Partially Internal Thermally Coupled Air Separation Column (P-ITCASC) is a highly energy-efficient and cost-effective technology. However, its complex dynamics resulting from thermal coupling pose a challenge to the operating stability of this technology. This article, therefore, proposes an adaptive model predictive control (AMPC) scheme for the P-ITCASC process. The controller incorporates an auto-regressive and exogenous inputs (ARX) model, a linear time-varying Kalman filter, and a recursive polynomial model estimator (RPME) algorithm. Within RPME, ARX polynomial models are identified and utilized to estimate the time-varying parameters and update the prediction model of the process. The process states are observed through the Kalman filter, and the constrained receding horizon optimization problem is solved using quadratic programming. This control scheme ensures the closed-loop system's feasibility and stability in the presence of output/input constraints. An adaptive generic model control, model predictive control, and adaptive internal model control schemes were also designed for benchmarking study. Numerical simulations show that AMPC is more efficient in handling nonlinear dynamics and maintaining product concentration to desired set points compared to other control schemes.