Total Number Of Positive Responses Research Articles

How Social Networks Influence Human Behavior: An Integrated Latent Space Approach for Differential Social Influence.

How social networks influence human behavior has been an interesting topic in applied research. Existing methods often utilized scale-level behavioral data (e.g., total number of positive responses) to estimate the influence of a social network on human behavior. This study proposes a novel approach to studying social influence that utilizes item-level behavioral measures. Under the latent space modeling framework, we integrate the two latent spaces for respondents' social network data and item-level behavior measures into a single space we call 'interaction map'. The interaction map visualizes the association between the latent homophily among respondents and their item-level behaviors, revealing differential social influence effects across item-level behaviors. We also measure overall social influence by assessing the impact of the interaction map. We evaluate the properties of the proposed approach via extensive simulation studies and demonstrate the proposed approach with a real data in the context of studying how students' friendship network influences their participation in school activities.

The Interaction of Dynamic Cerebral Autoregulation and Neurovascular Coupling in Cognitive Impairment.

Dynamic cerebral autoregulation (dCA) remains intact in both ageing and dementia, but studies of neurovascular coupling (NVC) have produced mixed findings. We investigated the effects of task-activation on dCA in healthy older adults (HOA), and patients with mild cognitive impairment (MCI) and Alzheimer's Disease (AD). Resting and task-activated data from thirty HOA, twenty-two MCI, and thirty-four AD were extracted from a database. The autoregulation index (ARI) was determined at rest and during five cognitive tasks from transfer function analysis. NVC responses were present where group-specific thresholds of cross-correlation peak function and variance ratio were exceeded. Cumulative response rate (CRR) was the total number of positive responses across five tasks and two hemispheres. ARI differed between groups in dominant (p=0.012) and non-dominant (p=0.042) hemispheres at rest but not during task-activation (p=0.33). ARI decreased during language and memory tasks in HOA (p=0.002) but not in MCI or AD (p=0.40). There was a significant positive correlation between baseline ARI and CRR in all groups (r=0.26, p=0.018), but not within sub-groups. dCA efficiency was reduced in task-activation in healthy but not cognitively impaired participants. These results indicate differences in neurovascular processing in healthy older adults relative to cognitively impaired individuals.

Measuring Implementation of Antibiotic Stewardship in Critical Access Hospitals Using the NHSN Annual Facility Survey

Background: Critical access hospitals (CAHs) serving rural communities have numerous limitations regarding resources, infrastructure, and staffing to support antibiotic stewardship programs (ASPs) and related quality improvement activities. The Federal Office of Rural Health Policy (FORHP) established the Medicare Beneficiary Quality Improvement Project (MBQIP) to provide CAHs with specialized technical assistance in quality improvement data collection and reporting to drive improvements in the quality of care and to reduce barriers to establishing ASPs. In 2016, FORHP developed an antibiotic stewardship process measure in partnership with the CDC to assess progress on implementing ASPs and to optimize hospital quality improvement practices related to antibiotic use. This is the first measure to be successfully implemented and reported at a national level to improve the judicious use of antibiotics in hospitals. Methods: A process measure was developed to assess adherence to the 7 core elements of a successful hospital ASP (ie, leadership, accountability, drug expertise, action, tracking, reporting, and education), as defined by CDC guidelines. Implementation was accomplished through CAH participation in the NHSN Annual Facility Survey (AFS). Responses were analyzed to assess fidelity to each core element, to identify trends, and to benchmark measure reporting among 1,350 CAHs across the United States. Responses were mapped to 7 core element categories, and the total number of positive responses were matched to each core element for a specific survey year to track progress. Overall, the measure assessed progress in meeting all 7 core elements, as well as program robustness in the number of actions implemented and the amount of data tracked and reported at each hospital. NHSN reports were generated to tailor technical assistance activities and to assist hospitals with measure uptake and reporting. Results: CAH participation in the NHSN significantly increased from 2014 to 2018 (83% response rate). From 2014 through 2018, reporting of the new antibiotic stewardship measure consistently increased. CAHs that met all core elements increased from 18% (2014) to 73% (2018). Performance-based benchmarks enabled hospital comparisons and the establishment of reporting goals. Conclusions: This study highlights viable approaches to measuring antibiotic stewardship at a national level to drive improvements in care at hospitals of any size. The implementation of the antibiotic stewardship measure across CAHs demonstrates the impact of federal programs like MBQIP for hospitals that are building capacity for quality improvement. For the first time, CAHs were able to measure and compare their implementation of ASPs to other hospitals at the state and national level.Funding: NoneDisclosures: None

Increasing Chocolate's Sugar Content Enhances Its Psychoactive Effects and Intake.

Chocolate elicits unique brain activity compared to other foods, activating similar brain regions and neurobiological substrates with potentially similar psychoactive effects as substances of abuse. We sought to determine the relationship between chocolate with varying combinations of its main constituents (sugar, cocoa, and fat) and its psychoactive effects. Participants consumed 5 g of a commercially available chocolate with increasing amounts of sugar (90% cocoa, 85% cocoa, 70% cocoa, and milk chocolates). After each chocolate sample, participants completed the Psychoactive Effects Questionnaire (PEQ). The PEQ consists of questions taken from the Morphine-Benzedrine Group (MBG), Morphine (M,) and Excitement (E) subscales of the Addiction Research Center Inventory. After all testing procedures, participants completed the Binge Eating Scale (BES) while left alone and allowed to eat as much as they wanted of each of the different chocolates. We found a measurable psychoactive dose–effect relationship with each incremental increase in the chocolate’s sugar content. The total number of positive responses and the number of positive responses on the E subscale began increasing after tasting the 90% cocoa chocolate, whereas the number of positive responses on the MBG and M subscales began increasing after tasting the 85% cocoa chocolate sample. We did not find a correlation between BES scores and the total amount of chocolate consumed or self-reported scores on the PEQ. These results suggest that each incremental increase in chocolate’s sugar content enhances its psychoactive effects. These results extend our understanding of chocolate’s appeal and unique ability to prompt an addictive-like eating response.

Advanced neuroimaging in the clinic: critical appraisal of the evidence base.

The shortage of high-quality systematic reviews in the field of radiology limits evidence-based integration of imaging methods into clinical practice and may perpetuate misconceptions regarding the efficacy and appropriateness of imaging techniques for specific applications. Diffusion tensor imaging for patients with mild traumatic brain injury (DTI-mTBI) and dynamic susceptibility contrast MRI for patients with glioma (DSC-glioma) are applications of quantitative neuroimaging, which similarly detect manifestations of disease where conventional neuroimaging techniques cannot. We performed a critical appraisal of reviews, based on the current evidence-based medicine methodology, addressing the ability of DTI-mTBI and DSC-glioma to (a) detect brain abnormalities and/or (b) predict clinical outcomes. 23 reviews of DTI-mTBI and 26 reviews of DSC-glioma met criteria for inclusion. All reviews addressed detection of brain abnormalities, whereas 12 DTI-mTBI reviews and 22 DSC-glioma reviews addressed prediction of a clinical outcome. All reviews were assessed using a critical appraisal worksheet consisting of 19 yes/no questions. Reviews were graded according to the total number of positive responses and the 2011 Oxford Centre for evidence-based medicine levels of evidence criteria. Reviews addressing DTI-mTBI detection had moderate quality, while those addressing DSC-glioma were of low quality. Reviews addressing prediction of outcomes for both applications were of low quality. Five DTI-mTBI reviews, but only one review of DSC-glioma met criteria for classification as a meta-analysis/systematic/quantitative review.

Survivors of a Kamikaze Attack: PTSD and Perceived Adjustment to Civilian Life

30 survivors of the U.S.S. Emmons (M age = 81.3 yr., SD = 2.3), which was sunk by kamikaze attacks during World War II, were given an adapted form of the Posttraumatic Stress Disorder Checklist-Civilian and a set of questions regarding the effects of their World War II experiences on seven clusters of 42 interpersonal and personal characteristics (Adjustment Characteristics). Participants were categorized into two groups, those who served on the Emmons at any given time during World War II (Any Service), and those who were serving on the Emmons when it was sunk during the battle for Okinawa (Okinawa). Analyses using Mann-Whitney U tests indicated that the Okinawa group reported higher checklist scores, but the scores were unrelated to 41 of the 42 Adjustment Characteristics. Also, Spearman rank-order correlations were statistically insignificant for all comparisons between checklist scores and Adjustment Characteristic clusters, and the total number of positive responses to the 42 characteristics. In contrast, Mann-Whitney U and chi square analyses comparing the Any Service and Okinawa groups indicated statistically significant differences for 14 Adjustment Characteristics, 4 clusters of those characteristics, and the total number of positive responses: The Okinawa group reported poorer outcomes in each comparison. Many of these differences were among Adjustment Characteristics evocative of the attributes of Lee's Agape love style. The findings suggest that for the survivors of the Emmons, the presence or absence of a traumatic event was a better predictor of adjustment to civilian life than the reported severity of PTSD symptoms.

The yield of head-up tilt testing is not significantly increased by repeating the baseline test.

Head-up tilt is widely used in evaluating patients with syncope. Data suggest that baseline tilt without isoproterenol is associated with few (< or = 10%) positive results in normals. However, there is considerable day-to-day variability in patients with syncope, resulting in low reproducibility. We hypothesized that repeating the baseline tilt would increase the total number of positive responses. In all, 193 patients with syncope of unknown etiology prospectively underwent serial baseline tilt (Tilt-1 and Tilt-2) at 70 degrees for 25 min on two consecutive days. Of 193 patients, 39 (20%) had a positive Tilt-1. Of these, 19 had a positive Tilt-2, (positive concordance rate: 19/39 = 49%). Of 154 patients with a negative Tilt-1, 145 had a negative Tilt-2 (negative concordance rate: 142/151 = 94%). Only 9 of 154 patients (6%) with a negative Tilt-1 had a positive Tilt-2. Thus, the yield increased from 20% (39/193) after Tilt-1, and to 25% (48/193) after Tilt-1 plus Tilt-2, p = NS. (1) Reproducibility of a positive Tilt-1 is moderate. (2) Reproducibility of a negative Tilt-1 is high. (3) Repetition of tilt in patients with a negative Tilt-1 does not significantly increase the number of positive results.

Mutagenic activity detected by the Ames test in river water under the influence of petrochemical industries

The present study was carried out on the waters of the Caí River (Rio Grande do Sul, Brazil) in an area under the influence of a petrochemical industrial complex, as the continuation of a study in which the mutagenic activity of water samples was evaluated in the internal area of this complex. In the previous study, the release of inducing substances was detected, revealing the need for a full analysis of the real ecological impact of the industrial complex on the river. Water samples from different sites along the Caí River were subjected to the Ames test during a study of 20 months duration for the detection of possible mutagens. Strains TA100 and TA98 were used for initial sample screening in the presence and absence of the S9 mix at a standard dose of 2000 μl/plate. When positive activity (values equal to twice the spontaneous mutation rate) and/or cytotoxic activity (cell survival below 60%) was detected, the dose-response relationship was studied. Thirty-four percent of the samples tested were mutagenic, with different values according to collection site. Of the total number of positive responses, 6% were obtained for samples collected at the blank site upstream from the area studied, 82% at sites closest to the industrial complex, and 12% in downstream areas. Strain TA98 was the most sensitive in assays with no metabolic activation. A low frequency of induction (2%) was observed for strain TA102. Application of the Ames test permitted the delimitation of three areas of influence of the petrochemical industrial complex, and the test proved to be adequate for the detection of contaminants from the petrochemical industry.

Development and construct validity of a knee pain questionnaire

A knee pain questionnaire, consisting of 15 dichotomous items, was submitted to an item analysis, based on the probabilistic model of Rasch. Five items had to be discarded but the remaining 10 constituted a homogeneous set, fit to be used as a scale. In particular, this meant that the total number of positive responses to the questionnaire could be used as a simple measure of the patients' knee pain. Further studies must be performed in order to analyze the reliability and empirical validity of the scale.

Criteria for acceptable levels of the Shinkansen Super Express train noise and vibration in residential areas

A survey of 1187 housewives living in 18 areas along the Shinkansen Super Express (bullet train) railway was conducted by means of a self-administered health questionnaire (modified Cornell Medical Index). In addition, geographically corresponding measurements of noise level and vibration intensity were taken. The relationship of noise and vibration to positive responses (health complaints) related to bodily symptoms, illness and emotional disturbances was analyzed. The factors which correlated with an increase in the average number of positive responses included noise, vibration, age and health status. Such factors as marital status, educational level, part time work, duration of inhabitancy and occupation of the head of the houshold correlated poorly with the number of positive responses. Unhealthy respondents compared to healthy respondents are more frequently affected by noise and vibration. The rate of positive responses in the visual, respiratory, cardiovascular, digestive and nervous systems, sleep disturbances and emotional disturbances increased accordingly as noise and vibration increased. Combined effects of noise and vibration stimuli on the total number of positive responses (an indicator of general health) were found. This study has produced results indicating that the maximum permissible noise level should not exceed 70 dB(A) in the residential areas along the Shinkansen railway.

The lateral tongue reflex in human neonates.

We undertook an investigation of the lateral tongue reflex to determine whether reflex sensitivity was systematically related to selected perinatal factors. The subjects were 24 male and 27 female newborns with a mean age of 28.9 hr. (SD = 16.8, range 5--72 hr.). The lateral tongue reflex was elicited by applying tactile stimulation of varying intensity to the lateral edge of the tongue approximately 1 cm off midline. Eight different stimuli from the Semmes-Weinstein esthesiometer were used; forces ranged from 68 mg to 3.6 gm. A total of 32 stimulations were given in two repetitions of 16 each (8 on the right side and 8 on the left side). The mean number of positive responses was 19.9 (SD = 3.2, range 13--25), with a 5% response at the lowest level of stimulation and a 100% response at the highest level. There were not differences in total number of positive responses or thresholds on the right and left sides, or in Repetitions I and II. There were no differences between males and females, vaginally and caesarian delivered infants, or resuscitated and non-resuscitated infants. No systematic differences were observed as a function of length of labor, obstetric medications, postnatal age at time of testing, Apgar scores, birth weight, or gestational age. The results suggest that the lateral tongue reflex is a stable and reproducible response that could be used to measure oral sensation, both in normal neonates and in subjects with various anatomical and/or neurosensory deficits.