Toxic Effects Research Articles

Traditional Chinese medicine in chronic rhinosinusitis: Mechanisms and postoperative recovery.

Traditional Chinese medicine in chronic rhinosinusitis: Mechanisms and postoperative recovery.

The effects and toxicological mechanisms of leucaena toxicity on ruminant reproduction: a review.

The effects and toxicological mechanisms of leucaena toxicity on ruminant reproduction: a review.

Drug repurposing of 6-AZA-UTP and itraconazole reveals novel B3GALT5 inhibitors for pancreatic cancer.

Drug repurposing of 6-AZA-UTP and itraconazole reveals novel B3GALT5 inhibitors for pancreatic cancer.

Elaidic acid induces testicular oxidative stress, inflammation, Wnt/β-catenin disruption and abnormalities in steroidogenesis, spermatogenesis and histo-architecture in Sprague Dawley rats.

Elaidic acid induces testicular oxidative stress, inflammation, Wnt/β-catenin disruption and abnormalities in steroidogenesis, spermatogenesis and histo-architecture in Sprague Dawley rats.

Insecticidal effects of Sargassum vulgare and Caulerpa racemosa extracts on Aedes aegypti.

Insecticidal effects of Sargassum vulgare and Caulerpa racemosa extracts on Aedes aegypti.

Oxidative damage to DNA, expression of Mt-1, and activation of repair mechanisms induced by vanadium trioxide in cultures of human lymphocytes.

Oxidative damage to DNA, expression of Mt-1, and activation of repair mechanisms induced by vanadium trioxide in cultures of human lymphocytes.

Profiling of lincRNAs and differential regulatory mechanisms in response to nanoplastic toxicity at environmentally relevant concentrations in Caenorhabditis elegans.

Profiling of lincRNAs and differential regulatory mechanisms in response to nanoplastic toxicity at environmentally relevant concentrations in Caenorhabditis elegans.

Microplastics bioaccumulation in fish: Its potential toxic effects on hematology, immune response, neurotoxicity, oxidative stress, growth, and reproductive dysfunction.

After being exposed, microplastics mostly bioaccumulated in guts and gills of fish, then, through circulation, spread and bioaccumulated in other tissues. Circulatory system of fish is impacted by the microplastic bioaccumulation in their tissues, influencing a number of hematological indices that are connected with immunity, osmotic pressure, blood clotting, molecular transport and fat metabolism. Variables like size, dose, duration, food consumption and species, all affect the bioaccumulation and toxicity of the microplastic, rather than the exposure routes. Microplastics lead to an imbalance in the generation of ROS and antioxidant defense of fish, which resulting in oxidative injury. Moreover, microplastics affect immunological responses through physico-chemical damage, hence produce neurotoxicity and modifies the activity of the acetylcholine esterase. Exposure to microplastics caused damage to the hepatic and gut tissue, affect intestinal barrier function and dysbiosis of microbial composition, altered the metabolism of host, affecting the activities of the digestive enzymes, eventually affecting the growth performance of fish. Microplastics exposure target the HPG axis and interfere with the process of steroidogenesis, apoptosis of the gonadal tissue, ultimately causing reproductive dysfunction. Fish exposed to microplastics have a range of toxic effects viz. alteration to immune, antioxidant and hematological indices, bioaccumulation, neurotoxicity, growth and reproductive dysfunction, all were examined in this present review by using different indicators.

Toxic effects of fluoxetine-loaded onto virgin or aged polypropylene, polyamide and polyvinyl chloride microparticles on Daphnia magna.

There is an increasing recognition that microplastics can act as a vector for micropollutants when co-occurring in the environment and that pollutant-loaded microplastics can become integral to food-webs. To evaluate whether fluoxetine-loaded microplastics can act as a vector for fluoxetine to enter the food chain, a toxicity assay with Daphnia magna neonates was performed. This study evaluated the fluoxetine availability when adsorbed onto virgin or aged polypropylene, polyamide, and polyvinyl chloride (PVC). Results demonstrated that fluoxetine-loaded microplastics displayed toxic effects for all microplastic types, with varying toxicity depending on plastic type and weathering. D. magna ingested microplastics in all experiments that microplastics were present, but survival rates were not significantly affected by microplastics alone. Neonate mortality did not correlate with the adsorption/desorption capacity of the microplastics. Fluoxetine showed the highest adsorption on virgin and aged polypropylene (83-98 %), followed by aged polyamide (25-68 %) and PVC (38-90 %). While negligible desorption occurred with polypropylene, polyamide and PVC exhibited up to 20 % desorption. However, higher mortality was observed with fluoxetine-loaded virgin polypropylene (30 %), polyamide (40 %), and PVC (35 %) compared to aged particles (0-10 %). The results indicate that microplastic can enter the food-chain and act as a vector for pollutants, exhibiting hazardous effects to wildlife.

Comprehensive investigation into the discrete toxicity of curcumin on β-cell viability and insulin secretion.

Comprehensive investigation into the discrete toxicity of curcumin on β-cell viability and insulin secretion.

Review of mechanisms and impacts of nanoplastic toxicity in aquatic organisms and potential impacts on human health.

Review of mechanisms and impacts of nanoplastic toxicity in aquatic organisms and potential impacts on human health.

Hydrogen sulfide mitigates the immunotoxicity and neurotoxicity induced by cadmium in Tegillarca granosa.

Hydrogen sulfide mitigates the immunotoxicity and neurotoxicity induced by cadmium in Tegillarca granosa.

Cadmium exposure and its role in joint disease: A brief review of experimental and population-based evidence.

Cadmium exposure and its role in joint disease: A brief review of experimental and population-based evidence.

Toxicological impact of Thiamethoxam on adult male rats: Histopathological, biochemical, and oxidative DNA damage assessment.

Toxicological impact of Thiamethoxam on adult male rats: Histopathological, biochemical, and oxidative DNA damage assessment.

Identification of molecular signatures for azole fungicide toxicity in zebrafish embryos by integrating transcriptomics and gene network analysis.

Identification of molecular signatures for azole fungicide toxicity in zebrafish embryos by integrating transcriptomics and gene network analysis.

Spring festival firework activities exacerbate toxic effects of aerosol essential components.

Spring festival firework activities exacerbate toxic effects of aerosol essential components.

Pyriproxyfen toxicity to fish and crustaceans: A literature review.

Pyriproxyfen toxicity to fish and crustaceans: A literature review.

Quercetin liposomes conjugated with hyaluronidase: An efficient drug delivery system to block pancreatic cancer.

Quercetin liposomes conjugated with hyaluronidase: An efficient drug delivery system to block pancreatic cancer.

Composition characteristics, source analysis and risk assessment of PAHs in surface waters of Lipu.

Composition characteristics, source analysis and risk assessment of PAHs in surface waters of Lipu.

Insights on nitrate pollution-induced intestinal dysfunction in turbot (Scophthalmus maximus) revealed by integrated dynamic metabolomics and transcriptomics.

Insights on nitrate pollution-induced intestinal dysfunction in turbot (Scophthalmus maximus) revealed by integrated dynamic metabolomics and transcriptomics.