Objective: To compare the effects of topical corneal inhibitory agents on total antioxidant capacity (TAC), total oxidant capacity (TOC), and oxidative stress index (OSI) levels in rats with experimentally acquired corneal neovascularization (CNV).Materials and Methods: 35 Wistar male rats were divided into 5 Groups; Group I: 0.9% saline, Group II: 0.05% topical cyclosporine A, Group III: 1% topical propolis, Group IV: 3% topical propolis and Group V: 0.1% dexamethasone. CNV was formed with sodium hydroxide in the right eyes. All groups were treated 3/day for 10 days. Blood samples were taken from all of the rats. Results: The TAC of the groups were 1.32, 1.22, 1.75, 1.27, and 1.37 μmol Trolox equivalent/L, respectively. The highest statistically significant increase in the TAC parameter was determined in Group III (p=0.041). TOC of the groups were 4.80, 6.0, 5.98, 6.09, and 10,32mmol H2O2 equivalent/L. The highest statistically significant increment of the TOC parameter was determined in Group V (p=0.041). OSI in the groups was 355.39, 494.63, 346.55, 477.18, and 746.48, respectively. Statistically significant increment of the OSI parameter was determined in GroupV (p=0.002).Conclusion: Among these agents, 1% propolis was found to have the greatest effect on TAC. On the other hand, the use of Dexamethasone has caused a significant increase in OSI.