Based on the engineering background related to ±800 kV ultra-high voltage (UHV) transmission lines spanning the Yellow River, finite element models were developed for single-tower and transmission tower-line systems, with their wind-induced responses under wind loads were simulated and analysed. In addition, the coupling effect in a large-span transmission tower line system was investigated. The results showed that the natural vibration frequency of the tower-line system was slightly lower than that of a single tower and that the torsional natural frequency was the most significantly reduced. The transmission tower-line system has a maximum displacement of 1.92 times that of a single tower when the wind angle is 0°. The maximum axial force and stress in the tower-line system are 1.6 times and 1.37 times higher than those in a single tower. The interaction between the tower and wires significantly affects the wind-induced response of the tower body. Hence, considering the dynamic coupling effect of the tower-line transmission system is important when designing a tower.