Traditional Medicine Products Research Articles

Caesalpinia sappan Reduce Fever with An Anti-inflammatory and Antioxidant Mechanism: A Review

<p><em><span lang="EN-US">Caesalpinia sappan L</span></em><span lang="EN-US"> (Sappan wood) is an herbal plant that has long been trusted by the public as an herbal medicine for tuberculosis, diarrhea, dysentery, skin infections, anemia, and other diseases by utilizing the decoction of <em>C.sappan</em>. Sappan wood is an herbal plant widely used as a raw material for traditional medicinal products. Sappan wood has been reported to have substantial pharmacological effects in analgesic, antioxidant, antibacterial, anti-inflammatory, and anti-viral. Fever is a clinical manifestation of certain conditions or diseases characterized by increased body temperature above the normal range (36.5–37.5 °C). Many studies declare that antioxidant and anti-inflammatory activity in <em>C.sappan</em> reduces oxidative stress and pro-inflammatory cytokines. This literature review shows that the antioxidant and anti-inflammatory properties of <em>C.sappan</em> are linked to fever as a sign of illness. Literature review using the last ten years' Scopus, ScienceDirect, and Pubmed databases. There are as many as 20 journals regarding sappan wood's antioxidant and anti-inflammatory effects. Sappan wood has been shown to have an antioxidant effect by lowering reactive oxygen species levels via SOD, GPx, or CAT markers. It inhibits inflammation cytokines such as IL-1, IL-6, TNF-</span><span lang="EN-US">𝝰</span><span lang="EN-US">, and INF produced during fever. Sappan wood also has an anti-inflammatory effect by inhibiting PGE2 production when someone has a fever. The findings of our review state that <em>C.sappan</em> can be used to treat fever for both of these reasons. The use of <em>C.sappan</em> as a component in producing traditional health beverages has potential.</span></p>

Analysis of Investment Value in the Traditional Chinese Medicine Industry: A Case Study of Yiling Pharmaceutical Co., Ltd.

Over the past five years, the Chinese pharmaceutical industry has experienced new opportunities and challenges with the implementation of a new round of medical reforms nationwide. Since the outbreak of the COVID-19 pandemic in 2019, the increasing awareness of health and the continuous demand for medical services have led to a sustained growth in demand for traditional Chinese medicine products and services in China. This study takes a comprehensive fundamental analysis approach, incorporating relevant knowledge from finance, to examine the financial indicators and development of Yiling Pharmaceutical Co., Ltd., a typical company in the pharmaceutical industry. Through financial statement analysis, the profitability of Yunnan Baiyao is assessed, along with the prediction of debt-paying ability during the evaluation process. Lastly, a fundamental analysis is conducted to summarize the strengths and weaknesses of Yiling Pharmaceutical Co., resulting in the conclusion of its investment value.

Correlation between microbial communities and volatile flavor compounds in the fermentation of Semen Sojae Praeparatum

SSP (Sojae Semen Praeparatum, SSP), a traditional medicinal and edible product, undergoes natural fermentation resulting in a unique flavor. However, the complexity of the natural fermentation system results in inconsistent quality. This study utilized E-nose, headspace solid-phase microextraction combined with full two-dimensional gas chromatography-mass spectrometry, and high-throughput sequencing techniques to reveal the correlation between key volatile flavor compounds and dominant microbial communities during SSP fermentation. The results showed that total organic acids increased from 50.61 mg/g to 72.29 mg/g during SSP fermentation, and levels of umami and sweet amino acids significantly increased. Alcohols, esters, and acids were the main flavor compounds during SSP fermentation, with 52 being identified as key volatile flavor compounds. In the microbial community, bacterial communities dominated by Proteobacteria, Cyanobacteria, and Firmicutes exhibited dynamic solid changes, while fungal communities dominated by Ascomycota, Basidiomycota, unclassified_Fungi, and Mortierellomycota showed relatively stable abundance. Spearman correlation analysis showed that 9 dominant microbial genera were significantly correlated with 27 key volatile flavor compounds, among which Cladosporium, Leuconostoc, Weissella, and Lactiplantibacillus may be the core functional microbial community for SSP characteristic flavors. This study provided theoretical references for the targeted control of SSP quality and the screening of starter fermentation cultures.

The Ius Constituendum Implementation of Simple Patents for the Management of Traditional Medicines

<p>Traditional medicine in Indonesia actually has the potential to be developed and has economic value for society. One effort to develop it is by optimizing aspects of intellectual property, especially through simple patents. This research aims to answer two legal issues, namely: the urgency of a simple patent orientation for traditional medicines in Indonesia and the formulation of a simple patent orientation for traditional medicines in Indonesia. This research method uses normative legal research with a conceptual and statutory approach. The research results confirm that the urgency of a simple patent orientation for the management of traditional medicines in Indonesia has three benefits at once, namely from the aspect of technology development, developing types of traditional medicine products, to increasing economic value. In the aspect of technology development, a simple patent for traditional medicine entrepreneurs can increase the value of creativity and innovation to always develop existing technology. Future arrangements that can be made are by establishing special regulations that regulate increasing the economic value of traditional medicines through the development of simple patents. Ideally, this regulation must also regulate three main substances, namely: an inventory of the potential for traditional medicines in a place, the potential for technological development through simple patents, and an effective and efficient marketing network for traditional medicines.</p>

A randomized double-blind clinical trial: Comparison of oclacitinib with a traditional Chinese herbal medicine product (Dihuang Guiqin capsule) in the treatment of canine atopic dermatitis

Canine atopic dermatitis (cAD) is a common chronic inflammatory skin disease, which seriously affects the quality of life for both dogs and their owners. Currently, the common therapeutic drugs in the clinic have disadvantages such as obvious adverse effects and high prices. Traditional Chinese herbal medicine (TCHM) has great potential for the treatment of cAD. The aim of this study is to compare the effects of different doses of the TCHM product (Dihuang Guiqin capsule) and oclacitinib in the treatment of cAD through a randomized, double-blind trial. Sixty dogs diagnosed with AD were randomly and evenly divided into four groups (n = 15). The TCHM treatment group consisted of three subgroups that received three different oral doses (20, 40, and 60 mg/kg BW), while the control group received 0.5 mg/kg BW of oclacitinib. Each group was administered twice daily for 14 consecutive days. The results showed that both TCHM and oclacitinib significantly improved cAD-induced itching (evaluated by pVAS) and skin lesions (evaluated by CADESI-04), while interleukin 31 (IL-31) concentrations decreased significantly (P < 0.05) and serum biochemical indicators returned to normal. In particular, The therapeutic effects of TCHM medium- and high-dose groups were similar to those of oclacitinib (P > 0.05). The preliminary recommended dose of Dihuang Guiqin capsule for the treatment of cAD has been determined to be 40–60 mg/kg BW twice daily for 14 consecutive days, which can be reduced to once daily as appropriate. Dihuang Guiqin capsule was safe and well tolerated, which may be a new option for the treatment of cAD.

Unpredictable Chemical Diversity of Essential Oils in Cinnamomum burmanni (Lauraceae) Living Collections: Beyond Maternally Inherited Phylogenetic Relationships.

The genus Cinnamomum encompasses diverse species with various applications, particularly in traditional medicine and spice production. This study focuses on Cinnamomum burmanni, specifically on a high-D-borneol-content chemotype, known as the Meipian Tree, in Guangdong Province, South China. This research explores essential oil diversity, chemotypes, and chloroplast genomic diversity among 28 C. burmanni samples collected from botanical gardens. Essential oils were analyzed, and chemotypes classified using GC-MS and statistical methods. Plastome assembly and phylogenetic analysis were conducted to reveal genetic relationships. Results showed distinct chemotypes, including eucalyptol and borneol types, with notable variations in essential oil composition. The chloroplast genome exhibited conserved features, with phylogenetic analysis revealing three major clades. Borneol-rich individuals in clade II suggested a potential maternal inheritance pattern. However, phylogenetic signals revealed that the composition of essential oils is weakly correlated with plastome phylogeny. The study underscores the importance of botanical gardens in preserving genetic and chemical diversity, offering insights for sustainable resource utilization and selective breeding of high-yield mother plants of C. burmanni.

Traditional medicinal plants and plant products sold in open markets in Africa for COVID-19, their uses, medicinal properties, trade and sustainability: A review

Traditional medicinal plants and plant products sold in open markets in Africa for COVID-19, their uses, medicinal properties, trade and sustainability: A review

Empowering public health awareness through dissemination of traditional medicine products

Traditional medicines have been an integral part of the cultural heritage and health systems of various societies around the world. To promote the use of traditional medicine and understand it more deeply, the dissemination of traditional medicine products is a crucial step. The purpose of this service is to explore the importance of the dissemination of traditional medicinal products and their benefits to the community. The main target of this activity were people who have a history of chronic disease. In addition, public awareness to obtain information related to traditional medicine products was still lacking. The method of implementing this service activity was carried out by providing direct education related to traditional medicine to the community. As a result of the service, 19 traditional medicine products were disseminated and increased public awareness about traditional medicine. This result implies that the use of traditional medicine should be widely encouraged to a larger community.

Ethanolic extract from fruiting bodies of Cordyceps militaris HL8 exhibits cytotoxic activities against cancer cells, skin pathogenic yeasts, and postharvest pathogen Penicillium digitatum.

Cordyceps militaris is a well-known medicinal mushroom in Asian countries. This edible fungus has been widely exploited for traditional medicine and functional food production. C. militaris is a heterothallic fungus that requires both the mating-type loci, MAT1-1 and MAT1-2, for fruiting body formation. However, recent studies also indicated two groups of C. militaris, including monokaryotic strains carrying only MAT1-1 in their genomes and heterokaryotic strains harboring both MAT1-1 and MAT1-2. These strain groups are able to produce fruiting bodies under suitable cultivating conditions. In previous work, we showed that monokaryotic strains are more stable than heterokaryotic strains in fruiting body formation through successive culturing generations. In this study, we report a high cordycepin-producing monokaryotic C. militaris strain (HL8) collected in Vietnam. This strain could form normal fruiting bodies with high biological efficiency and contain a cordycepin content of 14.43mg/g lyophilized fruiting body biomass. The ethanol extraction of the HL8 fruiting bodies resulted in a crude extract with a cordycepin content of 69.15mg/g. Assays of cytotoxic activity on six human cancer cell lines showed that the extract inhibited the growth of all these cell lines with the IC50 values of 6.41-11.51µg/mL. Notably, the extract significantly reduced cell proliferation and promoted apoptosis of breast cancer cells. Furthermore, the extract also exhibited strong antifungal activity against Malassezia skin yeasts and the citrus postharvest pathogen Penicillium digitatum. Our work provides a promising monokaryotic C. militaris strain as a bioresource for medicine, cosmetics, and fruit preservation.

Eco-Innovation for Sustainability in Traditional Herbal (Jamu) Agroindustry: OGSM-Gap Analysis Based on Employee Perception

This research is motivated by the importance of eco-innovation in traditional herbal medicine agroindustry by using local ethnobotanical raw materials to support sustainability and answer increasingly stringent market demands. This research aims to identify gaps between objectives, goals, strategies, and performance measurements related to eco-innovation in the traditional herbal medicine agroindustry based on employee perceptions. The data analysis method used is the OGSM-Gaps model by collecting data through questionnaires distributed to traditional herbal medicine agroindustry employees at the research location, namely Solo Raya. The research population was employees of the traditional herbal medicine agroindustry. The research sample was taken using a simple random sampling method of 100 respondents. The research results highlight the need for improvement in several aspects of the organization. First, organizations need to focus on providing education and training for salespeople or store staff so that they can provide accurate information about traditional herbal medicine products. Second, increasing the promotion and branding of traditional herbal medicine products is needed to broaden public understanding. Furthermore, increasing the competitiveness of traditional herbal medicine products in the market is a priority, with an emphasis on market research and product innovation. Finally, operational efficiency needs to be improved through operational audits, adopting more efficient technology, and involving employees in these improvement efforts. These improvement efforts will support the organization in achieving sustainability goals and sustainable business growth.

Mechanism and application prospects of microbial fertilizers in regulating quality formation of medicinal plants

With the promotion of chemical fertilizer and pesticide reduction and green production of traditional Chinese medicines, microbial fertilizers have become a hot way to achieve the zero-growth of chemical fertilizers and pesticides, improve the yield and qua-lity of medicinal plants, maintain soil health, and promote the sustainable development of the planting industry of Chinese herbal medicines. Soil conditions and microenvironments are crucial to the growth, development, and quality formation of medicinal plants. Microbial fertilizers, as environmentally friendly fertilizers acting on the soil, can improve soil quality by replenishing organic matter and promoting the metabolism of beneficial microorganisms to improve the yield and quality of medicinal plants. In this regard, understanding the mechanism of microbial fertilizer in regulating the quality formation of medicinal plants is crucial for the development of herbal eco-agriculture. This study introduces the processes of microbial fertilizers in improving soil properties, participating in soil nutrient cycling, enhancing the resistance of medicinal plants, and promoting the accumulation of medicinal components to summarize the mechanisms and roles of bacterial fertilizers in regulating the quality formation of medicinal plants. Furthermore, this paper introduces the application of bacterial fertilizers in medicinal plants and makes an outlook on their development, with a view to providing a scientific basis for using microbial fertilizers to improve the quality of Chinese herbal medicines, improve the soil environment, promote the sustainable development of eco-agriculture of traditional Chinese medicine, and popularize the application of microbial fertilizers.

Could pharmacy technicians play a role in supporting the appropriate and safe use of traditional and complementary medicines?

Across the world traditional and complementary medicine (T&CM) product use is prevalent with some countries reporting greater than 50% of the population using these products. T&CM products are primarily self-selected through retail outlets including pharmacies. Pharmacists across the world generally agree they should play a role in ensuring the appropriate and safe use of T&CM products but report being time and resource poor to do so. In this commentary, it is proposed that pharmacy technicians as members of the pharmacy workforce, who with adequate education, and supportive technologies could support pharmacists in providing guidance to consumers and patients about the appropriate and safe use of T&CM products. Pharmacy technicians play a crucial role in the pharmacy workforce, serving as integral members of healthcare teams fulfilling a wide array of tasks essential for the efficient functioning of pharmacies and ensuring the safe dispensation of medications. They have been described by pharmacists as the “the face of the pharmacy” in the community setting and relied on not only for mitigating and triaging problems, but also be primarily responsible for developing rapport, eliciting trust and even loyalty from pharmacy patrons. As such, there is a momentous opportunity for pharmacy technicians to play a role in providing T&CM advice and triaging the need for pharmacists’ intervention where harm, or risk of is identified.

Deciphering the mysteries of Aconitum pendulum: Unique identification of various processed products and characteristic chemical markers

Aconitum pendulum, a member of the Aconitum genus within the Ranunculaceae family, is known for its remarkable anti-inflammatory, anti-tumor, and analgesic properties. However, the application of Aconitum pendulum in traditional medicine is often restricted by its inherent toxicity, necessitating specific processing methods to ensure safe usage. Tibetan medicine utilizes distinctive processing techniques such as the barley wine, Hezitang, and zanba frying systems to render the herb safe for medicinal use. Despite the known pharmacological importance, scant research exists on how these processing methods affect the phytochemical profile of Aconitum pendulum, indicating a necessity for comparative analysis of the resulting concoctions. In this study, we employed 1H nuclear magnetic resonance (1H NMR) spectroscopy and ultra-performance liquid chromatography coupled with quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS) to explore the metabolomic variations among different processed products of Aconitum pendulum. Multivariate data analysis techniques, including pattern recognition, allowed us to investigate the intricacies of the compound profiles. To discover signature chemical markers that can differentiate the various processed products, we conducted paired t-tests and generated heat maps highlighting the detected differences. Our integrated analysis of the 1H NMR and UPLC-Q-TOF-MS data revealed distinct chemical signatures unique to each method of Aconitum pendulum processing. By employing chemometric analysis with variable importance in projection (VIP) scores greater than 1.0, and coupled with the statistical rigor of paired t-tests (P < 0.05), we successfully identified significant chemical markers in various processed products, including ferulic acid (FA), caffeic acid (CA), 3-acetylaconitine (AAC) and benzoylaconitine (BAC). Our findings provide a rapid and robust analysis of the chemical constituencies within raw and processed Aconitum pendulum. The discovery of potential chemical markers through an array of advanced pattern recognition techniques offers a substantial contribution to the pharmaceutical analysis. The results of this research pave the way for future comparative studies and facilitate the recognition of distinctively processed Aconitum pendulum products in traditional medicine.

Exploration on Standardization of Clinical Research Data in a Clinical Trial Institute of Traditional Chinese Medicine

Traditional Chinese Medicine(TCM) products and practices are widely used worldwide with increasing popularity. The number of TCM clinical trials has increased significantly in the past two decades. There is an urgent need to standardize TCM data and terminology for use in clinical studies. It will ensure data quality, improve the efficiency and expedite scientific communications in TCM. This paper illustrates our exploration processes in the application and development of the data standards in TCM clinical trials. We hope these explorations will help TCM data exchange, sharing, and aggregation which will ultimately accelerate the launch of TCM products and bring benefits to people.

Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf.

The oncogenic transcription factor c-Maf has been proposed as an ideal therapeutic target for multiple myeloma (MM), a not-yet-curable malignancy of plasma cells. In the present study, we establish a c-Maf-based luciferase screen system and apply it to screen a homemade library composed of natural products from which bruceine B (BB) is identified to display potent antimyeloma activity. BB is a key ingredient isolated from the Chinese traditional medicinal plant Brucea javanica (L.) Merr. (Simaroubaceae). BB inhibits MM cell proliferation and induces MM cell apoptosis in a caspase-3-dependent manner. The mechanism studies showed that BB inhibits c-Maf transcriptional activity and downregulates the expression of CCND2 and ITGB7, the downstream genes typically modulated by c-Maf. Moreover, BB induces c-Maf degradation via proteasomes by inducing c-Maf for K48-linked polyubiquitination in association with downregulated Otub1 and USP5, two proven deubiquitinases of c-Maf. We also found that c-Maf activates STAT3 and BB suppresses the STAT3 signaling. In the in vivo study, BB displays potent antimyeloma activity and almost suppresses the growth of myeloma xenografts in 7 days but shows no overt toxicity to mice. In conclusion, this study identifies BB as a novel inhibitor of c-Maf by promoting its degradation via the ubiquitin-proteasomal pathway. Given the safety and the successful clinical application of bruceine products in traditional medicine, BB is ensured for further investigation for the treatment of patients with MM.

Optimization of ethanol precipitation process of Nauclea officinalis extract based on concept of quality by design(QbD)

The ethanol precipitation process of Nauclea officinalis extract was optimized based on the concept of quality by design(QbD). Single factor tests were carried out to determine the levels of test factors. The ethanol volume fraction, pre-ethanol precipitation drug concentration, and ethanol precipitation time were taken as critical process parameters(CPPs). With the comprehensive scores of strictosamide transfer rate and solid removal rate as the critical quality attributes(CQAs), Box-Behnken design was employed to establish the mathematical models and space design between CPPs and CQAs, and the obtained optimal operating space was validated. The optimal operating space included ethanol volume fraction of 65%-70%, pre-ethanol precipitation drug concentration of 22-27 mg·mL~(-1), and ethanol precipitation time of 12 h. Based on the concept of QbD, this study adopted the design space to optimize the ethanol precipitation process of N. officinalis extract, which provided a reliable theoretical basis for the quality control in the production process of N. officinalis preparations. Moroever, this study provided a reference value for guiding the research and industrial production of traditional Chinese medicines.

Education on family medicinal plants (TOGA) for KWT Berkah Tani 2, Ngasem Village, Karanganyar

The residents of Ngasem Village already possess knowledge about the importance of Family Medicinal Plants (TOGA). However, they are not yet familiar with the benefits and methods of processing these medicinal plants. KWT Berkah Tani 2, located in Ngasem Village, Colomadu District, Karanganyar Regency, Central Java, has a large yard that remains underutilized, presenting the potential for planting TOGA. Therefore, the objective of this community service initiative is to educate the members of KWT Berkah Tani 2 about family medicinal plants, covering everything from planting to their health benefits. The program was carried out in six stages, including pre-testing, initial socialization, TOGA planting, simple processing of traditional medicinal products, post-testing, maintenance activities, and supervision. Ten types of medicinal plants were cultivated on a 700m2 area. The TOGA education program successfully increased participants' knowledge of basic TOGA concepts by 50%. Furthermore, there was a 20% rise in the number of participants who planted TOGA in their yards, and a 61.5% increase in knowledge regarding the health benefits of TOGA.

Evaluation of genotoxicity of dry powders of pomelo (Citrus maxima) flowers by micronucleus assay

Plants have been used as traditional medicine or health products for several thousands of years. The present study was aimed to evaluate the genotoxicity of pomelo flower powders by micronucleus assay In vivo. During the In vivo genotoxicity-evaluated experiment, the experimental animal’s clinical behavior, body weight (BW), food consumption, and the percentage of RET/RBCs (reticulocytes/red blood cells) and MN-RET/RETs (micronucleated reticulocytes/reticulocytes) after the treatments of pomelo (Citrus maxima) flower powders were evaluated. Both sexes ICR mice were treated three daily treatments by intraperitoneal injection of 2 mg/kg of mitomycin C (genotoxicity induction) or by oral route of 200 μL of PBS (the normal control group). Until 30th hours after the last treatment, K2-EDTA-anticoagulated peripheral blood specimens were collected. These blood samples were processed for the microscopy-based analysis using Giemsa stain and the percentage of reticulocytes and micronucleated reticulocytes was determined. The results were shown that the experimental animal’s clinical behaviors were normal in all groups. The BW and food consumption were no significant difference between all groups. RET/RBCs (%) in male or female ICR mice in the negative control group, the normal control group, the low dose of pomelo (C. maxima) flower powder group, the middle dose of pomelo (C. maxima) flower powder group, and the high dose of pomelo (C. maxima) flower powder group were respectively 8.8 ± 2.3 / 9.6 ± 2.6, 23.0 ± 2.5 / 22.4 ± 2.3, 23.4 ± 2.1 / 23.2 ± 3.8, 24.2 ± 3.6 / 23.0 ± 1.9, and 21.6 ± 3.2 / 21.6 ± 2.4; MN-RET/RETs (‰) in male or female ICR mice in the negative control group, the normal control group, the low dose of pomelo (C. maxima) flower powders group, the middle dose of pomelo (C. maxima) flower powder group, and the high dose of pomelo (C. maxima) flower powder group were 43.0 ± 12.5 / 39.4 ± 9.8, 2.6 ± 1.5 / 2.6 ± 1.5, 2.4 ± 1.1 / 2.2 ± 1.3, 2.2 ± 1.3 / 2.0 ± 1.2, and 1.8 ± 0.8 / 1.8 ± 0.8, respectively. Both RET/RBCs (%) and MN-RET/RETs (%) in male or female ICR mice in the negative control group were significantly difference than the other groups (p &lt; 0.001). Taken all results together, pomelo (C. maxima) flower powders were without genotoxicity. Therefore, pomelo (C. maxima) flower powders were safety.

Classification and Authentication of Lonicerae Japonicae Flos and Lonicerae Flos by Using 1H-NMR Spectroscopy and Chemical Pattern Recognition Analysis.

Lonicerae japonicae flos and Lonicerae flos are increasingly widely used in food and traditional medicine products around the world. Due to their high demand and similar appearance, they are often used in a confused or adulterated way; therefore, a rapid and comprehensive analytical method is highly required. In this case, the comparative analysis of a total of 100 samples with different species, growth modes, and processing methods was carried out by nuclear magnetic resonance (1H-NMR) spectroscopy and chemical pattern recognition analysis. The obtained 1H-NMR spectrums were employed by principal component analysis (PCA), partial least-squares discriminant analysis (PLS-DA), orthogonal partial least-squares discriminant analysis (OPLS-DA), and linear discriminant analysis (LDA). Specifically, after the dimensionality reduction of data, linear discriminant analysis (LDA) exhibited good classification abilities for the species, growth modes, and processing methods. It is worth noting that the sample prediction accuracy from the testing set and the cross-validation predictions of the LDA models were higher than 95.65% and 98.1%, respectively. In addition, the results showed that macranthoidin A, macranthoidin B, and dipsacoside B could be considered as the main differential components of Lonicerae japonicae flos and Lonicerae Flos, while secoxyloganin, secologanoside, and sweroside could be responsible for distinguishing cultivated and wild Lonicerae japonicae Flos. Accordingly, 1H-NMR spectroscopy combined with chemical pattern recognition gives a comprehensive overview and provides new insight into the quality control and evaluation of Lonicerae japonicae flos.

Review of bioactive components property of Malaysian propolis: A review

Over the past few decades, traditional medicinal products have grown in popularity. It is estimated that 80% of patients worldwide use them for basic health treatment. Due to its extraordinary bioactive properties, propolis is a bee product commonly utilised in alternative medicines. Propolis is a complicated mixture of substances, procured by bees from diverse vegetations and mix them with beeswax and bee saliva enzymes. Propolis bioactivities have been examined and reported in the treatments of numerous chronic diseases. Given the differences in pharmacological activity and compound markup of propolis, huge variation exists due to numerous hive localities. This study intends to define and explore the bioactive qualities of propolis in Malaysia. Information on the antibacterial, antioxidant, anti-inflammatory, and other bioactivity properties from studies conducted on Malaysian propolis have been consolidated in this review. This research would result in an enhanced understanding of the safe consumption of Malaysian propolis and may spur the development of novel and more affordable treatments for various infections.