Abstract: This article explores the potential of causal AI-driven what-if simulations in enhancing decision-making across various industries. Causal AI uses theories and causal reasoning to figure out and model the underlying cause-and-effect relationships that govern a system or domain. It can make strong predictions even when it only has limited data. The article discusses the advantages of causal AI over traditional AI approaches and its ability to handle sparse data, enable counterfactual reasoning, and address bias issues. It delves into the applications of what-if simulations powered by causal AI in manufacturing, oil and gas, supply chain management, and contract management, presenting scenarios and demonstrating how causal AI can offer valuable insights and optimize decision-making. The article also highlights the challenges and opportunities associated with causal AI, including the need for domain expertise, integration with existing systems, interpretability and explainability, competitive advantage, positive social impact, research and development, and ethical considerations. The impact of causal AIdriven what-if simulations on decision-making across industries is substantial, enabling organizations to make informed decisions, mitigate risks, and seize opportunities in an ever-changing business landscape.