Predicting the International Roughness Index (IRI) is crucial for maintaining road quality and ensuring the safety and comfort of road users. Accurate IRI predictions help in the timely identification of road sections that require maintenance, thus preventing further deterioration and reducing overall maintenance costs. This study aims to develop robust predictive models for the IRI using advanced machine learning techniques across different climatic conditions. Data were sourced from the Ministry of Energy and Infrastructure in the UAE for localized conditions coupled with the Long-Term Pavement Performance (LTPP) database for comparison and validation purposes. This study evaluates several machine learning models, including regression trees, support vector machines (SVMs), ensemble trees, Gaussian process regression (GPR), artificial neural networks (ANNs), and kernel-based methods. Among the models tested, GPR, particularly with rational quadratic specifications, consistently demonstrated superior performance with the lowest Root Mean Square Error (RMSE) and highest R-squared values across all datasets. Sensitivity analysis identified age, total pavement thickness, precipitation, temperature, and Annual Average Daily Truck Traffic (AADTT) as key factors influencing the IRI. The results indicate that pavement age and higher traffic loads significantly increase roughness, while thicker pavements contribute to smoother surfaces. Climatic factors such as temperature and precipitation showed varying impacts depending on the regional conditions. The developed models provide a powerful tool for predicting pavement roughness, enabling more accurate maintenance planning and resource allocation. The findings highlight the necessity of tailoring pavement management practices to specific environmental and traffic conditions to enhance road quality and longevity. This research offers a comprehensive framework for understanding and predicting pavement performance, with implications for infrastructure management both locally and worldwide.