Tissue Equivalent Proportional Counter Research Articles

Capture enhanced neutron irradiation for the treatment of the Alzheimer Disease: Micro-nanodosimetric characterization of beta amyloid peptide samples

Alzheimer Disease (AD) is the most common cause of dementia. 46.8 million people live with AD worldwide, with numbers projected to almost double every 20 years. The etiological mechanisms underlying the neuropathological changes in AD remain unclear. The beta amyloid peptide Aβ is considered to be the main culprit of the pathological processes. NECTAR (NEutron Capture-enhanced Treatment of neurotoxic Amyloid aggRegates) project proposes an alternative and revolutionary strategy to address AD, investigating the safety, feasibility and effectiveness of a Capture-Enhanced Neutron Irradiation to structurally damage Aβ aggregates, by exploiting capture agent vectors containing B-10 and Gd-157.Among many others, one of the goals of the project is to perform calculations and measurements of microdosimetric and nanodosimetric quantities to characterize the effect of reaction products at local level and to link it to the fibrils depolymerization process. In this framework, a new low-pressure tissue-equivalent proportional counter (TEPC) was designed and developed. The system is a wall-free TEPC able to measure micro-nanometric dose deposition for different biological samples. It is characterized by two main features: i) a wall-less structure allows the charged particles produced by the sample to access the sensitive volume, where their effects are studied; ii) a trigger system enables the assessment of the number of ionizations induced in the sensitive volume related to a single primary particle for obtaining nandosimetric information.The prototype system was tested in the PGNAA (Prompt Gamma Neutron Activation Analysis) facility of the LENA reactor (Pavia) to directly study secondary particles from Aβ fibrils, loaded with Boron. Results of the micro-nanodosimetric characterization of high LET secondaries from Aβ-fibrils were compared to a reference Boron sample. For a 500 nm simulated site size, the presence of Boron in the Aβ sample greatly populates microdosimetric spectra at high lineal energy values. Instead, lower LET particles (photons, protons) from reactions on the other Aβ aggregate solution molecules populate the low lineal energy portion of the distribution.The nanodosimetric distributions highlights the presence of different field components on the nanodosimetric spectra: low LET particles (protons/electrons) produce small ionization clusters, while alpha and Lithium ions induce larger clusters, thus have a higher biological effect. The nanodosimetric measurements have been compared with Monte Carlo simulations performed with a track-structure code, showing a good agreement.This multi-level approach provides a deeper physical understanding of the mixed secondaries field coming from B-enriched target, as well as a reference for the biological effect on Aβ fibrils at nanometer level. These preliminary measurements represent the first microdosimetric and nanodosimetric characterization of the secondary mixed field directly emitted by a biological sample irradiated with neutrons.

Sensitivity of a mini-TEPC to radiation quality variations in clinical proton beams

PurposeThis work aims at studying the sensitivity of a miniaturized Tissue-Equivalent Proportional Counter to variations of beam quality in clinical radiation fields, to further investigate its performances as radiation quality monitor. MethodsMeasurements were taken at the CATANA facility (INFN-LNS, Catania, Italy), in a monoenergetic and an energy-modulated proton beam with the same initial energy of 62 MeV. PMMA layers were placed in front of the detector to measure at different depths along the depth-dose profile. The frequency- and dose-mean lineal energy were compared to the track- and dose-averaged LET calculated by Monte Carlo simulations. A microdosimetric evaluation of the Relative Biological Effectiveness (RBE) was performed and compared with cell survival experiments. ResultsMicrodosimetric distributions measured at identical depths in the two beams show spectral differences reflecting their different radiation quality. Discrepancies are most evident at depths corresponding to the Spread-Out Bragg Peak, while spectra at the entrance and in the dose fall-off regions are similar. This can be explained by the different energy components that compose the pristine and spread-out peaks at each depth. The trend of microdosimetric mean values matches that of calculated LET averages along the entire penetration depth, and the microdosimetric estimation of RBE is consistent with radiobiological data not only at 2 Gy but also at lower dose levels, such as those absorbed by healthy tissues. ConclusionsThe mini-TEPC is sensitive to differences in radiation quality resulting from different modulations of the proton beam, confirming its potential for beam quality monitoring in proton therapy.

Boron Neutron Capture Therapy: Microdosimetry at Different Boron Concentrations

This paper explores the role of microdosimetry in boron neutron capture therapy (BNCT), a cancer treatment involving the selective accumulation of boron-containing compounds in cancer cells, followed by neutron irradiation. Neutron interactions with 10B induces a nuclear reaction, releasing densely ionizing particles, specifically alpha particles and recoiling lithium-7 nuclei. These particles deposit their energy within a small tissue volume, potentially targeting cancer cells while sparing healthy tissue. The microscopic energy distribution, subject to significant fluctuations due to the short particle range, influences treatment efficacy. Microdosimetry, by studying this distribution, plays a crucial role in optimizing BNCT treatment planning. The methodology employs paired tissue equivalent proportional counters (TEPCs), one with cathode walls enriched with boron and the other without. Precise assessment of boron concentration is essential, as well as the ability to extrapolate results to the actual 10B concentration within the treatment region. The effective 10B concentrations within four boronated TEPCs, containing 10, 25, 70, and 100 ppm of 10B, have been determined. Results show variations of less than 3% from nominal values. Additionally, dose enhancement due to BNC interactions was measured and found to be proportional to the 10B concentration, with a proportionality factor of 7.7 × 10−3 per ppm of boron. Based on these findings, a robust procedure is presented for assessing the impact of BNCT in the treatment region, considering potential variations in boron content relative to the TEPC used.

First microdosimetric measurements with a tissue-equivalent proportional counter at the MedAustron ion-beam therapy facility.

The aim of this work is to present the first microdosimetric spectra measured with a miniaturised tissue-equivalent proportional counter in the clinical environment of the MedAustron ion-beam therapy facility. These spectra were gathered with a 62.4-MeV proton beam and have been compared with microdosimetric spectra measured in the 62-MeV clinical proton beam of the CATANA beam line. Monte Carlo simulations were performed using the Geant4 toolkit GATE and a fully commissioned clinical beam line model. Finally, similarities and discrepancies of the measured data to simulations based on a simple and complex detector geometry are discussed.

Comparison of biological weighting functions to estimate the microdosimetric RBE in BNCT.

In the framework of the MUNES project, a prototype accelerator-based thermal neutron source was developed and installed at the Legnaro National Laboratories of INFN. The microdosimetric characterization of this radiation field was performed with a Tissue-Equivalent Proportional Counter with interchangeable cathode walls, either doped with 100ppm of 10B or without boron doping. A suitable subtraction procedure allowed to discriminate the gamma, neutron and BNC dose components (Selva etal., 2022, Appl. Radiat. Isot. 182, 110144). The measured microdosimetric spectra can be weighted with a biological weighting function to estimate the Relative Biological Effectiveness of the radiation field, for the purpose of intercomparison between different thermal neutron sources. This work compares, therefore, the biological doses resulting from four different weighting functions applied to the same initial microdosimetric spectrum, discussing strengths and limitations of each of them.

Microdosimetric analysis of the radiation quality of two different proton beams in the distal edge of the depth-dose profile.

Proton-therapy exploits the advantageous depth-dose profile of protons to induce the highest damage to tumoral cells in the last millimetres of their range in sharp Bragg Peak. To cover the whole tumoral volume, beams of different energies are combined to create the Spread Out Bragg Peak (SOBP). In passive modulated beams, the energy spread is created with modulators in which the highest energy beam is degraded through different thicknesses of calibrated plastic materials. The highest energy is chosen depending on the deepest point that needs to be treated. This study aims to investigate differences in the radiation quality in the distal edge of SOBP beams with different initial energy and modulation techniques based on microdosimetric measurements with mini Tissue-Equivalent Proportional Counters. The beams investigated are the 62MeV proton SOBP of the clinical facility of CATANA and the 148MeV proton SOBP of the research beam line of the proton-therapy centre of Trento.

Monte Carlo-based identification of electron and proton edges for calibration of miniaturized tissue equivalent proportional counter

Miniaturized tissue equivalent proportional counters (mini-TEPCs) are proper for radiation dosimetry in medical application because the small size of the dosimeter could prevent pile-up effect under the high intensity of therapeutic beam. However, traditional methods of calibrating mini-TEPCs using internal alpha sources are not feasible due to their small size. In this study, we investigated the use of electron and proton edges on Monte Carlo-generated lineal energy spectra as markers for calibrating a 0.9 mm diameter and length mini-TEPC. Three possible markers for each spectrum were calculated and compared using different simulation tools. Our simulations showed that the electron edge markers were more consistent across different simulation tools than the proton edge markers, which showed greater variation due to differences in the microdosimetric spectra. In most cases, the second marker, yδδ, had the smallest uncertainty. Our findings suggest that the lineal energy spectra from mini-TEPCs can be calibrated using Monte Carlo simulations that closely resemble real-world detector and source geometries.

Improvement of the hybrid approach between Monte Carlo simulation and analytical function for calculating microdosimetric probability densities in macroscopic matter

Objective. Estimation of the probability density of the microdosimetric quantities in macroscopic matter is indispensable for applying the concept of microdosimetry to medical physics and radiological protection. The Particle and Heavy Ion Transport code System (PHITS) enables estimating the microdosimetric probability densities due to its unique hybrid modality between the Monte Carlo and analytical approaches called the microdosimetric function. It can convert the deposition energies calculated by the macroscopic Monte Carlo radiation transport simulation to microdosimetric probability densities in water using an analytical function based on the track-structure simulations. Approach. In this study, we improved this function using the latest track-structure simulation codes implemented in PHITS. The improved function is capable of calculating the probability densities of not only the conventional microdosimetric quantities such as lineal energy but also the number of ionization events occurring in a target site, the so-called ionization cluster size distribution, for arbitrary site diameters from 3 nm to 1 μm. Main results. The accuracy of the improved function was well verified by comparing the microdosimetric probability densities measured by tissue-equivalent proportional counters with the corresponding data calculated in this study. Test calculations for clonogenic cell survival using the improved function coupled with the modified microdosimetric kinetic model suggested a slight increase of its relative biological effectiveness compared with our previous estimations. As a new application of the improved function, we calculated the relative biological effectiveness of the single-strand break and double-strand break yields for proton irradiations using the updated PHITS coupled with the simplified DNA damage estimation model, and confirmed its equivalence in accuracy and its superiority in computational time compared to our previously proposed method based on the track-structure simulation. Significance. From these features, we concluded that the improved function could expand the application fields of PHITS by bridging the gap between microdosimetry and macrodosimetry.

Microdosimetry

The interest in the application of microdosimetry for assessing the radiation quality of hadrontherapy fields has grown in the last two decades. The reference detector for microdosimetry is the tissue-equivalent proportional counter (TEPC). Novel types of microdosimeters have been developed by the Nuclear Measurement Laboratory of the Politecnico di Milano in collaboration with the INFN National Legnaro Laboratories. This work describes the main features of an avalanche confinement TEPC, capable of simulating sites down to 25 nm and a silicon telescope detector. The main dosimetric and microdosimetric quantities are also given and discussed in the Introduction for the sake of clarity.

Monte Carlo simulation for the interaction characteristics of gamma-rays with several tissues and water as a tissue substitute

The study aimed to present an alternative method that is applicable to develop the perfect tissue-equivalent material that is completely tissue equivalent in all of its gamma-ray interaction properties. In this work, a Monte Carlo code has been written and simulations have been performed to achieve the gamma-ray interaction data details for the selected body tissues and tissue substitutes quoted from the ICRU Reports that are required for accurate assessment in radiotherapy, radiodiagnosis patient dosimetry and radiation protection. Accurate values of the linear attenuation coefficient for the selected absorber samples have been calculated by using simulation outputs. A comparison has been made with theoretical and experimental data that has appeared in the literature. The results presented in the tables, appear to be close to each other, which shows that the simulation procedure used in this work is suitable for use in such kinds of studies. The results reported here imply that the method presented in this study is important and reliable in providing convenient substitutes for certain treatment procedures for phantoms, radiation detectors, detector walls and tissue-equivalent proportional counters.

Study of a planar cascaded GEM TEPC with sealed chamber for the radiation detection in microdosimetry

In the field of radiation detection in microdosimetry, the Tissue Equivalent Proportional Counters (TEPCs) are the key detector options in determining the radiation quality. In this paper, two different structures of TEPCs were introduced, and their electric field uniformity and angular dependence were disscussed. A planar cascaded GEM TEPC with sealed chamber was developed in the laboratory and the general materials used in the detector were tested for outgassing characteristics. The experimental results showed that the polyether ether ketone (PEEK) had the lowest outgassing rate among all tested materials and were selected as the main assembly materials of the TEPC detector. The 241Am was used as the built-in radioactive source for detector calibration, and the detector gain characteristics were studied. The long-term operating stability was tested at working pressure of 54.72 kPa, with a gain consistency of better than 97.8% over 7 days (168 hours) and relative gain variation less than 1% over 4 days (96 hours).

Prediction of fast neutron spectra with a spherical TEPC using a machine-learning algorithm

For many years, new unfolding methods based on machine learning have been studied and developed to improve the prediction capabilities of fluence spectra in neutron fields. These methods are mainly applied to traditional devices used for specific measurements like Bonner spheres, activation detectors or liquid scintillators. In this paper, we attempt to develop a new method based on the unfolding of the fluence spectrum from the micro-dosimetric spectrum measured by a tissue-equivalent proportional counter (TEPC). This type of counter is commonly used for neutron kerma measurements and quality factor assessments, but has never been employed as a neutron spectrometer. This work focuses on the fast neutron region, which is an extremely relevant subject in various fields of nuclear energy. We have tested different machine-learning models to define an unfolding algorithm that can be used to reconstruct the energy distribution of the fluence for spectra of various origins, ranging between 50 keV and 20 MeV.

TOPAS simulations of the response of a mini-TEPC: benchmark with experimental data

Objective. Microdosimetry offers a fast tool for radiation quality (RQ) verification to be implemented in treatment planning systems in proton therapy based on variable LET or RBE to move forward from the use of a fixed RBE of 1.1. It is known that the RBE of protons can increase up to 50% higher than that value in the last few millimetres of their range. Microdosimetry can be performed both experimentally and by means of Monte Carlo (MC) simulations. This paper has the aim of comparing the two approaches. Approach. Experimental measurements have been performed using a miniaturized Tissue equivalent proportional counter developed at the Legnaro National Laboratories of the Italian National Institute for Nuclear Physics with the aim of being used as RQ monitors for high intensity beams. MC simulations have been performed using the microdosimetric extension of TOPAS which provides optimized parameters and scorers for this application. Main results. Simulations were compared with experimental microdosimetric spectra in terms of shape of the spectra and their average values. Moreover, the latter have been investigated as possible estimators of LET obtained with the same MC code. The shape of the spectra is in general consistent with the experimental distributions and the average values of the distributions in both cases can predict the RQ increase with depth. Significance. This study aims at the comparison of microdosimetric spectra obtained from both experimental measurements and the microdosimetric extension of TOPAS in the same radiation field.

Investigation of In-Field and Out-of-Field Radiation Quality With Microdosimetry and Its Impact on Relative Biological Effectiveness in Proton Therapy

Using microdosimetry, this study investigated the relative biological effectiveness (RBE) and quality factor (Q¯) variations in field and out of field as a function of radiation quality for clinical protons. A water phantom with a spread-out Bragg peak (SOBP) was irradiated to acquire microdosimetric spectra at several distal and lateral depths with a tissue equivalent proportional counter. The measurements were used as inputs to microdosimetric kinetic and Loncol models to determine the RBE spatial distribution and compare it with predictions from the dose-averaged linear energy transfer-based McNamara model. Q¯ values and biological and dose equivalent values were also calculated. The data demonstrated that radiation quality changed more rapidly with depth than lateral distance from the SOBP. In beam, yD ranged from approximately 4 keV/μm at the entrance to 8 keV/μm at the SOBP far end, reaching approximately 15 keV/μm at the penumbra. Out of field, the overall highest value of 23 ± 2 keV/μm was observed at the beam-edge penumbra. Radiation quality changes caused RBE deviations from the clinical value of 1.1, whose extent depends on the approach used for assessing radiation quality as well as on the radiobiological model. For RBE10, microdosimetry-based models appeared to better reproduce the radiobiological data than the dose-averaged linear energy transfer model. Out of field, both the RBE and Q¯ values appeared to have limitations in describing the radiation biological effectiveness. This research also presents a first comprehensive benchmark of TOPAS code against in-field and out-of-field microdosimetric spectra of therapeutic protons. Further investigation will be necessary to evaluate the quantitative effects of RBE variations on treatment planning and assess the clinical consequences in terms of both tumor control and normal-tissue toxicity. The achievement of this goal calls for accurate radiobiological data to validate the RBE models.

Microdosimetry for hadron therapy: A state of the art of detection technology

The interest in hadron therapy is growing fast thanks to the latest technological advances in accelerators and delivery technologies, to the development of more and more efficient and comprehensive treatment planning tools, and due to its increasing clinical adoption proving its efficacy. A precise and reliable beam quality assessment and an accurate and effective inclusion of the biological effectiveness of different radiation qualities are fundamental to exploit at best its advantages with respect to conventional radiotherapy. Currently, in clinical practice, the quality assurance (QA) is carried out by means of conventional dosimetry, while the biological effectiveness of the radiation is taken into account considering the Relative Biological Effectiveness (RBE). The RBE is considered a constant value for protons and it is estimated as a function of the absorbed dose in case of carbon ions. In this framework, microdosimetry could bring a significant improvement to both QA and RBE estimation. By measuring the energy deposited by the radiation into cellular or sub-cellular volumes, microdosimetry could provide a unique characterisation of the beam quality on one hand, and a direct link to radiobiology on the other. Different detectors have been developed for microdosimetry, from the more conventional tissue equivalent proportional counter (TEPC), silicon-based and diamond-based solid-state detectors, to ΔE-E telescope detectors, gas electrons multiplier (GEM), hybrid microdosimeters and a micro-bolometer based on Superconducting QUantum Interference Device (SQUID) technology. However, because of their different advantages and drawbacks, a standard device and an accredited experimental methodology have not been unequivocally identified yet. The establishment of accepted microdosimetry standard protocols and code of practice is needed before the technique could be employed in clinical practice. Hoping to help creating a solid ground on which future research, development and collaborations could be planned and inspired, a comprehensive state of the art of the detector technologies developed for microdosimetry is presented in this review, discussing their use in clinical hadron therapy conditions and considering their advantages and drawbacks.

Microdosimetry with a mini-TEPC in the spread-out Bragg peak of 148 MeV protons

A new miniaturized Tissue Equivalent Proportional Counter (mini‒TEPC) with cylindrical sensitive volume of 1.0 mm in diameter and height, and with external diameter of 1.53 cm, has been developed to work without gas flow. With this mini counter we have measured the radiation quality of the 148 MeV energy-modulated proton beam at the radiobiological research line of the Trento Proton Therapy Centre. The irradiation field had a diameter of about 6 cm, a modulation width of 2.5 cm and a range of about 13.5 cm. At four specific depths, the response function of the new microdosimeter has also been compared to that of a commercial spherical microdosimeter, the LET-1/2” Spherical TEPC produced by Far West Technology. Afterwards, measurements were performed with the mini‒TEPC at nine precise positions across the Spread-Out Bragg Peak (SOBP).From the microdosimetric spectra the frequency and the dose‒mean lineal energy values, y‾F and y‾D, were derived for both detectors. Afterwards, microdosimetric assessment of Relative Biological Effectiveness (RBEμ) has been performed by weighting the dose distribution of the lineal energy, d(y), with the Loncol’s biological weighting function r(y).RBEμ has been used to calculate the RBEμD at different dose levels D. In the distal fall-off region the RBEμD(d) increases significantly, up to a factor 3. Finally, the RBEμD-weighted dose was calculated and compared to that obtained with a fixed RBE = 1.1. The use of a variable RBE to weight the physical dose leads to a biological range extension evaluated at R80 of about 2.0 mm, with respect to the R80 obtained with a fixed RBE = 1.1.The use of a mini‒TEPC in proton therapy has been so far limited to 60 MeV proton beams, used for the treatment of ocular melanoma. This is the first time that a mini-TEPC was used with an higher energy proton beam of 148 MeV, and the spectra measured with the mini-TEPC were compared to those measured with the commercial FWT LET1/2 counter for the first time.These new results corroborate the usability of mini-TEPCs in proton therapy.

Experimental and Monte Carlo based study of different microdosimetric quantities at mixed radiation environments of nuclear reactor, reprocessing facility and D-D accelerator

Personnel working in the environment of nuclear reactors, fuel reprocessing facilities, high energy accelerators get exposed to a mixed radiation field of electrons, photons, and neutrons with a wide range of energy and fluence. Performance evaluations of the passive personnel dosimeters in these mixed radiation environments require knowledge of the external dose contributed by different types of radiations having variation in their energy, etc. Tissue Equivalent Proportional Counters (TEPC), sensitive to a wide range of particles and energy (Linear Energy Transfer (LET) ∼ 0–1500 keV μm−1), is one of the standard reference detectors which can be used for the characterization of mixed radiation fields. In the present work, HAWK TEPC was used to evaluate different microdosimetric parameters such as dose mean lineal energy (ӯD), average quality factor (Ǭ), the contribution of gamma and neutron dose equivalents for the characterizations of the radiation fields inside in a nuclear research reactor hall, fuel reprocessing facility, D-D neutron beam facility, radionuclide source based neutron calibration facilities, etc. Measured results were compared with Monte Carlo simulated values using radiation transport code PHITS. TEPC measurement shows that the radiation work field around nuclear reactor facility is dominated by gamma rays with approximate ӯD and Ǭ of ∼42 keV μm−1 and ∼2.3, respectively. Whereas ӯD and Ǭ values for neutron dominated locations in fuel reprocessing facility are 82 keV μm−1 and 8.2, respectively. Ǭ values near thermal neutron beam line in research reactor are close to 1 due to (n, γ) reaction. For 2.54 MeV mono-energetic D-D neutron beam, measured and calculated dose mean lineal energies (ӯD) are 52.5 keV μm−1 and 59.6 keV μm−1, respectively, whereas corresponding Ǭ values are 11.23 and 13.01. Obtained values can be utilized to correlate the neutron and gamma dose equivalents measured by passive detectors used for personnel monitoring program to enhance confidence in the dosimetry.

4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification

Objective. In the present hadrontherapy scenario, there is a growing interest in exploring the capabilities of different ion species other than protons and carbons. The possibility of using different ions paves the way for new radiotherapy approaches, such as the multi-ions treatment, where radiation could vary according to target volume, shape, depth and histologic characteristics of the tumor. For these reasons, in this paper, the study and understanding of biological-relevant quantities was extended for the case of 4He ion. Approach. Geant4 Monte Carlo based algorithms for dose- and track-averaged LET (Linear Energy Transfer) calculations, were validated for 4He ions and for the case of a mixed field characterised by the presence of secondary ions from both target and projectile fragmentation. The simulated dose and track averaged LETs were compared with the corresponding dose and frequency mean values of the lineal energy, and , derived from experimental microdosimetric spectra. Two microdosimetric experimental campaigns were carried out at the Italian eye proton therapy facility of the Laboratori Nazionali del Sud of Istituto Nazionale di Fisica Nucleare (INFN-LNS, Catania, I) using two different microdosimeters: the MicroPlus probe and the nano-TEPC (Tissue Equivalent Proportional Counter). Main results. A good agreement of and with and experimentally measured with both microdosimetric detectors MicroPlus and nano-TEPC in two configurations: full energy and modulated 4He ion beam, was found. Significance. The results of this study certify the use of a very effective tool for the precise calculation of LET, given by a Monte Carlo approach which has the advantage of allowing detailed simulation and tracking of nuclear interactions, even in complex clinical scenarios.

Range-shifter effects on the stray field in proton therapy measured with the variance-covariance method.

Measurements in the stray radiation field from a proton therapy pencil beam at energies 70 and 146 MeV were performed using microdosimetric tissue-equivalent proportional counters (TEPCs). The detector volumes were filled with a propane-based tissue-equivalent gas at low pressure simulating a mean chord length of 2 μm in tissue. Investigations were performed with and without a beam range shifter, and with different air gaps between the range shifter and a solid water phantom. The absorbed dose, the dose-mean lineal energy, and the dose equivalent were determined for different detector positions using the variance–covariance method. The influence from beam energy, detector- and range-shifter positions on absorbed dose, LET, and dose equivalent were investigated. Monte Carlo simulations of the fluence, detector response, and absorbed dose contribution from different particles were performed with MCNP 6.2. The simulated dose response for protons, neutrons, and photons were compared with, and showed good agreement with, previously published experimental data. The simulations also showed that the TEPC absorbed dose agrees well with the ambient absorbed dose for neutron energies above 20 MeV. The results illustrate that changes in both dose and LET variations in the stray radiation field can be identified from TEPC measurements using the variance–covariance method. The results are in line with the changes seen in the simulated relative dose contributions from different particles associated with different proton energies and range-shifter settings. It is shown that the proton contribution scattered directly from the range shifter dominates in some situations, and although the LET of the radiation is decreased, the ambient dose equivalent is increased up to a factor of 3.

Detectors for measurement of microdosimetric quantities

Microdosimetric quantities have been used for assessing the radiation quality of hadron therapy fields since long. They are stochastic quantities whose distributions depend on the fluctuations of energy deposition in cellular and/or sub-cellular structures. The present work overviews the detectors which are used mainly for assessing the radiation quality of hadron therapy fields (protons and carbon ions), discussing their advantages and limitations based on the author's experience. The microdosimeters which are described and discussed herein are, in particular, tissue-equivalent proportional counters (TEPCs), gas detectors based on gas-electron multiplication (GEMs), silicon and diamond detectors.