Abstract Friction stir welding (FSW) is a well-established technique developed extensively over the past two decades for various applications. This study investigates the effect of repositioning the tool pin shoulder (0.18 mm) above the surface of a 12 mm thick dissimilar aluminum alloy (AA6063-AA5083) on tensile strength, welding temperature, and micro-hardness. Trials were conducted according to the L9 Taguchi method and further simulated using ABAQUS software. The input parameters spindle speed (SS), tool pin length (TPL), and traversing speed (TS) were each tested at three levels. The impact of these parameters on weld quality was analyzed using ANOVA. Optimization of the process to achieve desired temperature and tensile strength was carried out using grey relational analysis (GRA) for both experimental and simulated results. Mathematical models were generated using the multi-variable regression method (MVRM) and response surface method (RSM). Predicted data from the RSM model were compared to experimental outcomes, revealing a maximum deviation of 8.69% for temperature and 5.17% for tensile strength. Furthermore, the study demonstrated that ABAQUS accurately simulates the FSW process with an accuracy of up to 93.71%.