Reinforced concrete (RC) moment-resistant frame structures are very commonly used worldwide. However, previous earthquakes have revealed the occurrence of strong beam–weak column (SBWC) failure, causing heavy human casualties and economic losses. This study analyzed the SBWC failure mechanism in RC frame structures with the pseudoclassic construction named "Que Ti" near the top of a slope topography, based on the author's recent investigation of the Ms 6.8 Luding earthquake in China. Eight refined finite element models (FEMs) were developed to simulate and analyze the influence of slope topography, pseudoclassic construction, and some structural characteristics on structural damage during an earthquake. Furthermore, discussions on using column-to-beam flexural strength ratios (CBFSRs) to mitigate SBWC failure are presented. The results demonstrated the proposed FEMs effectively simulated the performance of the pseudoclassic structure, especially the SBWC failure mode, as validated by their consistency with the observed structural damage during the earthquake. Moreover, it revealed that structures closer to the slope top experienced amplified ground motions during earthquakes, resulting in more severe damage. In addition, the Que Ti and infill walls increased the vulnerability to column damage and maximum requirement for the column shear force. Finally, to achieve the design objective of a strong column–weak beam (SCWB), the CBFSR should be at least increased to 1.8 for this pseudoclassic RC frame. This ensures a probability of the SBWC failure mode of less than 17% (meet less than 20% of recommendations) and proportion of the beam plastic energy dissipation exceeding 80% of the total plastic energy dissipation. The findings of this study are significant for enhancing seismic design and preventing earthquake disasters for the pseudoclassic structure.