibiting PGE2 production when someone has a fever. The findings of our review state that <em>C.sappan</em> can be used to treat fever for both of these reasons. The use of <em>C.sappan</em> as a component in producing traditional health beverages has potential.</span></p>

Analysis of Investment Value in the Traditional Chinese Medicine Industry: A Case Study of Yiling Pharmaceutical Co., Ltd.

Over the past five years, the Chinese pharmaceutical industry has experienced new opportunities and challenges with the implementation of a new round of medical reforms nationwide. Since the outbreak of the COVID-19 pandemic in 2019, the increasing awareness of health and the continuous demand for medical services have led to a sustained growth in demand for traditional Chinese medicine products and services in China. This study takes a comprehensive fundamental analysis approach, incorporating relevant knowledge from finance, to examine the financial indicators and development of Yiling Pharmaceutical Co., Ltd., a typical company in the pharmaceutical industry. Through financial statement analysis, the profitability of Yunnan Baiyao is assessed, along with the prediction of debt-paying ability during the evaluation process. Lastly, a fundamental analysis is conducted to summarize the strengths and weaknesses of Yiling Pharmaceutical Co., resulting in the conclusion of its investment value.

Correlation between microbial communities and volatile flavor compounds in the fermentation of Semen Sojae Praeparatum

SSP (Sojae Semen Praeparatum, SSP), a traditional medicinal and edible product, undergoes natural fermentation resulting in a unique flavor. However, the complexity of the natural fermentation system results in inconsistent quality. This study utilized E-nose, headspace solid-phase microextraction combined with full two-dimensional gas chromatography-mass spectrometry, and high-throughput sequencing techniques to reveal the correlation between key volatile flavor compounds and dominant microbial communities during SSP fermentation. The results showed that total organic acids increased from 50.61 mg/g to 72.29 mg/g during SSP fermentation, and levels of umami and sweet amino acids significantly increased. Alcohols, esters, and acids were the main flavor compounds during SSP fermentation, with 52 being identified as key volatile flavor compounds. In the microbial community, bacterial communities dominated by Proteobacteria, Cyanobacteria, and Firmicutes exhibited dynamic solid changes, while fungal communities dominated by Ascomycota, Basidiomycota, unclassified_Fungi, and Mortierellomycota showed relatively stable abundance. Spearman correlation analysis showed that 9 dominant microbial genera were significantly correlated with 27 key volatile flavor compounds, among which Cladosporium, Leuconostoc, Weissella, and Lactiplantibacillus may be the core functional microbial community for SSP characteristic flavors. This study provided theoretical references for the targeted control of SSP quality and the screening of starter fermentation cultures.

The Ius Constituendum Implementation of Simple Patents for the Management of Traditional Medicines

<p>Traditional medicine in Indonesia actually has the potential to be developed and has economic value for society. One effort to develop it is by optimizing aspects of intellectual property, especially through simple patents. This research aims to answer two legal issues, namely: the urgency of a simple patent orientation for traditional medicines in Indonesia and the formulation of a simple patent orientation for traditional medicines in Indonesia. This research method uses normative legal research with a conceptual and statutory approach. The research results confirm that the urgency of a simple patent orientation for the management of traditional medicines in Indonesia has three benefits at once, namely from the aspect of technology development, developing types of traditional medicine products, to increasing economic value. In the aspect of technology development, a simple patent for traditional medicine entrepreneurs can increase the value of creativity and innovation to always develop existing technology. Future arrangements that can be made are by establishing special regulations that regulate increasing the economic value of traditional medicines through the development of simple patents. Ideally, this regulation must also regulate three main substances, namely: an inventory of the potential for traditional medicines in a place, the potential for technological development through simple patents, and an effective and efficient marketing network for traditional medicines.</p>

A randomized double-blind clinical trial: Comparison of oclacitinib with a traditional Chinese herbal medicine product (Dihuang Guiqin capsule) in the treatment of canine atopic dermatitis

Canine atopic dermatitis (cAD) is a common chronic inflammatory skin disease, which seriously affects the quality of life for both dogs and their owners. Currently, the common therapeutic drugs in the clinic have disadvantages such as obvious adverse effects and high prices. Traditional Chinese herbal medicine (TCHM) has great potential for the treatment of cAD. The aim of this study is to compare the effects of different doses of the TCHM product (Dihuang Guiqin capsule) and oclacitinib in the treatment of cAD through a randomized, double-blind trial. Sixty dogs diagnosed with AD were randomly and evenly divided into four groups (n = 15). The TCHM treatment group consisted of three subgroups that received three different oral doses (20, 40, and 60 mg/kg BW), while the control group received 0.5 mg/kg BW of oclacitinib. Each group was administered twice daily for 14 consecutive days. The results showed that both TCHM and oclacitinib significantly improved cAD-induced itching (evaluated by pVAS) and skin lesions (evaluated by CADESI-04), while interleukin 31 (IL-31) concentrations decreased significantly (P < 0.05) and serum biochemical indicators returned to normal. In particular, The therapeutic effects of TCHM medium- and high-dose groups were similar to those of oclacitinib (P > 0.05). The preliminary recommended dose of Dihuang Guiqin capsule for the treatment of cAD has been determined to be 40–60 mg/kg BW twice daily for 14 consecutive days, which can be reduced to once daily as appropriate. Dihuang Guiqin capsule was safe and well tolerated, which may be a new option for the treatment of cAD.