Ratio Of Total Area Research Articles

Improved algorithm for fracture-dissolution pore detection in resistivity imaging logging based on dung beetle optimization

Abstract Resistivity imaging logging has become a direct and precise method for visualizing the structural complexities of reservoir fractures and dissolution pores. The current use of Otsu's thresholding for segmentation results in poor segmentation quality and significant noise. Accurate segmentation of sub-images containing fracture and dissolution pore targets is essential for automated structure identification and subsequent parameter calculation. This study leverages the rapid convergence and robust global optimization capabilities of the Dung Beetle Optimizer to develop enhanced image segmentation approaches. Specifically, it introduces a refined K-Means algorithm for multi-category image segmentation and an Otsu algorithm for multi-threshold image segmentation, both optimized by the Dung Beetle Optimizer. Compared to conventional binary segmentation algorithms, this new algorithm effectively isolates noise and extracts multi-category information. Using the segmented sub-images, this paper integrates mathematical morphology techniques to compute parameters such as area, perimeter, tortuosity length, and pore shape factor for identified targets. Additionally, Principal Component Analysis is used to derive recognition factors for fractures and dissolution pores. Applications show that this factor can identify matrix, fracture, and dissolution pore targets in complex background images. By combining parameter information of the target area, the method effectively removes false information in resistivity imaging and segments sub-images of fractures and dissolution pores, calculating fracture area ratio, dissolution pore area ratio, and total area ratio.

Data-driven analysis of heating and cooling base temperatures for buildings: Case studies in South Korea

To investigate statistical differences in the heating (Tbh) and cooling base temperatures (Tbc) across various building types, vintages, and sizes, we conducted case studies in Seoul, South Korea, based on data from more than 10,000 buildings. To assess the relative impacts of internal and external loads on Tbh and Tbc, we used a core-to-perimeter zone ratio approximated by the average floor area, defined as the floor area per building floor. Employing the energy signature method, change-point regression, and calendarization, we determined the best-fit change-point model and the corresponding Tbh and Tbc for each building. Our findings revealed statistically significant differences in Tbhs and Tbcs, with variations of up to 6 and 4 °C, respectively, across six building types. Notably, for most building types, Tbh and Tbc decreased as the average floor area increased, possibly influenced by a higher core zone to total area ratio. This highlights the predominant impact of internal loads over external loads. The influence of the average floor area on Tbh and Tbc outweighed that of building vintage, particularly for lodging, medical, and sales facilities, where Tbh and Tbc decreased in the more recent vintage buildings. However, this influence was less pronounced for facilities for senior citizens and children and education and research facilities, possibly due to factors such as diverse building shapes and the thermal preferences of occupants. Although this study focuses on South Korea, our data-driven approach provides statistical evidence for refining base temperature and improving traditional degree-day methods. Our findings suggest the need to establish base temperatures that consider various building types, vintages, and average floor areas, especially for large metropolitan cities where these factors vary widely.

Biphilic Functional Surfaces for Frost Prevention and Efficient Active Defrosting

AbstractThe present work addresses the systematic accurate fabrication and design of biphilic surfaces having superhydrophobic circular islands surrounded by a hydrophilic background by investigating their condensation frosting and defrosting behavior. A significant delay in frost formation is observed on samples with higher superhydrophobicity ratio A*, defined as superhydrophobic area to total area ratio. As the superhydrophobic island diameter D increases from D = 500 µm to D = 700 µm (A* from 19.62% to 38.46%), a 50% improvement/delay is observed in terms of frost formation or densification. Besides delaying icing/frosting, the presence of superhydrophobic areas empowers the formation of porous and nonuniform frost structure, which facilitates ice removal during the defrosting process. To this end, as the surface is recovered the ambient temperature, almost complete passive cleaning performance within only 23 s is observed on the biphilic design having superhydrophobic islands with the diameter of D = 500 µm, that is, a superhydrophobicity ratio A* of 19.62%. This work concludes on the optimum biphilic ratio, which is not only effective as a passive method by hindering frosting but also leads to a slush/water free surface after defrosting eased by the Laplace pressure gradient which is imposed by the different biphilic wettability patterns.

Clinical, imaging and histopathological characterization of a series of three cats with cerebellar cortical degeneration

BackgroundNeurological inherited disorders are rare in domestic animals. Cerebellar cortical degeneration remains amongst the most common of these disorders. The condition is defined as the premature loss of fully differentiated cerebellar components due to genetic or metabolic defects. It has been studied in dogs and cats, and various genetic defects and diagnostic tests (including magnetic resonance imaging (MRI)) have been refined in these species. Cases in cats remain rare and mostly individual, and few diagnostic criteria, other than post-mortem exam, have been evaluated in reports with multiple cases. Here, we report three feline cases of cerebellar cortical degeneration with detailed clinical, diagnostic imaging and post-mortem findings.Case presentationThe three cases were directly (siblings, case #1 and #2) or indirectly related (same farm, case #3) and showed early-onset of the disease, with clinical signs including cerebellar ataxia and tremors. Brain MRI was highly suggestive of cerebellar cortical degeneration on all three cases. The relative cerebrospinal fluid (CSF) space, relative cerebellum size, brainstem: cerebellum area ratio, and cerebellum: total brain area ratio, were measured and compared to a control group of cats and reference cut-offs for dogs in the literature. For the relative cerebellum size and cerebellum: total brain area ratio, all affected cases had a lower value than the control group. For the relative CSF space and brainstem: cerebellum area ratio, the more affected cases (#2 and #3) had higher values than the control group, while the least affected case (#3) had values within the ranges of the control group, but a progression was visible over time. Post-mortem examination confirmed the diagnosis of cerebellar cortical degeneration, with marked to complete loss of Purkinje cells and associated granular layer depletion and proliferation of Bergmann glia. One case also had Wallerian-like degeneration in the spinal cord, suggestive of spinocerebellar degeneration.ConclusionOur report further supports a potential genetic component for the disease in cats. For the MRI examination, the relative cerebellum size and cerebellum: total brain area ratio seem promising, but further studies are needed to establish specific feline cut-offs. Post-mortem evaluation of the cerebellum remains the gold standard for the final diagnosis.

Sitting Pressure Measurements in Wheelchair Users-Can the Effects of Daily Relief Activities Be Depicted?

Seat pressure measurements in wheelchair users have been available for some time; however, repeated measurements from a commercially available pressure mat over 90 min did not differ in the pressure-loaded measurement area or the coordinates of the center of pressure, even in participants who were able to reposition themselves in the wheelchair. The question therefore arises: to what extent are there other parameters that reflect the activity of wheelchair users with the pressure mat? To investigate this, a commercial pressure mat (BodiTrak®) was used to perform the measurements of pressure of 33 adult wheelchair-dependent people with spinal cord injury after 30 and 90 min sitting on the cushion. In addition to the standard output of the pressure mat, graph-based surface analyses (calculation of the area of maximum pressure, calculation of the pressure-loaded measurement area, and pressure-area ratio) was performed retrospectively using Python 3.7. The analysis of the measurements after 30 and 90 min was performed by distinguishing the participants between those who could actively change their position (N = 24) and those who could not (N = 9). The parameters of the pressure mat and the graph-based analyses remained unchanged for active participants. In participants who were unable to actively change their position, the area of maximum pressure and the pressure-area ratio (ratio of maximum pressure area and total pressure-loaded area) increased. Significant differences between minutes 30 and 90 are only found for the pressure-area ratio. Thus, when measuring the seat pressure of wheelchair users, the pressure-area ratio should be taken into account as it reflects the daily relief activities of wheelchair users.

Estimation of canopy photon recollision probability from airborne laser scanning

The past two decades have witnessed the widespread application of the spectral invariant theory (p-theory) in modeling the shortwave radiation absorbed or scattered by vegetation. The basic principle of this theory is that the canopy reflectance is solely determined by the optical properties of leaves and the photon recollision probability p. As one of the spectral invariants, p serves as a critical bond between the spectral characteristics of the canopy at any wavelength and the reflectance, transmittance, or absorptance of the vegetation canopy, and is intimately associated with the solution of the radiative transfer equation. Currently, estimation of p-value is predominantly accomplished through canopy structural parameters, such as the spherically averaged silhouette to total area ratio (STAR¯) or Leaf Area Index (LAI). In this work, we provide an approach to estimate canopy photon recollision probability directly from Airborne Laser Scanning (ALS) data. We showed that the recollision probability can be interpreted as the interceptions of virtual rays emitted from sampling points within tree crowns described with turbid media, which avoided detailed reconstruction of leaf structures. The approach was evaluated with both virtual experiments as well as field measurements. The virtual experiments employed the Large-scalE remote Sensing data and image Simulation model (LESS) to simulate virtual ALS scanning data based on three RAdiation transfer Model Intercomparison (RAMI) actual canopies, with each divided into 25 segments, for which the p-values could be obtained through LESS. Our findings showed that p-values can be accurately estimated from ALS point clouds. Specifically, it exhibited great consistency with RMSE% less than 5% for broadleaved forest scenes, 25% for mixed forest scenes, and less than 10% for coniferous forest scenes in virtual experiments, respectively, and less than 25% compared to field measurements. This study displays the potential of ALS as a promising tool for forest structure characterization and short-wave radiation modeling in forest ecosystems.

Detection of milk adulteration using coffee ring effect and convolutional neural network

A low-cost and effective method is reported to identify water and synthetic milk adulteration of cow’s milk using coffee ring patterns. The cow’s milk samples were diluted with tap water (TW), distilled water (DW) and mineral water (MW) and drop cast onto glass slides to observe coffee ring patterns. The area of the ring, total particle area and average particle diameter were extracted from these patterns. For each ring, the ratio of total particle area versus total ring area was calculated. The area ratio, regardless of water adulterants, follows an exponential model with respect to average particle diameter. Unlike TW, the ratio for DW and MW adulterated milk are clustered and classified together with respect to the particle diameter. These results were independent of dilution level and are used for adulterant classification. The ring of milk adulterated using synthetic milk gave multiple concentric rings, flower-like structures, and oil globules throughout the dilution level. An Alexnet model was used to classify water and synthetic milk adulterants in authentic milk. The trained model could achieve 96.7% and 95.8% accuracy for binary and tertiary classification respectively. These results enable us to distinguish synthetic milk from pure milk and segregate DW and MW with respect to TW adulterated milk.

Investigation of the effects of cilostazol on the myocardial ischemia-reperfusion injury of rats.

<b><i>Background</i></b>. Myocardial ischemia, occurring as a consequence of imbalance between oxygen supply and demand, causes a rapid metabolic and structural<br /> impairment within the tissue. After a period of ischemia, sudden onset of reperfusion causes a transition to aerobic metabolism within living cells. Afterwards, emerging substrates initiate a chain of reactions leading to tissue injury. This situation is called “ischemia reperfusion injury”. Despite all technical advancements in anesthesia, myocardial protection and cardiac surgical techniques, we still face the clinical reflections of ischemia reperfusion (IR) injury.<br /> <b><i>Materials and methods</i></b>. The protective effect of cilostasole on IR injury in an animal model of experimental myocardial ischemia and reperfusion was investigated. In this regional myocardial ischemia model, male Wistar-Albino rats were used as subjects and they were allocated into three groups; ischemia (n=8), sham (n=8), and cilostazole (n=8). LAD was occluded for 45 minutes, and then reperfused for three hours. Rats received Cilostazole 20 mg/kg/d by gastric gavage once daily. During IR hemodynamic parameters were recorded. Serum analysis for CK-MB and Troponin T were analysed at 180th minute of ischemia. Ischemic zone was measured by dying with Evans Blue and infarct area was measured by dying with triphenyltetrazolium chloride.<br /> <b><i>Results.</i></b> Before the onset of LAD occlusion, as well as at 25th, 60th and 120th minutes of occlusion, all groups were similar in terms of blood pressure and pulse rate.<br /> The total area, affected area and necrotic area were calculated by using formulas; affected area ratio= affected area/total area X 100, necrotic area ratio = necrotic area/total affected area X 100, necrotic area and affected area ratio = necrotic area /affected area X 100.  Affected area and total area ratio was significantly higher in IR group, compared with cilostazole group (t=8.965; p<0.001). Similarly, necrotic area and total area ratio was higher in IR group, compared with cilostazole group (t=8.965; p<0.001). The necrotic area and affected area ratios were similar in IR and cilostazole groups (t=0.245; p=0.810). CK-MB level differences were not statistically significant between two groups (Z=0.382; p=0.721).<br /> Troponin levels were similar between IR and cilostazole groups and the difference was not statistically significant (Z=0.630; p=0.574). Pathological specimens of the heart were scanned for myocytolysis, PMNL and hemorrhage.  The difference between mean value of MDA enzyme levels were statistically significant (p<0.001) between all groups.  MDA enzyme levels, from higher to lower was IR, cilostazole and Sham group.  SOD levels (F=5.910; p=0.009) were significantly lower in Sham group when compared with IR group (p=0.008). The differences between Sham and cilostazole groups and IR and cilostazole gropus were not statistically significant (p=0.008). According to planimetric values and enzyme levels, cilostazole was found to be effective in reducing the ischemic zone, without effecting the necrotic zone in cardiac ischemia reperfusion damage. Therefore cilostazole has protective effects agains ischemia reperfusion damage.<br /> <br /> <b>Conclusion</b>. This study explored how cilostazol affects myocardial ischemia-reperfusion injury in rats, finding that cilostazol administration during reperfusion may protect against such injury. Through various analyses, we observed positive outcomes associated with cilostazol treatment, suggesting its potential in reducing myocardial damage. Further research is needed to understand the underlying mechanisms and optimize therapeutic strategies, but our findings highlight cilostazol's promise in improving clinical outcomes in cardiac interventions.

Abstract P187: Associations of Body Composition, Inflammation, and Lipids: The Multi-Ethnic Study of Atherosclerosis

Background: Prior evidence has linked inflammation with myopenic obesity (MO), a high cardiometabolic risk body composition phenotype characterized by low muscle and high fat mass. Inflammation may also alter lipid metabolism. This study aimed to examine the association between MO and lipids and whether inflammation is one potential mediator of their complex relationship. Methods: We conducted a cross-sectional analysis of 1,421 Multi-Ethnic Study of Atherosclerosis participants with abdominal computed tomography body composition, lipid, and inflammatory marker measurements. The ratio of total skeletal muscle area to total adipose tissue area (SM/AT) at L3-4 was used to identify MO (lowest sex-stratified tertiles of <0.52 in men and <0.44 in women). Principal component analysis was used to reduce six inflammatory markers by patterns of covariation. Parallel mediation analysis was conducted to examine whether the inflammatory components mediated the relationship between SM/AT and lipids, acknowledging the limitations of cross-sectional data. Results: The sample’s mean age was 64±10 years, 52.4% were female, and 42.1% were Caucasian. Participants with MO (n=474), compared to those without (n=947), had lower high-density lipoprotein cholesterol (HDL-C; 49±13 vs. 54±16, p<0.001), higher remnant cholesterol (RC; 28±13 vs. 24±13, p<0.001), and similar low-density lipoprotein cholesterol (LDL-C; 110±32 vs. 113±30, p=0.073). All inflammatory markers were higher in MO (p≤0.002). Parallel mediation analysis showed significant direct effects between SM/AT and both HDL-C and RC, which were mediated by component 1 but not component 2. There was no significant direct or indirect effect between SM/AT and LDL-C (Table 1). Conclusion: Participants with MO exhibited elevated levels of inflammation and unfavorable lipid profiles. Two inflammatory components were identified, one of which (IL-6, CRP, fibrinogen, and leptin) partially mediated the relationship of SM/AT with HDL-C and RC.

Vascular changes of the choroid and their correlations with visual acuity in diabetic retinopathy.

To investigate changes in the choroidal vasculature and their correlations with visual acuity in diabetic retinopathy (DR). The cohort was composed of 225 eyes from 225 subjects, including 60 eyes from 60 subjects with healthy control, 55 eyes from 55 subjects without DR, 46 eyes from 46 subjects with nonproliferative diabetic retinopathy (NPDR), 21 eyes from 21 subjects with proliferative diabetic retinopathy (PDR), and 43 eyes from 43 subjects with clinically significant macular edema (CSME). Swept-source optical coherence tomography (SS-OCT) was used to image the eyes with a 12-mm radial line scan protocol. The parameters for 6-mm diameters of region centered on the macular fovea were analyzed. Initially, a custom deep learning algorithm based on a modified residual U-Net architecture was utilized for choroidal boundary segmentation. Subsequently, the SS-OCT image was binarized and the Niblack-based automatic local threshold algorithm was employed to calibrate subfoveal choroidal thickness (SFCT), luminal area (LA), and stromal area (SA) by determining the distance between the two boundaries. Finally, the ratio of LA and total choroidal area (SA + LA) was defined as the choroidal vascularity index (CVI). The choroidal parameters in five groups were compared, and correlations of the choroidal parameters with age, gender, duration of diabetes mellitus (DM), glycated hemoglobin (HbA1c), fasting blood sugar, SFCT and best-corrected visual acuity (BCVA) were analyzed. The CVI, SFCT, LA, and SA values of patients with DR were found to be significantly lower compared to both healthy patients and patients without DR (P< 0.05). The SFCT was significantly higher in NPDR group compared to the No DR group (P < 0.001). Additionally, the SFCT was lower in the PDR group compared to the NPDR group (P = 0.014). Furthermore, there was a gradual decrease in CVI with progression of diabetic retinopathy, reaching its lowest value in the PDR group. However, the CVI of the CSME group exhibited a marginally closer proximity to that of the NPDR group. The multivariate regression analysis revealed a positive correlation between CVI and the duration of DM as well as LA (P < 0.05). The results of both univariate and multivariate regression analyses demonstrated a significant positive correlation between CVI and BCVA (P = 0.003). Choroidal vascular alterations, especially decreased CVI, occurred in patients with DR. The CVI decreased with duration of DM and was correlated with visual impairment, indicating that the CVI might be a reliable imaging biomarker to monitor the progression of DR.

The area ratio of Modic changes has predictive value for postoperative surgical site infection in lumbar spine surgery: a retrospective study

BackgroundIncreasing evidence suggests an association between Modic changes (MC) and subclinical infection and inflammatory reactions. However, the relationship between preoperative MC and surgical site infection (SSI) has not been fully explored. This study aims to investigate the correlation between MC and SSI.MethodsA retrospective analysis was conducted on patients (n = 646) who underwent single-level lumbar spine surgery for lower back pain in our hospital between 2018 and 2023. According to the Centers for Disease Control and Prevention (CDC) criteria, the patients were divided into an SSI group (n = 40) and a Non-SSI group (n = 606). Univariate analysis was performed to determine the statistical differences in variables between the two groups, and the variables with significant differences were included in a multivariable logistic regression analysis to identify independent risk factors for SSI. Receiver operating characteristic (ROC) curve analysis was performed on the independent risk factors.ResultsThe SSI group and the Non-SSI group exhibited significant differences in diabetes prevalence, MC prevalence, Total endplate score (TEPS) and area ratio of MC (P < 0.05). Age, gender, American Society of Anesthesiologists(ASA)score, hypertension, coronary heart disease (CHD), chronic obstructive pulmonary disease (COPD), MC classification, and the location of MC in the endplate showed no significant differences (P > 0.05). Multivariate binary logistic regression analysis was performed on the variables with significant differences, and the results indicated a significant correlation between TEPS (P = 0.009) and the area ratio of MC changes (P = 0.001) with SSI. ROC curve analysis was performed on the TEPS and area ratio of MC changes, and the results showed that the diagnostic value of TEPS (AUC: 0.641; CI: 0.522–0.759) is lower than the area ratio of MC (AUC: 0.722; CI: 0.621–0.824), and the combined diagnosis did not significantly improve the diagnostic value (AUC: 0.747; CI: 0.653–0.842). The area ratio of MC had moderate diagnostic value for SSI (AUC: 0.722; CI: 0.621–0.824), with a cut-off value of 24.62% determined by the Youden index (sensitivity: 69.2%; specificity: 73.1%), and for every 1% increase in the area ratio of MC changes, the risk of SSI in MC patients increased by 10.3% (OR = 1.103; CI: 1.044–1.167).ConclusionThe area ratio MC and the TEPS are independent risk factors for SSI after lumbar spine surgery. The predictive value of the area ratio of MC is greater than TEPS, and when the two are combined, the predictive value is not significantly improved. When the rate of MC exceeds 24.62%, caution should be exercised regarding the occurrence of SSI.

Histological outcome evaluation of selected brain preparation protocols for white fiber dissection.

White fiber dissection is essential for studying brain connections. However, preparation protocols have not been validated. We microstructurally analyzed Klingler's brain preparation method and freezing process and assessed changes under two protocols:freeze-only and freeze-thaw. The microstructure changes of these protocols were evaluated by measuring the ratio of the total gap area to the white matter area and determining the mean eccentricity value to assess the degree of anisotropy. Sixty hemispheres were allocated to ten different freezing protocols. In the freeze-only protocols, the total gap area ratio was significantly higher compared to that of specimens fixed with only formaldehyde, particularly after continuous freezing for 3-4 weeks;however, the difference in eccentricity was not significant. In the freeze-thaw protocols, both the area ratio and eccentricity were significantly higher compared to the freeze-only. The optimum degree of fiber separation in the freeze-thaw protocols reached its peak with four cycles of 1-week freezing periods interrupted by six hours of thawing. The Klingler method assists in the separation of the white fibers through the gaps formed by ice crystals, but an appropriate degree of anisotropy is reached when the freezing protocol is interrupted by at least four thawing cycles.

The detection of pomegranate (Punica granatum L.) peel apoptotic effects using AgNOR staining in MDA-MB-231.

In present study, it was purposed to determine the in vitro effect of the extract obtained from the pomegranate (Punica granatum L.) peel on the breast cancer cell line. MDA-MB-231 cells were exposed to pomegranate peel extract (PoPx) at 37°C and 5% CO2 for varying durations (24 and 48h) and doses (25 and 50μg/mL). At the end of the incubation periods, argyrophilic nucleolus organizer regions (AgNOR) protein status, cell viability/apoptosis and cell cycle of MDA-MB-231 cells were examined in the Muse Cell Analyzer device. Cell viability was observed to be decreased when the groups treated with PoPx were compared with the control group. The group in which apoptosis was observed with the highest value was 50μg/mL PoPx group (p<0.05). In the cell cycle test, the number of cells in the G0/G1 stage was found to be significantly higher in the 25μg/mL PoPx group compared to the control and 50μg/mL PoPx groups at the end of the 24-h incubation period (p<0.05) The results also supported cell cycle and apoptosis, and at the end of 24h, Total AgNOR area(TAA)/Total nuclear area (NA) ratio and AgNOR numbered decreased on the 50μg/mL PoPx group and were found to be statistically significant compared to the control group (p<0.05). Consequently, it was determined that PoPx increased apoptosis on breast cancer cells by various mechanisms and inhibited cell viability/cell growth. This study showed that the widespread consumption of PoPx may be effective in preventing cancer formation and slowing its progression.

The influence of large-diameter multifocal contact lens on ocular surface, visual quality, and visual function for presbyopic adults with dry eye syndromes

This study investigated the influence of large-diameter multifocal contact lenses on the ocular surface, visual quality, and visual function for presbyopic adults with dry eye syndromes. The study enrolled 40–55-year-old adults with presbyopia and dry eye syndromes (DES). The subjects were randomly assigned to three groups wearing different designs of contact lenses (Proclear, SMR, and Optimum) for 6–8 h a day for two weeks. Ocular surface health, tear quality, visual quality, and visual function were measured before and after lens wear. No significant difference was observed across all three groups for the amount of conjunctival redness, blink frequency (lens on), and stereopsis vision before and after wearing. Although there seemed to be a significant declining trend for corneal staining and limbal redness, non-invasive tear break-up time (TBUT), and lipid layer thickness while lens wear, the measured values were all within the normal range. Vice-versa after lens removal, results also showed significant improvement on lipid layer thickness, blink frequency (lens off), and contact TBUT. A significant improvement was observed in the modulation transfer function (MTF) of the total area ratio after wearing contact lenses. In contrast, the MTF of the high-order aberration area ratio resulting from lens wear was lower than that of the baseline measurement. There are also significant improvements observed for SMR and Optimum regarding near visual acuity, near point of accommodation, and the subjective questionnaire (OSDI and VBP) scores. Although it is difficult to avoid a specific negative impact on the ocular surface and tear film, visual function and visual quality can still be positively improved, especially shown on larger diameter and distance-center designed multifocal contact lenses.

Numerical Investigations on Enhancement of Pool Boiling Heat Transfer on a Mixed Wettability Surface Employing Lattice Boltzmann Method

Abstract In this paper, a systematic numerical study of pool boiling heat transfer on a mixed wettability heated surface is done using the lattice Boltzmann method (LBM) with a multiple relaxation time (MRT)-based collision operator. The effect of the design parameters, viz, size of the hydrophobic patch (D), spacing between hydrophobic patches (L), number of hydrophobic patches (N), and uneven-sized patches, on pool boiling was studied and results are explained through detailed analysis of bubble nucleation, growth, coalescence, and departure from the heated surface. The results show that mixed wettability surfaces with strategically sized and positioned hydrophobic patches on a hydrophilic surface can result in high heat flux for pool boiling across the entire range of surface superheat or Jacob number (Ja) by combining the advantages of hydrophobic surface in nucleate boiling and hydrophilic surface in transition and film boiling. Further, the mixed wettability surface can delay the onset of film boiling compared to a pure or superhydrophilic surface thereby resulting in higher critical heat flux (CHF). A hydrophobic to total surface area ratio of 30–40% was found to be optimal for all ranges of surface superheat or Jacob number (Ja), which agrees well with the experimental result of 38.46% reported by Motezakker et al. (2019, “Optimum Ratio of Hydrophobic to Hydrophilic Areas of Biphilic Surfaces in Thermal Fluid Systems Involving Boiling,” Int. J. Heat Mass Transfer, 135, pp. 164–174).

Migration and sedimentation of proppant and its influencing factors in a visual plate fracture model

Hydraulic fracturing technology is the main method used to form high-conductivity fracture networks in unconventional oil and gas reservoirs, and the effective filling of quartz sand proppant in the fracture network is key to its successful implementation. Conventional experiments on the evaluation of sand carrying migration are mainly based on the migration and sedimentation law of a single-mesh proppant in the main fracture; the results obtained are inconsistent with the field observations. To improve our understanding of the migration and sedimentation law of the proppant in the main and branch fractures, in this study, the influences of injection time, injection rate, fracturing fluid viscosity, and proppant combination type on the migration and sedimentation law of a proppant in single and branch fractures were analyzed based on the injection parameters of the sand-carrying fracturing fluid obtained using a similarity criterion through a visual large-scale parallel-plate fracture model system built indoors. The results showed that the rapid accumulation stage of the proppant in the fracture is during the injection time of 5–10 min; the injection rate affected the accumulation area and height of the proppant to a certain extent but had little effect on the final sand dike morphology. A low viscosity of the fracturing fluid was not conducive to the sedimentation of the proppant in the branch fractures; an excessively high fracturing fluid viscosity was not conducive to the sedimentation of the proppant in both the main and branch fractures. When the fracture morphology is single, the viscosity of the fracturing fluid is recommended to be between 30 and 60 mPa·s. When the fracture morphology is complex, the recommended value is between 40 and 50 mPa s. Taking the migration and sedimentation laws of the proppant in the main fracture as an example, the flow of fracturing fluid in the fracture after the formation of a stable sand dike could be divided into five regions: ① inlet scour zone; ② buffer zone; ③ sand dike stable transition zone; ④ sand dike stability zone; and ⑤ outlet scour zone. The higher the large mesh proppant ratio used in the fracturing fluid, the lower the total area ratio of the corresponding sand dike; however, the proppant sedimentation ratio in the branch fracture increases. This study enriches and improves the relevant theoretical research on the migration and sedimentation of proppants and has a certain effect on improving the success rate of the hydraulic fracturing technology applied to unconventional oil and gas reservoirs.

THU065 Evaluation Of Sarcopenia And Bone Health In Patients With Acromegaly

Abstract Disclosure: I. Eroglu: None. B. Gonul İremli: None. A. Erkoc: None. I. Idilman: None. D. Yuce: None. E. C. Kutukcu: None. D. Akata: None. T. Erbas: None. Background: Although many complications related to high GH exposure develop in patients with acromegaly, musculoskeletal complications are among the most important complications that reduce the quality of life of patients. However, the effects of acromegaly on muscle and bone have not been adequately researched and are still not entirely understood. We aimed to investigate muscle and bone quality in acromegalic patients in this cross-sectional, case-controlled study. Methods: The study consisted of thirty-two (15F/17M) acromegalic patients (n=15 active acromegaly - AA and n=17 controlled acromegaly - CA) and 19 healthy controls (C). Dual energy X-ray absorptiometry (DXA) was used to determine body composition, appendicular skeletal muscle mass (ASM), relative skeletal muscle index (RSMI), and bone mineral density (BMD). The handgrip strength (HGS) and quadriceps muscle strength were measured by hand dynamometer. Magnetic resonans imaging at the L3 level was used to measure total abdominal muscle area (TAMA, cm2) and vertebral fat ratio (VFR). HGS adjusted by ASM (HGS/ASM) was used to define skeletal muscle quality (SMQ). SMQ was regarded “normal” when the HGS/ASM ratio was &amp;gt;1.53, and “weak” when the ratio was ≤1.36 in males and ≤1.35 in women. The SMQ of those with HGS/ASM levels between these ranges was considered “low”. Results: Age, gender, and BMI were similar between groups. The GH and IGF-1 levels in AA was greater than in CA, and C (p&amp;lt;0.001 for all). While lean tissue was higher in AA than CA and C (p=0.038 and p=0.041, resp.), body fat ratio was lower in AA than CA and C (p=0.04 and p=0.042 resp.). ASM, RSMI, TAMA, HGS and quadriceps strength were similar between groups. Median (IQR) HGS/ASM were 1.67 (1.15-1.9) in AA, 1.57 (1.36-1.79) in CA and 1.77 (1.67-1.93) in C. This difference was found to be significant between CA and C (p=0.008). According to skelatal muscle quality, 94.7% of the individuals in the C group were of normal SMQ, while this rate was 60% in the AA and 52.9% in CA. The ratio of those with low/weak SMQ was higher in the AA and CA compared to C (p=0.012 and p=0.013, resp.). Total and vertebra BMD were similar across groups. Pelvic BMD in CA was lower than C (p=0.02). VFR was higher in CA (56.5%) than in AA (43.75%) and C (42.6%) (p=0.04 and p=0.001 resp.). Conclusion: We showed for the first time that patients with acromegaly had lower muscle quality and pelvic BMD, while patients with controlled acromegaly had higher vertebral fat ratio. Even though lean tissue increased in AA patients, regional muscle distributions (ASM and TAMA) were shown to be similar. The increased muscle mass in acromegaly patients is not expressed as muscular strength, and muscle quality is low in these patients. The high vertebral fat ratio seen in patients with CA may be a result of ectopic adiposity with disease control, as well as the reason for the increased frequency of vertebral fractures seen in patients with acromegaly. Presentation: Thursday, June 15, 2023

Understanding the influence of polymeric ionic liquid sorbent coating substituents on cannabinoid and pesticide affinity in solid-phase microextraction

To understand factors that drive pesticide-cannabinoid selectivity in solid-phase microextraction (SPME), eight new polymeric ionic liquid (PIL) sorbent coatings were designed and compared to four previously reported PIL sorbent coatings for the extraction of pesticides. The four PIL sorbent coatings consisted of either vinylimidazolium or vinylbenzylimidazolium ILs with long alkyl chain substituents (i.e., -C8H17 or -C12H25) and bis[(trifluoromethyl)sulfonyl]imide ([NTf2−]) anions, from which the eight new PIL sorbent coatings were adapted. Modifications to the chemical structure of IL monomers and crosslinkers included incorporation of polymerizable p-styrenesulfonate or 3-sulfopropyl acrylate anions, the addition of aromatic moieties, and/or the addition of polar functional groups (i.e., -OH or -O- groups). A total of ten commonly regulated pesticides and six cannabinoids were examined in this study. The effect of salt on the solubility of pesticides and cannabinoids in aqueous solutions was assessed by determining their extraction efficiencies in the presence of varied methanol content. Differences in their solubilities appear to play a dominant role in enhancing pesticide-cannabinoid selectivity. The selectivity, represented as the ratio of pesticide total peak areas to cannabinoid total peak areas, also exhibited a moderate correlation to the affinity of the sorbent coatings towards both the pesticides and the cannabinoids. A positive correlation was observed for the pesticides and a negative correlation was observed for the cannabinoids, suggesting that selectivity was driven by more than the presence of salt in the samples. The sorbent coatings’ affinity towards each class of analytes were examined to determine specific interactions that might influence selectivity. The two main structural modifications increasing pesticide-cannabinoid selectivity included the absence of aromatic moieties and the addition of hydrogen bond donor functional groups. Extractions of simple aromatic molecules as probes were performed under similar extraction conditions as the cannabinoids and confirmed the influence of hydrogen bonding interactions on sorbent coating affinity.

The application of gap planting technology to rehabilitate degraded natural forest

In 2020 degraded forests in Indonesia reached 33.4 million ha. These forests must be rehabilitated. The purpose of this research was to show the application of gap planting technology to rehabilitate degraded natural forests. This improvement of forest regeneration methods by planting local intolerant tree species in gaps area was used. Artificial gaps area was designed and it’s location was adjusted to the topography and forest cover. The size of each gap area is 2,000 m2. The ratio of total gaps area to total natural forests area was about four to six. Open areas, soil density, forest fire risk, working time and cost of gap planting, and tree growth were studied. The results showed that after the gap planting: forest cover consists of 37.43% gap planting area and 62.57% natural forest area; forest soil is not compacted; the fire hazard rating in the gap and natural forests is low. Moreover, it is cost-effective and has positive impacts such as job creation for local communities and a productivity increase of rehabilitated forests. It is concluded that the gap planting technology was environment friendly technology, and it is recommended to be used for rehabilitation of degraded forests in Indonesia.

Quantifying stand-level clumping of boreal, hemiboreal and temperate European forest stands using terrestrial laser scanning

Clumping is critical for quantifying the radiation regime of forest canopies, but challenging to measure. We developed a method to measure clumping index (CI) of forest stands using voxel-based estimates of leaf area density from terrestrial lidar data. Our method uses the principle of the silhouette to total area ratio (STAR), a commonly used shoot clumping correction approach. We adapted the concept to forest stands, and derived that STAR at canopy scale (STARf) is no longer simply a clumping index, but a summary variable for forest structure in general. CI can be calculated from STARf when leaf area index is known.We measured CI and STARf of 38 forest stands in Finland, Estonia, and Czechia to study the natural range of these variables, their relationships to other forest variables, and to Landsat 8 OLI surface reflectance. CI did not include clumping below voxel scale (20 cm), and ranged from 0.6 to 0.9, with the lowest values (i.e., the most clumped canopies) in conifer forests and temperate oak forests, and the highest CI values (i.e., the most random canopies) in boreal broadleaved forests. CI was closely correlated with surface reflectance in conifer forests, which may be explained by contradicting influence of clumping that decreases canopy reflectance, but increases visibility of the forest floor.From the viewpoint of forest reflectance modeling, STAR is a useful variable due to its close relationship with the photon recollision probability, i.e., the probability that a photon will interact with a canopy element after being scattered from another canopy element. The photon recollision probability is used to model the influence of forest structure on reflectance. Our method provides a physically-based means of measuring STARf, and thus the photon recollision probability, hence contributing to the development of new methods for interpreting forest canopy structure from optical remote sensing data.