The assessment and regulation of water security system resilience (WSSR) are important ways to alleviate water resource crises. On the basis of the three characteristics of resilience, namely, resistance, restoration, and adaptability, an evaluation index system of the WSSR was built for the Yellow River Basin (YRB). A projection pursuit model based on the sparrow search algorithm (SSA-PP model) was constructed to assess the WSSR at the overall and provincial scales from 2009 to 2022. The factors influencing the spatial distribution patterns of WSSR was identified through factor detector and interactive detector techniques. The results revealed that: (1) From 2009 to 2022, the YRB exhibited a rising trend in WSSR, with the western region attaining the peak level, and the eastern region recording the lowest magnitude. (2) the adaptability capacity of most provinces and regions in the YRB tended to decrease to about 1.0, whereas the resistance and restoration capacities tended to increase towards 2.0. (3) Factors relevant to the restoration and adaptability subsystems, such as the development and utilization ratio of water resources and surface water resources (B2 and B3), water resource load index (C1), water consumption per 10,000 yuan of GDP (C8), and total precipitation (A1), significantly affected the WSSR. The interaction between factors exhibited significant enhancement effects on explanatory. Therefore, targeted countermeasures and recommendations were provided to improve the WSSR in the YRB.