Toxoplasmosis In Patient Research Articles

Serological and molecular evaluation of toxoplasmosis in patient undergoing chemotherapy for malignancies in southeast of Iran

Toxoplasma gondii is zoonotic protozoa that spread throughout the world. The aim of current study was determination of the prevalence of T. gondii infection in patient undergoing chemotherapy for malignancies using ELISA and two different molecular tests including Nested-PCR and LAMP techniques. This study was carried out in Ali Ibn Aboutaleb hospital in Zahedan cities, southeast of Iran. Totally, 154 serum samples from patient were test for detection of IgG and IgM antibodies against T. gondii by ELISA test. All of the samples were also test by Loop amplification (LAMP) and Nested-PCR with RE gene. Totally, 39.4% of the sample sera from cases were positive for IgG against T. gondii. After using RE-Nested-PCR technique, 29.8% sample sera were positively. After using LAMP technique, 33.1% of the samples were found to be positive. Based on our result, the RE-LAMP technique was more effective than RE-nested-PCR method in the detection of T. gondii DNA.

Cerebral Toxoplasmosis in a Patient with Systemic Lupus Erythematosus

Toxoplasma gondii is a globally distributed protozoan parasite that causes toxoplasmosis and is frequently associated with infections in the immune compromised and in neonates. On initial infection, the parasite enters the host through the intestinal epithelium, usually after oocysts are ingested. Additionally, vertical transmission from mother to fetus can occur as well as infection from organ transplantation. In immune competent hosts, presentation is commonly flu-like with fever, headache and lymphadenopathy. The host’s immune response typically contains the infection, limiting it to tissue cysts comprised of slowly replicating bradyzoites. In immune deficient hosts, when tissue cysts containing bradyzoites rupture, the compromised immune system is unable to halt progression of the parasite. Bradyzoites differentiate into rapidly replicating tachyzoites and as the parasite proliferates, host cell death occurs and necrotic foci develop. Most commonly, immune deficient hosts present with encephalitis, pneumonitis, and chorioretinitis [1]. We report a case of cerebral toxoplasmosis in a female patient with systemic lupus erythematosus (SLE) being treated with hydroxy chloroquine, mycophenolate mofetil and prednisone.

Toxoplasmosis testicular: un caso raro de masa testicular

AbstractToxoplasma gondii is an intracellular protozoan infecting birds and mammals. Acute infection is asymptomatic in immune competent people. For immune deficient patients (acquired immune deficiency syndrome, lymphoma patients or those under steroids to prevent organ transplantation rejection) infection may be lethalWe describe an uncommon case of testicular toxoplasmosis in patient under steroids after organ transplantation with no positive serum test for HIV and/or systemic toxoplasmosis

Toxoplasmosis in a patient with non-Hodgkin’s lymphoma: the need for a good differential diagnosis

Toxoplasma gondii is an obligate intracellular parasite responsible for toxoplasmosis. Congenital and acquired forms of the disease have now been reported. In immunocompromised patients, the disease entity may resemble other diseases. Presented for discussion is an interesting case of acquired toxoplasmosis in an immunocompromised patient with several confounding factors necessitating a good differential diagnosis list. Also provided is a comprehensive review of toxoplasmosis diagnosis and management.

Fatal recurrent toxoplasmosis in a patient initially infected via a leukocyte transfusion.

Fatal recurrent toxoplasmosis in a leukemic patient apparently infected via a leukocyte transfusion from an asymptomatic carrier of the parasite is reported. Although the initial illness resolved with supportive treatment and antimicrobial therapy, the recurrent phase was fulminating, resulting in colonization of many tissues. Acute necrotizing pancreatitis due to Toxoplasma gondii is reported. The biphasic nature of the infection was established on clinical as well as histologic grounds.