Recently, the exposure to heavy metals from bottled waters raised huge concerns. In this context, for the first time the risk of non-carcinogenic exposure by the heavy metals in Iranian drinking water was assessed. Therefore, by using the obtained data in our previous published study, the target hazard quotient (THQ) and total target hazard quotient (TTHQ) by considering to the sexuality of consumers were calculated. THQ in females were determined as significantly higher (p < .05) in comparison with the males. The rank order of heavy metals based on THQ was As > Pb > Hg > Cd > Cu, respectively. The minimum and maximum of THQ for the males were observed in age groups of +65 and 1–3 years, respectively. The minimum and maximum of THQ for females were noted in age groups of 11–14 and 1–3 years, respectively. Since TTHQ for all ages were less than 1 (p < .05), the consumers are not exposed to the non-carcinogenic risk by the heavy metals in the bottled water.