Background: Laser lipolysis is one of the most prevalent liposuction techniques and is widely preferred in cosmetic surgical procedures globally. Compared to traditional liposuction, some investigations have demonstrated a reduction in complications when using the laser lipolysis technique. However, the amount of research in this area remains limited. Objectives: This study aims to investigate changes in pre- and post-operative blood parameters, including hemoglobin level, hematocrit, WBC count, and platelet level. Additionally, the research explores potential complications following laser lipolysis. Methods: This retrospective study, conducted at the Isfahan Clinical Center (Najaf Abad Branch), included 100 patients (without previous hematological disorders) who underwent laser lipolysis. Demographic information about the patients was collected. Blood parameters (hemoglobin, hematocrit, WBC, and platelets) were measured before and 24 hours after the operation. Laser liposuction was performed using a 1064-nm Nd laser. Postoperative care instructions were provided. Statistical analysis included t-tests and mixed linear regression using SPSS 20 software for data analysis, with a significance level of P < 0.005. Results: Significant alterations were observed in hemoglobin, WBC, and platelet levels. Hemoglobin and platelet levels showed a notable reduction of 16.9% and 7.9%, respectively. Conversely, the WBC count increased by 100.5%. Conclusions: Our study found a significant decrease in hemoglobin levels following laser lipolysis surgery, likely due to intraoperative bleeding. Further research is recommended to compare hemoglobin level changes using different laser types.