Abstract A climatology of significant tornadoes [SIGTOR, tornadoes rated (E)F2+ on the (enhanced) Fujita scale] within China and in three subregions, including northern, central, and southern China, is first presented for the period 1980–2016. In total, 129 SIGTOR are recorded in China, with an average of 3.5 per year. The tornado inflow environments of the south-central and southeast regions of the United States (USC and USSE) are compared with those of China and its subregions based on sounding-derived parameters including shear, storm-relative helicity, convective available potential energy (CAPE), lifting condensation level (LCL), etc. Soundings are extracted from the ERA5 reanalysis dataset. The results confirm that the SIGTOR in USSE are characterized by high shear, low CAPE, and low LCL whereas those in USC are characterized by moderate-to-high shear, high CAPE, and high LCL. The thermodynamic conditions of tornadic cases are favorable for China, with moderate-to-high CAPE and low-to-moderate LCL, but their kinematic conditions are much less favorable than in the United States, a fact that is believed to be primarily responsible for the lower tornado frequency and intensity in China. The high CAPE in China is due mostly to high humidity. For three subregions in China, the central China cases account for 60% of total samples, and its environmental features are similar to those of China. The average shear with northern China cases is stronger than that with the other two subregions, and the midlayer is relatively dry. The southern China SIGTOR have the most conducive humidity conditions, but the CAPE and shear there are the lowest. The northern, central, and southern China environments can be considered as representative of midlatitude, subtropical, and tropical regions. Significance Statement We document the climatological characteristics of significant tornadoes (SIGTOR) within China and compare the inflow environments of SIGTOR in China and its subregions with those in the U.S. central and southeastern regions. The availability of hourly high-resolution ERA5 data makes the environments based on extracted proximity soundings much more accurate than possible with earlier reanalyses. The environmental characteristics show systematic differences in the tornado environments of different regions of China and the United States and suggest different roles played by thermodynamic and kinematic conditions for tornado formation. Overall, the environmental differences are consistent with the resulting frequency and intensities of SIGTOR. The findings are helpful toward improving tornado forecasting and warning or even understanding of potential impacts of climate change on SIGTOR, especially in China, where such studies are rarer.