Timing Of Intravenous Administration Research Articles

The Effect of Timing of Intravenous Muscle Relaxant on the Quality of Double-Contrast Barium Enema

AIM: To determine whether the timing of buscopan administration during double-contrast barium enema examination (DCBE) affects diagnostic quality.MATERIALS AND METHODS: In a prospective setting, 100 consecutive adult out-patients referred for DCBE received 20mg buscopan (hyoscine-N-butylbromide) intravenously, either before infusion of barium suspension (Group A) or after barium infusion and gas insufflation (Group B). A subjective assessment of ease of contrast medium infusion was made at the time of examination and the films subsequently analysed by two radiologists unaware of the mode of relaxant administration, who noted the quality of mucosal coating and made subjective and objective measurements of segmental distension.RESULTS: There was no significant difference in screening times, infusion difficulty or colonic contrast medium coating between the two groups. Subjective assessment of distension of the caecum, ascending colon, transverse colon and rectum were not significantly different. Patients receiving intravenous relaxant after barium and gas infusion had less subjective descending (P=0.05) and sigmoid (P=0.04) colon distension, but there was no significant difference with respect to maximal bowel diameter in any of the segments measured.CONCLUSION: The timing of intravenous administration during DCBE is likely to have no significant effect on the diagnostic quality of the study.Elson, E. M. (2000). Clinical Radiology55, 395–397.