Traditional Chinese Medicine Enema Research Articles

Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates inflammatory response ulcerative colitis through TLR4/NF-κB signaling pathway.

Ulcer colitis (UC) is a chronic, nonspecific, and noninfectious inflammatory bowel disease. Recently, Toll-like receptors (TLRs) have been found to be closely associated with clinical inflammatory diseases. Achieving complete remission in patients with intermittent periods of activity followed by dormancy is challenging. Moreover, no study has explored the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in UC. To explore the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in UC. This prospective clinical study included patients who met the exclusion criteria in 2020 and 2021. The patients with UC were divided into two groups (control and experimental). The peripheral blood of the experimental and control groups were collected under aseptic conditions. The expression of TLR4 protein, NF-κB, IL-6, and IL-17 was detected in the peripheral blood of patients in the experimental group and control group before and 1 month after taking the drug. Linear correlation analysis was used to analyze the relationship between the expression level of TLR4 protein and the expression levels of downstream signal NF-κB and inflammatory factors IL-6 and IL-17, and P < 0.05 was considered statistically significant. There were no significant differences in the patient characteristics between the control and experimental groups. The results showed that the expression levels of TLR4 and NF-κB in the experimental group were significantly lower than those in the control group (P < 0.05). The levels of IL-6 and IL-17 in the experimental group were significantly lower than those in the control group (P < 0.05). The TLR4 protein expression in the experimental group was positively correlated with the expression level of downstream signal NF-κB and was positively correlated with the levels of downstream inflammatory cytokines IL-6 and IL-17 (r = 0.823, P < 0.05). Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates the inflammatory response of UC through the TLR4/NF-κB signaling pathway.

WITHDRAWN: The application of Traditional Chinese Medicine in the treatment of ulcerative colitis and the elucidation of relevant mechanisms

Ulcerative colitis (UC) is a chronic, non-specific intestinal disease of unknown etiology, with high incidence rates worldwide. At present, western medicine treatments have been associated with more adverse effects and poor efficacy, so Traditional Chinese medicine (TCM) is commonly used as an adjuvant treatment. TCM has unique advantages in regulating immune function, repairing intestinal mucosa, and alleviating intestinal inflammation. At the same time, network pharmacology is also providing new ideas and innovations about TCM and the development of new drugs. Network pharmacology expounds on the molecular mechanisms of TCM in treating diseases. This is achieved by studying the multiple network relationships between diseases, targets, genes, and drugs. This review systematically discusses the progress of research with regard to treating UC using TCM, with a main focus on aspects such as intestinal flora balance, intestinal mucosal barrier, TCM enema, acupuncture therapy, and acupoint embedding. This study provides new ideas that clarify the therapeutic targets of UC and the development of TCM.

A systematic review of the efficacy of traditional Chinese medicine retention enema in the treatment of ulcerative colitis

The objective of this study is to summarize the efficacy and safety of traditional Chinese medicine (TCM) enema in the treatment of ulcerative colitis (UC). The randomized controlled trials on TCM enema intervention in the treatment of UC were searched in seven databases: PubMed, Embase, Web of Science, CBM, CNKI, Wanfang Database, and VIP Database from January 1, 2013 to June 6, 2022, and the data were analyzed using RevMan 5.3 software. A total of 18 studies involving 1514 UC patients were included. Meta analysis results showed that compared with conventional Western medicine, Chinese medicine enema had a significant effect on UC, and the clinical effective rate of the experimental group using Chinese medicine enema was 4.45 times that of the control group using conventional Western medicine (odds ratio = 4.45, 95% confidence interval [3.27, 6.06]). Therefore, Chinese medicine enema is effective in the treatment of UC, and can significantly reduce related symptoms.

Effect of Traditional Chinese Medicine enema combined with injection via gastric tube in the treatment of gastrointestinal dysfunction in ICU patients

Effect of Traditional Chinese Medicine enema combined with injection via gastric tube in the treatment of gastrointestinal dysfunction in ICU patients

Nursing of a patient with infertility induced by fallopian tube obstruction treated with midnight-midday ebb flow Traditional Chinese Medicine enema

Nursing of a patient with infertility induced by fallopian tube obstruction treated with midnight-midday ebb flow Traditional Chinese Medicine enema

Nursing of a patient with chronic renal insufficiency treated with the Traditional Chinese Medicine enema combined with Baduanjin exercise

Nursing of a patient with chronic renal insufficiency treated with the Traditional Chinese Medicine enema combined with Baduanjin exercise

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis.

Severe acute pancreatitis (SAP) is characterized by high mortality rates, numerous complications, and extreme difficulties in treatment. A traditional Chinese medicine (TCM) enema has been widely utilized in clinical and experimental studies of SAP. It has been demonstrated to have beneficial effects in protecting pancreatic function and delaying disease progression. The procedure of TCM enema is to perfuse the Chinese medicinal liquid of raw rhubarb (Rheum officinale Baill. DaHuang) from the anus into the rectum and colon. Basic steps of the procedure include boiling the herbal solution in advance, using a disposable enema kit to assist patients in taking a left lying position, raising the patient's hip 10 cm, and carefully inserting the enema 30-35 cm into the anus, with a drip speed of 60-80 drops/min. The medicine liquid temperature should be equivalent to the patient's body temperature, typically between 37-39 °C. The end of the enema operation should be slow, and Tui na (massage therapy) should be administered before extubation. The medication liquid should be kept in the rectum for more than 1 h. After issuing an enema, it is essential to observe the patient's feces and abdomen, and to evaluate the remission of abdominal signs and symptoms.

Nursing of a patient with acute intestinal obstruction treated by moxibustion combined with Traditional Chinese Medicine enema

Nursing of a patient with acute intestinal obstruction treated by moxibustion combined with Traditional Chinese Medicine enema

Experience of Traditional Chinese Medicine enema and emergency care for 8 patients with acute drug poisoning

Experience of Traditional Chinese Medicine enema and emergency care for 8 patients with acute drug poisoning

Efficacy and safety of colonic dialysis combined with traditional Chinese medicine retention enema in the treatment of chronic renal failure: A protocol for systematic review and meta-analysis.

Background:Chronic renal failure (CRF) is a major public health problem worldwide nowadays. It is characterized by a slow reduction in kidney function identified by an increase of serum creatinine levels and a reduction of urine output. CRF is easier to diagnose than to treat. Clinical evidence shows that colonic dialysis combined with traditional Chinese medicine (TCM) enema can treat CRF by reducing serum creatinine. To assess the therapeutic efficacy and safety of colonic dialysis combined with Traditional Chinese medicine retention enema in CRF, we created a protocol for a systematic review to inform future clinical applications.Methods:Eligible random controlled trials were collected from 8 bibliographic databases (PubMed, EMBASE, Web of Science, The Cochrane Library, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, Wanfang Database), completed before October 2021. The primary outcome is the serum creatinine, Urea nitrogen, total effective rate, uric acid, creatinine clearance. Secondary outcome: TCM syndrome score, glomerular filtration rate, hemoglobin, adverse reactions, and adverse events. Data extraction and quality assessment were independently conducted by 2 researchers. The quality and bias of the data were assessed using RevMan5.4 software.Results:This study will provide a clinical basis for colonic dialysis combined with TCM retention enema in the treatment of CRF.Conclusion:Colonic dialysis combined with TCM retention enema in the treatment of CRF can delay the progression of renal disease, proving its effectiveness and safety.INPLASY Registration number:INPLASY2021100116

The Efficacy of Traditional Chinese Herbs Retention Enema Combined with Perineal Massage on Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)

Purpose: To explore the clinical effect of traditional Chinese medicine retention enema combined with penis massage in the treatment of chronic prostatitis complicated with sexual dysfunction. Materials and methods: 200 patients with chronic prostatitis complicated with sexual dysfunction were randomly divided into two groups, 100 cases in each group. The combined treatment group was treated with traditional Chinese medicine retention enema combined with penis massage, and the control group was treated with traditional Chinese medicine retention enema alone. National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), Chronic Prostatitis Related Sexual Function Index (CPSFI), International Index of Erectile Function-5 (IIEF-5), Chinese Index of Sexual Function for Premature Ejaculation (CIPE), Hamilton Anxiety Scale (HAMA) and Hamilton Depression Rating Scale (HAMD) and Routine examination of prostatic secretions (EPS) were used to evaluate the clinical effect before and after treatment. Results: The effective rate of the combined treatment group was significantly higher than that of the simple traditional Chinese medicine enema group. The total effective rate was 90% in the combined treatment group and 67% in the control group. The combined treatment group was significantly higher than the control group, and the difference was statistically significant (P<0.05). The scores of NIH-CPSI, IIEF-5, CIPE-5, HAMA and HAMD in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion: Traditional Chinese medicine retention enema combined with penile massage for chronic prostatitis combined with ED can significantly improve the symptoms associated with chronic prostatitis, and can also significantly improve the patient's sexual function.

Efficacy and safety of retention enema with traditional Chinese medicine for ulcerative colitis: A meta-analysis of randomized controlled trials

ObjectiveTo assess the efficacy and safety of retention enema with traditional Chinese medicine (TCM) for ulcerative colitis (UC) through a meta-analysis of published studies. MethodsLiteratures were retrieved from five electronic databases. Quality evaluation and meta-analysis were respectively conducted using the Cochrane collaboration and RevMan5.3. Overall quality of evidence was evaluated using GRADE system. Effect sizes were pooled using random effect models. ResultsSeventeen RCTs were included. Compared with routine pharmacotherapies (RPs), TCM enema exhibited a statistically significant difference in clinical efficacy and reduction of the recurrence rate. The results of qualitative description for other endpoints, such as improvements in anabrosis, ulcer, diarrhea, and hematochezia, suggested that TCM enema had better efficacy than RPs. Furthermore, the incidence of side effects in TCM was lower than that in RPs. ConclusionThis meta-analysis confirmed the efficacy and safety of TCM enema for improving UC symptoms. However, further well-designed researches are needed.

Traditional Chinese medicine enema for acute chronic liver failure: A protocol of systematic review and meta-analysis of randomized clinical trials.

Background:Acute chronic liver failure (ACLF) is the most common type of liver failure. The clinical symptoms are complex and changeable, the treatment is difficult and the fatality rate is high. It has become an urgent problem to actively seek effective treatment means and improve the clinical efficacy of ACLF patients. Studies have shown that decreased intestinal barrier function and bacterial endotoxin translocation in ACLF patients are considered to be the key causes of enterogenic endotoxemia, and traditional Chinese medicine enema has certain advantages in adjuvant treatment of this disease. However, due to the lack of evidence, there is no specific method or suggestion, so it is necessary to carry out systematic evaluation on Traditional Chinese medicine enema for ACLF and provide effective evidence for further research.Methods:We will search the following electronic databases from their inception to July 2020: Electronic database includes PubMed, Embase, Cochrane Library, Chinese Biomedical Database WangFang, VIP medicine information, and China National Knowledge Infrastructure. Primary outcomes: survival rates, TCM syndrome score. Secondary outcomes: liver function (alanine aminotransferase, aspartic acid amino transferase, total bilirubin), blood coagulation function (prothrombin activity), adverse events. Data will be extracted by 2 researchers independently, risk of bias of the meta-analysis will be evaluated based on the Cochrane Handbook for Systematic Reviews of Interventions. All data analysis will be conducted by data statistics software Review Manager V.5.3. and Stata V.12.0.Results:The results of this study will systematically evaluate the effectiveness and safety of Traditional Chinese medicine enema for ACLF.Conclusion:The systematic review of this study will summarize the currently published evidence of Traditional Chinese medicine enema for ACLF to further guide its promotion and application.

Meta-analysis of therapeutic effect of retention enema with traditional Chinese medicine on ulcerative colitis

To evaluate the therapeutic effect of traditional Chinese medicine( TCM) retention enema in treating ulcerative colitis( UC) by Meta-analysis method. Randomized controlled trials( RCTs) of TCM retention enema in treatment of UC were retrieved from databases as CNKI,Wan Fang,CBM,VIP and PubMed from inception to June 2019. The quality of RCTs was assessed by using the Cochrane collaboration's tool for assessing risk of bias,Meta-analysis were performed with Rev Man 5. 3 software and publication bias was tested by using Stata 15. 1 software. There were twenty-eight articles enrolled,and 2 477 patients were included. The result of Meta-analysis showed that retention enema with TCM had significantly better effectiveness in overall curative effect( RRSASP= 1. 18,95%CI[1. 13,1. 22],Z = 8. 32,P < 0. 01; RR5-ASA= 1. 13,95% CI[1. 03,1. 21],Z = 2. 61,P < 0. 01) symptom curative effect( RR =1. 44,95%CI[1. 22,1. 71],Z = 4. 25,P<0. 01) than those of the control group,and the treatment group was lower than the control group in terms of recurrence( RR = 0. 31,95% CI[0. 17,0. 56],Z = 3. 88,P< 0. 01) and adverse events( RR = 0. 38,95% CI[0. 18,0. 78],Z = 2. 64,P<0. 01),with statistically significant differences. However,there was no significant difference in Meta-analysis result of colonoscopic mucosal change between the two groups. TCM enema is an effective method to treat ulcerative colitis.

Clinical study on TCM enema combined with continuous renal replacement therapy on the treatment of severe acute renal injury

Objective To evaluate the clinical efficacy of TCM enema combined with continuous renal replacement therapy on the treatment of severe acute renal injury. Methods A total of 100 patients of severe AKI patients were divided into 2 groups by random digital table, each of which was 50 cases. The control group was treated with CRRT, and the observation group cooperated with the traditional Chinese medicine enema on the basis of the control group. The 2 groups were treated continuously for 14 d. The renal function and urine volume recovery time were observed; 24 h urinary protein and 24 h urinary albumin excretion rate were determined by automatic biochemical analyzer.The blood urea nitrogen (BUN), serum creatinine (SCr), serum cystatin C (Cys C) were detected. And theclinical efficacy was compared between the two groups. Results The total effective rate of the observation group was 70.0% (35/50) and the control group was 50.0% (25/50). The difference between the 2 groups was statistically significant. After treatment, the levels of serum BUN (6.51 ± 1.07 mol/L vs. 8.22 ± 2.31 mol/L, t=4.750), SCr (91.29 ± 21.05 μmol/L vs. 108.67 ± 19.34 μmol/L, t=4.299) and Cys C (0.85 ± 0.33 mg/L vs. 1.03 ± 0.45 mg/L, t=2.281) in the observation group were significantly lower than those of the control group (P<0.01 or P<0.05). The urinary albumin excretion rate of 24 h urine protein (115.37 ± 26.15 mg/24 h vs. 167.55 ± 38.66 mg/24 h, t=7.905) and 24 h urine (198.41 ± 33.24 μg/min vs. 226.19 ± 38.35 μg/min, t=3.871) was significantly lower than that of the control group (P<0.01). Conclusions TCM enema combined with CRRT can promote the recovery of renal function in patients with severe AKI, can effectively delay the progression of renal injury. Key words: Acute kidney injury; Enema; Compounds (TCD); Hemodiafiltration; Blood urea nitrogen; Serum creatinine; Cys C

Influence of acupuncture combined with enema on uterine hemodynamics and HMGB1, TLR4 in the patients with acute pelvic inflammatory

Objective To investigate the clinical effects of acupuncture combined with enema in the treatment of acute pelvic inflammatory, and its effects on uterine hemodynamics and seurm levels of high mobility group box-1 protein (HMGB1), toll-like receptor 4 (TLR4). Methods A total of 66 patients with acute pelvic inflammatory were enrolled in the study, randomly divided into the combination treatment group (n=33) and conventional treatment group (n=33). The patients in the combination treatment group were given with acupuncture combined with enema on the basis of conventional therapy. After 10 d treatment, the effective rate was observed. The changes of serum HMGB1 and TLR4 were compared and analyzed. Results After 10 d treatment, the total effective rate was 90.91% (30/33) in the combination treatment group, and 69.70% (23/33) in the conventional treatment group. There were statistically significant differences between the two groups (χ2=8.246, P<0.05). After treatment, the left Vmax (39.16 ± 0.73 cm/s vs. 35.47 ± 0.83 cm/s), right Vmax (41.23 ± 1.12 cm/s vs. 36.24 ± 0.75 cm/s), left PI (2.23 ± 0.25 cm/s vs. 3.11 ±0.45 cm/s), right PI (2.17 ± 0.22 cm/s vs. 2.62 ± 0.23 cm/s), left RI (0.48 ± 0.08 cm/s vs. 0.73 ± 0.13 cm/s) and right RI (0.43 ± 0.11 cm/s vs. 0.71 ± 0.16 cm/s) of the combined treatment group were significantly superior to the conventional treatment group (all P<0.01). The levels of serum HMGB1 (17.45 ± 5.01 ng/ml vs. 21.32 ± 6.15 ng/ml, t=2.803) and TLR4 (1.05 ± 0.64 ng/ml vs. 1.75 ± 0.91 ng/ml, t=3.614) in the combination treatment group were significantly lower than those in conventional treatment group (all P<0.01). Conclusions Acupuncture combined with traditional Chinese medicine enema treatment of acute pelvic inflammatory disease is better, improve the uterine hemodynamics. The mechanism may be related to inhibit the release of HMGB1, TLR4 and its induced inflammatory response. Key words: Pelvic inflammatory disease; Acute disease; Hemodynamics; High mobility group proteins; TLR4

Clinical curative effect observation on functional electrical stimulation combined with biofeedback pelvic floor exercise of pelvic congestion syndrome

Objective : Analyze the curative effect of functional electrical stimulation combined with biofeedback pelvic floor muscle training in the treatment of pelvic congestion comprehensive syndrome. Methods : A retrospective analysis of our hospital during June 2013 to June 2015 45 cases by analgesic drugs and traditional Chinese medicine enema poor treatment of pelvic congestion syndrome in patients with functional electrical stimulation combined with biofeedback pelvic floor muscle training in the treatment, current frequency 10-20Hz period of 200 microseconds pulse, current intensity for 10 ~ 50mA, for 30 min each time, 2 times a week, continuous treatment for 5 weeks. Before and after the treatment of pelvic vein diameter and blood flow rate, as well as the pain score [using the pain score table (VAS)]. Results : Patients in the treatment without adverse reaction and after treatment of pelvic vein diameter (2.9 + 1.6 mm was significantly lower than the treatment of 7.5 + 2.6) mm, P < 0.05, venous blood flow velocity (84.9 + 3.8) mm / s significantly faster than before treatment (53.6 + 2.9) mm / s, P < 0.05. The total effective rate was 91.1%, pain score (2.52 + 1.29) were significantly lower than those before treatment (4.82 + 1.29) (P < 0.05). Conclusion : functional electrical stimulation combined with biological feedback and pelvic muscle exercise can significantly alleviate the pelvic congestion syndrome pain symptoms. The curative effect is distinct and worth popularization in clinical.

Comparison between Chinese Herbal Medicines and Conventional Therapy in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial

Background. This study was made to evaluate the efficacy of Chinese herbal medicines, Reduning injection, and a traditional Chinese medicine (TCM) granule, in patients with severe hand, foot, and mouth disease (HFMD) by conducting a prospective, controlled, and randomized trial. Methods. 355 severe HFMD patients were randomly assigned to receive conventional therapy alone, Reduning injection plus conventional therapy, or TCM enema plus conventional therapy for 7–10 days. Results. There was no significant difference in the incidence of major complications between the groups. Median time to fever clearance was 20 hours (95% CI: 6.0–25.0) for conventional therapy recipients, 18 hours (95% CI: 4.0–24.0) for Reduning combination-treated patients, and 6 hours (95% CI: 4.0–16.0) for TCM combination-treated patients. Only the difference in time to fever clearance between TCM combination group and conventional group reached statistical significance (P = 0.048). Reduning combination group showed a significant reduction in sedative administration compared with conventional therapy group (P = 0.008). No HFMD-related death and no important adverse events were observed. Conclusions. Reduning injection plus conventional therapy significantly reduced the concomitant use of sedatives, which may help decrease HFMD-related neurologic complications in children. TCM effectively reduced time to fever clearance and may become a complementary therapy for relieving the symptoms of severe HFMD.

Research in effect of traditional Chinese medicine enema on renal insufficiency of diabetic nephropathy

Objective To observe the effect of traditional Chinese medicine enema on renal insufficiency of diabetic nephropathy.Methods 76 patients with diabetic nephropathy were divided into the treatment group and the control group with 38 patients in each group.The treatment group were offered traditional Chinese medicine enema based upon routine treatment for 8 weeks,the control group received routine treatment only.The clinical symptom,fasting blood glucose,24h urine albumin,serum creatinine (Scr),urea nitrogen (BUN) were observed and compared before and after treatment.Results The two groups showed significant differences in clinical symptom and degree of renal function alleviation.Conclusions Traditional Chinese medicine enema proved to be one of the effective methods for treatment of renal insufficiency of diabetic nephropathy. Key words: Traditional Chinese medicine enema; Diabetic nephropathy; Renal insufficiency