Timing Of Umbilical Cord Clamping Research Articles

Influence of umbilical cord clamping time on cerebral oxygenation and early cardiac function in term infants.

Delayed cord clamping is the standard of care for both term and preterm infants worldwide. The aim of this study was to evaluate the effect of 60-second or 180-second delayed cord clamping during labor on cerebral oxygenation and cardiac function. Healthy newborns were divided into two groups: a 60-second delay in cord clamping (60-s DCC) and a 180-second delay in cord clamping (180-s DCC) at birth. Pulse oximetry and cerebral near-infrared spectroscopy (cNIRS) probes were placed during postnatal care. A total of 84 healthy newborns were included in this study. Preductal oxygen saturation (SpO2), heart rate, and cNIRS values were recorded at 5 and 10 minutes after delivery. The cardiac function of the infants was assessed by echocardiography at 3-7 days postnatally. There was no significant difference between the groups in SpO2 and cNIRS values at 5 and 10 min. While there was no significant difference in the number of neonates with targeted SpO2 at the 5th and 10th min and targeted cNIRS values at the 10th min, there was a significant difference in the number of neonates with target cNIRS values at the 5th min between groups (p < 0.001). Echocardiographic findings showed that pulmonary flow velocity was increased in the 180-s DCC group; the difference was statistically significant (p = 0.04). Our results showed that the number of infants with normal cNIRS values regarding cerebral oxygenation was higher in the 180-s DCC group. The pulmonary flow velocity was significantly increased in the 180-s DCC group in terms of echocardiographic findings.

Physiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial—statistical analysis plan for a multicenter randomized controlled trial

BackgroundMortality, cerebral injury, and necrotizing enterocolitis (NEC) are common complications of very preterm birth. An important risk factor for these complications is hemodynamic instability. Pre-clinical studies suggest that the timing of umbilical cord clamping affects hemodynamic stability during transition. Standard care is time-based cord clamping (TBCC), with clamping irrespective of lung aeration. It is unknown whether delaying cord clamping until lung aeration and ventilation have been established (physiological-based cord clamping, PBCC) is more beneficial. This document describes the statistical analyses for the ABC3 trial, which aims to assess the efficacy and safety of PBCC, compared to TBCC.MethodsThe ABC3 trial is a multicenter, randomized trial investigating PBCC (intervention) versus TBCC (control) in very preterm infants. The trial is ethically approved. Preterm infants born before 30 weeks of gestation are randomized after parental informed consent.The primary outcome is intact survival, defined as the composite of survival without major cerebral injury and/or NEC. Secondary short-term outcomes are co-morbidities and adverse events assessed during NICU admission, parental reported outcomes, and long-term neurodevelopmental outcomes assessed at a corrected age of 2 years.To test the hypothesis that PBCC increases intact survival, a logistic regression model will be estimated using generalized estimating equations (accounting for correlation between siblings and observations in the same center) with treatment and gestational age as predictors. This plan is written and submitted without knowledge of the data.DiscussionThe findings of this trial will provide evidence for future clinical guidelines on optimal cord clamping management at birth.Trial registrationClinicalTrials.gov NCT03808051. Registered on 17 January 2019.

Impact of the Timing of Umbilical Cord Clamping on Maternal and Neonatal Outcomes in Saudi Arabia.

The optimal time for umbilical cord clamping after delivery has been under debate for several decades. This study aimed to assess the time-dependent effects of umbilical cord clamping on maternal and neonatal outcomes. An observational correlational design was used to recruit 161 pregnant women conveniently. Outcomes were observed and recorded using a structured checklist developed by the authors.Pregnant females aged ≥18 years, with uncomplicated delivery, and who were willing to participate were recruited. Exclusion criteria included stillbirths, newborns with congenital anomalies, newborns too small for their gestational age, intra-uterine growth restriction, nuchal cord, and meconium-stained liquor. The mean age of the participants was 29.93 ± 6 years. Early clamping (<1 minute) was performed for 93.8% of the participants with a mean of 29.58 ± 18 seconds. Delayed clamping was associated with a decrease in blood loss and the length of hospital stay in addition to an increase in first-minute APGAR score and neonatal temperature (P < 0.05). Delayed cord clamping was associated with improved maternal and neonatal outcomes.

Effect of Umbilical Cord Clamping time of Term Infants on Maternal and Neonatal Outcome

Effect of Umbilical Cord Clamping time of Term Infants on Maternal and Neonatal Outcome

EFFECT OF EARLY VS. DELAYED CORD CLAMPING IN NEONATE'S HEART RATE AND OXYGEN SATURATION IN THE FIRST 10 MINUTES OF LIFE

The timing of umbilical cord clamping after birth can influence neonatal physiological parameters, which may affect immediate neonatal outcomes. This study sought to determine the effects of early cord clamping (ECC) and delayed cord clamping (DCC) on neonates' heart rate and oxygen saturation during the first ten minutes of life. The Obstetrics and Gynecology Department of Liaquat National Hospital, Karachi, carried out the randomized controlled trial with 200 participants. Two groups of newborns were assigned: ECC (cord clamped within 60 seconds of birth) and DCC (cord clamped after 60 seconds of birth). A pulse oximeter was used to monitor heart rate and oxygen saturation continuously from birth to 10 minutes of life. In most observed intervals, the heart rates of neonates in the DCC group fell within the range of 111 to 150 bpm. A significant proportion of ECC neonates had heart rates between 151 and 170 beats per minute at one minute. In addition, during the early postnatal period, DCC neonates consistently exhibited higher oxygen saturation levels, particularly within the 96-100% range, compared to ECC neonates. Delayed cord clamping appeared to promote stability in neonatal heart rate and enhance oxygen saturation in the immediate post-birth period. These findings highlighted the physiological advantages of DCC and its function in optimizing early neonatal outcomes.

A RIGOROUS EXAMINATION OF THE APPROPRIATENESS AND CONSEQUENCES OF DEFERRED CORD CLAMPING IN PRETERM BABIES

The timing of umbilical cord clamping is a pivotal decision in neonatal care, especially for preterm babies. Recent discussions have pivoted around the merits and drawbacks of Delayed Cord Clamping (DCC) compared to Immediate Cord Clamping (ICC). This study aimed to assess and contrast the implications of DCC versus ICC on clinical, respiratory, developmental, and maternal outcomes among preterm neonates. A multicentric, forward-looking, cross-sectional investigation was executed. The study encompassed 350 preterm neonates from various centers. They were categorically split: 175 underwent DCC, while the other 175 experienced ICC. Diverse outcomes, spanning clinical to maternal, were meticulously evaluated. DCC neonates demonstrated elevated early post-birth hemoglobin and hematocrit measurements. The DCC group reported reduced polycythemia occurrences, diminished transfusion necessities, and lesser demands for cardiovascular interventions. Regarding respiratory metrics, the DCC faction showed a decreased incidence of RDS. Neurodevelopmental indicators, such as cognitive and motor capabilities, were more pronounced in the DCC segment. The DCC group manifested reduced neonatal mortality rates and fewer sepsis cases. Maternally, post-delivery hemorrhage was comparable between groups, yet the DCC set displayed heightened satisfaction and a more pronounced initiation and continuity in breastfeeding. The evidence suggests that DCC may present multiple benefits over ICC for preterm neonates in terms of health and developmental outcomes. This underscores the potential of DCC as an integral component of best practices in neonatal care for premature babies.

Midwifery care providers' childbirth and immediate newborn care competencies: A cross-sectional study in Benin, Malawi, Tanzania and Uganda.

Evidence-based quality care is essential for reducing sub-Saharan Africa's high burden of maternal and newborn mortality and morbidity. Provision of quality care results from interaction between several components of the health system including competent midwifery care providers and the working environment. We assessed midwifery care providers' ability to provide quality intrapartum and newborn care and selected aspects of the working environment as part of the Action Leveraging Evidence to Reduce perinatal morTality and morbidity (ALERT) project in Benin, Malawi, Tanzania, and Uganda. We used a self-administered questionnaire to assess provider knowledge and their working environment and skills drills simulations to assess skills and behaviours. All midwifery care providers including doctors providing midwifery care in the maternity units were invited to take part in the knowledge assessment and one third of the midwifery care providers who took part in the knowledge assessment were randomly selected and invited to take part in the skills and behaviour simulation assessment. Descriptive statistics of interest were calculated. A total of 302 participants took part in the knowledge assessment and 113 skills drills simulations were conducted. The assessments revealed knowledge gaps in frequency of fetal heart rate monitoring and timing of umbilical cord clamping. Over half of the participants scored poorly on aspects related to routine admission tasks, clinical history-taking and rapid and initial assessment of the newborn, while higher scores were achieved in active management of the third stage of labour. The assessment also identified a lack of involvement of women in clinical decision-making. Inadequate competency level of the midwifery care providers may be due to gaps in pre-service training but possibly related to the structural and operational facility characteristics including continuing professional development. Investment and action on these findings are needed when developing and designing pre-service and in-service training. Trial registration: PACTR202006793783148-June 17th, 2020.

The effect of cord clamping time on cord blood gas in term newborn babies delivered by cesarean section

Objective: Umbilical cord clamping time is a situation that should be planned before delivery. It is recommended that the umbilical cord be clamped for at least 30–60 seconds after birth in healthy preterm and term newborns. There are few studies investigating the effect of umbilical cord clamping time on cord blood gas. If the umbilical cord is clamped before 30 seconds after birth, it is considered early clamping, and if it is clamped after 30 seconds, it is considered late clamping. In this study, we aimed to compare the early or late clamping time of the umbilical cord with the acid-base parameters and lactate values of babies. Methods: A total of 217 term newborn infants who were delivered by cesarean section between December 2020 and December 2021 in our hospital, whose umbilical cord clamping times were recorded and who had cord blood samples, were included in our study retrospectively. pH, pCO2, pO2, HCO3, BE, lactate, Hb and bilirubin values in cord blood gas samples were compared between the two groups. Results: Two hundred seventeen term newborn babies were included in the study. Cord clamping time of infants was delayed in 125 (57.6%) and early in 92 (42.4%) infants. The mean pH in cord blood gas was 7.37±0.07 (7.16–7.57), pCO2 was 39.73 ±8.97 (20.3–65.4) mmHg, pO2 was 53.42±41.95 (14.8–198) mmHg, BE was -2.18±2.90 (-11.9–13.6) mmol/L, lactate was 2.12±0.88 (0.50–5.90) mmol/L, Hb was 14.57± 2.54 (10–23.7) g/dl, and bilirubin was 1.71±1.33 (0–3.7) mg/dl. Conclusion: There was no significant relationship between early and late clamping of the umbilical cord and acid-base parameters, and hemoglobin values in cord blood gas in term newborn babies delivered by cesarean section.

Timing of umbilical cord clamping in infants with congenital diaphragmatic hernia

Congenital diaphragmatic hernia (CDH) is a severe birth anomaly where a defect in the diaphragm allows abdominal organs to herniate into the chest with compression of the intrathoracic structures, specifically the lungs and heart. Pulmonary and left ventricular hypoplasia result in respiratory insufficiency after birth with disordered transition and persistent pulmonary hypertension of the newborn (PPHN). As a result, infants need immediate intervention after birth to support the transition. Delayed cord clamping (DCC) is recommended for all healthy newborns and improves outcomes in infants born preterm and in infants with congenital heart disease; however, DCC may not be feasible in newborns needing immediate intervention after birth. Recent studies have explored resuscitation with intact umbilical cords, to determine feasibility, safety, and efficacy in infants with CDH, with promising results. In this report we discuss the physiologic basis for intact cord resuscitation in infants with CDH and review the above reports with a view to determining optimal timing of umbilical cord clamping in infants with CDH.

Knowledge and practices of delivery room midwives on delayed umbilical cord clamping time: a descriptive study from Turkey

This study aimed to evaluate the knowledge and practices of delivery room midwives on delayed umbilical cord clamping (DCC). This descriptive study was conducted with a total of 1,274 delivery room midwives from five regions of Turkey. The data were collected using a Google survey form. Most of the midwives defined DCC as clamping the umbilical cord in term newborns after cessation of pulsations (47.2%), and as clamping the umbilical cord in preterm newborns within 15-30 seconds of birth (31.2%). Their highest DCC time ranged between 0-10 seconds for term and preterm newborns (34.7% and 54.8%, respectively). The rates of applying DCC were 17.6% and 5.3% in term and preterm newborns, respectively. Dealing with the mother (75.6% and 33.4%, respectively), having workload (27.5% and 24.6%, respectively), considering that the newborn would have respiratory distress (16.1% and 33.4%), considering that the newborn would get cold (10.7% and 13.9%, respectively), preventing polycythemia and hyperbilirubinemia (6.7% and 9.7%, respectively), and being afraid of dropping the newborn (5.3% and 19%, 8, respectively) are the most common reasons for midwives not to apply DCC to term and preterm newborns. The majority of the midwives reported that they had no DCC protocol in their institution (80.5%) and did not receive in-service training on DCC (76.5%). This study has concluded that most midwives do not know the correct definition of DCC, do not apply DCC correctly, have quite short DCC times, have no DCC protocol in their institutions and do not receive in-service training on DCC

Umbilical cord clamping time and maternal satisfaction

ObjectiveClamping of the umbilical cord is part of the third stage of delivery. Delayed cord clamping (DCC) is recommended due to its contribution to prevention of anaemia. There is no evidence on the effect of DCC on maternal satisfaction. The aim of this study is to evaluate the effect of different sociodemographic and obstetric factors, including the timing of cord clamping, on maternal satisfaction with the birth experience in our healthcare system. DesignPragmatic non-drug intervention study with simple random assignment of participating mothers (Clinical Trials N°: NCT03624335). SettingA public, university-level hospital in Villarreal city, eastern Spain. ParticipantsChildbearing woman, gestation week between 35 and 42 weeks, with regular medical pregnancy checks, single pregnancy and vaginal delivery (N = 198, 80% of the women recruited). Interventionsumbilical cord clamping within 60 seconds of the birth (Early cord clamping, ECC) versus umbilical cord clamping after pulsation had been ceased (Delayed cord clamping, DCC). MeasurementsBirth satisfaction was measured using the Mackey Childbirth Satisfaction Rating Scale (MCSRS). Additionally, sociodemographic data, degree of knowledge about the moment of clamping and type of breastfeeding data were recorded. The Mann-Whitney and Kruskal-Wallis tests for comparison of the mean of two, three, or more groups, respectively, and Chi-square and Spearman for comparison of two qualitative and quantitative variables, respectively, were used. To determine the weight of each factor of MCSRS, an exploratory factor analysis was carried out using the maximum likelihood method for factor extraction and the varimax method for factor rotation. The adequacy of the factor analysis was checked by mean of Kaiser-Meyer-Olkin test and Bartlett sphericity test. The level of significance was set at a p-value of < 0.05. FindingsThe average degree of satisfaction was 4.55/5 (SD: 0.37). No statistically significant difference was observed between mothers’ satisfaction according to mother level of study or mother's place of birth, while it changed significantly with age (p = 0.0398). Within the obstetric variables, satisfaction was significantly associated with spontaneous amniorrhexis, the duration of the second stage of delivery, and the Apgar value of the newborn at the first minute of life, and was independent of the number of previous pregnancies and deliveries, use of intrapartum oxytocin, epidural analgesia, episiotomy, the weight of the child at birth and type of breastfeeding. Furthermore, there was no relationship between the time of clamping and satisfaction (p = 0.5178). Key ConclusionsMaternal satisfaction with the birth experience varies with the age of the childbearing woman, and some intrapartum factors and the result is not influenced by the time of clamping of the umbilical cord. Therefore, this component of the physiological management of childbirth provides additional benefits for the health of the neonate, without negative consequences on the final perception of the maternal health care received. Implications for practiceIf there are no reasons that justify an early umbilical cord clamping, delaying it brings benefits to the neonate, without negatively affecting the maternal assessment of the experience of childbirth.

Major obstetric hemorrhage management

Postpartum hemorrhage (PPH) is to this day one of the leading causes of maternal death and its diagnosis is still highly subjective, as it relies on unprecise estimates of the amount of blood loss. There are three areas in which PPH outcomes can be improved: prevention, treatment and rescue. PPH can escalate to a graver clinical picture of Severe Acute Maternal Morbidity (SAMM) due to an inaccurate estimate of the blood loss, inability to identify an at-risk patient, delays in testing and availability of hemoderivatives, and lack of clear guidelines and interdisciplinary communication. Many factors can predispose to PPH and in clinical practice the many causes of its insurgence are summarized with the 4T formula: Tone (uterine atony), Trauma (laceration/hematoma), Tissue (retained tissue/invasive placenta), Thrombin (coagulation). Some precautions can be taken in preventing PPH such as the use of uterotonics, the administration of oxytocin, the timing of umbilical cord clamping, and the monitoring of anemia and the platelet to fibrinogen concentration ratio. In recent years studies have been published with the goal of leading PPH diagnosis and management through universal guidelines, point-of-care testing and interdisciplinary approaches. The proposed algorithms, albeit not yet validated, are useful in the clinical practice; similarly beneficial is the use of reliable predictive panels such as the Modified Early Obstetric Warning System.

Iron Deficiency Anemia in Children Younger than Six Months and Time of Umbilical Cord Clamping. Anemia in 6 Months Old Infants and Delayed Clamping of the Umbilical Cord

Iron Deficiency Anemia in Children Younger than Six Months and Time of Umbilical Cord Clamping. Anemia in 6 Months Old Infants and Delayed Clamping of the Umbilical Cord

Association between umbilical cord clamping time, hemoglobin and total serum bilirubin in term neonates admitted for phototherapy

BackgroundThe aim of the study was to investigate relationship between cord clamping status, total hemoglobin (THb) and total bilirubin (TBil) in term infants requiring phototherapy for neonatal jaundice. MethodsThis retrospective study included term infants admitted at the study hospital for management of physiological neonatal jaundice between 2013 and 2019. Associations between THb, TBil, cord clamping status and Direct Coombs Test (DCT) status, as well as correlation between laboratory and blood gas analyzer (BGA) methods were investigated. Results258 term infants were included. 147 infants had cord clamping status documented; 111 had unknown cord clamping status. Delayed cord clamping (DCC) was associated with significantly higher mean THb in DCT negative infants only. Negative DCT was associated with higher THb and TBil regardless of cord clamping status. Mean TBil concentration did not change with increasing THb or cord clamping status. The incidence of term infants admitted for phototherapy increased over the study period. There was strong positive correlation between BGA and laboratory assays. ConclusionsDCC was associated with a higher THb in DCT negative infants only. There was no correlation between THb and TBil. There was strong positive correlation of TBil between BGA and laboratory assays thus supporting BGA use in ambulatory care settings.

A Quality Improvement Project to Delay Umbilical Cord Clamping Time.

Introduction:Delayed cord clamping (DCC) has numerous benefits to the neonate, including increased hemoglobin levels, decreased need for red blood cell transfusions, and decreased incidence of necrotizing enterocolitis and intraventricular hemorrhage. A preliminary observational study at our institution demonstrated 12% of the observed deliveries met the DCC standard, defined as umbilical cord clamping at least 30–60 seconds after birth. Therefore, we designed a quality improvement project to increase the percentage of deliveries using DCC.Methods:We planned a quality improvement project aiming to increase DCC rates on the university obstetrics service. Our interventions included provider education, installation of timers in the delivery suites, and modification to documentation in the electronic health record. We measured our results through the documented status of cord clamping, either: (1) greater than or equal to 30 seconds or (2) less than 30 seconds. We analyzed the DCC rates weekly and compared those results to the DCC goal of 80% of all deliveries.Results:Postintervention DCC rates were 96% overall. Rates of DCC met our aim of 80% or greater each of the 6 weeks we collected data.Conclusion:Simple and inexpensive interventions quickly led to improvements in DCC rates on our university obstetrics service. Our interventions including, provider education, installation of timers in delivery suites, and modification to cord clamping documentation in the electronic health record can be easily instituted at other hospitals. Additionally, the simplicity of this system can produce long-term sustainability of DCC.

Impact of early respiratory care for extremely preterm infants

Despite advances in neonatal intensive care, more than half of surviving infants born extremely preterm (EP; < 28 weeks’ gestation) develop bronchopulmonary dysplasia (BPD). Prevention of BPD is critical because of its associated mortality and morbidity, including adverse neurodevelopmental outcomes and respiratory health in later childhood and beyond. The respiratory care of EP infants begins before birth, then continues in the delivery room and throughout the primary hospitalization. This chapter will review the evidence for interventions after birth that might improve outcomes for infants born EP, including the timing of umbilical cord clamping, strategies to avoid or minimize exposure to mechanical ventilation, modes of mechanical ventilation and non-invasive respiratory support, oxygen saturation targets, postnatal corticosteroids and other adjunct therapies.

Umbilical cord clamping in preterm infants

For several years now, the survival of preterm infants has been increasing, which has shifted our concern to preterm infants born before 28 weeks of gestation in particular. The timing of umbilical cord clamping may lead to several disorders, especially when done early (10-15 seconds). In the last two decades, several investigations have shown the considerable benefits of delayed cord clamping (2-3 minutes). Delayed cord clamping has been practiced in obstetrics and neonatal care based on the recommendations made by scientific societies and in systematic reviews, which have provided solid evidence to support this practice in preterm infants. This review describes the most relevant articles from the last years, which strongly support the use of delayed cord clamping versus early cord clamping. In addition, this practice reduces the rate of severe disorders in preterm infants.

Timing of umbilical cord clamping for preterm infants in low-and-middle-income countries: A survey of current practice

IntroductionThe optimal timing of umbilical cord clamping in preterm infants has been contested for years. Previously, it was common practice to clamp the cord immediately after birth. There is now high-quality evidence that delayed cord clamping (DCC) (>60 seconds) reduces mortality in preterm infants by allowing placental transfusion. However, it is unclear how well DCC has been implemented into practice. This study aims to assess current practice of timing of cord clamping for both stable and unstable preterm infants in LMICs, where rates of preterm birth and neonatal mortality are high and where there is the potential to see the greatest benefit from implementation of DCC. MethodsAn online survey was created and, following user-testing, circulated to maternity workers in LMICs via The International Federation of Gynaecology and Obstetrics (FIGO), social media and other existing collaborators. Analyses were conducted using SPSS. Results70 responses were received across 10 LMICs. 42/70 (60%) participants reported practising DCC for stable preterm infants, compared to only 4/70 (6%) for unstable infants. For stable infants, 22/42 (52%) of those who practised DCC gave their main reason as being “recommended by guidelines”. 13/70 (19%) participants said they didn’t follow any guidelines for the timing of cord clamping. Only 25/70 (36%) were aware of guidelines for cord clamping in their hospitals, and 9/70 (13%) were aware of related quality improvement projects (QIPs). DiscussionDespite evidence to support the use of DCC, timing of cord clamping in LMICs is variable. Unstable infants requiring stabilisation could benefit most from placental transfusion, yet few respondents practised DCC and few hospitals had QIPs in place. Higher-quality guidelines and training could increase implementation of DCC, and development of affordable equipment to allow bedside resuscitation with the cord intact could aid in reducing neonatal mortality.

A STUDY ON ATTITUDE, BEHAVIOR AND UMBILICAL CORD CLAMPING ON NEONATAL JAUNDICE IN PREGNANCY: TREATMENT APPROACHES AFTER PARTURITION

The aim of the present study was to investigate cord clamping practice and treatment approaches for term vaginal births in Indian hospital, where the majority of births have an Obstetrician as the lead. A stopwatch was used to time the cord clamping interval at 55 term vaginal births in a tertiary hospital. The stopwatch was pressed once at the time of the birth and once when the first clamp was applied to the umbilical cord. Mode of birth, maternal position for birth and whether midwives and or doctors and neonatal health practitioners were involved in the birth was documented alongside the cord clamping timing. Cord clamping timing ranged from a minimum of 14 seconds to a maximum of 34 minutes. The median umbilical cord clamping time for all births in the study was 3.5 minutes. The median cord clamping time was likely to be longer when the woman had a spontaneous vaginal birth rather than an instrumental birth; when she birthed in a side-lying or upright position rather than a seated position; when a midwife facilitated the birth rather than a doctor and when there was no neonatal team present at the birth. The median cord clamping time of 3.5 minutes is aligned with current local, national and international guidelines. Midwives are likely to facilitate longer cord clamping times as they are more likely than doctors to attend spontaneous uncomplicated births which do not warrant immediate separation of mother and baby for preventative or resuscitative measures.&#x0D; Keywords: Resuscitative measures, Cord clamping, Spontaneous vaginal birth, Behavior and Umbilical Cord Clamping, Neonatal Jaundice

The Impact of Umbilical Cord Clamping Time on the Infant Anemia: A Randomized Controlled Trial.

Background:Anemia during infancy causes irreversible physical, cognitive, motor, and behavioral development disorders. This study aimed to determine the effect of delaying umbilical cord clamping time on certain parameters regarding anemia during the infancy.Methods:This randomized controlled trial was conducted at a university hospital in west of Turkey (Dec 2017–Dec 2018). Overall, 110 participants were evaluated for the research, 65 participants were randomized after excluding those who did not meet the inclusion criteria (intervention=32, control=33). Randomly assigned to delayed clamping (1 min after delivery) or early clamping (in 15 sec after delivery), and followed up until 4 months postpartum. 48th-hour hematocrit, bilirubin values, need for phototherapy and hematocrit, hemoglobin values, diagnosis of anemia at the postnatal fourth month were compared between two groups. The data showing normal distribution were assessed using the parametric tests. The level of statistical significance was determined as P<0.05.Results:The 48th-hour hematocrit and bilirubin levels of the intervention group were significantly higher than the control (P<0.01 and P<0.05, respectively). No significant difference regarding the need for phototherapy due to postnatal hyperbilirubinemia was observed between the two groups (P>0.05). Means of the intervention group hematocrit and hemoglobin levels measured during anemia screening performed at the fourth month were found to be higher than those of the infants in the control group (P<0.05 and P<0.05, respectively).Conclusion:Delaying umbilical cord clamping had a positive impact on the haematological parameters of infants. Clamping the cord at least one minute in birth can be performed to prevent the iron deficit anemia that could be seen during the first years of infants’ lives.