Time Task Research Articles

Modifying reaction time tasks parameters in the automated IntelliCage identifies heightened impulsivity and impaired attention in the 3xTg-AD model of Alzheimer’s disease

BackgroundThe 3xTg-AD transgenic mouse model of Alzheimer’s disease (AD) is an important tool to investigate the relationship between development of pathological amyloid-β (Aβ) and tau, neuroinflammation, and cognitive impairments. Traditional behavioral tasks assessing aspects of learning and memory, such as mazes requiring spatial navigation, unfortunately suffer from several shortcomings, including the stress of human handling and not probing species-typical behavior. The automated IntelliCage system was developed to circumvent such issues by testing mice in a social environment while measuring multiple aspects of cognition. Water consumption can serve as a primary motivator for task engagement. Once animals adapt to the cage and can access water, mice can be subjected to operant tasks. Each of the four corners of a cage contains doors to manipulate access to water, visual LED cues, and a valve allowing administration of an air puff. Previously, we detected significant impairments in 3xTg-AD mice in the IntelliCage, however a high failure rate and genotypical differences in water motivation were observed.MethodsHere, we implemented an IntelliCage paradigm where mice underwent progressively more difficult reaction time tasks to assess attention and impulsivity, behaviors mediated by the prefrontal cortex. Mice were placed in the IntelliCage at 11.5 months of age, which corresponds with the presence of widespread pathology.ResultsAs the difficulty of the reaction time tasks increased, 3xTg-AD mice exhibited lower percent Correct Responses than NonTg. When implementing varying pre-cue durations, where animals are required to wait between the initiation of the trial and the LED turning on (which then requires a nose-poke to access water), 3xTg-AD mice prematurely nose-poked on trials requiring a longer delay before a second nose poke would allow water access, demonstrating heightened impulsivity. The presence of soluble and insoluble fractions of cortical Aβ40 and 42, and phosphorylated tau epitopes threonine 181 and serine 396 confirmed the presence of neuropathological hallmarks in 3xTg-AD mice.ConclusionTogether, this study describes a novel protocol that overcomes motivational differences and detects attention and impulsivity deficits in 3xTg-AD mice utilizing the IntelliCage.

Followers’ Regulatory Mode and Leadership Style Preferences: Does the Task Time Perspective Moderate Their Relation?

Leadership style preferences are in part shaped by differences in people’s self-regulation. However, research shows inconsistent findings regarding the relation between followers’ regulatory mode (locomotion – a need for maintaining movement and change; and assessment – a need for evaluating and critically comparing) and their preferences for directive versus participative leadership styles. The present research aimed to test whether a short-term versus long-term task time perspective moderates this relation, and as such whether time perspective might reconcile previous findings. In three preregistered studies, we measured participants’ regulatory mode and manipulated task time perspective by asking participants to recall short- versus long-term tasks they had completed in the past (Study 1, N = 304; Study 2, N = 373) or to imagine working in a company and having to complete short- versus long-term tasks (Study 3, N = 355). Participants then indicated their leadership style preferences for the respective task. Contrary to predictions, the results of all studies and an internal meta-analysis indicated that task time perspective does not moderate the relation between followers’ regulatory mode and their leadership styles preferences. However, independent of the task time perspective, followers’ locomotion mode was consistently and positively associated with a preference for participative leadership. The present findings point to the importance of taking into account followers’ regulatory mode when considering their leadership preferences. Indeed, considering locomotors’ participative leadership style preference is crucial to ensure leadership style fit and foster motivation at work.

Finding the Mole and Choosing the Apple: Executive Function Challenges in Children with Developmental Language Disorder (DLD)

Background: Children with a developmental language disorder (DLD) frequently experience deficits in cognitive skills such as working memory (WM) and sustained attention (SA), which are closely related to language development. Yet, these cognitive deficits remain underexplored in early childhood, particularly during the preschool years. Objective: This study explores WM and SA in Chilean preschoolers with a DLD compared to their typically developing (TD) peers, using the nonverbal tasks “Torpo the Clumsy Mole” for WM and the Continuous Performance Task (CPT) “Duno and the Worms” for SA, both from the Child Neuropsychological Evaluation Test (TENI in Spanish). Method: Thirty DLD and 30 TLD peers (aged 4 to 4 years 11 months) participated. Accuracy and reaction times in both tasks were assessed. Results: The children with a DLD demonstrated significant deficits in working memory accuracy and poorer sustained attention accuracy despite exhibiting shorter reaction times in the sustained attention task compared to TLD children. Conclusions: The findings highlight the multifaceted nature of a DLD, particularly in relation to cognitive dimensions beyond language, such as working memory and sustained attention. Early identification of these differences emphasizes the important role of executive functions in DLDs.

Sensitivity of Functional Arterial Spin Labelling in Detecting Cerebral Blood Flow Changes

Aims/Background Arterial spin labelling (ASL) is a non-invasive magnetic resonance imaging (MRI) method. ASL techniques can quantitatively measure cerebral perfusion by fitting a kinetic model to the difference between labelled images (tag images) and ones which are acquired without labelling (control images). ASL functional MRI (fMRI) provides quantitative perfusion maps by using arterial water as an endogenous tracer instead of depending on vascular blood oxygenation level.This study aimed to assess the number of pulsed ASL blocks that were needed to provide accurate and reliable regional estimates of cerebral blood flow (CBF) changes when participants engaged in visually guided saccade and fixation task; evaluate the localization to cortical control saccade versus fixation; investigate the relationship between the sensitivity of ASL fMRI and the number of blocks; and compare the sensitivity of blood oxygen level-dependent (BOLD) fMRI and ASL fMRI. Methods The experiment was a block-design paradigm consisting of two conditions: fixation and saccade. No response other than the eye movements of the participants was recorded during the scans. ASL and BOLD fMRI scans were conducted on all participants during the same session. The fMRI study consisted of two functional experiments: a CBF contrast was provided using the ASL sequence, and an optimized BOLD contrast was provided using the BOLD sequence. Results From group analysis in all divided blocks of ASL sessions (4, 6, 8...... 14, 16, 18......26, 28, 30), ASL yielded significant activation clusters in the visual cortex of the bilateral hemisphere from block 4. There was no false activation from block 4. No activation cluster was found by reversing analysis of block 2. Robust and consistent activation in the visual cortex was observed in each of the 14 divided blocks group analysis, and no activation was found in the eye field of the brain. The sensitivity of 4-block was found to be better than that of 8-block. More significant activation clusters of the visual cortex were found in BOLD than in ASL. No activation cluster of parietal eye field (PEF), frontal eye field (FEF) and supplementary eye field (SEF) was detected in ASL. The voxel size of the activation cluster increased with the increasing number of blocks, and the percent signal change in the activation cluster decreased with the escalating block number. The voxel size was positively correlated with the number of blocks (correlation coefficient = 0.98, p < 0.0001), and the percent signal change negatively correlated with the number of blocks (correlation coefficient = –0.90, p < 0.0001). Conclusion The 4-block pulsed functional ASL (fASL) presents accurate and reliable activation, with minimal time-on-task effect and little adverse impact of time, in participants engaging in visually guided saccade and fixation tasks. Despite having lower sensitivity than BOLD fMRI, ASL can determine accurate activation location. Although the time-on-task effects affect the observation for the sensitivity of ASL over task time, it is suggested that ASL fMRI may provide a powerful method for pinpointing the time-on-task effect over a long period of time.

Profiles of academic and cognitive abilities differ in younger and older children from diverse socioeconomic neighbourhoods

ABSTRACT Objective Research indicates that socioeconomic status (SES) influences developmental outcomes, particularly in language, executive functions, and intelligence, though findings have been mixed. This study examines the relationship between academic, cognitive and intellectual abilities in a cross-section of children at two age levels in low-SES vs. high-SES schools. Method We administered a computerised battery of tests to 46 children in Grade Two (youngest 6.9 years old) and 67 children in Grade Six (oldest 12.4 years old) across four primary schools from low-SES and high-SES neighbourhoods. The test battery comprised two academic ability tests, five cognitive ability tests, and two intelligence tests. Results In Grade Two, the low-SES group showed disadvantages on all measures except the Wisconsin Card Sorting Task and Choice Reaction Time. In Grade Six, while academic differences persisted between SES groups, cognitive differences were limited to the Wisconsin Card Sorting Task, where the high-SES group performed better than the low-SES group. Conclusions Though our results pertain to cross-sectional data using neighbourhood indices of SES, our findings contrast with previous research showing broad and pervasive disadvantages associated with lower SES. Future research should further examine the potential differences and similarities in developmental outcomes across SES groups using longitudinal methods.

A distributed algorithm for the multi-robot minimum time task allocation problem

Purpose The purpose of this study is to address the challenge of task allocation in multi-robot systems by getting the minimum overall task completion time and task allocation scheme while also minimizing robot energy consumption. This study aims to move away from traditional centralized methods and validate a more scalable distributed approach. Design/methodology/approach This paper proposes a distributed algorithm for the multi-robot task allocation problem, aimed at getting the minimum task completion time along with the task allocation scheme. The algorithm operates based on local interaction information rather than global information. By using the Consensus-Based Auction Algorithm (CBAA), it seeks to effectively minimize energy consumption without affecting the minimum completion time required for overall task allocation. Findings The proposed distributed algorithm successfully reduces robot energy consumption while effectively obtaining the shortest overall task completion time and corresponding task allocation scheme. Numerical simulations conducted using MATLAB software demonstrated its superior performance, and empirical testing on the Turtlebot3-Burger robot platform further substantiated these findings. Originality/value The original contribution of this study lies in the development of an enhanced distributed task allocation strategy using CBAA to improve efficiency in multi-robot environments. Its value extends to applications that require rapid and resource-aware coordination, such as automated logistics or search-and-rescue operations.

Analysis and selection of the structure of a multiprocessor computing system according to the performance criterion

Objectives. Analysis of the various architectures of computing systems (CSs) used in recent decades has allowed us to identify the most common structures. One of the key features is the use of mass-produced equipment to create data processing subsystems (for example, multicore processors and high-capacity semiconductor memory), as well as network equipment to build communication subsystems. This reduces hardware costs and allows typical or cluster configurations to be created, which is especially important for expensive CSs. The desire to achieve high computational speed and performance in such CSs requires minimizing the time to complete the task and balancing time delays both in data processing subsystems and in the communication subsystem which provides data transmission inside the CS. The aim of this work is to analyze computing modules (CMs) and structures on the basis of which the construction of cluster CSs is carried out.Methods. The main results of the work were obtained using methods of mathematical analysis and modeling.Results. The study considers the structure of modern multicore microprocessors as the basis for building CMs of cluster CSs. As the number of cores in the microprocessor structure increases, the communication network which unites them into a single structure becomes more complicated. It has been shown that in new developments of microprocessors, communication between cores is performed in the form of a network. The microprocessors themselves are MIMD structures in accordance with the well-known Flynn classification.Conclusions. The proposed method of selecting an effective structure of a CS allows us to obtain the optimal structure of a CS according to the criterion of performance.

Beat by Beat: Designing a Rhythm Game for Screening Dyslexia

Dyslexia, a language-based disorder, affects children’s reading, writing, and spelling abilities despite adequate classroom instruction. Early screening is crucial to mitigate the adverse effects of delayed detection. Dyslexia also impairs precise timing tasks, including rhythm skills essential for reading. This study explores the potential of serious games incorporating rhythms to screen for dyslexia, leveraging the natural synchronization of rhythm skills observed in body movements. Existing rhythm games fail to accurately address dyslexia-related difficulties, lacking relevant performance data and user-centred design. Our research aims to design a 2D sidescrolling platformer game, integrating established rhythmic activities to identify children at risk for dyslexia and engage them in gameplay. A multidisciplinary team collaborates on this initiative, including neuropsychologists, music therapists, and game designers. Using the Design Thinking Methodology, we focus on identifying effective music compositions, game mechanics, dynamics, and visual elements that enhance the gaming experience for children with dyslexia and support early dyslexia screening.

EAAT2 Activation Regulates Glutamate Excitotoxicity and Reduces Impulsivity in a Rodent Model of Parkinson's Disease.

Parkinson's disease (PD) is a systemic disease characterized by motor and nonmotor impairments. Loss of dopaminergic neurons in the substantia nigra pars compacta region in PD disrupts dopamine-glutamate homeostasis in the corticostriatal circuit, contributing to cognitive impairment. In addition, excitatory amino acid transporter-2 (EAAT2), localized predominantly to astrocytes and responsible for > 80% of synaptic glutamate clearance, is downregulated in PD, causing glutamate spillover and excitotoxicity. This altered dopamine-glutamate homeostasis and excitotoxicity may affect reward-mediated decision-making behaviors and promote impulsive behaviors in PD. In this study, we hypothesized that GTS467, a small-molecule activator of EAAT2, could effectively reduce excitotoxicity and treat cognitive impairment without promoting impulsive behavior in PD. Rats that were unilaterally lesioned with the 6-OHDA toxin to produce Parkinsonian symptoms were referred to as lesioned rats. Lesioned rats were trained to meet baseline criteria in a 5-choice serial reaction time task, and the chronic effects of GTS467 were assessed after 3weeks of treatment. The results showed that chronic treatment with GTS467 significantly improved correct responses and reduced premature impulsive responses and omissions compared with saline treatment. This improvement in performance correlated with a reduction in glutamate levels, an increase in EAAT2 expression, and normalization of NMDA receptor subunit expression and signaling. Furthermore, transcriptomic studies on the prefrontal cortex tissue have shown the differential expression of genes involved in neuroprotection, neuroinflammation, learning, and memory. These results validate the role of glutamate excitotoxicity in promoting impulsive behaviors and suggest that GTS467 can be developed as a therapeutic agent to reduce cognitive impairment and impulsive behaviors in PD.

Ramifications of flipped classroom model on second language teachers’ professional identity in Turkish tertiary hybrid education context

As the traditional teaching paradigm is reversed in Flipped Classroom Model (FCM), it has the potential to empower the teacher to allocate more valuable face-to-face classroom time for productive language tasks. Digital flipped course contents encourage the students and the teacher to take advantage of becoming a member in an online learning community and engage in a social-constructive learning approach. Such a profound shift from the traditional teaching and learning paradigm may influence the identity progression of L2 teachers. This longitudinal study aims to explore the ramifications of flipped grammar teaching on four L2 teachers’ identity progression over the course of two academic years within the three fundamental modes of belonging for identity formation, namely engagement, alignment, and imagination, identified by Wenger (1999) at tertiary level. Methodological triangulation was adopted to boost the transferability and reliability of the findings. Semi-structured interviews provided in-depth insights into the four L2 teachers’ relational thinking about flipped grammar teaching and their professional identity progression. The data also included four hours of classroom observations to witness the real-life implications of teachers’ accounts. The twofold data was analyzed using deductive content analysis. The results indicated that English teachers need to make long lasting and conscious efforts towards a reconciliation between their existing identities and FCM. The teachers not only need to find accommodation strategies to ensure better integration of reluctant students into FCM but also overcome their own accuracy-based exam anxiety as they redefine their grammar identities incorporating FCM.

Optimising Outpatient Registration System Implementation Using Critical Path Method: A Case Study.

Today, hospital information systems (HISs) play an irreplaceable role in hospital management. At present, HIS construction projects in many hospitals have faced the setback of 'project quagmire' to varying degrees. The critical path method (CPM) mainly aims to find the critical path, thus managing project progress. To explore the importance and practical application of the CPM to the management of HIS project schedules. This study used the construction project of a hospital's outpatient registration subsystem as an example. CPM was used to determine the critical path. The time and workload required for the project were calculated using the forward and backward extrapolation methods. The earliest start time and earliest completion time as well as the latest start time and latest completion time of each task could be calculated using the forward and backward extrapolation methods. The path with the longest construction period was determined to be the critical path, and the unit speed rate of each activity was calculated on this basis. Then, the time schedule of the outpatient registration subsystem was compressed and the project schedule optimised. Path 3 [outpatient registration demand analysis (A)-basic data preparation (C)-subsystem test (F)-simulation test (G)] was determined to be the critical path according to the construction period, and the task time was compressed on this basis. Considering many factors, the time of the subsystem test task (F) was reduced from 7 weeks to 4 weeks. The total cost was saved by 1000 yuan, which not only ensured the progress ahead but also saved the overall cost. The CPM could effectively measure the completion and deviation of each stage of the registration system project, which provided an effective guarantee for the subsequent schedule compression to ensure that the project was completed as scheduled and was of sufficient quality. However, all conditions had to be considered comprehensively; doing otherwise would lead to increased risks and costs.

Task and Timing Effects in Argument Role Sensitivity: Evidence From Production, EEG, and Computational Modeling.

Comprehenders generate expectations about upcoming lexical items in language processing using various types of contextual information. However, a number of studies have shown that argument roles do not impact neural and behavioral prediction measures. Despite these robust findings, some prior studies have suggested that lexical prediction might be sensitive to argument roles in production tasks such as the cloze task or in comprehension tasks when additional time is available for prediction. This study demonstrates that both the task and additional time for prediction independently influence lexical prediction using argument roles, via evidence from closely matched electroencephalogram (EEG) and speeded cloze experiments. In order to investigate the timing effect, our EEG experiment used maximally simple Japanese stimuli such as Bee-nom/acc sting, and it manipulated the time for prediction by changing the temporal interval between the context noun and the target verb without adding any further linguistic content. In order to investigate the task effect, we conducted a speeded cloze study that was matched with our EEG study both in terms of stimuli and the time available for prediction. We found that both the EEG study with additional time for prediction and the speeded cloze study with matched timing showed clear sensitivity to argument roles, while the EEG conditions with less time for prediction replicated the standard pattern of argument role insensitivity. Based on these findings, we propose that lexical prediction is initially insensitive to argument roles but a monitoring mechanism serially inhibits role-inappropriate candidates. This monitoring process operates quickly in production tasks, where it is important to quickly select a single candidate to produce, whereas it may operate more slowly in comprehension tasks, where multiple candidates can be maintained until a continuation is perceived. Computational simulations demonstrate that this mechanism can successfully explain the task and timing effects observed in our experiments.

From Nutritional Patterns to Behavior: High-Fat Diet Influences on Inhibitory Control, Brain Gene Expression, and Metabolomics in Rats.

Impulsive and compulsive behaviors are associated with inhibitory control deficits. Diet plays a pivotal role in normal development, impacting both physiology and behavior. However, the specific effects of a high-fat diet (HFD) on inhibitory control have not received adequate attention. This study aimed to explore how exposure to a HFD from postnatal day (PND) 33 to PND77 affects impulsive and compulsive behaviors. The experiment involved 40 Wistar rats subjected to HFD or chow diets. Several tasks were employed to assess behavior, including variable delay to signal (VDS), five choice serial reaction time task (5-CSRTT), delay discounting task (DDT), and rodent gambling task (rGT). Genetic analyses were performed on the frontal cortex, and metabolomics and fatty acid profiles were examined by using stool samples collected on PND298. Our results showed that the HFD group exhibited increased motor impulsive behaviors while not affecting cognitive impulsivity. Surprisingly, reduced impulsive decision-making was shown in the HFD group. Furthermore, abnormal brain plasticity and dopamine gene regulation were shown in the frontal cortex, while metabolomics revealed abnormal fatty acid levels.

Enhancing Care Coordination in Oncology and Nononcology Thoracic Surgery Care Pathways Through a Digital Health Solution: Mixed Methods Study.

Health-system fragmentation in Quebec significantly impacts care coordination, leading to interruptions in patients' care pathways and adverse effects on their health. Coordinating interfacility service corridors is complex and requires collaboration between multiple health care providers (HCPs) and care settings. Effective care coordination is essential to ensure optimal patient management at transition points. This study aims to improve oncology and nononcology thoracic surgery care pathways by enhancing care coordination during interfacility transfers through a digital health solution. A multicenter implementation study was conducted across 2 health regions and 2 health care facilities in Quebec. We conducted 27 semistructured interviews with HCPs and managers to better understand the care pathways. Participatory design workshops were held with future users and key stakeholders at an early stage of the technology's design to validate the prototype's functionalities and workflows. A web survey was sent to all end users (N=13) to assess their experience with the platform. All participants (100%) either "agreed" or "strongly agreed" that the platform provided significant benefits. It enhanced interestablishment coordination (4/13, 31% agreed and 9/13, 69% strongly agreed) and continuity of care and services (8/13, 62% agreed and 5/13, 38% strongly agreed), and it contributed to better management and patient intake (10/13, 77% agreed and 3/13, 23% strongly agreed) and process fluidity (3/13, 77% agreed and 3/13, 23% strongly agreed). Surgeons from the McGill University Health Centre confirmed that the platform facilitated and secured information transmission (2/5, 40% agreed and 3/5, 60% strongly agreed) and kept track of oncology patient referrals, follow-up needs, and cases where surgery is unnecessary (2/5, 40% agreed and 3/5, 60% strongly agreed). Nursing staff from the Centre intégré de santé et de services sociaux de l'Outaouais and McGill University Health Centre reported high satisfaction with the platform's support during preoperative visit, surgery, and discharge processes. All participants perceived the platform as intuitive and easy to use. Additionally, participants valued its efficiency in providing rapid access to patient data, which reduces task time and ensures document security, thereby improving care coordination across facilities. The project's success has convinced the HCPs and senior management at both health care facilities to pursue long-term use of the Akinox digital health platform. This pilot project represents a significant advancement in thoracic surgery care pathways and the coordination of interfacility health care service corridors. The project provides care pathways that are adaptable to other surgical specialties. It also paves the way for improving care in cancer and other health care networks while highlighting the key role of nurse navigators in patient care management. The project underscores the value of strategic leadership and stakeholders' collaboration to improve care coordination and operational efficiency by demonstrating technology's essential role in patient care pathways.

Explicit and implicit timing across the adult lifespan.

The study of whether temporal processing in the millisecond-to-seconds range changes with age is an active and debated research field. Here, we adopted a lifespan approach in which younger to older participants performed both explicit and implicit timing tasks (time bisection and foreperiod tasks, respectively) in a single session. Three hundred seven participants (age range: 20-85 years) took part in the study. Participants performed two timing tasks to test explicit and implicit time processing. Age was used as a continuous predictor to elucidate whether explicit and implicit temporal processing change with increasing age. The results from the explicit timing task showed reduced precision with age, as indexed by a flatter psychometric curve and greater just noticeable difference metrics. By contrast, implicit processing of time was not significantly affected by age, as evinced by a comparable foreperiod effect across age. These findings provide first adult lifespan evidence that only explicit, but not implicit, timing is sensitive to age-related changes. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

From instantaneous schedulability to worst case schedulability: a significant moment approach

ABSTRACT The method of significant moment analysis has been used to derive instantaneous schedulability tests for real-time tasks. However, the instantaneous schedulability can only be checked within a finite time window. On the other hand, worst-case schedulability guarantees schedulability of tasks for infinite time. This paper derives the classical worst-case schedulability conditions for pre-emptive periodic tasks starting from instantaneous schedulability, hence unifying the two notions of schedulability. The results provide a rigorous justification for the critical time instants being the worst case for scheduling pre-emptive periodic tasks. The paper also shows that the critical time instant is not the only worst-case moments.

Inhibition of RtTg neurons reverses methamphetamine-induced attention deficits

Chronic methamphetamine (METH) use, a prevalent psychostimulant, is known to impair attention, yet the cellular mechanisms driving these deficits remain poorly understood. Here, we employed a rat model of repeated passive METH injections and evaluated attentional performance using the 5-choice serial reaction time task (5-CSRTT). Using single-nucleus RNA sequencing, immunofluorescence and in situ hybridization, we characterized the response of neurons in the reticulotegmental nucleus (RtTg) to METH exposure. Our results indicate that METH exposure disrupts RtTg neurons at the transcriptional level and results in an increased activation ratio of RtTg under 5-CSRTT conditions. Crucially, chemogenetic inactivation of these neurons or RtTg lesion attenuated METH-induced attention deficits, whereas their activation reproduced the deficits. These findings underscore the critical role of RtTg neurons in mediating METH-induced attention deficits, positioning RtTg as a promising therapeutic target for the treatment of attention deficits linked to chronic METH use.

Subliminal priming modulates motor sequence learning.

Sequential behaviour is underpinned by the selection and inhibition of movement at appropriate points in space and time. Sequences embedded among movement patterns must be learnt, yet the contribution of response selection and inhibition to the acquisition of motor sequences remains poorly understood. We addressed this issue by overlaying the serial reaction time task (SRTT) with subliminal masked primes that differentially weighed response tendencies. In Experiment 1, twenty-four healthy young adults, and in Experiment 2, thirty-six participants, performed the SRTT with congruent (same position), incongruent (different position), or neutral (no prime) subliminal masked primes. Each condition featured an embedded eight-digit (Experiment 1) or ten-digit (Experiment 2) second-order sequence, with conditions presented in counterbalanced order during a single session. Sequence specific learning was observed under neutral and congruent prime conditions. Independent of sequence awareness, congruent primes reduced initial response latency and led to greater sequence specific learning compared with neutral primes. However, incongruent primes appeared to attenuate learning (Experiment 1). These results demonstrate that prime congruency modulates sequence specific learning below the threshold of conscious awareness. Congruent primes may elevate the salience of stimulus-response compounds and accentuate learning, but at the cost of increased awareness. Incongruent primes, and the induction of response conflict, attenuate sequence specific learning (Experiment 1) and may prevent the formation of cross-temporal contingencies necessary for implicit motor sequence learning.

Optimization of Reclaiming–Loading Scheduling in Dry Bulk Terminals Based on Knowledge-Driven Memetic Algorithm

Reclaiming–loading operations in dry bulk terminals often face conflicts and delays due to limitations in equipment processing capacity and operational line accessibility, which significantly compromise the safety and efficiency of these operations. This paper aims to optimize the reclaiming–loading schedule for each incoming vessel by considering parallel equipment operations and potential conflicts, with the goal of enhancing both the safety and efficiency of the loading processes. Through a detailed analysis of bulk reclaiming and reclaiming–loading mechanisms, we formulate the dry bulk terminal loading scheduling problem to minimize the total operational time for all loading tasks, taking into account constraints such as parallel reclaiming, collaborative loading, operational conflicts, and line accessibility. In order to obtain a good solution, including task execution sequences and allocation of reclaimers and shiploaders, a knowledge-driven memetic algorithm is developed by integrating knowledge-driven mechanisms with problem-specific operators within a memetic computing framework. Finally, numerical experiments for various scales are conducted using the layout and operational data from the Huanghua Port’s coal port area. The experimental results demonstrate the effectiveness of the proposed optimization algorithm.

Environmental enrichment reduces adgrl3.1-Related anxiety and attention deficits but not impulsivity

Environmental factors play a role in the development and severity of neuropsychiatric disorders. Externalizing disorders are characterized by disruptive, impulsive, and often aggressive behaviors, including difficulties with self-control, rule-breaking, and a tendency to act out in ways that may harm oneself or others. Externalizing disorders frequently co-occur with internalizing disorders, such as anxiety. Individuals experiencing both externalizing/internalizing disorders are often among the most likely to seek healthcare services, as this co-occurrence is associated with more severe symptomatology and greater functional impairment. Here, we investigated the impact of environmental enrichment (EE) on adgrl3.1, a gene associated with impulsivity and attention deficits in zebrafish (Danio rerio). This gene encodes a receptor involved in cell adhesion and signaling and has been linked to susceptibility to externalizing disorders. Zebrafish were reared in either standard or enriched environments (from 15 days-post fertilization), and attention, impulsivity, and anxiety-related phenotypes were assessed at adult stages (4 months-post fertilization) using the open field test and a 5-choice serial reaction time task. EE mitigated anxiety-related behaviors in adgrl3.1 knockouts, normalizing locomotor patterns and decreasing thigmotaxis. Although attention deficits were reduced in adgrl3.1-/- fish reared in EE, impulsive behaviors were not. Together, these findings suggest that while environmental enrichment (EE) mitigates externalizing and internalizing symptoms in adgrl3.1 mutants, impulsivity remains less responsive to EE used in this study, indicating its distinct resistance to modulation.