Toxicity Effects Of Aqueous Extract Research Articles

Evaluation of Acute Toxicity of Aqueous Extract of Libyan Globularia Alypum in Albino Mice

Aims. Lorke’s method was used to evaluate the acute toxicity effect of aqueous extract from the aerial part of Libyan Globularia alypum on albino mice. Methods. The study involved intra-peritoneal administration of different doses of the extract to groups of female mice. Results. Signs resultant toxicity and possible death of animals were monitored for 14 days to ascertain the median lethal dose (LD50) of the extract. At the end of the two-week study, all the animals in all the dose groups were survived. Conclusion. Globularia alypum plant can be considered as safe plant, as long as the LD50 is greater than 5000 mg/kg body weight.

Comparative acute toxicity effect of the aqueous extract ofFicus ovata vahton white albino rats.

Lorke's and Arithmetic methods was used to study the acute toxicity effect of aqueous extract from the stem bark of Ficus Ovata Vaht on albino rats. The study involved intraperitoneal (IP) administration of different doses of the extract to groups of albino rats. Sign accompanying toxicity and possible death of animals were monitored to ascertain the median lethal dose (LD50) of the extract. At the end of the experiment the median lethal dose value for the two methods were compared. The LD50 for the Lorke's was found to be 288.5 mg/kg compared to the Arithmetic method which is 660 mg/kg. There was a significant difference between the two methods observed. The safety usage of extract from this plant in traditional medicines is discussed.

Effects of heart of palm (Palmito) extract on reproductive system of adult male rats

To evaluate the toxicity effects of aqueous extract of heart of palm (Palmito) on plasma testosterone, estradiol, LH and FSH hormone levels and testicular tissue in male rats. A total of 70 male Sprague-Dawley rats were divided into seven groups. The control group was given 1 mL of distilled water, and the experimental groups were given 25, 50, 100, 150, 200, and 250 mg/kg/day of extract for 56 days. The effect of the treatment on the male reproductive system was evaluated by assessing plasma testosterone, estradiol, LH, and FSH levels, as well as spermatogenesis process. A significant decrease in testosterone and estradiol levels were observed in rats treated with different doses of palmito. The extract consumption provided no remarkable change in the serum levels of LH and FSH, and weights of bodies, and testes in the six treated-groups compared to those in the control group. Also, treatment with the palmito resulted in a decrease of the mean seminiferous tubular diameter and the number of spermatogonia, preleptoten and pachytene spermatocytes, round spermatids, and Leydig cells. The ethanol extract of palmito has anti-androgenic properties, which affected spermatogenetic activity in all experimental groups.