To optimize the inclined rim design, multi-objective optimization was numerically conducted on the suction-side rim of the squealer tip in the GE-E3 rotor blade. The RANS equations, incorporating with the standard k-ω model, were numerically solved. Through the implementation of a Kriging surrogate model coupled with the NSGA-II evolutionary optimization technique, six geometric parameters on the suction-side rim went through iterative optimization. This process yielded three optimized squealer tip geometries on the Pareto front: Structure 1 with minimum total pressure loss, Structure 2 with optimal comprehensive aerothermal performance, and Structure 3 with minimum tip heat load. Comparative analysis revealed that with the inner and external wall inclined toward the cavity and passage respectively, the optimization results in a 3 %–11 % reduction in tip heat load, accompanied by an 8.5 %–10.2 % reduction in aerodynamic loss, facilitated by an attenuated upper passage vortex (UPV) and strengthened tip leakage vortex (TLV). The critical inclined region of the external rim wall, spanning 7 %–80 %, influences the exit total pressure loss distribution. The inclined inner wall upstream of 50 % Cax obstructs coolant jets from exiting the cavity, reducing the heat load on the cavity bottom. However, the inclined external wall from 66 % to 90 % Cax amplifies the impingement of the scraping vortex (SV), increasing local heat transfer. The thermal behavior of Structure 1 is sensitive to changes in tip clearance, whereas Structure 2 and 3 show more robust advantages. As the clearance increased, the aerodynamic losses associated with the TLV rise for all three optimized tips, but losses from the UPV remain similar. This study provides a novel approach for designing efficient squealer tip geometries incorporating an inclined rim.