Previous studies have proposed compressed air injection to mitigate seawater intrusion, as a substitute for a hydraulic barrier created using freshwater injection. However, the current understanding of this strategy is based almost entirely on numerical simulation, and therefore, there is a need to investigate the complex processes accompanying this method within a physical setting. This study used sand tank experiments to explore the influence of air injection on the behavior of saltwater within a coastal confined aquifer, extending previous experiments by accounting for freshwater-saltwater density differences. Numerical modeling of the experiments assisted in interpreting experimental observations and allowed for field-scale conditions to be assessed. Numerical models were well matched to experimental observations, which showed a 34 % reduction in saltwater volume and a retreat of the saltwater toe length from 59 cm to 40 cm following air injection. A hypothetical field-scale confined aquifer model indicated that the largest seaward shift in the seawater wedge toe is obtained when the air-injection well is above the initial seawater wedge toe. However, maximal reductions in the seawater volume within the aquifer were obtained from injecting air within the original wedge rather than landward of the toe. This study provides the first physical evidence (through laboratory experiments) that injecting compressed air can effectively mitigate seawater intrusion. We considered a period of one year for field-scale applications, which show that the extent of desaturation likely needs to be mitigated from prolonged application of the method. Initial guidance is developed for the selection of air-injection locations, at least under simplified conditions (e.g. homogeneous, uniform aquifer, etc.).